The Molecular Basis of Embryonic Stem Cell Self-Renewal

Lead Research Organisation: University of Cambridge
Department Name: Wellcome Trust - MRC Cam Stem Cell Inst

Abstract

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Technical Summary

Stem cells may be defined as cells that must make a choice at each cell division between producing identical stem cell progeny, self-renewal, or entering into a specialisation programme, differentiation. Embryonic stem (ES) cells are in vitro propagated stem cell lines derived directly from pre-implantation mammalian embryos. Under appropriate conditions these cells can undergo symmetrical self-renewing divisions without number. During the process of timeless self-renewal the stem cells remain fully permissive for multilineage differentiation. This is revealed by ?spontaneous? differentiation upon change in the culture milieu. We propose that self-renewal requires the active inhibition of stem cell differentiation and that this is achieved by neutralisation of inductive signaling pathways and downstream transcription factor targets.
We have developed culture conditions for mouse ES cells that avoid both co-cuture and serum. Elimination of these variables allows characterisation of the extrinsic stimuli and associated intracellular pathways that determine either self-renewal or lineage commitment. This approach has uncovered an unsuspected and critical contribution to ES cell self-renewal of factors that induce the ID class of negative helix-loop-helix (HLH) proteins. The classical mode of ID action is to prevent the activity of differentiation inducing basic HLH transcription factors such as the proneural and myogenic factors. Our findings suggest that IDs act similarly in ES cells to suppress commitment to specific lineages triggered by promiscuous expression of lineage determination genes. This is consistent with the perspective that stem cells are transcriptionally poised for differentiation and that the essence of self-renewal lies in the active suppression of lineage entry, probably at multiple levels.
The investigations proposed here are focussed on two principal objectives:
1) To delimit fully the ES cell culture environment in order to define the essential extrinsic stimuli for derivation of new lines, optimal self-renewal of established lines, and directed lineage specification.
2) To characterise the key actors in the transcriptional determination of ES cell self-renewal. and to delineate their functional interactions (cross-talk).
Throughout the programme we will seek to exemplify in human ES cells research findings from primary investigations on mouse ES cells. Available data on the molecular relatedness between mouse and human ES cells is scant. We aim to test rigorously whether the two cell types are regulated by the same signalling and transcription factor pathways, with trivial species-specific differences, or whether there are fundamental distinctions in their molecular control networks.

Organisations

Publications

10 25 50
 
Description Academy of Medical Sciences Report on Embryo Research and Chimaeras
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description EMBO Membership Committee
Geographic Reach Europe 
Policy Influence Type Membership of a guidance committee
 
Description EMBO Science and Society Report on Stem Cell Research
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
 
Description Erasmus University Medical Centre, Stem Cell Initiative for Regenerative Medicine, international External Scientific Advisory Board
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
 
Description European Court of Justice decision on patents on Embryonic stem cell research
Geographic Reach Europe 
Policy Influence Type Participation in a national consultation
 
Description G-COE Advisory Board
Geographic Reach Asia 
Policy Influence Type Participation in advisory committee
 
Description House of Commons Science and Technology Committee Consultation
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Hubrecht Institute International Eveluation Committee
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
 
Description ISSCR Advisory Board
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
 
Description MEP Briefing
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
 
Description MRC-Chinese Academy of Sciences Workshop
Geographic Reach Asia 
Policy Influence Type Participation in advisory committee
 
Description Meeting with iPS Cell Surveillance Project, Japan Science and Technology Agency
Geographic Reach Asia 
Policy Influence Type Membership of a guidance committee
 
Description OICR Cancer Stem Cell Program, Scientific Advisory Board
Geographic Reach North America 
Policy Influence Type Participation in advisory committee
 
Description REVIVE Stem Cell Network
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
 
Description RIKEN Advisory Council
Geographic Reach Asia 
Policy Influence Type Participation in advisory committee
 
Description Science Foundation Ireland, REMEDEI CSET Site Visit
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
 
Description UK Stem Cell Bank Management Committee
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description UKRMP Advisory Board
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description University of Lund BMC Scientific Advisory Council
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
 
Description Addenbrookes Charitable Trust award of Consumables for Dr. K.Kurian to work within Biochemistry: Stem Cell Institute
Amount £10,000 (GBP)
Organisation Addenbrooke's Charitable Trust (ACT) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description BB/H012737/1 Gene Targetting by homologous recombination in the Rat
Amount £612,215 (GBP)
Funding ID BB/H012737/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2011 
End 05/2015
 
Description Beit Memorial Fellowship for Medical Research
Amount £126,043 (GBP)
Organisation Wellcome Trust 
Department Wellcome-Beit Prize Fellowships
Sector Private
Country United Kingdom
Start 10/2007 
End 09/2010
 
Description BetaCellTherapy: Beta Cell Therapy in Diabetes
Amount £823,424 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2010 
End 12/2014
 
Description Centre for Stem Cell Biology & Regenerative Medicine
Amount £795,134 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2009 
End 12/2011
 
Description Characterisation of new human ES cell derived in novel
Amount £55,624 (GBP)
Funding ID 4-2005-821 
Organisation Juvenile Diabetes Research Foundation (JDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2007 
End 12/2007
 
Description Collaborative bursary MiRNA expression in brain cancer stem cells
Amount £6,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Core Support for Wellcome Trust Centre for Stem Cell Research
Amount £6,956,531 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2007 
End 12/2011
 
