UCL Centre for Medical Molecular Virology

Lead Research Organisation: University College London
Department Name: Immunology and Molecular Pathology

Abstract

Persistent viral disease is a significant problem in the UK. 30,000 people are estimated to be living with HIV-1, the virus that causes AIDS and 50,000 people are carriers of hepatitis B, which causes chronic liver disease. Viral infection also hampers advanced medical technologies, such as bone marrow or liver transplantation. This Centre proposal aims to link groups working on basic virus biology, the response of patients to viruses and the development of new viral diagnostics and treaments.

Technical Summary

The applicants aim to pursue their current peer-reviewed research programmes, with collaborations enhanced by the Medical Molecular Virology Centre.
Our efforts are focused on persistent, pathogenic, human viral disease and we study:
(i) Virus/cell interactions: identification and study of cellular pathways involved in viral infection and oncogenesis.
(ii) Virus/host interactions: identification and study of pathways involved in viral immunity and pathogenesis.
(iii) Translational research: learning facets of basic virology from clinical studies and applying basic knowledge from the above programmes to improve diagnosis and treatment.

Publications

10 25 50
 
Description 'Bench to Bedside' PhD programme (BENNY CHAIN)
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Newly established studentship scheme providing translational context for basic sceince PhDs in area of Infection & Immunity
 
Description EMBO course (MARY COLLINS)
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Provided advancement of training in this area to postgraduate+ level audiences
 
Description FSA-MRC joint workshop (BENNY CHAIN)
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Participant in owrkshop which promotes opportunities for synergy between basic immunology and food allergy research
 
Description INSERM lentiviral vector course (MARY COLLINS)
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Provided advancement of training in this area to postgraduate+ level audiences
 
Description Member of DH Gene and Stem Cell therapy advisory committee (MARY COLLINS)
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact Provides advice on policy and safety at national level
 
Description Member sub-panel 1, REF (M COLLINS)
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact contribution to determining research standards of national institutes
 
Description SAB CIRI, Lyon (M COLLINS)
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
Impact improved research practices at CIRI
 
Description SAB Heinrich Pette Institute (M COLLINS)
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
Impact improved research practices at the Institute
 
Description Unilver sponsored workshop (BENNY CHAIN)
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Invited planer speaker for 'T-lymphocytes: Orcehstrators of skin sensitisation'.
 
Description Biomedical Research Centre research grant (M COLLINS)
Amount £140,888 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Public
Country United Kingdom
Start  
 
Description CBRC grant award CBRC grant Measuring T cell repertoire perturbation in HIV infection (B CHAIN)
Amount £58,000 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Public
Country United Kingdom
Start  
 
Description CRUK research grant (M COLLINS)
Amount £180,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description EMBO Long-Term Fellowship (R JENNER)
Amount £50,711 (GBP)
Organisation European Molecular Biology Organisation 
Sector Learned Society
Country European Union (EU)
Start 10/2011 
End 09/2013
 
Description EU FP7 HEALTH 2012 INNOVATION-1 (STAUSS)
Amount € 6,000,000 (EUR)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
End 10/2015
 
Description LupusUK Consumables Fund (R JENNER)/LupusUK
Amount £37,500 (GBP)
Organisation LUPUS UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description PROJECT GRANT (BENNY CHAIN)/GATES FOUNDATION GRAND CHALLENGE GRANT
Amount £50,000 (GBP)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start  
 
Description PhD Studentship - Khaled Sanber (M COLLINS)
Amount £20,000 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start 09/2011 
 
Description PhD studentship (MARY COLLINS)/University College London
Amount £25,000 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start 01/2008 
End 02/2009
 
Description Rosetrees: relationship between vitamin D deficiency and the immune response (B CHAIN)
Amount £12,000 (GBP)
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description UCLH BRC Funding for Wolfson Gene Therapy Unit, 2013-2016 (M. Collins)
Amount £520,000 (GBP)
Organisation Hungarian Academy of Sciences (MTA) 
Department Biological Research Centre (BRC)
Sector Academic/University
Country Hungary
Start 01/2013 
End 01/2016
 
Description Wellcome Trust Project Grant (R JENNER)
Amount £237,518 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust Senior Research Fellowship in basic biomedical science
Amount £1,559,842 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2010 
End 09/2015
 
