Inflammation and Immunity
Lead Research Organisation:
Health Data Research UK
Department Name: UNLISTED
Abstract
The Inflammation and Immunity research programme will transform the UK capabilities to understand the inner workings of disease. The research will develop ways to map the people suffering from common allergic and breathing conditions alongside information on their care and outcomes across the UK. The maps will be used to explore variation in how people are cared for and develop tools to help healthcare services improve and reduce inequalities.
This will lay the foundations, building tools and new ways, for other researchers to understand and improve care for other causes of breathing conditions, and develop ways to better predict, prevent and manage illness.
This will lay the foundations, building tools and new ways, for other researchers to understand and improve care for other causes of breathing conditions, and develop ways to better predict, prevent and manage illness.
Technical Summary
This work is funded by the UKRI Medical Research Council, UKRI Engineering and Physical Sciences Research Council, UKRI Economic and Social Research Council, Department of Health and Social Care, National Institute for Health Research (England), Chief Scientist Office (Scottish Government), Health and Care Research Wales, Public Health Agency HSC (Northern Ireland), British Heart Foundation and Cancer Research UK
The Inflammation and Immunity Driver Programme will explore inflammation and immunity as general underpinning mechanisms, using highly prevalent respiratory and allergic diseases in the first instance. These illnesses can be exacerbated by acute inflammatory episodes due to infections (i.e., rhinovirus, coronaviruses, influenza, pneumonia, RSV), pollution, tobacco, pollen, weather, drugs, foods and stinging insects, and are exemplars of seasonal, chronic inflammatory respiratory illnesses. Although efforts will initially be focused here, the long-term plan is to extend the data science capabilities and capacity to other inflammatory mediated diseases in the future.
Impact and legacy
The programme will provide a data foundation to contribute to novel respiratory health and clinical strategies that better predict, prevent and manage respiratory conditions. The programme will follow the principles of team science and build on the achievements of the first five years made by the team and by HDR UK more widely. This will include building on and developing new collaborations developed through the BREATHE Hub and leveraging core support by attracting external funding. It will give back to the scientific community by developing open-source tools and methods, providing a framework and approach for studying the surveillance and trajectory of other inflammatory and immune disorders. The programme will develop future research leaders and engage with and involve patients and the public through all workstreams whilst contributing to and utilising the HDR UK Infrastructure and Services pillars and global strategy.
The Inflammation and Immunity Driver Programme will explore inflammation and immunity as general underpinning mechanisms, using highly prevalent respiratory and allergic diseases in the first instance. These illnesses can be exacerbated by acute inflammatory episodes due to infections (i.e., rhinovirus, coronaviruses, influenza, pneumonia, RSV), pollution, tobacco, pollen, weather, drugs, foods and stinging insects, and are exemplars of seasonal, chronic inflammatory respiratory illnesses. Although efforts will initially be focused here, the long-term plan is to extend the data science capabilities and capacity to other inflammatory mediated diseases in the future.
Impact and legacy
The programme will provide a data foundation to contribute to novel respiratory health and clinical strategies that better predict, prevent and manage respiratory conditions. The programme will follow the principles of team science and build on the achievements of the first five years made by the team and by HDR UK more widely. This will include building on and developing new collaborations developed through the BREATHE Hub and leveraging core support by attracting external funding. It will give back to the scientific community by developing open-source tools and methods, providing a framework and approach for studying the surveillance and trajectory of other inflammatory and immune disorders. The programme will develop future research leaders and engage with and involve patients and the public through all workstreams whilst contributing to and utilising the HDR UK Infrastructure and Services pillars and global strategy.