Description ESTOOLS: Platforms for Biomedical Discovery with Human ES cells
Amount £373,970 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 08/2006 
End 07/2010
 
Description EURATRANS European large-scale functional genomics in the rat for translational research (10.5m euros across 19 participants)
Amount £517,672 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2010 
End 09/2014
 
Description EUROSTEMCELL: European Consortium for Stem Cell Research (0.8m euros across 11 participants)
Amount £38,175 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 09/2006 
End 01/2008
 
Description EUROSTEMCELL: European Consortium for Stem Cell Research (0.8m euros across 11 participants)
Amount £6,457 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 03/2010 
End 02/2015
 
Description EUROSYSTEM European consortium for systematic stem Cell Biology (12m euros across 24 participants)
Amount £1,184,402 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 03/2008 
End 08/2012
 
Description Embryonic Stem Cells, Neural stem cells and Neurons
Amount £102,527 (GBP)
Organisation Fidelity Biosciences 
Sector Private
Country United States
Start 05/2007 
End 05/2009
 
Description Japanese Partnership
Amount £56,594 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 07/2010 
End 06/2014
 
Description MRC Stem Cell Career Development Fellowship
Amount £279,872 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2008 
End 07/2011
 
Description NeuroStemcell Project - European consortium for stem Cell therapy
Amount £652,985 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 12/2008 
End 05/2013
 
Description Ole Wiskow Studentship
Amount £22,500 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 01/2007 
End 12/2009
 
Description Precision Transgenesis in Rats via Embryonic Stem Cells
Amount £52,827 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 08/2006 
End 01/2009
 
Description Regulation and function of the pluripotency determinant Nanaog
Amount £844,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2006 
End 10/2010
 
Description Regulation of Self Renewal, Commitment and Differentiation in Brain Cancer Cells
Amount £177,218 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2008 
End 05/2011
 
Description Steering Embryonic Stem Cells towards Pancreatic
Amount £43,902 (GBP)
Organisation Juvenile Diabetes Research Foundation (JDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2007 
End 04/2010
 
Description Stem Cell Initiative (Core Grant)
Amount £1,143,873 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2006 
End 12/2008
 
Description Stemstroke: Towards a Stem Cell Therapy for Stroke
Amount £294,553 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2007 
End 12/2009
 
Description Summer Studentship for Magdelena Stasiulewicz
Amount £2,500 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2010 
End 08/2010
 
Description SyBoSS Project - Systems Biology of Stem Cells and Reprogramming
Amount £374,310 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 06/2010 
End 05/2015
 
Description The Discovery of future Neuro-therapeutic Molecules (NEUROscreen)
Amount £195,139 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 08/2007 
End 07/2010
 
Description The Road from Pluripotency to Lineage
Amount £1,736,222 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2010 
End 10/2015
 
Description The Stat3 pathway in Stem Cell Self renewal and the germline
Amount £1,211,904 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2009 
End 05/2013
 
Description Transplantation protocols to assess the ability of ES cell derived endodermal populations to differentiate towards pancreatic lineages
Amount £26,596 (GBP)
Organisation Juvenile Diabetes Research Foundation (JDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Title 2i 
Description Defined media (2i) for rodent ES cell and iPS culture 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact N/A 
 
Title Human ESC 
Description Human Embryonic Stem Cells 
Type Of Material Cell line 
Year Produced 2006 
Provided To Others? Yes  
Impact N/A 
 
Title Human FNSC 
Description Human Foetal Neural Stem Cells 
Type Of Material Cell line 
Year Produced 2006 
Provided To Others? Yes  
Impact N/A 
 
Title Human iPSC 
Description Human Induced Pluripotent Stem Cells 
Type Of Material Cell line 
Year Produced 2006 
Provided To Others? Yes  
Impact N/A 
 
Title Rat ESC 
Description Rat Embryonic Stem Cells 
Type Of Material Cell line 
Year Produced 2010 
Provided To Others? Yes  
Impact N/A 
 
Description ESTOOLS 
Organisation Academy of Sciences of the Czech Republic
Country Czech Republic 
Sector Learned Society 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation Babraham Institute
Department Stem Cell Sciences UK Ltd
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation Bellvitge Biomedical Research Institute
Country Spain 
Sector Charity/Non Profit 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation Hebrew University of Jerusalem
Country Israel 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation Lund University
Country Sweden 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation Netherlands Cancer Institute (NKI)
Country Netherlands 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation Stem Cell Technologies
Country Canada 
Sector Private 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation Tampere University of Technology
Country Finland 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation Technical University of Dresden
Country Germany 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation University of Basel
Country Switzerland 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation University of Bonn
Department Medical Centre Bonn
Country Germany 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation University of Helsinki
Country Finland 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation University of Milan
Country Italy 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description ESTOOLS 
Organisation University of Turku
Country Finland 
Sector Academic/University 
PI Contribution PI
Collaborator Contribution 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI
Impact Not Given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation Babraham Institute
Department Stem Cell Sciences UK Ltd
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation Cancer Research UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation European Molecular Biology Laboratory
Country Germany 
Sector Public 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation Lund University
Country Sweden 
Sector Academic/University 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation NeuroNova AB
Country Sweden 
Sector Private 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation NsGene A/S
Country Denmark 
Sector Private 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation Pasteur Institute, Paris
Country France 
Sector Academic/University 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation San Raffaele Hospital
Department Stem Cell Research Institute
Country Italy 
Sector Hospitals 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation Swiss Federal Institute of Technology in Lausanne (EPFL)
Country Switzerland 
Sector Public 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation University of Bonn
Department Medical Centre Bonn
Country Germany 
Sector Academic/University 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description EUROSTEMCELL 
Organisation University of Milan
Country Italy 
Sector Academic/University 
PI Contribution Austin Smith was the coordinator of this collaboration.
Collaborator Contribution xxx
Impact Not given
Start Year 2006
 
