Establishment of a Resource for Long-Term Study of Hepatitis C Virus Infection in the UK - HCV Research UK

Lead Research Organisation: MRC Virology Unit

Abstract

Clinical problems associated with chronic infection by hepatitis C virus (HCV) will continue
to increase in the UK for the foreseeable future. While there has been considerable
progress with understanding the biology of the virus and improvements in healthcare
provision, many issues relevant to the characteristics of HCV infection in the UK remain
unresolved, such as the factors that contribute to development of serious liver disease
and failure to respond to treatment. To address these issues, this proposal aims to create
the infrastructure that will allow recruitment of a national cohort of at least 10,000
patients. Assembling a cohort of this size is necessary to generate a representative but
sufficiently diverse collection of patient characteristics and clinical samples to explore in
detail the determinants that may contribute to HCV pathogenesis and response to
treatment. The key components of the national resource that will be created are a clinical
research database for retaining details of patient characteristics, a biobank of clinical
samples, which will form a UK repository, and a sequence and bioinformatics database to
hold viral and host genetic information. The infrastructure will be supported by and build
upon existing knowledge and expertise at national agencies (Health Protection Agency
and Health Protection Scotland), the Gastroenterology and Liver Disease Biomedical
Research Unit at Nottingham and the MRC Virology Unit in Glasgow. Patients will be
recruited from clinical centres across most of the UK who provide care for HCV-infected
patients. To provide proof of principle for the utility of clinical research and sequence
databases combined with the availability of a biobank of clinical samples, a limited series
of research projects will be performed. The projects will focus on examining whether
there is a correlation between patient genetic markers and treatment outcome. In
addition, the viral sequences of a large number of isolates for HCV genotypes 1 and 3 in
different ethnic groups will be determined. These studies will provide the foundation for
the information that will be deposited in the sequence and bioinformatics database. The
availability of such a well-structured resource is highly likely to stimulate greater clinical
and fundamental research into HCV infection in the UK and will also form the basis for
longitudinal studies into the natural history of chronic infection in a large cohort of
patients.

Technical Summary

The healthcare burden associated with chronic hepatitis C virus (HCV) infection will
continue to increase in the UK for the foreseeable future. While there has been
considerable progress with understanding the biology of the virus and improvements in
healthcare provision, many issues relevant to the characteristics of HCV infection in the
UK remain unresolved, such as the host, viral, and environmental factors that
contribute to development of serious liver disease and failure to respond to treatment.
To address these issues, this proposal aims to: a) Establish a national cohort of 10,000
HCV-infected patients, supported by an integrated, standardised clinical database with
demographic, clinical and laboratory parameters, b) Create a biobank of biological
samples from the cohort for studies of host and viral factors associated with disease
outcome and treatment response, c) Execute a limited set of research studies to
generate viral and host sequence data to demonstrate the value and potential of the
cohort and biobank, and d) Generate a bioinformatics database from the viral and host
sequence data [acquired in c)], which can be linked to the clinical database [in a)].
Assembling a cohort of this size is necessary to generate a representative but
sufficiently diverse collection of patient characteristics and clinical samples to explore in
detail the determinants that may contribute to HCV pathogenesis and response to
treatment. The infrastructure will be supported by and build upon existing knowledge
and expertise at national agencies (Health Protection Agency and Health Protection
Scotland), the Gastroenterology and Liver Disease Biomedical Research Unit at
Nottingham and the MRC Virology Unit in Glasgow. Patients will be recruited from
clinical centres across most of the UK who provide care for HCV-infected patients. To
provide proof of principle for the utility of clinical research and sequence databases
combined with the availability of a biobank of clinical samples, a limited series of
research projects will be performed. The projects will focus on examining whether there
is a correlation between single polynucleotide polymorphisms in host genomic
sequences and treatment outcome. In addition, the viral sequences of a large number
of isolates for HCV genotypes 1 and 3 in different ethnic groups will be determined.
These studies will provide the foundation for the information that will be deposited in
the sequence and bioinformatics database. The availability of such a well-structured
resource is highly likely to stimulate greater clinical and fundamental research into HCV
infection in the UK and will also form the basis for longitudinal studies into the natural
history of chronic infection in a large cohort of patients.

