Learning, memory and neuronal plasticity in mammalian systems

Lead Research Organisation: Cardiff University
Department Name: Sch of Psychology

Abstract

Please see relevant Section in Report of Past Progress

Technical Summary

The Co-Operative Group consists of researchers in the schools of Biosciences and Psychology at Cardiff University. The Group will conduct a multi-disciplinary, multi-level study into the neuroscience of learning, memory and plasticity. Thus the effects of molecular manipulations upon learning at the level of the synapse, the anatomical system, and the whole organism will be examined in an integrated manner. Similarly, the effects of manipulations, either the whole organism, or at the structural level, will be pursued at the molecular level. The proposed research will concentrate on the contributions of limbic and neocortical processes to memory. An important concept will be the use of transgenic rodent lines to explore both the basic mechanisms and pathological processes in models of such diseases as Alzheimer?s which afflict learning, memory and attention.

Publications

10 25 50

publication icon
Bridger EK (2009) Neural correlates of individual differences in strategic retrieval processing. in Journal of experimental psychology. Learning, memory, and cognition

 
Description BBSRC Responsive Mode
Amount £295,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2006 
End 07/2010
 
Description MRC Project Grant
Amount £280,613 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2006 
End 07/2009
 
Description Transcriptome analysis and behaviour 
Organisation Cardiff University
Department School of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Design of experiments for brain transcriptome analysis
Collaborator Contribution Implementation of transcriptome analysis in behavioural paradigms has contibuted to my research capability and knowledge.
Impact Poirier, G., Shires, K.L., Sugden, D., Amin, E., Thomas, K.L., Carter D.A., and Aggleton, J.P. (2008) Anterior thalamic lesions produce chronic and profuse transcriptional de-regulation in retrosplenial cortex: A model of retrosplenial hypoactivity and covert pathology. Thalamus & Related Systems 4, 59-77.
 
Description Cardiff Science Cafe 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Well attended, lively discussion

Opportunity to disseminate ideas regarding animal intelligence.
Year(s) Of Engagement Activity 2006
 
Description Cardiff Scientific Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Talk on animal intelligence to interested/curious audience.

Stimulate debate and interest in topic area.
Year(s) Of Engagement Activity 2007
 
Description Lecture, British & Irish Orthoptic Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact opening lecture at annual BIOS meeting, attended by 100+ participants, follwowed by questions and discussion with individual attendees

I was invited to write an article for the BIOS Journal, which was published in 2008
Year(s) Of Engagement Activity 2007
 
Description Radio 4 interview 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Broad dissemination of information relevent to neuropsychology (Radio 4 'All in the Mind'

Opportunity to widen audience for neuroscience research
Year(s) Of Engagement Activity 2008
 
Description Research and recruitment presentations 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Prospective undergraduates, postgraduates and parents attended talks and research presentations on cognitive neuroscience and memory. Presentations were given in UK and in Schools and Universities in Malaysia, Hong Kong and mainland China.

Increased interest in neuroscience elements of Psychology study amongst applicants.
Year(s) Of Engagement Activity 2007,2008,2009