Description Euratrans 
Organisation Academy of Sciences of the Czech Republic
Country Czech Republic 
Sector Learned Society 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation Alternative Energies and Atomic Energy Commission (CEA)
Country France 
Sector Public 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation European Molecular Biology Laboratory
Country Germany 
Sector Public 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation Helmholtz Association of German Research Centres
Department The Max Delbrück Center for Molecular Medicine (MDC)
Country Germany 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation Max Planck Society
Department Max Planck Institute of Biochemistry
Country Germany 
Sector Public 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation Medical College of Wisconsin
Country United States 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Public 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation Research Network Services (RNSL) Ltd Berlin
Country Germany 
Sector Private 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation Royal Institute of Technology
Country Sweden 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation Royal Netherlands Academy of Arts and Sciences
Department Hubrecht Institute
Country Netherlands 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation University of Groningen
Country Netherlands 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation University of Kyoto
Country Japan 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description Euratrans 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith is a PI on this collaboration.
Collaborator Contribution European large-scale functional genomics in the rat for translational research
Impact http://www.euratrans.eu/
Start Year 2010
 
Description EuroStemCell 
Organisation Centre for Genomic Regulation (CRG)
Country Spain 
Sector Academic/University 
PI Contribution Austin is a principal investigator for this collaboration
Collaborator Contribution EuroStemCell, launched in March 2010, unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about our science. It is a partnership of scientists, clinicians, ethicists, social scientists and science communicators. It is coordinated by the University of Edinburgh
Impact www.eurostemcell.org
Start Year 2010
 
Description EuroStemCell 
Organisation Dando, Weiss & Colucci Ltd
Country United Kingdom 
Sector Private 
PI Contribution Austin is a principal investigator for this collaboration
Collaborator Contribution EuroStemCell, launched in March 2010, unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about our science. It is a partnership of scientists, clinicians, ethicists, social scientists and science communicators. It is coordinated by the University of Edinburgh
Impact www.eurostemcell.org
Start Year 2010
 
Description EuroStemCell 
Organisation JDRF Center for Beta Cell Therapy in Diabetes
Country Belgium 
Sector Academic/University 
PI Contribution Austin is a principal investigator for this collaboration
Collaborator Contribution EuroStemCell, launched in March 2010, unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about our science. It is a partnership of scientists, clinicians, ethicists, social scientists and science communicators. It is coordinated by the University of Edinburgh
Impact www.eurostemcell.org
Start Year 2010
 
Description EuroStemCell 
Organisation Life and Brain GmbH
Country Germany 
Sector Private 
PI Contribution Austin is a principal investigator for this collaboration
Collaborator Contribution EuroStemCell, launched in March 2010, unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about our science. It is a partnership of scientists, clinicians, ethicists, social scientists and science communicators. It is coordinated by the University of Edinburgh
Impact www.eurostemcell.org
Start Year 2010
 
Description EuroStemCell 
Organisation Lund University
Country Sweden 
Sector Academic/University 
PI Contribution Austin is a principal investigator for this collaboration
Collaborator Contribution EuroStemCell, launched in March 2010, unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about our science. It is a partnership of scientists, clinicians, ethicists, social scientists and science communicators. It is coordinated by the University of Edinburgh
Impact www.eurostemcell.org
Start Year 2010
 
Description EuroStemCell 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Public 
PI Contribution Austin is a principal investigator for this collaboration
Collaborator Contribution EuroStemCell, launched in March 2010, unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about our science. It is a partnership of scientists, clinicians, ethicists, social scientists and science communicators. It is coordinated by the University of Edinburgh
Impact www.eurostemcell.org
Start Year 2010
 
Description EuroStemCell 
Organisation National University of Ireland, Galway
Country Ireland 
Sector Academic/University 
PI Contribution Austin is a principal investigator for this collaboration
Collaborator Contribution EuroStemCell, launched in March 2010, unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about our science. It is a partnership of scientists, clinicians, ethicists, social scientists and science communicators. It is coordinated by the University of Edinburgh
Impact www.eurostemcell.org
Start Year 2010
 
Description EuroStemCell 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin is a principal investigator for this collaboration
Collaborator Contribution EuroStemCell, launched in March 2010, unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about our science. It is a partnership of scientists, clinicians, ethicists, social scientists and science communicators. It is coordinated by the University of Edinburgh
Impact www.eurostemcell.org
Start Year 2010
 
Description EuroStemCell 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin is a principal investigator for this collaboration
Collaborator Contribution EuroStemCell, launched in March 2010, unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about our science. It is a partnership of scientists, clinicians, ethicists, social scientists and science communicators. It is coordinated by the University of Edinburgh
Impact www.eurostemcell.org
Start Year 2010
 
Description EuroStemCell 
Organisation University of Milan
Country Italy 
Sector Academic/University 
PI Contribution Austin is a principal investigator for this collaboration
Collaborator Contribution EuroStemCell, launched in March 2010, unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about our science. It is a partnership of scientists, clinicians, ethicists, social scientists and science communicators. It is coordinated by the University of Edinburgh
Impact www.eurostemcell.org
Start Year 2010
 