Organisations

Publications

10 25 50
 
Description Gilead Clinical Trial
Amount £35,000 (GBP)
Organisation Gilead Sciences, Inc. 
Department Gilead
Sector Private
Country United Kingdom
Start 11/2013 
End 12/2014
 
Title HCV Research UK Clinical Database and Biobank 
Description Information from consenting patients have been entered into a clinical database. These patients also provide clinical samples for the biobank. The clinical database and management system for the biobank are bespoke systems built specifically for HCV Research UK. They have been developed such that interaction between the two database systems can be achieved. The data and samples are made available to researchers (either in academia or the pharmaceutical industry; both UK- and non-UK-based) 
Type Of Material Biological samples 
Year Produced 2013 
Provided To Others? Yes  
Impact The establishment of HCV Research UK has underpinned and directly enabled the following: 1. Award of £4M grant on MRC call for Stratified Medicine to the STOP-HCV consortium, a group of academic institutions, national health agencies and pharmaceutical companies. 2. Requests from several pharmaceutical companies for access to data for submissions to NICE for new anti-viral compounds. 3. Requests from pharmaceutical companies for access to samples for new diagnostic tests. 4. Access to data and samples from HCV-infected patients from across the UK for phyloepidemiological studies. 5. Provided a large number of samples for development of high throughput sequencing methodologies. 6. Provided the samples for a Health Innovation Challenge Fund award by Wellcome Trust for enabling roll-out of high throughput sequencing across NHS sites. 7. Enabled collection of data and samples on Early Access Programme, an initiative funded by NHS England to allow patients access to interferon-free therapies for HCV infection ahead of NICE approval. 
URL http://www.hcvresearchuk.org/
 
Title HCV Research UK 
Description HCV Research UK holds the clinical data for approximately 11,000 patients infected with hepatitis C virus in the UK. We also have a linked biobank database for holding the information on all samples processed and stored in the HCV Research UK biorepository. 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact The data and samples have been used for a number of purposes including: 1. Submissions to NICE by pharma companies 2. Submission to the European Medicines Agency on drug utilisation 3. Data provided, in combination with samples, for extensive viral sequencing and host genetic studies. 4. Acting as the data and sample repository for a Gilead-funded phase III clinical trial in the UK, USA and Australia (BOSON) 5 Acting as the data and sample repository for the NHS England Early Access Programme that provides IFN-free, all oral therapy to HCV-infected patients with serious liver disease. 6. Underpins the data and samples provided to the STOP-HCV MRC-funded consortium. 7. Provides infrastructure support for the STOP-HCV Cirrhosis study and the STOP-HCV1 EME study. 
URL http://www.hcvresearchuk.org
 
Description HCV Research UK - Aberdeen Royal Infirmary 
Organisation Aberdeen Royal Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Provision of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Addenbrooke's Hospital 
Organisation Addenbrooke's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - BMS 
Organisation Bristol-Myers Squibb
Country United States 
Sector Private 
PI Contribution Provision of data from the HCV Research UK database
Collaborator Contribution Financial contribution
Impact N/A
Start Year 2013
 
Description HCV Research UK - Birmingham Children's Hospital 
Organisation Birmingham Women's and Children's NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Provision of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Derriford Hospital 
Organisation Derriford Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Freeman Hospital 
Organisation Freeman Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - GSK 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Storage of samples from Eltrombopag Prospective Observational Cohort Study Nested Within the HCV Research UK National Registry
Collaborator Contribution Financial contribution
Impact N/A
Start Year 2013
 
Description HCV Research UK - Gartnavel General Hospital 
Organisation Gartnavel General Hospital, Glasgow
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Gilead 
Organisation Gilead Sciences, Inc.
Department Gilead
Country United Kingdom 
Sector Private 
PI Contribution Provision of samples from HCV Research UK Biobank
Collaborator Contribution Funding for a research assistant to work in the HCV Research UK biobank
Impact N/A
Start Year 2013
 
