Establishment of a Muscle Assessment and Training Laboratory at Newcastle University
Lead Research Organisation:
Newcastle University
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Newcastle University were awarded #759K to establish a Muscle Assessment and Training Laboratory. The potential benefits of exercise in ageing, age-related disease and neuromuscular disease are much debated and there has been little progress in translating scientific advances into new treatments. Building on the recent successes in terms of MRC Centres and the NIHR Specialist Biomedical Centre, there is a real opportunity to develop protocols and training regimes that will have direct patient benefit within a short time frame. The initiative would also enable the University to link in with other centres internationally and become a focus of research within the UK.||The MRC Muscle Assessment and Training Laboratory would be central to the success of three major initiatives in Newcastle funded by the MRC and NIHR - Newcastle University Centre for Brain Ageing and Vitality sponsored by BBSRC, EPSRC, ESRC and MRC (Director: Turnbull); MRC Centre for Translational Research in Neuromuscular Disease (co-PI in Newcastle: Turnbull) between Newcastle and London (UCL PI Hanna); NIHR Specialist Biomedical Research Centre for Ageing and Age-related Diseases (Director: Chinnery, Leader on Mitochondria strand; Turnbull).||Newcastle University Centre for Brain Ageing and Vitality sponsored by BBSRC, EPSRC, ESRC and MRC is started in September 2008 and one of the main strands of this major new Centre is to understand the mechanisms by which exercise and diet influence vitality (and prevent frailty). Specifically this will be exploring the mechanisms involved in the protective effect of different forms of exercise on musculoskeletal ageing in terms of physiology, perfusion, mitochondrial function and muscle/joint pathology. This links in with a major initiative to understand the changes that occur in muscle with age and the causes of loss of muscle mass and strength. At least some of these changes are reversed by exercise, but key questions on the best form of exercise (resistance or endurance), whether limitations on the age at which this can be started, effects of such exercise on skeletal and joint ageing are still to be addressed. The MRC Muscle Assessment and Training Laboratory would provide a focus for this research and greatly enhance the Universitys ability to develop protocols which could then be applied widely in the community. This would also link in with related research being developed in the Centre for Brain Ageing and Vitality which is focused on understanding the ways older citizens interact with scientific knowledge about exercise and thus help ensure wide acceptance of best practice.|
Organisations
- Newcastle University (Lead Research Organisation)
- University of Glasgow (Collaboration)
- COUNTY DURHAM AND DARLINGTON NHS FOUNDATION TRUST (Collaboration)
- Philips Research (Collaboration)
- University of Calgary (Collaboration)
- Boots UK (Collaboration)
- NORTHUMBRIA UNIVERSITY (Collaboration)
- National Institute for Health Research (Collaboration)
- Sirtris Pharmaceuticals (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Maastricht University (UM) (Collaboration)
- Leeds Beckett University (Collaboration)
- ALZHEIMER'S SOCIETY (Collaboration)
- University of Texas (Collaboration)
- Unilever (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- Alere (Collaboration)
People |
ORCID iD |
| Doug Turnbull (Principal Investigator) |
Publications
Ahmed ST
(2017)
Using a quantitative quadruple immunofluorescent assay to diagnose isolated mitochondrial Complex I deficiency.
in Scientific reports
Alston C
(2016)
The genetics and pathology of mitochondrial disease
in The Journal of Pathology
Backshall J
(2015)
Physical activity in the management of patients with coronary artery disease: a review.
in Cardiology in review
Bates MG
(2013)
Defining cardiac adaptations and safety of endurance training in patients with m.3243A>G-related mitochondrial disease.
in International journal of cardiology
Campbell G
(2014)
Dissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle.
in Human molecular genetics
Campbell GR
(2012)
Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis.