Description EuroStemCell 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin is a principal investigator for this collaboration
Collaborator Contribution EuroStemCell, launched in March 2010, unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about our science. It is a partnership of scientists, clinicians, ethicists, social scientists and science communicators. It is coordinated by the University of Edinburgh
Impact www.eurostemcell.org
Start Year 2010
 
Description EuroSyStem 
Organisation Austrian Academy of Sciences
Department Institute of Molecular Biotechnology
Country Austria 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation European Institute of Oncology (IEO)
Country Italy 
Sector Charity/Non Profit 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation German Cancer Research Center
Country Germany 
Sector Public 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation Helmholtz Association of German Research Centres
Department Helmholtz Zentrum Munchen
Country Germany 
Sector Public 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation Institute of Genetics and Molecular and Cellular Biology (IGBMC)
Country France 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation Lund University
Country Sweden 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation Netherlands Cancer Institute (NKI)
Country Netherlands 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation Oxford Gene Technology
Country United Kingdom 
Sector Private 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation Pasteur Institute, Paris
Country France 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation Royal Netherlands Academy of Arts and Sciences
Department Hubrecht Institute
Country Netherlands 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation San Raffaele Hospital
Department San Raffaele Scientific Institute (SRSI)
Country Italy 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation Swiss Federal Institute of Technology in Lausanne (EPFL)
Country Switzerland 
Sector Public 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation Technical University of Dresden
Country Germany 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation University Medical Center Gronigen
Country Netherlands 
Sector Hospitals 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation University of Leipzig
Department Ingo Roeder Institute for Medical Informatics
Country Germany 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation University of Milan
Country Italy 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description EuroSyStem 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution PI and Scientific Coordinator
Collaborator Contribution 4 PIs2 PIs 2 PIs 1 PI1 PI2 PIs 1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI1 PI2 PIs 1 PI1 PI3 PIs
Impact see website http://www.eurosystemproject.eu
Start Year 2007
 
Description NeuroStemCell 
Organisation Babraham Institute
Department Stem Cell Sciences UK Ltd
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description NeuroStemCell 
Organisation Cardiff University
Department School of Biosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description NeuroStemCell 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description NeuroStemCell 
Organisation Institute of Biomedical Imagery (I2BM)
Country France 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description NeuroStemCell 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description NeuroStemCell 
Organisation Lund University
Country Sweden 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description NeuroStemCell 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Public 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description NeuroStemCell 
Organisation NsGene A/S
Country Denmark 
Sector Private 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description NeuroStemCell 
Organisation Sapio
Department BioRep
Country Italy 
Sector Private 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description NeuroStemCell 
Organisation University of Bonn
Country Germany 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description NeuroStemCell 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description NeuroStemCell 
Organisation University of Milan
Country Italy 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration. Austin will contribute extensively to WP1 and 2 and play a role in stability studies in WP5. The group will provide to the consortium recently derived rat ES cells and rat NS cells, in addition to human NS cells.
Collaborator Contribution European Consortium for Stem Cell Therapy in Neurodegenerative Diseases. NeuroStemcell, which comprises 13 academic partners and 2 SMEs and 1 Research Enterprise from 6 European countries and the United States of America, is formed to create a world-leading consortium that can develop stem cell based therapies for Parkinson´s disease and Huntington´s disease toward clinical application. NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesencephalic dopaminergic and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from induced Pluripotent Stem (iPS) cells, or from neural stem cells derived from either ES cells, iPS cells or fetal brain, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animal models.
Impact http://www.neurostemcell.org/
Start Year 2008
 
Description Sinergia 
Organisation Friedrich Miescher Institute for Biomedical Research (FMI)
Country Switzerland 
Sector Academic/University 
PI Contribution Analysis of self-renewal mechanism in pluripotent stem cells, in particular the role of leukaemia inhibitory factor.
Collaborator Contribution Analysis of self-renewal mechanism in pluripotent stem cells, in particular the role of leukaemia inhibitory factor.
Impact none - this is not multidisciplinary
Start Year 2010
 
Description Sinergia 
Organisation University of Basel
Country Switzerland 
Sector Academic/University 
PI Contribution Analysis of self-renewal mechanism in pluripotent stem cells, in particular the role of leukaemia inhibitory factor.
Collaborator Contribution Analysis of self-renewal mechanism in pluripotent stem cells, in particular the role of leukaemia inhibitory factor.
Impact none - this is not multidisciplinary
Start Year 2010
 
Description Sinergia 
Organisation University of Zurich
Department Institute of Anatomy
Country Switzerland 
Sector Academic/University 
PI Contribution Analysis of self-renewal mechanism in pluripotent stem cells, in particular the role of leukaemia inhibitory factor.
Collaborator Contribution Analysis of self-renewal mechanism in pluripotent stem cells, in particular the role of leukaemia inhibitory factor.
Impact none - this is not multidisciplinary
Start Year 2010
 
