Molecular and cellular studies of synaptic receptors and ion channels

Lead Research Organisation: University College London
Department Name: Neuroscience Physiology and Pharmacology

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Alexander SP (2013) The Concise Guide to PHARMACOLOGY 2013/14: overview. in British journal of pharmacology

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Miller PS (2005) Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors. in The Journal of biological chemistry

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Thomas P (2005) HEK293 cell line: a vehicle for the expression of recombinant proteins. in Journal of pharmacological and toxicological methods

 
Description MRC Programme Grant
Amount £3,200,000 (GBP)
Funding ID G9722520 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2007 
End 07/2012
 
Description Kenji Sakimura, University of Niigata Medical School, Japan (g-7 knockout) 
Organisation Niigata University
Department School of Medicine
Country Japan 
Sector Academic/University 
PI Contribution Functional electrophysiological analysis and molecular biology
Collaborator Contribution Generation of specific types of transgenic mice for our functional studies on AMPA receptor auxiliary subunits.
Impact None
Start Year 2016
 
Description Mechanism of action of THIP 
Organisation Merck
Country Germany 
Sector Private 
PI Contribution We used multi-disciplinary approaches to exactly determine how THIP acts at the GABA-A receptor deriving new infomation about how GABA-A receptors are activated.
Collaborator Contribution Provision of resources to study the action of this hypnotic
Impact We have deduced at the molecular level how THiP activates GABA receptors. This drug was developed as a hypnotic and reached phase II trials. We have a publication currently under revision
Start Year 2007
 
Description 9th Winter Brain Conference, Solden, Austria: Electrophysiological approaches to study membrane dynamics of GABAA receptors in the brain. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research seminar to academics

None so far
Year(s) Of Engagement Activity 2007
 
Description 9th Winter Brain Conference, Solden, Austria: Electrophysiological approaches to study membrane dynamics of GABAA receptors in the brain. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary lecture

Recognition by peers
Year(s) Of Engagement Activity 2007
 
Description Distinguished Gowdey Lecture 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Prize lecture on GABA-A receptors, basic science and clinical

Recognition by peers
Year(s) Of Engagement Activity 2009
 
Description Eisai, UCL. The Inhibitory Synapse. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Seminar to acadmics & industrialists

Part of Eisai scientific advisory board
Year(s) Of Engagement Activity 2006
 
Description Kyoto symposium on Mechanisms of GABAergic Synaptic Transmission, Japanese Neuroscience Society meeting. Autocrine mGluR1 activation in cerebellar Purkinje cells regulates GABA-mediated synaptic inhibition. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary lecture

Representing UK neuroscience
Year(s) Of Engagement Activity 2006
 
Description MRC Clinical Sciences Centre, Imperial College London: 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Lecture to academics & students

Highlighting pharmacological approaches to CNS study
Year(s) Of Engagement Activity 2006
 
Description MRC Showcase Symposium, Neuroscience and Mental Health Board. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture to academics, clinicians & students, policy makers

part of MRC showcase
Year(s) Of Engagement Activity 2006
 
Description Max Planck symposium Ringberg Castle, Munich: Intercellular communication in the nervous system, from development to roles in health and disease. Keynote Lecture: Structure-function studies on inhibitory amino acid receptors. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote lecture

none so far
Year(s) Of Engagement Activity 2007
 
Description Max Planck symposium Ringberg Castle, Munich: Intercellular communication in the nervous system, from development to roles in health and disease. Keynote Lecture: Structure-function studies on inhibitory amino acid receptors. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary lecture

Recognition by peers
Year(s) Of Engagement Activity 2007
 
Description Neuroscience and Pharmacology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Schools
Results and Impact >100 pupils attended a careers talk and demonstration of the outreach of science

Sixth form and work experience applications made to the college
Year(s) Of Engagement Activity 2012
 
Description Paris, CNRS: Molecular regulation of the GABAA receptor. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture to academics & students

Recognition by peers, collaborative research links established
Year(s) Of Engagement Activity 2006
 
Description Scottish Neuroscience meeting: Plenary Keynote Lecture: 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary keynote lecture

Recognition by peers
Year(s) Of Engagement Activity 2006
 
Description UCL Institute Structural and Molecular Biology retreat, Keynote lecture: Molecular regulation of the GABAA receptor. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Plenary lecture

Recognition by peers
Year(s) Of Engagement Activity 2007