Description HCV Research UK - Glasgow Royal Infirmary 
Organisation Glasgow Royal Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Glasgow Victoria Hospital 
Organisation NHS Greater Glasgow and Clyde (NHSGGC)
Department NHS Greater Glasgow and Clyde Endowments
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Great Ormond Street 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Provision of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - John Radcliffe Hospital 
Organisation Oxford University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - King's College Hospital 
Organisation King's College Hospital NHS Foundation Trust (NCH)
Department Paediatric Services
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Provision of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - LASER 
Organisation Laser Analytica
Country United Kingdom 
Sector Private 
PI Contribution Study program using electronic healthcare registers/databases
Collaborator Contribution Financial contribution
Impact N/A
Start Year 2012
 
Description HCV Research UK - Leeds Children's Hospital 
Organisation Leeds Teaching Hospitals Charitable Foundation
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Provision of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Leicester Royal Infirmary 
Organisation Leicester Royal Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Lincoln County Hospital 
Organisation United Lincolnshire Hospitals NHS Trust
Department Lincoln County Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Provision of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Monklands Hospital 
Organisation Monklands District General Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Ninewells Hospital and Medical School 
Organisation Ninewells Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Queen Elizabeth Hospital, Birmingham 
Organisation Queen Elizabeth Hospital Birmingham
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Provision of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Queen's Medical Centre 
Organisation Queen's Medical Centre
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Royal Aberdeen Children's Hospital 
Organisation NHS Grampian
Department Royal Aberdeen Children's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Royal Alexandra Hospital 
Organisation Royal Alexandra Children's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Royal Derby Hospital 
Organisation Royal Derby Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Provision of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Royal Free Hospital 
Organisation Royal Free Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Royal Hallamshire Hospital 
Organisation Royal Hallamshire Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Royal Hospital for Sick Children, Glasgow 
Organisation Royal Hospital for Children
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Provision of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Royal Infirmary of Edinburgh 
Organisation Royal Infirmary of Edinburgh
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Sandwell & City Hospitals, Birmingham 
Organisation Sandwell and West Birmingham Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Provision of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Southern General Hospital 
Organisation Queen Elizabeth University Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - St Mary's Hospital 
Organisation St Mary's Hospital, London
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - St Mary's Paediatric 
Organisation St Mary's Hospital, London
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Provision of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Tayside Children's Hospital, Dundee 
Organisation Tayside Children’s Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - The Royal London Hospital, Whitechapel 
Organisation Royal London Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Uni Nottingham 
Organisation University of Nottingham
Department Clinical Virology
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr John McLauchlan is co-chair of the HCV Research UK Steering Committee and, Management Group. He shares responsibility for the day-to-day running of HCV Research UK with Prof Will Irving.
Collaborator Contribution Prof Will Irving is co-Chair of the HCV Research UK Steering Committee and, Management Group. He shares responsibility for the day-to-day running of HCV Research UK with Dr John McLauchlan. In addition, he acts as line manager for the Project Manager and oversees the co-ordination of the HCV Research UK network and clinical database.
Impact N/A
Start Year 2012
 
Description HCV Research UK - University College Hospital 
Organisation University College London Hospital
Country United Kingdom 
Sector Public 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Description HCV Research UK - Western General Hospital 
Organisation Western General Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Inclusion of HCV samples in HCV Research UK biobank
Collaborator Contribution Collection of HCV samples
Impact N/A
Start Year 2012
 
Title HCV Research UK - database framework 
Description HCV Research UK database is a bespoke design undertaken by Illuminaries Ltd. The framework for this database is now also being used by PBC UK. 
Type Support Tool - For Fundamental Research
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2012
Development Status Under active development/distribution
Impact N/A 
URL http://www.hcvresearchuk.org
 
Description Abbvie Medical Team 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Organised an afternoon of speakers and presentations on a) HCV diagnostics now an din the future, b) sequencing methods for identifying resistance in patients who fail therapy and c) possible issues for difficult-to-treat patients with new therapies.
Year(s) Of Engagement Activity 2014,2017
 