Description SyBoSS 
Organisation Claudius Regaud Hospital
Country France 
Sector Hospitals 
PI Contribution Austin Smith is a Principal Investigator on this collaboration
Collaborator Contribution Biologists, chemists, physicists and bioinformaticians from five European countries have been engaged by the EU Seventh Framework to work out how stem cells differentiate. How a simple stem cell becomes a highly specialized member of a network, and how those conditions could be recreated in treating disease, is the focus of the Systems Biology of Stem Cells and Reprogramming project. When most human tissues are damaged, the wound is healed by cell division, to grow back skin, muscle or bone. On injury, the injured part is temporarily returned to a less specialized state. Once the signals to keep dividing are gone, the new cells establish different molecular interactions that give them their special functions. Adult nerve cells were previously not thought to regenerate. However, we now know that even in the adult human brain, new nerve cells arise. Exercise, enriched environment, good nutrition, sunlight, and fresh air all help to regenerate nerve cells. Exactly how this happens, is what the SyBoSS research initiative intends to find out.
Impact not currently known
Start Year 2010
 
Description SyBoSS 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration
Collaborator Contribution Biologists, chemists, physicists and bioinformaticians from five European countries have been engaged by the EU Seventh Framework to work out how stem cells differentiate. How a simple stem cell becomes a highly specialized member of a network, and how those conditions could be recreated in treating disease, is the focus of the Systems Biology of Stem Cells and Reprogramming project. When most human tissues are damaged, the wound is healed by cell division, to grow back skin, muscle or bone. On injury, the injured part is temporarily returned to a less specialized state. Once the signals to keep dividing are gone, the new cells establish different molecular interactions that give them their special functions. Adult nerve cells were previously not thought to regenerate. However, we now know that even in the adult human brain, new nerve cells arise. Exercise, enriched environment, good nutrition, sunlight, and fresh air all help to regenerate nerve cells. Exactly how this happens, is what the SyBoSS research initiative intends to find out.
Impact not currently known
Start Year 2010
 
Description SyBoSS 
Organisation European Molecular Biology Laboratory
Country Germany 
Sector Public 
PI Contribution Austin Smith is a Principal Investigator on this collaboration
Collaborator Contribution Biologists, chemists, physicists and bioinformaticians from five European countries have been engaged by the EU Seventh Framework to work out how stem cells differentiate. How a simple stem cell becomes a highly specialized member of a network, and how those conditions could be recreated in treating disease, is the focus of the Systems Biology of Stem Cells and Reprogramming project. When most human tissues are damaged, the wound is healed by cell division, to grow back skin, muscle or bone. On injury, the injured part is temporarily returned to a less specialized state. Once the signals to keep dividing are gone, the new cells establish different molecular interactions that give them their special functions. Adult nerve cells were previously not thought to regenerate. However, we now know that even in the adult human brain, new nerve cells arise. Exercise, enriched environment, good nutrition, sunlight, and fresh air all help to regenerate nerve cells. Exactly how this happens, is what the SyBoSS research initiative intends to find out.
Impact not currently known
Start Year 2010
 
Description SyBoSS 
Organisation Helmholtz Association of German Research Centres
Country Germany 
Sector Public 
PI Contribution Austin Smith is a Principal Investigator on this collaboration
Collaborator Contribution Biologists, chemists, physicists and bioinformaticians from five European countries have been engaged by the EU Seventh Framework to work out how stem cells differentiate. How a simple stem cell becomes a highly specialized member of a network, and how those conditions could be recreated in treating disease, is the focus of the Systems Biology of Stem Cells and Reprogramming project. When most human tissues are damaged, the wound is healed by cell division, to grow back skin, muscle or bone. On injury, the injured part is temporarily returned to a less specialized state. Once the signals to keep dividing are gone, the new cells establish different molecular interactions that give them their special functions. Adult nerve cells were previously not thought to regenerate. However, we now know that even in the adult human brain, new nerve cells arise. Exercise, enriched environment, good nutrition, sunlight, and fresh air all help to regenerate nerve cells. Exactly how this happens, is what the SyBoSS research initiative intends to find out.
Impact not currently known
Start Year 2010
 
Description SyBoSS 
Organisation Max Planck Society
Department Max Planck Institute for Molecular Cell Biology and Genetics
Country Germany 
Sector Public 
PI Contribution Austin Smith is a Principal Investigator on this collaboration
Collaborator Contribution Biologists, chemists, physicists and bioinformaticians from five European countries have been engaged by the EU Seventh Framework to work out how stem cells differentiate. How a simple stem cell becomes a highly specialized member of a network, and how those conditions could be recreated in treating disease, is the focus of the Systems Biology of Stem Cells and Reprogramming project. When most human tissues are damaged, the wound is healed by cell division, to grow back skin, muscle or bone. On injury, the injured part is temporarily returned to a less specialized state. Once the signals to keep dividing are gone, the new cells establish different molecular interactions that give them their special functions. Adult nerve cells were previously not thought to regenerate. However, we now know that even in the adult human brain, new nerve cells arise. Exercise, enriched environment, good nutrition, sunlight, and fresh air all help to regenerate nerve cells. Exactly how this happens, is what the SyBoSS research initiative intends to find out.
Impact not currently known
Start Year 2010
 
Description SyBoSS 
Organisation Technical University of Denmark
Country Denmark 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration
Collaborator Contribution Biologists, chemists, physicists and bioinformaticians from five European countries have been engaged by the EU Seventh Framework to work out how stem cells differentiate. How a simple stem cell becomes a highly specialized member of a network, and how those conditions could be recreated in treating disease, is the focus of the Systems Biology of Stem Cells and Reprogramming project. When most human tissues are damaged, the wound is healed by cell division, to grow back skin, muscle or bone. On injury, the injured part is temporarily returned to a less specialized state. Once the signals to keep dividing are gone, the new cells establish different molecular interactions that give them their special functions. Adult nerve cells were previously not thought to regenerate. However, we now know that even in the adult human brain, new nerve cells arise. Exercise, enriched environment, good nutrition, sunlight, and fresh air all help to regenerate nerve cells. Exactly how this happens, is what the SyBoSS research initiative intends to find out.
Impact not currently known
Start Year 2010
 
