UCL Centre for Medical Molecular Virology
Lead Research Organisation:
University College London
Department Name: Immunology and Molecular Pathology
Abstract
Persistent viral disease is a significant problem in the UK. 30,000 people are estimated to be living with HIV-1, the virus that causes AIDS and 50,000 people are carriers of hepatitis B, which causes chronic liver disease. Viral infection also hampers advanced medical technologies, such as bone marrow or liver transplantation. This Centre proposal aims to link groups working on basic virus biology, the response of patients to viruses and the development of new viral diagnostics and treaments.
Technical Summary
The applicants aim to pursue their current peer-reviewed research programmes, with collaborations enhanced by the Medical Molecular Virology Centre.
Our efforts are focused on persistent, pathogenic, human viral disease and we study:
(i) Virus/cell interactions: identification and study of cellular pathways involved in viral infection and oncogenesis.
(ii) Virus/host interactions: identification and study of pathways involved in viral immunity and pathogenesis.
(iii) Translational research: learning facets of basic virology from clinical studies and applying basic knowledge from the above programmes to improve diagnosis and treatment.
Our efforts are focused on persistent, pathogenic, human viral disease and we study:
(i) Virus/cell interactions: identification and study of cellular pathways involved in viral infection and oncogenesis.
(ii) Virus/host interactions: identification and study of pathways involved in viral immunity and pathogenesis.
(iii) Translational research: learning facets of basic virology from clinical studies and applying basic knowledge from the above programmes to improve diagnosis and treatment.
Organisations
- University College London, United Kingdom (Collaboration, Lead Research Organisation)
- University of Oxford, United Kingdom (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- The Wellcome Trust Sanger Institute (Collaboration)
- International Centre for Genetic Engineering and Biotechnology (Collaboration)
- University of Massachusetts Lowell, United States (Collaboration)
- Biodim Laboratory (Collaboration)
- Medical Research Council (Collaboration)
- Imperial Cancer Research Fund (Collaboration)
- Whitehead Institute for Biomedical Research (Collaboration)
- Weizmann Institute of Science, Israel (Collaboration)
- University of Wuerzburg, Germany (Collaboration)
- Scripps Research Institute (Collaboration)
- Pasteur Institute, Paris (Collaboration)
- University of Nottingham (Collaboration)
- King's College London, United Kingdom (Collaboration)
Publications
Ageichik A
(2011)
Lentiviral vectors targeted to MHC II are effective in immunization.
in Human gene therapy
Ahsan F
(2018)
Preventing the N-terminal processing of human interferon a-2b and its chimeric derivatives expressed in Escherichia coli.
in Bioorganic chemistry
Alpizar YA
(2011)
Ten years of progress in vaccination against cancer: the need to counteract cancer evasion by dual targeting in future therapies.
in Cancer immunology, immunotherapy : CII
Anderson I
(2014)
Heat shock protein 90 controls HIV-1 reactivation from latency.
in Proceedings of the National Academy of Sciences of the United States of America
Aslett M
(2010)
TriTrypDB: a functional genomic resource for the Trypanosomatidae.
in Nucleic acids research
Berkhout B
(2013)
Obituary: Kuan-Teh Jeang.
in Retrovirology
Berkhout B
(2013)
Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: landmark HIV-1 research honoured.
in Retrovirology
Berry NJ
(2012)
Diversity of TRIM5a and TRIMCyp sequences in cynomolgus macaques from different geographical origins.