Description BBC News Story - HCV Alert Carol Leitch 23 February 2016 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Carol Leitch, at the request of Health Protection Scotland carried out the phylogenetic analysis of the 2 patient samples suspected of being infected by a healthcare worker in Lanarkshire. She was able to show that the HCV infecting these individuals was closely related and this was backed up by individuals from PHE who performed another analysis. This led to the realisation that these patients had likely been infected during a procedure carried out by the healthcare worker. This information formed the basis of a report submitted by NHS Lanarkshire to the UK Advisory Panel for Healthcare Workers Infected with Blood Borne Viruses and the national body endorsed the health board's proposal to carry out a patient notification exercise. 8383 patients treated by this healthcare worked will now be contacted and offered screening for HCV. As a result, the BBC featured a news story about the security alert- http://www.bbc.co.uk/news/uk-scotland-glasgow-west-35639826. This is an example how the work of the CVR has a direct influence on Policy, Practice, along with patients and public interests.
Year(s) Of Engagement Activity 2016
URL https://www.facebook.com/centreforvirusresearch/
 
Description BBC Scotland - Report on introduction of HCV into Scotland 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Media interview with BBC Scotland and release of information on BBC website.
Year(s) Of Engagement Activity 2015
URL http://www.bbc.co.uk/news/uk-scotland-34658098
 
Description Blog Post #4: Measles (Connor Bamford) - March 2015 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This post received 179 views along with online comments and discussion, and likes and tweets on social media.

Connor Bamford, the author of the post, received 4 emails providing positive feedback both from other CVR researchers but also from external colleagues, demonstrating that the blog was gaining further interest and was viewed in a positive light.
Year(s) Of Engagement Activity 2015
URL https://www.facebook.com/centreforvirusresearch/
 
Description Blog for MRC Insight - 2013 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog written for MRC Insight to describe the aims of HCV Research UK.
Year(s) Of Engagement Activity 2013
URL http://www.insight.mrc.ac.uk/2013/01/21/a-helping-hand-for-hepatitis-c-treatment/
 
Description CVR Blog #10 Viral Hepatitis - Connor Bamford July 2015 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Our 10th blog post about Hepatitis C infection. The blog post reached 776 people on Facebook and received 563 views.
Year(s) Of Engagement Activity 2015
URL https://www.facebook.com/centreforvirusresearch/
 
Description CVR Blog #12 CVR at the Glasgow Science Festival - July 2015 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Our 12th blog showcased the CVR's activities at the Glasgow Science Festival in June 2015. The post reached 792 people on Facebook and received 183 views.
Year(s) Of Engagement Activity 2015
URL https://www.facebook.com/centreforvirusresearch/
 
Description CVR Blog #17 ADAP2 Inhibition Connor Bamford October 2015 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Our 17th Blog post by Connor Bamford on the topic of ADAP2 inhibition and virus entry into cells. The post was viewed 144 times.
Year(s) Of Engagement Activity 2015
URL https://www.facebook.com/centreforvirusresearch/
 
Description CVR Blog #7 Microtalks - Connor Bamford May 2015 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Our 7th Blog post promoting a CVR Glasgow Science Festival event. Reached 131 people on Facebook and received 160 views.
Year(s) Of Engagement Activity 2015
URL https://www.facebook.com/centreforvirusresearch/
 
Description CVR Blog Post 2: Meet the Expert Dr John Mclachlan (Veronica Rezelj) - February 2015 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact 192 people read the blog post with likes reported on Facebook and Twitter.

The increased number of views versus the first post demonstrated a heightened awareness of the blog and therefore, demonstrated an uplift in followers.
Year(s) Of Engagement Activity 2015
URL https://www.facebook.com/centreforvirusresearch/
 
Description CVR Blog post 1: Hepatitis C Virus (Connor Bamford) - February 2015 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The blog post encouraged online comments and discussion among readers.