in Acta neuropathologica
| Description | Capacity building in ageing research |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Guideline Title | Preventing type 2 diabetes: population and community-level interventions in high-risk groups and the general population |
| Description | Contributions to NICE guidelines for Type 2 diabetes |
| Geographic Reach | National |
| Policy Influence Type | Citation in clinical guidelines |
| URL | http://www.nice.org.uk/PH35 |
| Description | DH Physical Activity Taskforce |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | DH Working Group on Physical Activity and Exercise |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Movement as Medicine: for diabetes |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Movement as Medicine: for your heart |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | NICE Liver Disease guidelines |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://www.nice.org.uk/guidance/indevelopment/gid-dgwave0692 |
| Description | NU-AGE undergraduate module |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | As a result of participating in this module, undergraduates from faculties other than the Medical Sciences Faculty have chosen undergraduate degree projects to pursue a PhD in ageing research, The NU-AGE teaching module was shortlisted for a CATE by the Higher Education Academy. |
| URL | http://www.ncl.ac.uk/module-catalogue/module.php?code=AGE2000 |
| Description | National Writing Group Lead on the Pathway for Physical Activity and Diabetes Research |
| Geographic Reach | Asia |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Biomedical Research Centre Studentship |
| Amount | £62,849 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2012 |
| End | 08/2015 |
| Description | Bridging the Urban Divide - UK India initiative |
| Amount | £2,100,000 (GBP) |
| Organisation | Research Councils UK (RCUK) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | CASE studentship |
| Amount | £98,180 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2012 |
| End | 09/2016 |
| Description | Changing the Physical Activity Landscape (CPAL)/County Durham and Darlington Primary Care Trust |
| Amount | £448,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | County Durham Primary Care Trust |
| Amount | £450,000 (GBP) |
| Organisation | County Durham and Darlington NHS Foundation Trust |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | County Durham Primary Care Trust: Diabetes Theme/County Durham and Darlington Primary Care Trust |
| Amount | £106,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Diabetes Research Network |
| Amount | £5,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Diabetes UK: PhD studentship |
| Amount | £81,000 (GBP) |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2009 |
| End | 09/2012 |
| Description | ESRC Knowledge exchange opportunities |
| Amount | £100,473 (GBP) |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2013 |
| End | 06/2014 |
| Description | European Union Framework Project 7:Liver Disease Call |
| Amount | £420,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | FP7 |
| Amount | € 2,500,000 (EUR) |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2012 |
| End | 12/2015 |
| Description | Industrial CASE Studentship - Philips |
| Amount | £22,482 (GBP) |
| Organisation | Koninklijke Philips Electronics N.V. |
| Department | Philips |
| Sector | Private |
| Country | Global |
| Start | 09/2013 |
| End | 10/2016 |
| Description | Industrial CASE studentship - ESRC |
| Amount | £67,443 (GBP) |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 10/2016 |
| Description | Knowledge Transfer Program |
| Amount | £200,000 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC Centre for Neuromuscular Diseases |
| Amount | £957,958 (GBP) |
| Funding ID | MR/K000608/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2013 |
| End | 01/2018 |
| Description | NIHR Biomedical Research Centre |
| Amount | £101,109 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 03/2017 |
| Description | NIHR Newcastle Biomedical Research Centre Industry Partnership |
| Amount | £125,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2013 |
| End | 06/2015 |
| Description | NIHR Senior Investigator |
| Amount | £60,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2009 |
| End | 04/2012 |
| Description | NIHR Senior Investigator Award |
| Amount | £45,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 03/2018 |
| Description | NIHR Senior Research Fellowship |
| Amount | £989,710 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | NIHR: Biomedical Research Centre for Ageing and Age Related Disease |
| Amount | £32,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Newcastle Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | NIHR: Flexibility and Sustainability Funding |
| Amount | £276,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Newcastle BRC |
| Amount | £9,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Newcastle Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 12/2010 |
| Description | Newcastle Hospital Trust: Pump priming/Newcastle Hospitals Trust |
| Amount | £48,415 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | North East Health Innovation and Education Cluster |
| Amount | £100,000 (GBP) |
| Organisation | Newcastle University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | RD Lawrence Fellowship |