in Immunogenetics
| Description | 'Bench to Bedside' PhD programme (BENNY CHAIN) |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Newly established studentship scheme providing translational context for basic sceince PhDs in area of Infection & Immunity |
| Description | EMBO course (MARY COLLINS) |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Provided advancement of training in this area to postgraduate+ level audiences |
| Description | FSA-MRC joint workshop (BENNY CHAIN) |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Participant in owrkshop which promotes opportunities for synergy between basic immunology and food allergy research |
| Description | INSERM lentiviral vector course (MARY COLLINS) |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Provided advancement of training in this area to postgraduate+ level audiences |
| Description | Unilver sponsored workshop (BENNY CHAIN) |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Invited planer speaker for 'T-lymphocytes: Orcehstrators of skin sensitisation'. |
| Description | Biomedical Research Centre research grant (M COLLINS) |
| Amount | £140,888 (GBP) |
| Organisation | National Institute for Health Research |
| Department | UCLH/UCL Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | CBRC grant award CBRC grant Measuring T cell repertoire perturbation in HIV infection (B CHAIN) |
| Amount | £58,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | UCLH/UCL Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | CRUK research grant (M COLLINS) |
| Amount | £180,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | EMBO Long-Term Fellowship (R JENNER) |
| Amount | £50,711 (GBP) |
| Organisation | European Molecular Biology Organisation |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 09/2011 |
| End | 09/2013 |
| Description | EU FP7 HEALTH 2012 INNOVATION-1 (STAUSS) |
| Amount | € 6,000,000 (EUR) |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| End | 10/2015 |
| Description | LupusUK Consumables Fund (R JENNER)/LupusUK |
| Amount | £37,500 (GBP) |
| Organisation | LUPUS UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | PROJECT GRANT (BENNY CHAIN)/GATES FOUNDATION GRAND CHALLENGE GRANT |
| Amount | £50,000 (GBP) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | |
| Description | PhD Studentship - Khaled Sanber (M COLLINS) |
| Amount | £20,000 (GBP) |
| Organisation | University College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2011 |
| Description | PhD studentship (MARY COLLINS)/University College London |
| Amount | £25,000 (GBP) |
| Organisation | University College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2008 |
| End | 02/2009 |
| Description | Rosetrees: relationship between vitamin D deficiency and the immune response (B CHAIN) |
| Amount | £12,000 (GBP) |
| Organisation | Rosetrees Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | UCLH BRC Funding for Wolfson Gene Therapy Unit, 2013-2016 (M. Collins) |
| Amount | £520,000 (GBP) |
| Organisation | Hungarian Academy of Sciences (MTA) |
| Department | Biological Research Centre (BRC) |
| Sector | Academic/University |
| Country | Hungary |
| Start | 01/2013 |
| End | 01/2016 |
| Description | Wellcome Trust Project Grant (R JENNER) |
| Amount | £237,518 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Trust Senior Research Fellowship in basic biomedical science |
| Amount | £1,559,842 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2010 |
| End | 09/2015 |
| Title | Analysis pipeline for ChIP-Seq data (R JENNER) |
| Description | Analysis pipeline for ChIP-Seq data |
| Type Of Material | Data analysis technique |
| Provided To Others? | No |
| Impact | Aid the research of own and other groups in this field, useful resource tool |
| Title | Database short RNAs transcribed in CD4+ T-cells (R JENNER) |
| Description | Database short RNAs transcribed in CD4+ T-cells |
| Type Of Material | Database/Collection of Data/Biological Samples |
| Provided To Others? | No |
| Impact | Aid the research of own and other groups in this field, useful resource tool |
| Title | Mouse gene knockout cathepsin E (BENNY CHAIN) |
| Description | Mouse gene knockout of cathepsin E (aspartic proteinase involved in immune function) |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Provided To Others? | No |
| Impact | offers the opportunity for further studies of cathepsin E in vivo based on this mouse model |
| Description | Ari Fassati collaboration (R JENNER) |
| Organisation | University College London |
| Department | Division of Infection and Immunity |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | intellectual input into research |
| Collaborator Contribution | resulting in publication 20937817 |
| Impact | na |
| Start Year | 2011 |
