Trafficking and surface expression of AMPA receptors.

Lead Research Organisation: University of Bristol
Department Name: Anatomy

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Ashby MC (2006) Lateral diffusion drives constitutive exchange of AMPA receptors at dendritic spines and is regulated by spine morphology. in The Journal of neuroscience : the official journal of the Society for Neuroscience

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Ashby MC (2004) Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs. in The Journal of neuroscience : the official journal of the Society for Neuroscience

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Braithwaite SP (2000) Interactions between AMPA receptors and intracellular proteins. in Neuropharmacology

 
Description BBSRC 3 year Grant (Protein interactions and posttranslational modification in the trafficking of neuronal kainate receptors)
Amount £1,000,000 (GBP)
Funding ID BB/F00723X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2008 
End 09/2011
 
Description EU 7th Framework Marie Curie Initial Training Grant
Amount £80,000 (GBP)
Funding ID Grant agreement no. 238608 
Organisation Marie Sklodowska-Curie Actions 
Sector Academic/University
Country Global
Start 10/2010 
End 09/2013
 
Description European Research Council - 'Mechanisms and consequences of synaptic SUMOylation in health and disease'
Amount £1,700,000 (GBP)
Funding ID 232881 
Organisation European Research Council (ERC) 
Sector Public
Country European Union (EU)
Start 03/2009 
End 02/2013
 
Description MRC Programme Grant (Mechanisms controlling the number and location of synaptic AMPARs)
Amount £1,600,000 (GBP)
Funding ID G0601810 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2008 
End 09/2013
 
Description Manipulating protein SUMOylation for neuroprotection in Parkinson's disease
Amount £64,711 (GBP)
Funding ID G-1605 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2017 
End 05/2018
 
Description Royal Society-Wolfson Merit Award
Amount £75,000 (GBP)
Funding ID WRSA09R2/HLL 
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start  
 
Title AMPAR subunit pHluorin cDNAs 
Description fluorophore tagged AMPAR subunits that allow real-time live cell imaging of receptor trafficking and surface expression 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact Multiple papers have been published by other groups using these reagents 
 
Title SEP-GluRs 
Description flourophore tagged proteins and mutant cDNA clones 
Type Of Material Technology assay or reagent 
Year Produced 2008 
Provided To Others? Yes  
Impact improved experimental design 
 
Description GSK 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Collaborators at GSK made hippocalcin specific antibodies to peptides we provided
Collaborator Contribution Antibody manufacture
Impact Neuron paper on role of hippocalcin in AMPAR trafficking
 
Description UCB 
Organisation UCB Pharma
Country United Kingdom 
Sector Private 
PI Contribution Work wholly in my lab. UCB funds student and provides occasional reagents.
Collaborator Contribution UCB funds a PhD student in my lab
Impact UCB funded PhD studentship - work ongoing
Start Year 2007
 
Description Media interviews 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Primary Audience Media (as a channel to the public)
Results and Impact Media interest in our results that we published in Nature.

e-mails and inquiries from general public
Year(s) Of Engagement Activity 2007
 
Description School Talks 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Talking to 6th form and FE college students about brain science in general and our research in particular

Avid interest and follow up comments from students. Repeated invitations to revisit same schools each year
Year(s) Of Engagement Activity 2006,2007,2008
 
Description Schools 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Presentations to 6th form and FE students

interaction and interest
Year(s) Of Engagement Activity 2006,2007,2008,2009