Description SyBoSS 
Organisation Technical University of Dresden
Country Germany 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration
Collaborator Contribution Biologists, chemists, physicists and bioinformaticians from five European countries have been engaged by the EU Seventh Framework to work out how stem cells differentiate. How a simple stem cell becomes a highly specialized member of a network, and how those conditions could be recreated in treating disease, is the focus of the Systems Biology of Stem Cells and Reprogramming project. When most human tissues are damaged, the wound is healed by cell division, to grow back skin, muscle or bone. On injury, the injured part is temporarily returned to a less specialized state. Once the signals to keep dividing are gone, the new cells establish different molecular interactions that give them their special functions. Adult nerve cells were previously not thought to regenerate. However, we now know that even in the adult human brain, new nerve cells arise. Exercise, enriched environment, good nutrition, sunlight, and fresh air all help to regenerate nerve cells. Exactly how this happens, is what the SyBoSS research initiative intends to find out.
Impact not currently known
Start Year 2010
 
Description SyBoSS 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Austin Smith is a Principal Investigator on this collaboration
Collaborator Contribution Biologists, chemists, physicists and bioinformaticians from five European countries have been engaged by the EU Seventh Framework to work out how stem cells differentiate. How a simple stem cell becomes a highly specialized member of a network, and how those conditions could be recreated in treating disease, is the focus of the Systems Biology of Stem Cells and Reprogramming project. When most human tissues are damaged, the wound is healed by cell division, to grow back skin, muscle or bone. On injury, the injured part is temporarily returned to a less specialized state. Once the signals to keep dividing are gone, the new cells establish different molecular interactions that give them their special functions. Adult nerve cells were previously not thought to regenerate. However, we now know that even in the adult human brain, new nerve cells arise. Exercise, enriched environment, good nutrition, sunlight, and fresh air all help to regenerate nerve cells. Exactly how this happens, is what the SyBoSS research initiative intends to find out.
Impact not currently known
Start Year 2010
 
Description SyBoSS 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration
Collaborator Contribution Biologists, chemists, physicists and bioinformaticians from five European countries have been engaged by the EU Seventh Framework to work out how stem cells differentiate. How a simple stem cell becomes a highly specialized member of a network, and how those conditions could be recreated in treating disease, is the focus of the Systems Biology of Stem Cells and Reprogramming project. When most human tissues are damaged, the wound is healed by cell division, to grow back skin, muscle or bone. On injury, the injured part is temporarily returned to a less specialized state. Once the signals to keep dividing are gone, the new cells establish different molecular interactions that give them their special functions. Adult nerve cells were previously not thought to regenerate. However, we now know that even in the adult human brain, new nerve cells arise. Exercise, enriched environment, good nutrition, sunlight, and fresh air all help to regenerate nerve cells. Exactly how this happens, is what the SyBoSS research initiative intends to find out.
Impact not currently known
Start Year 2010
 
Description SyBoSS 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Austin Smith is a Principal Investigator on this collaboration
Collaborator Contribution Biologists, chemists, physicists and bioinformaticians from five European countries have been engaged by the EU Seventh Framework to work out how stem cells differentiate. How a simple stem cell becomes a highly specialized member of a network, and how those conditions could be recreated in treating disease, is the focus of the Systems Biology of Stem Cells and Reprogramming project. When most human tissues are damaged, the wound is healed by cell division, to grow back skin, muscle or bone. On injury, the injured part is temporarily returned to a less specialized state. Once the signals to keep dividing are gone, the new cells establish different molecular interactions that give them their special functions. Adult nerve cells were previously not thought to regenerate. However, we now know that even in the adult human brain, new nerve cells arise. Exercise, enriched environment, good nutrition, sunlight, and fresh air all help to regenerate nerve cells. Exactly how this happens, is what the SyBoSS research initiative intends to find out.
Impact not currently known
Start Year 2010
 
Title Culture medium containing kinase inhibitors, and uses thereof 
Description Pluripotent cells are maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and, optionally, an antagonist of an FGF receptor. Pluripotent cells are also maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor and an antagonist of an FGF receptor. Also published as JP2009531054, US2008014638, GB2436737, and US2010041137 
IP Reference WO2007113505 
Protection Patent granted
Year Protection Granted 2007
Licensed No
Impact N/A
 
Title Directed neural differentiation 
Description Differentiation towards a neural fate, and away from a non-neural fate, is promoted by activation of Notch signalling in ES cells and then transferring the cells into neural differentiation protocols. Media for neural differentiation comprises a Notch activator, e.g. a notch ligand that can be clustered. Genetic manipulation is used as an alternative to media additives for Notch activation. Also published as JP2008532509, EP1877546 and US2008248568 
IP Reference WO2006095175 
Protection Patent granted
Year Protection Granted 2006
Licensed No
Impact N/A
 
