MRC Centre for Immune Regulation

Lead Research Organisation: University of Birmingham
Department Name: Immunity and Infection

Abstract

The immune system plays a vital role in protection against infectious disease caused by a range of micro-organisisms including viruses and bacteria. These responses are normally tightly regulated but when they run out of control they can also cause damage that leads to disease. These diseases include arthritis and inflammatory damage in the liver, kidneys and blood vessels which are a major contributor to the causes of ill health. It is therefore very important to understand how the immune response is regulated and controlled and what happens when this goes wrong. The MRC Centre brings together a series of internationally recognised research groups investigating different aspects of immune system control. These groups study basic mechanisms and apply this knowledge to selected diseases with the aim of identifying improved methods of treatment.

Technical Summary

The mission of the Centre is to gain a better understanding of the regulation of the immune response with a view to developing strategies to augment beneficial responses and limit harmful responses leading to disease. The distinctive feature of research in the Centre, that unifies its component programmes, is its focus on microenvironmental factors controlling lymphocyte responses. Elucidation of these basic mechanisms is targeted to selected diseases with a particular focus on immune factors in auto-immune and inflammatory disease in joints, liver and kidney, and on chronic bacterial and viral infections in man. This is achieved by incorporation into the Centre of groups working on basic mechanisms alongside those investigating disease specific processes. In support of its mission, the Centre has the key aims of providing a well found research environment with state of the art technologies and a training environment in which young scientists and clinicians can gain experience in a wide range of cellular, molecular and in-vivo techniques in immunology. Existing strengths in the Centre focus on four areas of activity, mechanisms in lymphocyte development; induction and regulation of immunity in secondary lymphoid tissues; mechanisms in chronic inflammation; and cellular immunity to viral infection and tumours. To complement these, 3 new initiatives will be developed to add expertise in chemokine biology to the Centre s basic science programmes, to develop the capacity of the Centre to study the impact of ageing on the immune response and to develop the translation of Centre discoveries to therapeutic benefit.

Publications

10 25 50
 
Description Christopher Buckley: Birmingham Experimental Arthritis Treatment Centre for Rheumatoid Arthritis
Amount £225,000 (GBP)
Funding ID 20015 
Organisation Versus Arthritis 
Start  
 
Description Infrastructure - Integrating innovative technologies for genotyping and phenotyping in stratified medicine
Amount £7,181,445 (GBP)
Funding ID MR/M009157/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2015 
End 03/2017
 
Description MRC Centre for Musculoskeletal Ageing Research
Amount £1,227,858 (GBP)
Funding ID MR/K00414X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2012 
End 08/2017
 
Description Strategic Appointment grant
Amount £900,000 (GBP)
Funding ID G0802838 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 08/2009 
End 02/2014
 
Description Adam Cunningam and Cal MacLennan Collaboration with Novartis Vaccines Institute for Global Health S.r.l. 
Organisation Novartis Institutes for BioMedical Research (NIBR)
Department Novartis Vaccines Institute for Global Health (NVGH)
Country United States 
Sector Private 
PI Contribution Research in relation to the mechanisms of protective immunity to Salmonella and its derivative antigens, epidemiology and seroepidemiology of Salmonella and associated aspects; development of vaccines for typhoid, nontyphoidal Salmonella and Shigella.
Collaborator Contribution Potential funding and access to expertise in vaccine devlopment
Impact PhD students registered at Birmingham but working at the Novartis Vaccines Institute. Calman MacLennan honarary Senior Lecturer at Birmingham now Head of the Exploratory programmes at the Vaccine's Institute but still has close ties with Birmingham and publishes papers of work supported by the MRC Centre
Start Year 2010
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation Academic Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation Harvard University
Country United States 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation MedImmune
Country United States 
Sector Private 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation Pfizer Ltd
Country United Kingdom 
Sector Private 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation University of California, Berkeley
Country United States 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation University of Glasgow
Department Institute of Infection, Immunity and Inflammation
Country United Kingdom 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation University of Zurich
Country Switzerland 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation Versus Arthritis
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description David Adams NIHR BIOMEDICAL RESEARCH LIVER UNIT 
Organisation University Hospitals Birmingham NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Research and clinical studies and trials
Collaborator Contribution research and clinical studies and trials
Impact Translational research on stem cell and immunotherapy in liver and liver cancer
Start Year 2009
 
Description 2 page article in the guardian on "How to live longer - the experts' guide to ageing" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Janet Lord featured prominently in a 2 page article in the guardian on "How to live longer - the experts' guide to ageing" The article also included work by PhD student Jerrald Rector about CMV, and Anna Phillips from Sports and exercise Sciences longehttp://www.theguardian.com/science/2013/sep/08/how-to-live-longer-experts-guide-ageingr-experts-guide-ageing

na
Year(s) Of Engagement Activity 2013
URL http://ongehttp://www.theguardian.com/science/2013/sep/08/how-to-live-longer-experts-guide-ageingr-e...
 