| Amount | £134,609 (GBP) |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Regional health Innovation and education cluster (Evaluation of the Movement as Medicine pathway in T2 diabetes) |
| Amount | £100,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Understanding the Ageing Heart workshop |
| Amount | £3,000 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Trust Centre for Mitochondrial Research |
| Amount | £4,500,000 (GBP) |
| Funding ID | 096919 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2012 |
| End | 04/2017 |
| Description | adaption to the Movement as Medicine programme |
| Amount | £155,000 (GBP) |
| Organisation | Sport England |
| Department | County Durham Sport |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 06/2015 |
| Title | Establishment of the Physical Activity and Exercise Research Group |
| Description | Funding allowed pump priming for the development of the laboratory and core staff. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Significant increase in physical activity and exercise research. Prior to this program approximately 30 people per year took part in physical activity or exercise research in Newcastle.In 2010 over 400 people took part in physical activity and exercise research across ageing, metabolic and neuromuscular disease. |
| Title | Immunohistochemistry to diagnose mitochondrial disease |
| Description | Improving the diagnosis of mitochondrial disease in muscle biopsies using a quadruple immunofluorescence technique |
| Type Of Material | Biological samples |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | This research method has been adopted in our diagnostic protocol. |
| Title | MOVEeCloud |
| Description | An online open analytical method for the collection and assessment of movement and sleep. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | MOVEeCloud is the first scalable secure platform for the collection, sharing and analysis of movement data. It reduces analytical processing time by over 90% and also allows common use of processing techniques. |
| URL | http://www.moveecloud.com |
| Title | Open source Physical Activity monitoring: OpenMovement |
| Description | Development of the first open platform for physical activity monitoring, data collection and data analysis. |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | We have developed the first open source physical activity monitoring system. The open source pervasive nature of this project will accelerate the use of physical activity monitoring in small and large scale epidemiological and interventional studies. |
| Title | Mito Disease Cohort UK |
| Description | A database of around 1503 patients with mitochondrial disease, 964 of which were collected in Newcastle. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2011 |
| Provided To Others? | No |
| Impact | All patient data collected is being used to develop clinical guidelines and enrolment in clinical trials. |
| Description | Alere |
| Organisation | Alere |
| Country | United States |
| Sector | Private |
| PI Contribution | Industrial collaborative partner on developing lifestyle interventions |
| Collaborator Contribution | Service development and service delivery |
| Impact | not available |
| Start Year | 2013 |
| Description | Be Smart, exercise your heart |
| Organisation | Alzheimer's Society |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | We are actively collaborating with the Alzheimer's Society on developing and implementing lifestyle service pathways for people at risk of or who have dementia. |
| Collaborator Contribution | The Alzheimer's Society have a wealth of experience working with people with memory problems and their care teams. The Society have been superb in providing insights into care and also assisting with the development of the service pathways and linking with end users and their care teams. |
| Impact | This project is multi disciplinary and is involving service designers, graphic designers, clinical care teams and physiotherapists. We are enhancing existing digital services in a co-design project with and for people with memory problems. These eHealth and mHealth tools will undergo clinical evaluation in 2015. |
| Start Year | 2013 |
| Description | Boots/Walgreens |
| Organisation | Boots UK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We are exploring the role of pharmacy enhanced services as a way to deliver lifestyle as a clinical service to people wit Type 2 diabetes. |
| Collaborator Contribution | We are leading on focus group work and redesigning our digital health assets to fulfil the needs of Boots. Boots are contributing commercial insight, staff time and access to Boots stores for pilot.feasibility studies. |
| Impact | none yet |
| Start Year | 2014 |
| Description | Collaboration with University of Calgary |
| Organisation | University of Calgary |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Expertise in mitochondrial analysis of muscle and spinal cord |
| Collaborator Contribution | Animal model and expertise in animal exercise physiology |
| Impact | New insights into sarcopenia, multidisciplinary involving clinical, histopathological, molecular genetics and exercise physiology |
| Start Year | 2009 |
| Description | Collaboration with University of Edinburgh |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in mitochondrial genetics |
| Collaborator Contribution | Expertise in genetics |