| Description | Collaboration with Adrian Hill and Helen McShane Oxford supported by UCL CBRC grant (COLLINS) |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Lentiviral vectors |
| Collaborator Contribution | Novel adjuvant molecules, TB antigens and models |
| Impact | in progress |
| Start Year | 2011 |
| Description | Dennis Burton Lab Visit (MCCOY) |
| Organisation | Scripps Research Institute |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | This travel grant was used to accelerate a HIV antigen development project |
| Collaborator Contribution | This travel grant was used to accelerate a HIV antigen development project |
| Impact | not known yet |
| Start Year | 2013 |
| Description | Discovery of new cellular targets for antiretroviral drug development (FASSATI) |
| Organisation | Biodim Laboratory |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Developed a novel cell-based, high through put screening assay. Discovered a new cell target important for HIV-1 infection. |
| Collaborator Contribution | Provided chemical library of 10,000 compounds to perform screening and cherry picked compounds. |
| Impact | Eleven new hits identified to be followed up |
| Start Year | 2012 |
| Description | Discovery of new cellular targets for antiretroviral drug development (FASSATI) |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | Developed a novel high through put screening, cell-based assay. Discovered a new cell target important for HIV |
| Collaborator Contribution | Provided novel lead compounds that inhibit the target identified in our high through put screening |
| Impact | in the process of testing the compounds |
| Start Year | 2013 |
| Description | Dr Marcus Dorner, Imperial College |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided data and expertise on the effect of Hsp90 on regulation of HIV-1 latency, provided specific Hsp90 inhibitor. |
| Collaborator Contribution | Humanized mouse models for HIV-1 infection to test the effect of selective Hsp90 inhbitors on HIV-1 latency. |
| Impact | experiments ongoing |
| Start Year | 2014 |
| Description | Dr Peter Cherepanov, CRUK |
| Organisation | Cancer Research UK |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | provision of expression constructs recomninat protein expression and methods for immunoprecipitation. Expertise on nuclear transport receptors. |
| Collaborator Contribution | Structural biology of transportin 3. |
| Impact | One paper in PNAS |
| Start Year | 2010 |
| Description | Dr Richard Benarous, Mutabilis, France |
| Organisation | University College London |
| Department | Metbolism and Endocrinology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Performed novel high through put screening to identify host factos necessary for HIV-1 replication. |
| Collaborator Contribution | Provided expertise and library of 10,000 small chemical compounds selected from a 150,000 compounds library. |
| Impact | Identified four new compounds with antiretroviral activity: they belong to a new class of antiretrovirals . |
| Start Year | 2012 |
| Description | Dr. Ian Taylor, MRC NIMR, Mill Hill (FASSATI) |
| Organisation | Medical Research Council (MRC) |
| Department | MRC National Institute for Medical Research (NIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided data and expertise on the role of the antibiotic Coumermycin-A1 in blocking HIV-1 replication |
| Collaborator Contribution | co-crystal structure of Coumermycin-A1 and HIV-1 capsid protein |
| Impact | one paper in preparation |
| Start Year | 2012 |
| Description | Hsp90 controls HIV-1 reactivation from latency (FASSATI) |
| Organisation | International Centre for Genetic Engineering and Biotechnology |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Discovered that Hsp90 is required for HIV-1 gene expression and reactivation from latency, described the pathway involved. |
| Collaborator Contribution | Discovered that hyperthermia stimulates HIV-1 replication and reactivation. Contributed imaging methods to visualise nuclear migration of Hsp90 and other components. |
| Impact | One paper in PLoS Path (2012), one invited review in Parasitology (to be submitted shortly), one manuscript submitted and one MRC grant application submitted in September 2013. |
| Start Year | 2011 |
| Description | Hsp90 controls HIV-1 reactivation from latency (FASSATI) |
| Organisation | Pasteur Institute, Paris |
| Country | France |
| Sector | Charity/Non Profit |
| PI Contribution | Discovered that Hsp90 is required for HIV-1 gene expression and reactivation from latency, described the pathway involved. |
| Collaborator Contribution | Discovered that hyperthermia stimulates HIV-1 replication and reactivation. Contributed imaging methods to visualise nuclear migration of Hsp90 and other components. |