Title Analysis pipeline for ChIP-Seq data (R JENNER) 
Description Analysis pipeline for ChIP-Seq data 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact Aid the research of own and other groups in this field, useful resource tool 
 
Title Database short RNAs transcribed in CD4+ T-cells (R JENNER) 
Description Database short RNAs transcribed in CD4+ T-cells 
Type Of Material Database/Collection of Data/Biological Samples 
Provided To Others? No  
Impact Aid the research of own and other groups in this field, useful resource tool 
 
Title Mouse gene knockout cathepsin E (BENNY CHAIN) 
Description Mouse gene knockout of cathepsin E (aspartic proteinase involved in immune function) 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Provided To Others? No  
Impact offers the opportunity for further studies of cathepsin E in vivo based on this mouse model 
 
Description Ari Fassati collaboration (R JENNER) 
Organisation University College London
Department Division of Infection and Immunity
Country United Kingdom 
Sector Academic/University 
PI Contribution intellectual input into research
Collaborator Contribution resulting in publication 20937817
Impact na
Start Year 2011
 
Description Collaboration with Adrian Hill and Helen McShane Oxford supported by UCL CBRC grant (COLLINS) 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Lentiviral vectors
Collaborator Contribution Novel adjuvant molecules, TB antigens and models
Impact in progress
Start Year 2011
 
Description Dennis Burton Lab Visit (MCCOY) 
Organisation Scripps Research Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution This travel grant was used to accelerate a HIV antigen development project
Collaborator Contribution This travel grant was used to accelerate a HIV antigen development project
Impact not known yet
Start Year 2013
 
Description Discovery of new cellular targets for antiretroviral drug development (FASSATI) 
Organisation Biodim Laboratory
Country France 
Sector Private 
PI Contribution Developed a novel cell-based, high through put screening assay. Discovered a new cell target important for HIV-1 infection.
Collaborator Contribution Provided chemical library of 10,000 compounds to perform screening and cherry picked compounds.
Impact Eleven new hits identified to be followed up
Start Year 2012
 
Description Discovery of new cellular targets for antiretroviral drug development (FASSATI) 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Developed a novel high through put screening, cell-based assay. Discovered a new cell target important for HIV
Collaborator Contribution Provided novel lead compounds that inhibit the target identified in our high through put screening
Impact in the process of testing the compounds
Start Year 2013
 
Description Dr Marcus Dorner, Imperial College 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided data and expertise on the effect of Hsp90 on regulation of HIV-1 latency, provided specific Hsp90 inhibitor.
Collaborator Contribution Humanized mouse models for HIV-1 infection to test the effect of selective Hsp90 inhbitors on HIV-1 latency.
Impact experiments ongoing
Start Year 2014
 
Description Dr Peter Cherepanov, CRUK 
Organisation Cancer Research UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution provision of expression constructs recomninat protein expression and methods for immunoprecipitation. Expertise on nuclear transport receptors.
Collaborator Contribution Structural biology of transportin 3.
Impact One paper in PNAS
Start Year 2010
 
Description Dr Richard Benarous, Mutabilis, France 
Organisation University College London
Department Metbolism and Endocrinology
Country United Kingdom 
Sector Academic/University 
PI Contribution Performed novel high through put screening to identify host factos necessary for HIV-1 replication.
Collaborator Contribution Provided expertise and library of 10,000 small chemical compounds selected from a 150,000 compounds library.
Impact Identified four new compounds with antiretroviral activity: they belong to a new class of antiretrovirals .
Start Year 2012
 
Description Dr. Ian Taylor, MRC NIMR, Mill Hill (FASSATI) 
Organisation Medical Research Council (MRC)
Department MRC National Institute for Medical Research (NIMR)
Country United Kingdom 
Sector Public 
PI Contribution Provided data and expertise on the role of the antibiotic Coumermycin-A1 in blocking HIV-1 replication
Collaborator Contribution co-crystal structure of Coumermycin-A1 and HIV-1 capsid protein
Impact one paper in preparation
Start Year 2012
 