The post encouraged readers to follow the CVR blog therefore encouraging further future interaction and engagement.
Year(s) Of Engagement Activity 2015
URL https://www.facebook.com/centreforvirusresearch/
 
Description Carol Monaghan MP visit - 30 October 2015 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact Local MP of the Glasgow North West Constituency Carol Monaghan came to visit the CVR to meet with our Director Massimo Palmarini to learn about the important research carried out at the centre along with taking in a tour of the facility. Carol was able to meet with several of our researchers who provided short presentations about their research. Carol was very enthusiastic to learn about our research, links with industry and also about importance of funding. She then went on to mention the CVR and what she had learned during the visit at a parliamentary meeting in Westminster later that week. Furthermore, she then went on to visit one of the other Biomedical research centres that forms part of the University of Glasgow to gain a further insight into some of the important work and research being carried out across the University.
Year(s) Of Engagement Activity 2015
URL https://www.facebook.com/centreforvirusresearch/
 
Description Clinical Staff - Invited Lecture on HCV Treatment 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Presented lecture on targets for new therapies for HCV infection and issues over drug resistance to clinicians and nursing staff. Feedback indicated that this improved knowledge of new treatments.
Year(s) Of Engagement Activity 2016
 
Description Connor Bamford - The Conversation Oct 2014 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Connor Bamford, CVR postdoc, discusses the shipment of an experimental Ebola vaccine to West Africa in a blog in The Conversation.

Due to the popularity of Connor's blogs, he is now featured as a regular writer in this popular online publication.
Year(s) Of Engagement Activity 2014
URL http://theconversation.com/high-hopes-rest-on-800-vials-of-experimental-ebola-vaccine-shipped-from-c...
 
Description Engagement with support groups for HCV-infected patients 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact HCV Research UK has created a Steering Committee to oversee its activities. Patient support groups (HepC Trust and British Liver Trust) both have representatives on this committee. They are full members with the ability to comment on any plans for HCV Research UK. In addition, I have given oral presentations and led discussions with local and national HepC support groups (Hepatitis Scotland and Waverley Care).

Patient groups feel part of the study and will be able to give feedback to their relevant groups. In addition, it enabled patients to ask questions about the types of research and clinical studies on new anti-viral compounds.
Year(s) Of Engagement Activity 2011,2013
 
Description European Biobank conference, Vienna, Austria 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Presented invited lecture on HCV Research UK to illustrate the sustainability of biobanks to an international audience.
Year(s) Of Engagement Activity 2016
 
Description HCV Research UK Launch January 2013 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact HCV Research UK is a multi-disciplinary collaborative enterprise funded by a £1.92m grant from the Medical Research Foundation and based at the MRC-University of Glasgow Centre for Virus Research.

This ground breaking initiative has involved the development of a Bio-repository of clinical samples and cohort study of greater than 10,000 patients infected by Hepatitis C Virus (HCV).

The database of information gathered about this cohort group is supporting the work of STOP-HCV and is also influencing prescribing decisions taken by the NHS. The information is also being made available for future research into HCV infection, thereby influencing and creating greater funding opportunities for research in this disease area.
Year(s) Of Engagement Activity 2013,2014,2015
URL http://hcvresearchuk.org
 
Description HCV Research UK Press Release December 2014 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact In November of 2014, HCV Research UK, a consortium of experts in the field of Hepatitis C Virus who are leading a ground-breaking cohort study of Hepatitis C Virus infected patients, reached a landmark point in the project - recruiting 10,000 patients to the study ahead of their target date of the 31st December 2014. As a result of this success, we circulated a press release to the national press to share the news and also shared a story in the December edition of MRC Life.