| Impact | One paper in PLoS Path (2012), one invited review in Parasitology (to be submitted shortly), one manuscript submitted and one MRC grant application submitted in September 2013. |
| Start Year | 2011 |
| Description | Hsp90 controls HIV-1 reactivation from latency (FASSATI) |
| Organisation | University College London |
| Department | Division of Biosciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Discovered that Hsp90 is required for HIV-1 gene expression and reactivation from latency, described the pathway involved. |
| Collaborator Contribution | Discovered that hyperthermia stimulates HIV-1 replication and reactivation. Contributed imaging methods to visualise nuclear migration of Hsp90 and other components. |
| Impact | One paper in PLoS Path (2012), one invited review in Parasitology (to be submitted shortly), one manuscript submitted and one MRC grant application submitted in September 2013. |
| Start Year | 2011 |
| Description | KCL Paul Lavender (R JENNER) |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Collaborator Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Impact | resulting in publication 21876034 |
| Start Year | 2010 |
| Description | Llama VHHantobody fragments to neutralise viruses (WEISS) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | virology |
| Collaborator Contribution | VHH technology |
| Impact | Research papers and 1 patent filed |
| Start Year | 2006 |
| Description | London Centre for Nanotechnology (A FASSATI) |
| Organisation | University College London |
| Department | London Centre for Nanotechnology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with the London Centre for Nanotechnology (Bart Hoogemboom and Ian Ford), which resulted in a shared IMPACT PhD studentship for Dino Osmanovic |
| Impact | a shared IMPACT PhD studentship for Dino Osmanovic |
| Start Year | 2011 |
| Description | MRC Clinical Sciences Centre (R JENNER) |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Clinical Sciences Centre (CSC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Collaborator Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Impact | In progress |
| Start Year | 2010 |
| Description | Mechanism of viral transport across nuclear pores (FASSATI) |
| Organisation | University College London |
| Department | London Centre for Nanotechnology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise on nucleo-cytoplasmic trafficking of viruses and large molecules. |
| Collaborator Contribution | Atomic force microscopy and physical modelling of nuclear pores. |
| Impact | One modelling paper (Phys. Rev. E. 2012), one review (Soft Matter 2013), one paper to be submitted shortly. |
| Start Year | 2011 |
| Description | National Facility for GMP production of lentiviral and AAV vectors for gene therapy (MARY COLLINS) |
| Organisation | University College London |
| Department | UCL Cancer Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Collaborator Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Impact | in progress (publications) |
| Start Year | 2009 |
| Description | Novel broadly neutralizing Llama VHH (FASSATI) |
| Organisation | University College London |
| Department | Division of Infection and Immunity |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Developed and performed high through put screening to identify novel broadly neutralizing LLama VHH, identified three new VHH. |
| Collaborator Contribution | Characterised VHH, area of binding, performed deep sequencing to demonstrate that novel VHH arised after immunization. |
| Impact | One paper to be submitted shortly. |
| Start Year | 2012 |
| Description | Population dynamics of T cell responses analysed using high-throughput sequencing of TCR repertoire (CHAIN) |
| Organisation | Weizmann Institute of Science |
| Country | Israel |
| Sector | Academic/University |
| PI Contribution | Developemnt of software for seqeunce analysis. |
| Collaborator Contribution | Immunisations and seqeuncing |
| Impact | Still in progress |
| Start Year | 2011 |
| Description | Prof. Olivier Schwartz, Pasteur Institute, Paris (FASSATI) |
| Organisation | Pasteur Institute, Paris |
| Country | France |
| Sector | Charity/Non Profit |
| PI Contribution | Provided data and expertise on the role of Hsp90 in HIV-1 infection |
| Collaborator Contribution | Provided data and expertise on mechanisms contributing to enhanced HIV-1 replication during hyperthermia (fever) |
| Impact | One paper in PLoS Pathogens describing the effect of fever on HIV-1 replication and the role of Hsp90 |
| Start Year | 2011 |
| Description | Professor Benny Chain, UCL and MRC Centre |
| Organisation | University College London |