Description Hsp90 controls HIV-1 reactivation from latency (FASSATI) 
Organisation International Centre for Genetic Engineering and Biotechnology
Country Italy 
Sector Charity/Non Profit 
PI Contribution Discovered that Hsp90 is required for HIV-1 gene expression and reactivation from latency, described the pathway involved.
Collaborator Contribution Discovered that hyperthermia stimulates HIV-1 replication and reactivation. Contributed imaging methods to visualise nuclear migration of Hsp90 and other components.
Impact One paper in PLoS Path (2012), one invited review in Parasitology (to be submitted shortly), one manuscript submitted and one MRC grant application submitted in September 2013.
Start Year 2011
 
Description Hsp90 controls HIV-1 reactivation from latency (FASSATI) 
Organisation Pasteur Institute, Paris
Country France 
Sector Academic/University 
PI Contribution Discovered that Hsp90 is required for HIV-1 gene expression and reactivation from latency, described the pathway involved.
Collaborator Contribution Discovered that hyperthermia stimulates HIV-1 replication and reactivation. Contributed imaging methods to visualise nuclear migration of Hsp90 and other components.
Impact One paper in PLoS Path (2012), one invited review in Parasitology (to be submitted shortly), one manuscript submitted and one MRC grant application submitted in September 2013.
Start Year 2011
 
Description Hsp90 controls HIV-1 reactivation from latency (FASSATI) 
Organisation University College London
Department Division of Biosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Discovered that Hsp90 is required for HIV-1 gene expression and reactivation from latency, described the pathway involved.
Collaborator Contribution Discovered that hyperthermia stimulates HIV-1 replication and reactivation. Contributed imaging methods to visualise nuclear migration of Hsp90 and other components.
Impact One paper in PLoS Path (2012), one invited review in Parasitology (to be submitted shortly), one manuscript submitted and one MRC grant application submitted in September 2013.
Start Year 2011
 
Description KCL Paul Lavender (R JENNER) 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution shared knowledge, materials & equipment leading to increased publication output
Collaborator Contribution shared knowledge, materials & equipment leading to increased publication output
Impact resulting in publication 21876034
Start Year 2010
 
Description Llama VHHantobody fragments to neutralise viruses (WEISS) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution virology
Collaborator Contribution VHH technology
Impact Research papers and 1 patent filed
Start Year 2006
 
Description London Centre for Nanotechnology (A FASSATI) 
Organisation University College London
Department London Centre for Nanotechnology
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration with the London Centre for Nanotechnology (Bart Hoogemboom and Ian Ford), which resulted in a shared IMPACT PhD studentship for Dino Osmanovic
Impact a shared IMPACT PhD studentship for Dino Osmanovic
Start Year 2011
 
Description MRC Clinical Sciences Centre (R JENNER) 
Organisation Medical Research Council (MRC)
Department MRC Clinical Sciences Centre (CSC)
Country United Kingdom 
Sector Academic/University 
PI Contribution shared knowledge, materials & equipment leading to increased publication output
Collaborator Contribution shared knowledge, materials & equipment leading to increased publication output
Impact In progress
Start Year 2010
 
Description Mechanism of viral transport across nuclear pores (FASSATI) 
Organisation University College London
Department London Centre for Nanotechnology
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise on nucleo-cytoplasmic trafficking of viruses and large molecules.
Collaborator Contribution Atomic force microscopy and physical modelling of nuclear pores.
Impact One modelling paper (Phys. Rev. E. 2012), one review (Soft Matter 2013), one paper to be submitted shortly.
Start Year 2011
 
Description National Facility for GMP production of lentiviral and AAV vectors for gene therapy (MARY COLLINS) 
Organisation University College London
Department UCL Cancer Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution shared knowledge, materials & equipment leading to increased publication output
Collaborator Contribution shared knowledge, materials & equipment leading to increased publication output
Impact in progress (publications)
Start Year 2009
 
Description Novel broadly neutralizing Llama VHH (FASSATI) 
Organisation University College London
Department Division of Infection and Immunity
Country United Kingdom 
Sector Academic/University 
PI Contribution Developed and performed high through put screening to identify novel broadly neutralizing LLama VHH, identified three new VHH.
Collaborator Contribution Characterised VHH, area of binding, performed deep sequencing to demonstrate that novel VHH arised after immunization.
Impact One paper to be submitted shortly.
Start Year 2012
 