Description 4 Events at British Science Festival 6-11 September 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Talk" Can you Prevent RA?"Rheumatoid arthritis is a common chronic disease. Whilst current treatments are unable to cure the disease, we are entering an era in which we may be able to prevent people developing the disease in the first place. This talk updated the public on some of the current developments relating to the latest research on what causes rheumatoid arthritis, predictive testing and preventive treatment. The talk sparked discussion about predictors of RA whether patients would like to know the they were likely to have the disease before symptoms became apparent and when in the life cycle would they like to be treated
"Your astonishing liver; Disease investigation to transplant innovation" informed the public about issues relating to liver disease, transplantation of livers, shortage of liver donors, new equipment being tested to recondition livers for transplant from patients who were not considered previously suitable as donors
"Use it or lose it" and "A cure for Ageing" promoted discussion on healthy ageing
"The first human cancer virus: A history" a talk by Alan Rickinson one of the founder directors of the MRC Centre for Immune Regulation recounted the fascinating story of the 50 years history since the Epstein-Barr virus (EBV) was discovered in a cancer in African children to how today EBV is linked to at least six different types of human cancer across the globe.



Greater understanding by those who attended of the diseases discussed and involovment of the public in research
Year(s) Of Engagement Activity 2014
URL http://www.britishscienceassociation.org/british-science-festival/
 
Description Agewell day to inform older adults about the research on ageing 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Janet Lord ran her annual Agewell day to inform older adults about the research on ageing going on across the university. This year talks covered dementia, liver disease, how to keep a healthy weight and trauma. Despite the venue having a maximum capacity of 100, 130 elders turned


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Year(s) Of Engagement Activity 2013
 
Description Big Bang 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Schools
Results and Impact Centre for Liver Research which is part of the MRC Centre for Immune Regulation took part in the Big Bang Fair on Saturday 17th March which was held at the NEC. This event is specifically aimed at children aged 5-18 years to show them how exciting science and engineering can be.

29,000 children attended,The stand's activities included an 'I'm A Celebrity' style box that children could put their hands in and blindly feel a normal liver compared to a liver with cirrhosis (jelly filled with popcorn feels just like a cirrhotic liver). There was also a tunic with detachable organs that children had to stick back in the correct places and label and a celebrity quiz showing why Homer Simpson may have a liver problem.

Staff also participated in the MRC Bing Bang stand as volunteers.

Peter Balfe promoted the STEM Scheme and ran careers advice workshops
Year(s) Of Engagement Activity 2012
 
Description Big Bang event 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Various staff associated with MRC Centre participated as judges in the Big Bang event in Coventry. They were asked to judge a range of science projects from school children from across the West Midlands. The winners selected will all go through to a national final in London.

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Year(s) Of Engagement Activity 2013
 
Description Demonstrators on the STEMNET stand at the Big Bang Fair 2014 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Sonia Parnell and others from Graham Anderson's Immunology research Group had a very fulfilling time volunteering as activity demonstrators on the STEMNET stand at the Big Bang Fair 2014 recently. The investigative activities were family-focused and suitable for pre-schoolers through to adults. Sonia said she "found it a brilliant opportunity introducing young minds to scientific investigations".




Over the past two years the Anderson/Jenkinson lab have organised 12 work placements in their laboratories in conjunction with King Edward VI and other secondary schools. This has been done in close partnership Julia Kingston, STEM Coordinator at the University of Birmingham STEM Centre. After the placements, Julia commented:

"Your students had a great experience. You and your group are doing a great job. Experiencing the actual lab environment is something they will never forget and it will certainly help them make up their minds [on a scientific career]."