| Department | MRC Centre for Medical Molecular Virology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided data and expertise on nuclear import of DNA. |
| Collaborator Contribution | Provided data and expertise on biophysical properties of transfected DNA and on innate Immunity. |
| Impact | One MSc Thesis (Tse Wang) and one paper published in the journal Traffic |
| Start Year | 2011 |
| Description | Professor Charles Bangham, Imperial College |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Discovered new host factor involved in HIV-1 replication that affects integration site selection. |
| Collaborator Contribution | High through put sequencing of HIV-1 integration sites. |
| Impact | One paper in preparation, one grant application submitted to MRC. |
| Start Year | 2012 |
| Description | Professor Christopher Moody and Dr Russell Kitson, University of Nottingham |
| Organisation | University of Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided data and expertise on the role of Hsp90 in HIV-1 latency. |
| Collaborator Contribution | Provided new chemical compounds inhibitors of Hsp90 |
| Impact | One paper in PNAS |
| Start Year | 2012 |
| Description | Professor Mike Stratton and Dr Elisabeth Murchison, Wellcome Trust Sanger Institute |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Provided data and expertise on the canine Venereal Transmissible Tumour (CTVT). |
| Collaborator Contribution | Provided data and expertise on the genome of CTVT |
| Impact | A paper describing the CTVT genome published in Science, another publication on the tumour transcriptional changes is in preparation. |
| Start Year | 2010 |
| Description | Professor Olivier Schwartz, Pasteur Institute, Paris |
| Organisation | Pasteur Institute, Paris |
| Country | France |
| Sector | Charity/Non Profit |
| PI Contribution | Provided data and expertise on the role of Hsp90 in HIV-1 infection. |
| Collaborator Contribution | Provided data and expertise on mechanisms contributing to enhanced HIV-1 replication during hyperthermia (fever). |
| Impact | One paper in PLoS Pathogens describing the effect of fever on HIV-1 replication and the role of Hsp90 |
| Start Year | 2011 |
| Description | Raymond Welsh Lab Visit (PEPPA) |
| Organisation | University of Massachusetts |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | address how T cell regulation by NK cells contribute to overall disease pathogenesis |
| Collaborator Contribution | development of valuable collaboration, also link with a planned project on regulatory potential of NK cells in HBV with the MRC unit in the Gambia |
| Impact | not yet known |
| Start Year | 2013 |
| Description | Restriction Factor Structure Function |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Laboratory of Molecular Biology (LMB) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have characterised host restriction factor relationships and evolution by collaborating with Leo James at the laboratory for Molecular Biology. Leo solves structures and performs biophysical measurements of protein/protein interactions and we characterise and assay mutant behavior thereby learning mechanistic molecular details of action and evolution. |
| Collaborator Contribution | The James lab has solved crystal structures of restriction factors and viral proteins and performed many biophysical and chemistry experiments allowing us to understand the mechanistic details of restriction factor virus interactions. |
| Impact | We have copublished PMIDs 21045130, 20808866, 19767750, 19073742 Collaboration is multidiciplinary in that we are molecular virologists and James is a biophysicist and protein crystallographer |
| Start Year | 2007 |
| Description | Super-resolution imaging: probe development (GROVE) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project conception, development and application |
| Collaborator Contribution | Project conception, development and application |
| Impact | not yet known |
| Start Year | 2013 |
| Description | UCL Dept Medicine (R JENNER) |
| Organisation | University College London |
| Department | Division of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Collaborator Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Impact | In progress |
| Start Year | 2010 |
| Description | UCL Paul Kellam (R JENNER) |
| Organisation | University College London |
| Department | Division of Infection and Immunity |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Paul Kellam resulting in a project grant from the UCLH/UCL Comprehensive Biomedical Research Centre. |
| Impact | awarded a grant of £99,940, outcomes (published material etc) yet to be recorded. |
| Start Year | 2011 |
| Description | Understanding the coordination of hepatitis C virus entry and humoral immune evasion (GROVE) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project conception, development and application |