Description Population dynamics of T cell responses analysed using high-throughput sequencing of TCR repertoire (CHAIN) 
Organisation Weizmann Institute of Science
Country Israel 
Sector Academic/University 
PI Contribution Developemnt of software for seqeunce analysis.
Collaborator Contribution Immunisations and seqeuncing
Impact Still in progress
Start Year 2011
 
Description Prof. Olivier Schwartz, Pasteur Institute, Paris (FASSATI) 
Organisation Pasteur Institute, Paris
Country France 
Sector Academic/University 
PI Contribution Provided data and expertise on the role of Hsp90 in HIV-1 infection
Collaborator Contribution Provided data and expertise on mechanisms contributing to enhanced HIV-1 replication during hyperthermia (fever)
Impact One paper in PLoS Pathogens describing the effect of fever on HIV-1 replication and the role of Hsp90
Start Year 2011
 
Description Professor Benny Chain, UCL and MRC Centre 
Organisation University College London
Department MRC Centre for Medical Molecular Virology
Country United Kingdom 
Sector Public 
PI Contribution Provided data and expertise on nuclear import of DNA.
Collaborator Contribution Provided data and expertise on biophysical properties of transfected DNA and on innate Immunity.
Impact One MSc Thesis (Tse Wang) and one paper published in the journal Traffic
Start Year 2011
 
Description Professor Charles Bangham, Imperial College 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Discovered new host factor involved in HIV-1 replication that affects integration site selection.
Collaborator Contribution High through put sequencing of HIV-1 integration sites.
Impact One paper in preparation, one grant application submitted to MRC.
Start Year 2012
 
Description Professor Christopher Moody and Dr Russell Kitson, University of Nottingham 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided data and expertise on the role of Hsp90 in HIV-1 latency.
Collaborator Contribution Provided new chemical compounds inhibitors of Hsp90
Impact One paper in PNAS
Start Year 2012
 
Description Professor Mike Stratton and Dr Elisabeth Murchison, Wellcome Trust Sanger Institute 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Provided data and expertise on the canine Venereal Transmissible Tumour (CTVT).
Collaborator Contribution Provided data and expertise on the genome of CTVT
Impact A paper describing the CTVT genome published in Science, another publication on the tumour transcriptional changes is in preparation.
Start Year 2010
 
Description Professor Olivier Schwartz, Pasteur Institute, Paris 
Organisation Pasteur Institute, Paris
Country France 
Sector Academic/University 
PI Contribution Provided data and expertise on the role of Hsp90 in HIV-1 infection.
Collaborator Contribution Provided data and expertise on mechanisms contributing to enhanced HIV-1 replication during hyperthermia (fever).
Impact One paper in PLoS Pathogens describing the effect of fever on HIV-1 replication and the role of Hsp90
Start Year 2011
 
Description Raymond Welsh Lab Visit (PEPPA) 
Organisation University of Massachusetts
Country United States 
Sector Academic/University 
PI Contribution address how T cell regulation by NK cells contribute to overall disease pathogenesis
Collaborator Contribution development of valuable collaboration, also link with a planned project on regulatory potential of NK cells in HBV with the MRC unit in the Gambia
Impact not yet known
Start Year 2013
 
Description Restriction Factor Structure Function 
Organisation Medical Research Council (MRC)
Department MRC Laboratory of Molecular Biology (LMB)
Country United Kingdom 
Sector Public 
PI Contribution We have characterised host restriction factor relationships and evolution by collaborating with Leo James at the laboratory for Molecular Biology. Leo solves structures and performs biophysical measurements of protein/protein interactions and we characterise and assay mutant behavior thereby learning mechanistic molecular details of action and evolution.
Collaborator Contribution The James lab has solved crystal structures of restriction factors and viral proteins and performed many biophysical and chemistry experiments allowing us to understand the mechanistic details of restriction factor virus interactions.
Impact We have copublished PMIDs 21045130, 20808866, 19767750, 19073742 Collaboration is multidiciplinary in that we are molecular virologists and James is a biophysicist and protein crystallographer
Start Year 2007
 
Description Super-resolution imaging: probe development (GROVE) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Project conception, development and application
Collaborator Contribution Project conception, development and application
Impact not yet known
Start Year 2013
 