Title Reprogramming and genetic modification of cells 
Description Methods for reprogramming and optional genetic modification of cells are provided. A pluripotent genome is obtained from a differentiated genome by fusing a pluripotent cell with a differentiated cell in the presence of Nanog or a MEK inhibitor. A cell is genetically modified by providing first and second cells, each containing chromosomes, fusing the first cell and the second cell, and culturing the fused cell so as to obtain a diploid cell containing at least one chromosome from the first cell and at least one chromosome form the second cell. A method of cell fusion comprises fusing a first cell and a second cell in the presence of Nanog or a MEK inhibitor. Cells obtained thereby and their uses are also described. Also published as JP2009515515, GB2445706, GB2434155, EP1957643 
IP Reference WO2007054720 
Protection Patent granted
Year Protection Granted 2007
Licensed No
Impact N/A
 
Title improved reprogramming of mammalian cells, and the cells obtained 
Description Expression of reprogramming factors such as Sox2, klf4, c-myc, Nanog, LIN28 and Oct4 followed by culture in a MEK inhibitor and a GSK3 inhibitor reprograms tissue cells. The invention provides new uses of these inhibitors, for example in inducing completion of the transcriptional resetting of so-called pre-pluripotent (pre-iPS) stem cells, for example as obtained from mammalian neural stem cells or epiblast stem cells treated with single or combinations of the reprogramming factors, expressed transiently or by integrative vectors. Also provided are systems for reprogramming an epiplast stem cells independently of the use of there inhibitors. 
IP Reference WO2009101407 
Protection Patent granted
Year Protection Granted 2009
Licensed Yes
Impact N/A
 
Description A Stem Cell Story, Edinburgh 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Editorial advisor and contributor to the animated film, "A Stem Cell Story"

Best TV/video production, Tromsø Science Media Festival
Best short film, Scinema (Australia)
In competition, Science Film Festival (Bangkok), BaKaFORUM 2007, Vedere la Scienza
Year(s) Of Engagement Activity 2006
 
Description A Stem Cell Story, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Work on animated film "A Stem Cell Story" for EuroStemCell.

N/A
Year(s) Of Engagement Activity 2006
 
Description A Student's Guide to DNA and Genetics, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Talk to 900 A-level students, The Training Partnership, Institute of Education, speaker

N/A
Year(s) Of Engagement Activity 2009
 
Description Alumni Weekend, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Alumni Weekend, Newnham College, Cambridge, Speaker

N/A
Year(s) Of Engagement Activity 2010
 
Description Cambridge Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 120 public attended the presentation and slide show. There was a Q&A at the end of the talk.

n/a
Year(s) Of Engagement Activity 2013
 
Description Cambridge ideas that could change the world, Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Cambridge Network Open Meeting

N/A
Year(s) Of Engagement Activity 2009
 
Description Cell Therapy, Filmed Interview 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact JDRF Centre for Beta Cell Therapy in Diabetes, interviewee

N/A
Year(s) Of Engagement Activity 2009
 
Description Comparing iPS cells and hES cells, Lund, Sweden 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact ESTOOL: Ethical Aspects of Research on Interspecies Embryos and IPS Cells, Panel participant

N/A
Year(s) Of Engagement Activity 2008
 
Description Debating Matters, Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Institute of Ideas and Pfizer Debating Matters Competition, Judge

N/A
Year(s) Of Engagement Activity 2008
 
Description Debating Matters, Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Institute of Ideas and Pfizer Debating Matters Competition, Judge

N/A
Year(s) Of Engagement Activity 2009
 
Description Discovery - The Stem Cell Story, BBC World Service 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with Sue Broom, presenter of "Discovery - The Stem Cell Story" on BBC World Service

N/A
Year(s) Of Engagement Activity 2009
 
Description Documentary, Edinburgh College of Art 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Filming 'The Definitive Story of Stem Cells' (working title)

N/A
Year(s) Of Engagement Activity 2008
 
Description Growing Businesses with Stem Cells, Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact CULIL/EESCN

N/A
Year(s) Of Engagement Activity 2009
 
Description Ideas to Reality, Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Cambridge Enterprise

N/A
Year(s) Of Engagement Activity 2009
 
Description International Summer School, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact University of Cambridge International Summer School, Guest Lecturer

N/A
Year(s) Of Engagement Activity 2007
 
Description International Summer School, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact University of Cambridge International Summer School, Guest Lecturer

N/A
Year(s) Of Engagement Activity 2009
 
Description International Summer School, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact University of Cambridge International Summer School, Guest Lecturer

N/A
Year(s) Of Engagement Activity 2008
 
Description International Summer School, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact University of Cambridge International Summer School, Guest Lecturer

N/A
Year(s) Of Engagement Activity 2006
 
Description Interview, BBC Radio, Cambridge 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interview on peer review with Palab Ghosh, BBC Radio

N/A
Year(s) Of Engagement Activity 2010
 
Description Interview, Milwaukee Journal Sentinel 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with Mark Johnson, Milwaukee Journal Sentinel

N/A
Year(s) Of Engagement Activity 2008
 
Description Interview, New Scientist etc 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Follow up interview to the above, New Scientist and other media

N/A
Year(s) Of Engagement Activity 2010
 
Description Interview, The Guardian 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interview with Sarah Boseley, Health Editor, The Guardian

N/A
Year(s) Of Engagement Activity 2008
 
Description Interview, The Sun 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview with Jane Symons, Health Correspondent, The Sun

N/A
Year(s) Of Engagement Activity 2008
 
Description Lecture, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Cambridge Society for Applied Research, lecturer