| Collaborator Contribution | Access to clinical samples |
| Impact | not yet known |
| Start Year | 2013 |
| Description | Veronique Birault, GSK, Stevenage. |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | Provided data on a new host factor to be used as an antiretroviral target. |
| Collaborator Contribution | Provided lead compounds that target the new host factor discovered by us. |
| Impact | In the process of performing SAR studies with GSK compounds |
| Start Year | 2013 |
| Description | WESTON VISITING PROFESSORSHIP (BENNY CHAIN) |
| Organisation | Weizmann Institute of Science |
| Country | Israel |
| Sector | Academic/University |
| PI Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Collaborator Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Impact | Led to award of a bilateral Weizmann/UCL grant (Making Connections programme) $100,000 over two years. |
| Start Year | 2009 |
| Description | Wellcome Trust Sanger Centre collaboration (DAN DEPLEDGE) |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Shared knowledge, materials and resources leading to publication output (in progress) |
| Collaborator Contribution | Shared knowledge, materials and resources leading to publication output (in progress) |
| Impact | In progress |
| Start Year | 2010 |
| Description | Whitehead Inst Biomed Res (R JENNER) |
| Organisation | Whitehead Institute for Biomedical Research |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Collaborator Contribution | shared knowledge, materials & equipment leading to increased publication output |
| Impact | In progress |
| Start Year | 2010 |
| Description | Wuerzburg Collaboration (STAUSS) |
| Organisation | University of Wurzburg |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | TBA |
| Collaborator Contribution | TBA |
| Impact | TBA |
| Start Year | 2009 |
| Title | patent application # 1015305.4 (R JENNER) |
| Description | NA |
| IP Reference | GB1015305.4 |
| Protection | Patent application published |
| Year Protection Granted | 2010 |
| Licensed | Commercial In Confidence |
| Impact | NA |
| Description | Carolton Primary School Visit 2012 (TOWERS/MILNE) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 40 local school children attended open day in the Centre labs; consisted of interactive introductory talk, followed by lab rotations where pupils preformed DNA extractions, microscope work, pipetting skills, artwork. Pupils asked many questions and the Centre received thank you letters expressing their increases interest in science and had a unique opportunity to do real lab-based tasks. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Contribution to the Financial Times "New synthetic life needs context and regulation"(A. Fassati) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | to be added |
| Year(s) Of Engagement Activity | 2010 |
| URL | http://www.ft.com/cms/s/0/3da6db20-6796-11df-a932-00144feab49a.html#axzz2hsOEkNfY |
| Description | HIV & AIDS (WEISS) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | too soon to say |
| Year(s) Of Engagement Activity | 2013 |
| Description | Institute of Arts talk (M COLLINS) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | presented talk titled 'Are Women Changing Science?' na |
| Year(s) Of Engagement Activity | 2011 |
| Description | Institute of Immunity and Transplantation Opening Symposium (GROVE) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The symposium was filmed and I worked with a video editor to create a digital version of the presentation for You Tube |
| Year(s) Of Engagement Activity | 2013 |
| Description | Lecture "Conscience and values in the response to infectious diseases", Thomas More Institute, London. (A. Fassati) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | to be added |
| Year(s) Of Engagement Activity | 2011 |
| URL | http://thomasmoreinstitute.org.uk/papers/conscience-and-values-in-the-response-toinfectious-diseases... |
| Description | Lecture on the AIDS epidemic for the charity "Mothers to Mothers" London. (A. Fassati) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | to be added |
| Year(s) Of Engagement Activity | 2011 |
| URL | http://www.m2m.org |
| Description | Lecture to Y6 children "Investigating microbes" at the Oratory RC Primary School, London. (A. Fassati) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | to be added |
| Year(s) Of Engagement Activity | 2014 |
| Description | Lecture: City of London Boyrs School (B CHAIN) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | 50+ pupils attended a lecture titled 'vaccinations' na |
| Year(s) Of Engagement Activity | 2011 |