| Impact | Wright AF, Murphy MP, Turnbull DM. Do organellar genomes function as long-term redox damage sensors? Trends Genet 2009; 25: 253-61 |
| Start Year | 2008 |
| Description | Collaboration with University of Texas |
| Organisation | University of Texas |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Analysis of muscle biopsies from patients undergoing exercise regimes |
| Collaborator Contribution | Exercise physiology |
| Impact | Murphy JL, Blakely EL, Schaefer AM, He L, Wyrick P, Haller RG, Taylor RW, Turnbull DM, Taivassalo T. Resistance training in patients with single, large-scale deletions of mitochondrial DNA. Brain 2008a; 131: 2832-40. Multidisciplinary involving exercise phsyiology, clinical and molecular genetics |
| Start Year | 2007 |
| Description | County Durham & Darlington Primary Care Trust |
| Organisation | County Durham and Darlington NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Collaborating on the design, evaluation and implementation of a professional development pathway for physical activity in the management of Type 2 diabetes. |
| Impact | This collaboration has led to further collaboration and funding for CVD prevention pathway in primary care. The collaboration also led to further funding from the regional Health Innovation and Education Cluster. The collaboration is multidisaplinary, including; physical activity specialists, health psychologists, diabetologists, physiologists, primary care teams, and designers. |
| Start Year | 2009 |
| Description | Glasgow University |
| Organisation | University of Glasgow |
| Department | BHF Glasgow Cardiovascular Research Centre |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Guidance and input on the non-invasive assessment of muscle and liver lipid. |
| Collaborator Contribution | Brought collaboration on other projects on Type 2 diabetes. |
| Impact | Data currently being collected (statin trial). This is a multi-disaplinary collaboration involving diabetologists, physiologists, clinical trials units, and nutritionists. |
| Start Year | 2009 |
| Description | Leeds Metropolitan University |
| Organisation | Leeds Beckett University |
| Department | Carnegie Faculty |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Input on non-invasive testing of muscle and liver metabolites during exercise. |
| Impact | Data is currently under analysis and will go into peer review in Dec 2010. This collaboration is multi-disaplinary and involves; nutritionists, physiologists and physicists. |
| Start Year | 2009 |
| Description | Liverpool University CIMA |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are collaborating with Liverpool University as part of the MRC/ARUK Centre for Integrated Musculoskeletal Ageing on a study looking at sedentary behaviour and muscle ageing. |
| Collaborator Contribution | Both sites are contributing clinical facilities and support. |
| Impact | no impact yet |
| Start Year | 2013 |
| Description | Maastricht University |
| Organisation | Maastricht University (UM) |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Molecular studies on samples collected in Maastricht |
| Collaborator Contribution | Maastricht provided samples for molecular studies |
| Impact | No outputs yet. This is a multidisciplinary study involving molecular biologists, exercise physiologists and physicians. |
| Start Year | 2011 |
| Description | NIHR Lifestyle BRU (Leicester) |
| Organisation | National Institute for Health Research |
| Department | NIHR Biomedical Research Unit, University Hospitals of Leicester NHS Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Active collaboration on NIHR Senior Fellowship project |
| Collaborator Contribution | Recruitment and delivery of novel analytical methods |
| Impact | none yet |
| Start Year | 2013 |
| Description | Northumbria University |
| Organisation | Northumbria University |
| Department | School of Psychology and Sports Science Northumbria |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Input on exercise testing and non-invasive assessment of muscle and liver metabolite sin athletes. |
| Impact | Publications: 19223653 & 17697427. Work on basic physiology studies to understand the effect of exercise on muscle and liver metabolites. The collaboration is multi-disaplinary and involves nutrition specialists, physicists, and physiologists. |
| Start Year | 2008 |
| Description | Philips CASE studentship |
| Organisation | Philips Research |
| Country | United States |
| Sector | Private |
| PI Contribution | Working with Philips to explore how technology can be used to help people with memory problems achieve and sustain a physically active lifestyle. |
| Collaborator Contribution | Philips bring a wealth of experience in developing consumer medical products and helping people achieve a more active lifestyle, |
| Impact | This is a multi-disciplinary project involving engineers, designers, physicians and social scientists. The outputs of this collaboration will be finalised in 2015/16. |
| Start Year | 2013 |
| Description | Sirtris Pharmaceuticals (GSK) |
| Organisation | Sirtris Pharmaceuticals |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Development of strategic evaluation of drugs which may mimic the effect of exercise. |
| Impact | These studies are ongoing and have no outputs to date. The collaboration is multi-disaplinary and involves physiologists, physiotherapists, neurologists, molecular biologists and physicists. |
| Start Year | 2009 |
| Description | Unilever - Physical activity monitoring platform |