The story featured in MRC Life, sharing this success story with other MRC Research Centres. The story was also features in the Viral Hepatitis in Practice publication in December 2014.
Year(s) Of Engagement Activity 2014
URL http://www.gla.ac.uk/researchinstitutes/iii/cvr/news/headline_391453_en.html
 
Description Hepatitis C Virus Origins Paper Press Release October 2015 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Following the publication of a CVR paper, which demonstrated the origins of Hepatitis C virus in Scotland, we issued a press release for distribution to the media. This resulted in news stories in several news papers including The Scotsman, The Herald, The Independent and the Daily Express as well as a feature on the BBC news website. Carol Leitch (one of the authors) also took part in an interview with BBC Radio Scotland. Links to stories as follows:
http://www.bbc.co.uk/news/uk-scotland-34658098
http://www.thetimes.co.uk/tto/news/uk/scotland/article4599284.ece
http://www.scotsman.com/news/health/scientists-track-hepatitis-c-roots-in-scotland-1-3930369#axzz3pwgMI6mV
http://www.heraldscotland.com/news/homenews/13901425.Research_traces_hepatitis_C_infection_roots_to_Second_World_War/
http://www.thenational.scot/news/wartime-glasgow-study-offers-hope-in-hepatitis-c-battle.9
http://medicalxpress.com/news/2015-10-hepatitis-infections-scotland-wwii.html
Year(s) Of Engagement Activity 2015
URL https://www.facebook.com/centreforvirusresearch/
 
Description ICGEB meeting on Human RNA Viruses, Costa Rica 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gave invited lecture and allowed advertising the CVR as an international centre for virological research.
Year(s) Of Engagement Activity 2016
URL http://www.icgeb.org/rna-virus-workshop-2016.html
 
Description Interviews 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact I have given interviews to journalists for newspapers.

There was no further contact with the journalists and so it is difficult to judge any impact.
Year(s) Of Engagement Activity 2006,2007
 
Description Invited Speaker at North of England Viral Hepatitis meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited to present findings on possible resistance to new antiviral therapies for treating hepatitis C virus (HCV) infection to a group of clinicians, pharma representatives and nurses. Discussion centred on potential difficulties with natural strains that may be resistant and also retreatment for those patients in whom the drugs did not clear the virus.
Year(s) Of Engagement Activity 2017
 
Description Invited seminar speaker at the University of Hvidore, Denmark. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to speak on the variability of hepatitis C virus (HCV) and the potential difficulties that this may pose for treating patients with new antiviral therapies. Discussion centred on the extent of variability of the virus as a possible problem for global eradication.
Year(s) Of Engagement Activity 2017
 
Description Invited speaker at a Gilead business event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact The presentation was an update on possible resistance to novel antiviral therapies for treating hepatitis C virus (HCV) infection to the UK group of Gilead, a pharma company with drugs that have been approved for clinical use in HCV therapy.
Year(s) Of Engagement Activity 2017
 
Description Kelvingrove Museum Science Weekend 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact We ran our 'Build a virus' and 'One Infection' activities - offering participants the opportunity to learn all about the structure of viruses and also key messages related to the transmission of viruses, hygiene and vaccination.

Participants were asked to provide feedback on the activities to help us determine how to improve the activity in future. We have been asked to submit a proposal to run an activity during the Glasgow Science Festival in June 2015.
Year(s) Of Engagement Activity 2014
 
Description MRC Centenary Celebrations 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Over the course of two events in June 2013, we interacted with approximately 350 children and their families. We used these interactions to communicate some basic facts about viruses - focussing on their size, structure, routes of transmission and how to limit spread. As part of the activity, we asked participants to consider the question 'If you were a virology researcher what would you study?' and collected responses using post-it note feedback. This provided a good opportunity to discuss the impact of medical research (we often used vaccines as an example), and the importance of the support of the Medical Research Council to help scientists tackle some of the greatest health problems facing humanity.

We have been invited to display the timeline at local schools and science centres across Scotland.
Year(s) Of Engagement Activity 2013
URL http://www.virusesacenturyofdiscovery.org.uk
 
Description MRC Festival of Medical Research 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact The event was aimed at individuals infected with hepatitis C virus (HCV) as well as carers, professionals and national support groups for those infected with the virus. The day was planned to include talks on various topics relevant to HCV-infected individuals (new treatments, likely outcomes, liver disease) and how the CVR was addressing these themes in its research portfolio. Feedback on the event was universally positive from those who attended.
Year(s) Of Engagement Activity 2016
 
Description MRC Insight Publication 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog for MRC Insight to update activities associated with HCV Research UK and STOP-HCV.
Year(s) Of Engagement Activity 2015
URL http://www.insight.mrc.ac.uk/2015/07/28/finding-the-right-treatment-for-patients-with-hepatitis-c/
 
Description MRC Life - John McLachlan July 2015 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The article was posted on our Facebook and Twitter pages and encouraged online comments and likes.