| Description | Live comment on the origin of the AIDS epidemic on Arise News (A. Fassati) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | to be added |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.arise.tv/arise-news-show/africa-wrap-03-10-8501 |
| Description | Lunchtime Lecture UCL (COLLINS) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | 800 You tube hits |
| Year(s) Of Engagement Activity | 2012 |
| Description | MRC@UCL Centenary Science Fair (ALL MEMBERS) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 500+ members of the public (families, adults, school children) attended a science fair held @ UCL, Centre members contributed 3 hands-on workshop stalls, and presented separate talks. The public were given opportunities to perform tasks associated with the work of the Centre, and asked questions/contributed to discussions about what the Centre does and general science queries. Feedback included saying children had increased interest in developing their science education and awareness of virology principles. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Mayflower & Gayhurst Primary School visits 2013 (TOWERS/MILNE) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Centre members visited local schools and presented an interactive talk about virology. Pupils asked many questions and the Centre received thank you letters expressing their increases interest in science and had a unique opportunity to do real lab-based tasks. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Mayflower & Gayhurst Primary schools visits 2012 (TOWERS/MILNE) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Centre members visited local schools and presented an interactive talk about virology. Pupils asked many questions and the Centre received thank you letters expressing their increases interest in science and had a unique opportunity to do real lab-based tasks. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Observer Interview (M COLLINS) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | "My Bright Idea"- Interview for The Observer, 24/4/11 na |
| Year(s) Of Engagement Activity | 2011 |
| Description | Public lecture (STAUSS) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Approximately 200 lay people attended lecture on T Cell therapy Lecture was recorded and is available on You-tube |
| Year(s) Of Engagement Activity | 2012 |
| Description | School Visit Primrose Hill (STAUSS) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Parents attended a presentation of our research and all children attended an assembly money raised for cancer research |
| Year(s) Of Engagement Activity | 2012 |
| Description | School visit (x2), 2011 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | R Milne & G Towers visited 2 primary schools (Gayhurst and Mayflower), various activities for 50+ pupils received many thank you letters and further questions from pupils |
| Year(s) Of Engagement Activity | 2011 |
| Description | School visit, London (3 visits) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | 50+ 6th form Biology students attended a talk given by Prof Mary Collins on both Virology and science careers. Provided further insights to virology and encouraged studetns further in choosing scientific careers |
| Year(s) Of Engagement Activity | 2010 |
| Description | Social Mobility Foundation Students (G TOWERS) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | We took 2 students for a week each in August. The idea is that students from poor backgrounds who wouldnt normally be exposed to opportunities for work experience can be helped out. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Talk in Bloomsbury Festival (M COLLINS) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Cosy Science, "viruses are our friends", The Marquis of Cornwallis pub, 2013 for 50+ local residents raised public awareness |
| Year(s) Of Engagement Activity | 2013 |
| Description | Thomas More Institute talk (A FASSATI) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | presented talk titled 'Conscience and Values in the Response to Infectious Diseases' given to 50+ adult members of the public na |
| Year(s) Of Engagement Activity | 2011 |
| Description | Work experience pupils (x4) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | high school students attending 1 week work experience placements in various member's labs; shadowing staff and performing experiments Provided further encouragement to take further study/career directions in virology or biomedical sciences |
| Year(s) Of Engagement Activity | 2010,2011 |
| Description | mothers2mothers charity talk (A FASSATI) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | presented talk titled 'The Current AIDS Epidemic' to 25+ members of the adult public all proceeds to mothers2mothers charity |
| Year(s) Of Engagement Activity | 2011 |