| Organisation | Unilever |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | One of the senior postdoctoral researchers is ocordinating the physicial activity monitoring platform. |
| Collaborator Contribution | This is a joint project |
| Impact | Joint project grant. This is a multidisciplinary project involving designers, software engineers, physiologists, physicians, physiotherapists and signal processors. |
| Start Year | 2011 |
| Title | SYSTEM FOR THE SELF-MONITORING AND REGULATION OF BLOOD GLUCOSE |
| Description | The present invention relates to a self monitoring device for attachment to the body, which incorporates real-time and correlated measurement of body movement and physiological analytes of metabolism (e.g. glucose) that can be modulated by physical activity. The system enables real time and personalised modulation of the selected physiological analyte(s) through appropriately selected cued activities and other evidence based clinical guidance dependent on previous and current analyte levels correlated with previous and current patterns of movement. The system also allows for personalisation of the outputs with regular calibration to the user. |
| IP Reference | WO2012123765 |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | No |
| Impact | None yet - part of current industrial collaboration award |
| Title | MOVEeCloud |
| Description | This is a cloud-internet based physical activity, function and sleep analysis platform developed in collaboration with the RCUK Social Inclusion through the Digital Economy hub in Newcastle. |
| Type | Support Tool - For Fundamental Research |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2011 |
| Development Status | Under active development/distribution |
| Impact | none yet |
| Title | Movement as Medicine |
| Description | The UK's first professional and patient development pathway for physical activity in the care of Type 2 diabetes. |
| Type | Therapeutic Intervention - Physical |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2011 |
| Development Status | Under active development/distribution |
| Impact | not known |
| Title | Movement as Medicine for Cardiovascular Disease |
| Description | Clinical trial currently underway |
| Type | Therapeutic Intervention - Psychological/Behavioural |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | Still under development |
| URL | http://www.movemedicine.co.uk |
| Title | Movement as Medicine for Type 2 diabetes |
| Description | A cluster-based randomised controlled trial to assess feasibility, acceptability and effectiveness of a multi-faceted behavioural intervention targeting levels of physical activity in adults with Type 2 diabetes in primary care: Movement as Medicine for Type 2 diabetes. |
| Type | Preventative Intervention - Behavioural risk modification |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2013 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | This trial has just finished and will yield results early next year |
| URL | http://www.movemedicine.com |
| Title | Movement as Medicine for CVD |
| Description | Online learning programme for people at risk of CVD and their care teams. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2014 |
| Impact | Currently undergoing clinical trial. |
| URL | http://www.movemedicine.co.uk |
| Title | Movement as Medicine for Type 2 diabetes |
| Description | An online learning programme for diabetes care teams |
| Type Of Technology | Webtool/Application |
| Year Produced | 2014 |
| Impact | This training platform has undergone clinical trial and will be made publicly available in 2015. |
| URL | http://www.movemedicine.com |
| Description | ABN 2015 Harrogate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at the Annual Meeting of the Association of British Neurologists 2015 in Harrogate |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.theabn.org/news/abn-annual-meeting-2015.html |
| Description | Autumn meeting of the Association of British Neurologists 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at the Autumn 2015 meeting of the ABN in London. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.theabn.org/media/2015%20London%20ABN%20programme%20final%2024%20June%202015.pdf |
| Description | British Science Festival 2013 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | We led an interactive workshop for the public on ageing and lifestyle. Public awareness of science and engaging children in science. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.britishscienceassociation.org/british-science-festival/newcastle-2013 |
| Description | DUK National Patient Engagement Day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Talk entitled, 'Standing up for Type 2 diabetes' to the Diabetes UK National Patient Engagement Day in June 2012 not known |
| Year(s) Of Engagement Activity | 2012 |
| Description | Diabetes UK Patient Group: Darlington |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 30 Patients with type 2 diabetes; lots of discussion on diabetes management and impact of physical activity. Patient questions and improved understanding of physical activity and diabetes |
| Year(s) Of Engagement Activity | 2010 |
| Description | Diabetes UK Patient Group: Newcastle |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 30 Patients with type 2 diabetes attended: discussion on diabetes and physical activity. Improved knowledge of diabetes and physical activity |