No notable impact.
Year(s) Of Engagement Activity 2015
URL https://www.facebook.com/centreforvirusresearch/
 
Description NHS Research Scotland conference, QEUH, Glasgow 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited lecture on STOP-HCV and HCV Research UK to demonstrate benefits of stratified medicine for treating HCV infection.
Year(s) Of Engagement Activity 2016
 
Description National Forum for HCV 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presented data on resistance identified in patients receiving new therapies for HCV infection to inform a national group about the possible importance of resistance testing.
Year(s) Of Engagement Activity 2016
 
Description PCR workshop - Glasgow Science Centre 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact The workshop was organised by Dr D Bhella from the Unit and he will no doubt provide more comprehensive details. Both of the CDFs employed on the project volunteered their time and expertise for the workshop.

As noted above, Dr D Bhella will most likely address this question on behalf of the Unit.
Year(s) Of Engagement Activity 2009
 
Description Presentations to school children 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Schools
Results and Impact Formal presentation by PhD students to sixth form school children about their research projects at Glasgow Science Centre (2006 and 2008). Also regular contributions made by team members to workshops and demonstrations at Glasgow Science Centre and the Edinburgh Science Fair. Team members have also participated regularly in workshops at Schools Open Days hosted by our establishment (MRC Virology Unit)

These activities have encouraged gifted school children about science. The formal talks in particular were very positively received by both pupils and teachers.
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description Scottish Society for Gastroenterology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presented lecture on targets for new therapies for HCV infection and issues over drug resistance to clinicians at a national conference.
Year(s) Of Engagement Activity 2016
 
Description Sheila Sherlock Updates, Royal Free London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented invited lecture on targets for new therapies for HCV infection and issues over drug resistance to clinicians and academic staff.
Year(s) Of Engagement Activity 2016
 
Description Showcase Event - HCV Research UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The event was organised by the British Association for Study of the Liver/British Viral Hepatitis Groups to showcase consortia involved in HCV infection but primarily HCV Research UK. The purpose was to demonstrate the impact of HCV Research UK at the national level on collecting data and clinical samples to promote research into the virus, in particular with reference to the new therapies now available for treatment.
Year(s) Of Engagement Activity 2015
 
Description Sun Yat-Sen University, Guangzhou, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture to promote collaboration between CVR and Sun Yat-Sen University. The outcome was a collaboration with the Guangzhou Blood Centre, which led to a 1 year working visit by a senior member of their staff to the CVR.
Year(s) Of Engagement Activity 2016
 
Description UK Clinical Pharmacists Association - Masterclass on HCV Treatment #1 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The workshop was aimed at clinical pharmacists to broaden their knowledge of new therapies for HCV infection and issues over drug resistance. Feedback from the event was that the presentation improved knowledge of new therapies and issues over their use.
Year(s) Of Engagement Activity 2016,2017,2018
 
Description UK Clinical Pharmacists Association - Masterclass on HCV Treatment #2 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The workshop was aimed at clinical pharmacists to broaden their knowledge of new therapies for HCV infection and issues over drug resistance. Feedback from the event was that the presentation improved knowledge of new therapies and issues over their use.
Year(s) Of Engagement Activity 2016
 
Description University of Leicester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Presentation on how different disciplines impact on virus research.
Year(s) Of Engagement Activity 2016
 
Description presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact I have given a presentation to a HepC support group and been involved in fund-raising activities.

Support groups are more aware of the activities funded by MRC to study HCV infection
Year(s) Of Engagement Activity 2006
 
Description presentations 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact I have given practical demonstrations and talks at open days for schools.

There are now well-established contacts with local schools and teachers. Students have expressed a greater interest in pursuing a scientific career after the open day events.
Year(s) Of Engagement Activity 2006,2007,2008