Feedback from a sixth form student who undertook a lab placement wrote ""Thanks for the amazing experience.it gave me some food for thought about my EPQ (Extended Project Qualifications) research"
Year(s) Of Engagement Activity 2014
 
Description House of Commons and meetings with Science Minister 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Speaker to MPs at the BBSRC information event on Ageing research in the UK - at House of Commons in 2008(Janet Lord) and meetings with Science Minister and invited journalists for a discussion of the ageing population at the Royal Society in 2008.

Not known
Year(s) Of Engagement Activity 2008
 
Description Immunology workshops in local schools 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact As part of a long standing and successful link with King Edward VI High School for Girls, Dr Adriana Flores-Langarica recently ran Immunology workshops with year 12 AS Biology groups who are looking to pursue careers in science or medicine.

Adrianna is an experienced STEM ambassador and is passionate about inspiring our future generation of scientists and medics and each of her workshops really challenged the girls understanding of immunology.


Increased understanding of an important area of research Mrs Janette Bagnall, Head of Biology, said "Adriana's questions to the girls demonstrated her careful scrutiny of the level of knowledge and understanding that should be expected at AS level Biology, whilst taking them beyond the confines of the specification to broaden their understanding of the topic".
Year(s) Of Engagement Activity 2014
 
Description MP pairing scheme 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Participation in Royal Society MP Scientist Pairing Scheme (Adam Cunningham)

Not known
Year(s) Of Engagement Activity 2008
 
Description Reigniting Regional Immunity; West Midlands BSI re-launch 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact The West Midlands Regional Affinity Group has traditionally been a very strong local grouping organising. Three early career researchers based in the MRC Centre for Immune Regulation Dave Withers, Zania Stamataki and Will Jenkinson the group organised a conference paid for by teh BSI with invited speakers including Adrian Hayday, Tracy Hussell, Burkhard Ludewig, and early career researchers showcasing research in immune regulation.

New regionally focussed interactions and potential collaborations on Immune Regulation
Year(s) Of Engagement Activity 2014
 
Description Rheumatology Research Patient Partners help shape nationally funded public awareness campaign for rheumatoid arthritis 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Outcomes in rheumatoid arthritis (RA) are significantly improved if patients receive treatment within 12 weeks of the onset of symptoms, this is the conclusion of work borne from researchers at the University of Birmingham and elsewhere.

The Rheumatology Research Group has been working hard to understand reasons for delay in patients with new onset RA seeing a Rheumatologist with a focus on understanding delays at the level of patients seeing their GP. Informed by this work, NHS England, Public Health England and the Department of Health have recently announced their decision to fund a pilot inflammatory arthritis awareness campaign.





The world-famous advertising company M&C Saatchi have been commissioned by the Government to work on this project and representatives have visited Birmingham to run a focus group with members of the Rheumatology Research Patient Partnership (R2P2) to discuss the development of the awareness raising material.
Year(s) Of Engagement Activity 2014
 
Description School Visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact 30 sixth form pupils attended talk on immunology and possible related career options and discussions with individual students

Not yet known
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description School Visits as part of world of work week 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Schools
Results and Impact Adriana Flores-Langarica and Jennifer Marshall from immunology, aided by undergraduate summer student Emma Dutton, visited Christ The King Primary School in Kingstanding as a part of their 'World of Work Week'.Two classes of year 6 pupils (10-11 years) were taught about the role and function of a scientist, the history of DNA and learnt how to extract DNA from kiwi and other fruits.

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Year(s) Of Engagement Activity 2013
 
Description School visits to talk about use of animals in research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Post-doctoral fellows based in the MRC Centre attended local schools to increase awareness amongst children of the use of animals in research

Increased understanding of why use of animals important
Year(s) Of Engagement Activity 2013,2014
 
Description University of Birmingham Community Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Centre for Liver Research who had a range of fun activities for adults and children. Staff in the MRC Centre for Immune Regulation working on stem cells ranan informal discussion on ethics and the role of stem cells . It was a public engagement success for the University. Although we don't know the official figures, there looked to be several thousand attending.





Not known
Year(s) Of Engagement Activity 2012
 
Description WI talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Group of 40 people attended talk on how medical research works and is funded.

Not yet known
Year(s) Of Engagement Activity 2010,2011
 
Description Wellcome Trust Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Various activities by Centre members particularly in relation to Rheumatoid Arthritis, Liver Disease and ageing

More participation in patient groups and increased awareness of clinical trials for clinical trial recruitment
Year(s) Of Engagement Activity 2009,2010,2011,2012,2013