| Year(s) Of Engagement Activity | 2010 |
| Description | Diabetes UK Patient Group: North Tyneside |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 30 Patients with type 2 diabetes; discussed diabetes and the role of physical activity Improved knowledge of diabetes and the role of physical activity. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Diabetes UK Patient Group: Tynedale |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 30 Patients with type 2 diabetes: discussion of diabetes and the role of physical activity Improved knowledge of diabetes and physical activity. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Diabetes UK Science and Research Advisory Board |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | members of the Diabetes UK working group setting the scientific direction of research undertaken by DUK. Links with Diabetes UK and other researchers as well as influencing research direction across the UK. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Diabetes UK: Meet the Professors |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 90 People with type 2 diabetes and 20 care professionals; discussion on diabetes and teh role of physical activity. Improved knowledge of diabetes and the role of physical activity. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Engage Conference Bristol |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Engage conferences are aimed at Universities and are designed to help researchers find better ways of involving people from outside academia in conceiving, shaping, producing and applying powerful research? |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www.publicengagement.ac.uk/events/engage-conference-2015 |
| Description | Fit as a Falcon |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | An activity day attended by over 100 school children showcasing the four themes of the Centre. The day was organised in collaboration with Newcastle Falcons Community Foundation and built on work they were already doing with schools in the area. The activities were designed to show how a healthy lifestyle when we are younger affects the way we age, focusing on exercise and nutrition. Feedback from the children, teachers and students and scientists involved in the event was very positive. It also worked well from the Falcons perspective and they have asked us to make this an annual event. There will also be opportunities to be involved with other engagement programmes that the Falcons Community foundation are running. |
| Year(s) Of Engagement Activity | 2016 |
| Description | IDF mHealth Expert Working Group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Member of the IDF Expert working group on mHealth developing policy advice on mobile technologies and their role in diabetes in partnership with the global mobile phone representative body (GSMA). Links wit policy forming groups and industry |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.idf.org |
| Description | Keeping active matters |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Engagement event on the benefits of physical activity for members of our Voice North panel and members of the public. Researchers gave talks during a number of interactive sessions. not yet known |
| Year(s) Of Engagement Activity | 2014 |
| Description | Led mHealth Tour |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | I led the world's first mHealth bike ride from Brussels to Barcelona to raise awareness of type 1 diabetes and the role of technology connection with patients and companies involved in digital health and diabetes |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.mhealthtour.com |
| Description | MEdia: Granada TV |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | ITV Documentary on "Exercise and the elderly" Regional discussion of the role of exercise in the elderly. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Media: Channel 4 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dispatched documentary on "Dispelling the myths of Ageing" National discussion of what ageing is and how to age well. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Mini Medical School for Older People |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | 50 people attended a workshop at the Newcastle University Centre for Life. Gave an insight into what research is happening in Newcastle and how the medical profession is involved in research. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Mini-Medical School: Public Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | 90 pupils who wished to do medicine at university attended; two presentation with interactive discussion. Provide insight into the work which medical researchers and the medical profession do. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Move Like A Pro |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Move Like A Pro is a 12-week programme funded by Premiership Rugby and Movember to encourage middle-aged men who are not particularly active to adopt a healthier lifestyle. One of our researchers presented her research on how being active affects healthy ageing to the group towards the end of the programme. The talk was well received and we have been asked to provide input to future rounds of the programme |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://movelikeapro.co.uk/ |
| Description | NE Physical Activity Forum |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Health professionals |
