Linking measles virus genotypes to phenotypes

Lead Research Organisation: Queen's University of Belfast
Department Name: Sch of Biological Sciences


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Description MRC Programme Grant (G0501427)
Amount £633,184 (GBP)
Funding ID G0501427 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2006 
End 07/2010
Description project grant support: molecular determinants of morbillivirus pathogenesis
Amount £237,275 (GBP)
Organisation Department of Health Social Services and Public Safety (DHSSPS) 
Sector Public
Country United Kingdom
Start 07/2006 
End 06/2008
Title new version of measles virus vectors and viruses with new phenotypes 
Description viruses that express autofluorescent proteins such as dsRED1, and 2 and Cyan fluorescent protein 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact increased collbaoration with others 
Description Belfast - Wuerzburg Partnership 
Organisation University of Wurzburg
Department Institute of Virology and Immunobiology Würzburg
Country Germany 
Sector Academic/University 
PI Contribution We organise an annual invitation only meeting of European measles virus researchers in Wuerzburg. Through this wehave provided ideas for development of work; supervised students when they visited here; supplied recombinant viruses and technology
Collaborator Contribution Long standing exchange of reagents; occasional visits and most importantly ideas
Impact PMedId: 16690928; 16760404; 17374768;17947537
Description Belfast Rotterdam partnership 
Organisation Erasmus University Rotterdam
Department Department of Virology
Country Netherlands 
Sector Academic/University 
PI Contribution We supply recombinant viruses and analyse histology and bio-imaging data for the joint project that resulted
Collaborator Contribution This partnesrship allowed us to apply for the grant under the MRC models call which we obtained because it allowed to contemplate work on macaques
Impact PMID: 18020706
Start Year 2007
Description Assisting the US vaccine Court in claims re MMR and autism 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Based on my reserach experience on measles and mumps viruses I was able to appear as a witness for the US department of justice in the vaccine court cases re the claim that meMMR vaccine causes autism.

My evidence was a crucial part of the that pesented thta led the Court to dismiss the claim that MMR caused autism in a test case which was part of a large claim agains the Vccine Court.
Year(s) Of Engagement Activity 2007