Description UCL Dept Medicine (R JENNER) 
Organisation University College London
Department Division of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution shared knowledge, materials & equipment leading to increased publication output
Collaborator Contribution shared knowledge, materials & equipment leading to increased publication output
Impact In progress
Start Year 2010
 
Description UCL Paul Kellam (R JENNER) 
Organisation University College London
Department Division of Infection and Immunity
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration with Paul Kellam resulting in a project grant from the UCLH/UCL Comprehensive Biomedical Research Centre.
Impact awarded a grant of £99,940, outcomes (published material etc) yet to be recorded.
Start Year 2011
 
Description Understanding the coordination of hepatitis C virus entry and humoral immune evasion (GROVE) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Project conception, development and application
Collaborator Contribution Access to clinical samples
Impact not yet known
Start Year 2013
 
Description Veronique Birault, GSK, Stevenage. 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Provided data on a new host factor to be used as an antiretroviral target.
Collaborator Contribution Provided lead compounds that target the new host factor discovered by us.
Impact In the process of performing SAR studies with GSK compounds
Start Year 2013
 
Description WESTON VISITING PROFESSORSHIP (BENNY CHAIN) 
Organisation Weizmann Institute of Science
Country Israel 
Sector Academic/University 
PI Contribution shared knowledge, materials & equipment leading to increased publication output
Collaborator Contribution shared knowledge, materials & equipment leading to increased publication output
Impact Led to award of a bilateral Weizmann/UCL grant (Making Connections programme) $100,000 over two years.
Start Year 2009
 
Description Wellcome Trust Sanger Centre collaboration (DAN DEPLEDGE) 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Shared knowledge, materials and resources leading to publication output (in progress)
Collaborator Contribution Shared knowledge, materials and resources leading to publication output (in progress)
Impact In progress
Start Year 2010
 
Description Whitehead Inst Biomed Res (R JENNER) 
Organisation Whitehead Institute for Biomedical Research
Country United States 
Sector Charity/Non Profit 
PI Contribution shared knowledge, materials & equipment leading to increased publication output
Collaborator Contribution shared knowledge, materials & equipment leading to increased publication output
Impact In progress
Start Year 2010
 
Description Wuerzburg Collaboration (STAUSS) 
Organisation University of Wurzburg
Country Germany 
Sector Academic/University 
PI Contribution TBA
Collaborator Contribution TBA
Impact TBA
Start Year 2009
 
Title patent application # 1015305.4 (R JENNER) 
Description NA 
IP Reference GB1015305.4 
Protection Patent application published
Year Protection Granted 2010
Licensed Commercial In Confidence
Impact NA
 
Description Carolton Primary School Visit 2012 (TOWERS/MILNE) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Schools
Results and Impact 40 local school children attended open day in the Centre labs; consisted of interactive introductory talk, followed by lab rotations where pupils preformed DNA extractions, microscope work, pipetting skills, artwork. Pupils asked many questions and the Centre received thank you letters expressing their increases interest in science and had a unique opportunity to do real lab-based tasks.
Year(s) Of Engagement Activity 2012
 
Description Contribution to the Financial Times "New synthetic life needs context and regulation"(A. Fassati) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact to be added
Year(s) Of Engagement Activity 2010
URL http://www.ft.com/cms/s/0/3da6db20-6796-11df-a932-00144feab49a.html#axzz2hsOEkNfY
 
Description HIV & AIDS (WEISS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact too soon to say
Year(s) Of Engagement Activity 2013
 
Description Institute of Arts talk (M COLLINS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact presented talk titled 'Are Women Changing Science?'

na
Year(s) Of Engagement Activity 2011
 
Description Institute of Immunity and Transplantation Opening Symposium (GROVE) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The symposium was filmed and I worked with a video editor to create a digital version of the presentation for You Tube
Year(s) Of Engagement Activity 2013
 
Description Lecture "Conscience and values in the response to infectious diseases", Thomas More Institute, London. (A. Fassati) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact to be added
Year(s) Of Engagement Activity 2011
URL http://thomasmoreinstitute.org.uk/papers/conscience-and-values-in-the-response-toinfectious-diseases...
 