N/A
Year(s) Of Engagement Activity 2010
 
Description Lecture, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Lecture for the Office of Lifelong Learning, University of Edinburgh

N/A
Year(s) Of Engagement Activity 2009
 
Description MRC/MRCT promotion, Tokyo 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Raise the Profile of MRC Funded Science in Japan, British Embassy

N/A
Year(s) Of Engagement Activity 2009
 
Description Master Class, Norwich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Institute of Food Research Teacher Scientist Network Master Class, Guest lecturer

N/A
Year(s) Of Engagement Activity 2008
 
Description Media Round Table, Amsterdam 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact "Stem cells: the next 20 years; natural versus induced pluripotency", EMBO, Amsterdam

N/A
Year(s) Of Engagement Activity 2009
 
Description Meeting with Dr Evan Harris, Liberal Democrat Shadow Science and Innovation Minister 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact NA
Year(s) Of Engagement Activity 2009
 
Description Network Meeting, Melbourne, Australia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact TeamVIC Network Meeting

N/A
Year(s) Of Engagement Activity 2009
 
Description Open Meeting, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Open meeting on Public Engagement on Stem Cell Research, panel member

N/A
Year(s) Of Engagement Activity 2008
 
Description Parliamentary Office of Science and Techonolgy, London 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Considering the scientific developments in stem cell research in last ten years, specifically:
1. ESC lineage restriction and induction of differentiation to produce specific cell types (lineage programming)
2. Scientific developments in cell transplantation, specially ESC-derived neuronal cells to treat neurodegenerative diseases
3. The potential of ESCs in cell replacement therapies
4. potential/limitations of iPSC research concerning therapeutic applications
5. Whether iPSC are equivalent to ESCs
6. Fundamental research on ESC is it necessary
7. Future outcomes for stem cell research

Meeting was with Parliamentary Adviser Dr Mara Almeida
Year(s) Of Engagement Activity 2011
 
Description Plenary Talk, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Caius Medical Association (approx 60-80 Caius medical alumni), plenary speaker

N/A
Year(s) Of Engagement Activity 2010
 
Description Post-doc careers workshop, Warwick 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact Post-doc careers Workshop @ University of Warwick, British Society of Cell Biology, Session Chair

N/A
Year(s) Of Engagement Activity 2010
 
Description Presentation, Cambridge Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Guest speaker (with Colin Blakemore, MRC Chief Executive)

N/A
Year(s) Of Engagement Activity 2007
 
Description Press Round Table, Dresden 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Press Round Table, 2nd International Congress on Stem Cells

N/A
Year(s) Of Engagement Activity 2008
 
Description Public Culture as Professional Science, London 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact LSEPS, Interview for SCOPE (Scientists on Public Engagement: from communication to deliberation), interviewee

N/A
Year(s) Of Engagement Activity 2009
 
Description Regenerative Medicine - a new frontier for therapeutic intervention, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact The Society of Medicines Research, speaker

N/A
Year(s) Of Engagement Activity 2010
 
Description School visit, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Presentation and discussion on stem cell, St George's School for Girls, presenter and discussion leader

N/A
Year(s) Of Engagement Activity 2007
 
Description School visit, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact 800 A-level biology students attended a lecture on Stem Cell Research as part of their annual programme which is called 'A Student's Guide to DNA and Genetics'.

After providing a similar talk in 2009 The Institute of Education in London requested a return lecture.
Year(s) Of Engagement Activity 2009,2011
 
Description Science Summer School, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact University of Cambridge Science Summer School, Guest Lecturer

N/A
Year(s) Of Engagement Activity 2006
 
Description Science Summer School, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact University of Cambridge Science Summer School, Guest Lecturer

N/A
Year(s) Of Engagement Activity 2009
 
Description Science Summer School, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact University of Cambridge Science Summer School, Guest Lecturer

N/A
Year(s) Of Engagement Activity 2007
 
Description Science Summer School, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact University of Cambridge Science Summer School, Guest Lecturer

N/A
Year(s) Of Engagement Activity 2008
 
Description Science Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public presentation on Stem Cells 'Hope or Hype' as part of the Cambridge Science Festival

n/a
Year(s) Of Engagement Activity 2013
 
Description Science in Society, Paris 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Ministere De Leenseignment Superieur, Science in Society

N/A
Year(s) Of Engagement Activity 2008
 
Description Stem Cells and their Secrets, Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact JDRF Cambridge Open Day.

N/A
Year(s) Of Engagement Activity 2009
 
Description Talk Science, British Library, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Presentation and discussion at the British Library, audience including researchers and scientific stakeholders

N/A
Year(s) Of Engagement Activity 2010
 
Description Talk to 6th Form Students, Canterbury 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Talk to 6th Form students, Simon Langton Grammar School for Boys, Speaker

N/A
Year(s) Of Engagement Activity 2009
 
Description Talk to Biomedical Students from Utrecht who were visiting the UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact A group of 50 final year undergraduate and masters students interested in stem cell and regenerative medicine research

To give them and impression of stem cell and regenerative medical research work at an international university for making choice in their academic careers.
Year(s) Of Engagement Activity 2011
 
Description Visit from MEP 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Vicky ford, MEP was interested in meeting to discuss the ECJ ruling on patents for Stem Cell Research

Ms Ford has asked for a follow-up meeting.
Year(s) Of Engagement Activity 2011
 
Description Youth Science Parliament, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Presentation and discussion with 15-20 6th Form Students

N/A
Year(s) Of Engagement Activity 2010