Investigating Novel Stress Response Pathways in Neurological Disease
Lead Research Organisation:
MRC Harwell Institute
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- MRC Harwell Institute (Lead Research Organisation)
- Francis Crick Institute (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- Buck Institute for Age Research (Collaboration)
- University of Genoa (Collaboration)
- Medical University of South Carolina (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
People |
ORCID iD |
Publications
Ang G
(2018)
Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders.
in Translational psychiatry
Castroflorio E
(2021)
The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour.
in Cellular and molecular life sciences : CMLS
Crawford K
(2021)
Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
in Cells
Finelli MJ
(2017)
TLDc proteins: new players in the oxidative stress response and neurological disease.
in Mammalian genome : official journal of the International Mammalian Genome Society
Finelli MJ
(2019)
The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons.
in Human molecular genetics
Finelli MJ
(2019)
Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase.
in Molecular neurobiology
Hunn BHM
(2019)
Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.
in Cell reports
Merkulova M
(2018)
Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice.
in American journal of physiology. Renal physiology
Parsons ALM
(2022)
The Interconnected Mechanisms of Oxidative Stress and Neuroinflammation in Epilepsy.
in Antioxidants (Basel, Switzerland)
| Description | Modulating the communication within brain cells by the epilepsy gene TBC1D24 |
| Amount | £20,000 (GBP) |
| Organisation | Epilepsy Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2018 |
| End | 06/2020 |
| Description | Investigating the protective role of OXR1 in models of Alzheimer's disease |
| Organisation | Buck Institute for Age Research |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Supplying mouse models of OXR1 over-expression |
| Collaborator Contribution | Supplying novel models of AD |
| Impact | N/A |
| Start Year | 2019 |
| Description | Protective role of OXR1 in Parkinson's disease |
| Organisation | Medical University of South Carolina |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Investigating the role of OXR1 as a protective factor in rodent models of PD - supplying mice |
| Collaborator Contribution | Investigating the role of OXR1 as a protective factor in rodent models of PD - supplying mice PD models and data analysis |
| Impact | Poster at SFN 2019 |
| Start Year | 2018 |
| Description | Role of TLDc proteins in lysosomal function |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing novel genetic tools |
| Collaborator Contribution | Providing expertise in lysosomal biology |
| Impact | ERUK Pilot Grant funding |
| Start Year | 2018 |
| Description | Role of TLDc proteins in viral infection |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supplying tissue samples for in vitro cellular assays at The Crick |
| Collaborator Contribution | Assayaing viral infection in vitro |
| Impact | Preliminary in vitro studies |
| Start Year | 2019 |
| Description | Role of TLDc proteins in viral infection |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supplying tissue samples for in vitro cellular assays at The Crick |
| Collaborator Contribution | Assayaing viral infection in vitro |
| Impact | Preliminary in vitro studies |
| Start Year | 2019 |
| Description | Synaptic function of TLDc proteins |
| Organisation | University of Genoa |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Providing new genetic (mouse) tools |
| Collaborator Contribution | Provided data on synaptic physiology and structure in mouse models |
| Impact | Manuscript is in preparation for submission in 2018 |
| Start Year | 2017 |
| Description | International League Against Epilepsy - meet the scientist session |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Brief presentation explaining new ERUK funding to public attendees to ILAR meeting in Birmingham followed by meet-and-greet session for questions |
| Year(s) Of Engagement Activity | 2019 |
| Description | University of the third age (U3A) site visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | MRC Harwell site visit by 20 U3A members including a set of talks on experimental work in the Unit, including one on neurological disease research |
| Year(s) Of Engagement Activity | 2018 |