Description Lecture on the AIDS epidemic for the charity "Mothers to Mothers" London. (A. Fassati) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact to be added
Year(s) Of Engagement Activity 2011
URL http://www.m2m.org
 
Description Lecture to Y6 children "Investigating microbes" at the Oratory RC Primary School, London. (A. Fassati) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact to be added
Year(s) Of Engagement Activity 2014
 
Description Lecture: City of London Boyrs School (B CHAIN) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact 50+ pupils attended a lecture titled 'vaccinations'

na
Year(s) Of Engagement Activity 2011
 
Description Live comment on the origin of the AIDS epidemic on Arise News (A. Fassati) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact to be added
Year(s) Of Engagement Activity 2014
URL http://www.arise.tv/arise-news-show/africa-wrap-03-10-8501
 
Description Lunchtime Lecture UCL (COLLINS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 800 You tube hits
Year(s) Of Engagement Activity 2012
 
Description MRC@UCL Centenary Science Fair (ALL MEMBERS) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 500+ members of the public (families, adults, school children) attended a science fair held @ UCL, Centre members contributed 3 hands-on workshop stalls, and presented separate talks. The public were given opportunities to perform tasks associated with the work of the Centre, and asked questions/contributed to discussions about what the Centre does and general science queries. Feedback included saying children had increased interest in developing their science education and awareness of virology principles.
Year(s) Of Engagement Activity 2013
 
Description Mayflower & Gayhurst Primary School visits 2013 (TOWERS/MILNE) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Schools
Results and Impact Centre members visited local schools and presented an interactive talk about virology. Pupils asked many questions and the Centre received thank you letters expressing their increases interest in science and had a unique opportunity to do real lab-based tasks.
Year(s) Of Engagement Activity 2013
 
Description Mayflower & Gayhurst Primary schools visits 2012 (TOWERS/MILNE) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Schools
Results and Impact Centre members visited local schools and presented an interactive talk about virology. Pupils asked many questions and the Centre received thank you letters expressing their increases interest in science and had a unique opportunity to do real lab-based tasks.
Year(s) Of Engagement Activity 2012
 
Description Observer Interview (M COLLINS) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Media (as a channel to the public)
Results and Impact "My Bright Idea"- Interview for The Observer, 24/4/11

na
Year(s) Of Engagement Activity 2011
 
Description Public lecture (STAUSS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Approximately 200 lay people attended lecture on T Cell therapy

Lecture was recorded and is available on You-tube
Year(s) Of Engagement Activity 2012
 
Description School Visit Primrose Hill (STAUSS) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Schools
Results and Impact Parents attended a presentation of our research and all children attended an assembly

money raised for cancer research
Year(s) Of Engagement Activity 2012
 
Description School visit (x2), 2011 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact R Milne & G Towers visited 2 primary schools (Gayhurst and Mayflower), various activities for 50+ pupils

received many thank you letters and further questions from pupils
Year(s) Of Engagement Activity 2011
 
Description School visit, London (3 visits) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact 50+ 6th form Biology students attended a talk given by Prof Mary Collins on both Virology and science careers.

Provided further insights to virology and encouraged studetns further in choosing scientific careers
Year(s) Of Engagement Activity 2010
 
Description Social Mobility Foundation Students (G TOWERS) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact We took 2 students for a week each in August.

The idea is that students from poor backgrounds who wouldnt normally be exposed to opportunities for work experience can be helped out.
Year(s) Of Engagement Activity 2011
 
Description Talk in Bloomsbury Festival (M COLLINS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cosy Science, "viruses are our friends", The Marquis of Cornwallis pub, 2013 for 50+ local residents

raised public awareness
Year(s) Of Engagement Activity 2013
 
Description Thomas More Institute talk (A FASSATI) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact presented talk titled 'Conscience and Values in the Response to Infectious Diseases' given to 50+ adult members of the public

na
Year(s) Of Engagement Activity 2011
 
Description Work experience pupils (x4) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact high school students attending 1 week work experience placements in various member's labs; shadowing staff and performing experiments

Provided further encouragement to take further study/career directions in virology or biomedical sciences
Year(s) Of Engagement Activity 2010,2011
 
Description mothers2mothers charity talk (A FASSATI) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact presented talk titled 'The Current AIDS Epidemic' to 25+ members of the adult public

all proceeds to mothers2mothers charity
Year(s) Of Engagement Activity 2011