| Results and Impact | Led a workshop module on physical activity and obesity. Improved networking and academic - clinical service links. |
| Year(s) Of Engagement Activity | 2009 |
| Description | NIHR Ageing Biomedical REsearch Centre lectures |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | One of 6 keynote lectures on ageing to a nationally representative group Links with other groups and raised awareness of ageing research. |
| Year(s) Of Engagement Activity | 2013 |
| Description | National Obesity Forum |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | 50 health professionals specialising in obesity management. Networking - improved links between clinical practice and academics. |
| Year(s) Of Engagement Activity | 2010 |
| Description | National Writing Group on Physical Activity and Diabetes |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | 10 clinical leads from UK institutions met to arrange the national direction of physical activiity research in Type 2 diabetes. Definition of a national pathway for physical activity and diabetes research. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Newcastle Diabetes UK voluntary group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Over 40 people belonging to the Diabetes UK patient group attended a lecture about physical activity. There was a lengthy question and answer session and a good deal of discussion afterwards. Provided information to people about how physical activity can be used as an effective 'medicine' to treat diabetes. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Newcastle Science Festival 2010 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented a poster entitled, "Should you put all your eggs in one basket? Fitting another piece to the Parkinson's disease puzzle." Attendees asked questions and discussed the findings. not known |
| Year(s) Of Engagement Activity | 2010 |
| Description | Newcastle University engagement activities |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Centre continues to provide funding towards the salary of Newcastle University's Public Engagement Team. The University has a broad programme of engagement activities. Over the last 12 months there have been over 15 events aimed at disseminating the University's research and activity to the general public. They communicate the activities of CBAV on a monthly basis through Voice North (the Regional Engagement Panel made up of a group of over 700 people reflecting the ag- structure and geographical and socioeconomic make-up of the North East) communications and events and through Years Ahead, the North East Regional Forum on Ageing. The activities of the public engagement team raise awareness of the research being undertaken by the Centre and the University as a whole. Voice North provides focus groups which contribute to the development of research projects and provide participants for research projects. |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011 |
| Description | Presentation to Peers in the Houses of Parliament |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Discussion with peers at the Houses of Parliament prior to the vote on changing the law to allow mitochondrial donation. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Press release: Walking and Type 2 diabetes |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release on physical activity research on diabetes: 27 mainstream papers worldwide, over 100 websites, and regional radio/television. Promoted discussion of the role of walking in the management of type 2 diabetes. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Progress Educational Trust meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at the PET annual confrence. The 2015 annual conference of the Progress Educational Trust (PET) focused on the advent of new methods of making enduring changes to the human embryo - changes that, if used in treatment, will affect not only the person born but also subsequent generations. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.progress.org.uk/conference2015 |
| Description | Response to Science comment article on mitochondrial transfer |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The article on the mitochondrial transfer technique sparked a media frenzy with articles appearing in many newspapers and magazines worldwide as well as extensive coverage on TV, radio and the internet. Below is a selection of items. http://www.sciencemediacentre.org/tag/mitochondrial-dna/ http://theconversation.com/viewpoints-the-promise-and-perils-of-three-parent-ivf-18402 http://www.bbc.co.uk/news/health-24158049 BBC News (quotes Robin Lovell-Badge and Doug Turnbull) http://www.bbc.co.uk/news/health-24158049 New Scientist (quotes Doug Turnbull) http://www.newscientist.com/article/dn24230-warning-sounded-over-threeparent-ivfsafety. html#.UjwUrz82nm4 Times (quotes Robin Lovell-Badge and Doug Turnbull) http://www.thetimes.co.uk/tto/health/news/article3874038.ece Science AAAS (quotes Robin Lovell-Badge) http://news.sciencemag.org/biology/2013/09/new-controversy-over-experimental-ivf-method BBC News (quotes Robin Lovell-Badge and Doug Turnbull) http://www.bbc.co.uk/news/health-24158049 The extensive media coverage has increased awareness of mitochondrial disease and we have received an increased number of enquiries and hits on our website. |
| Year(s) Of Engagement Activity | 2014 |
| Description | School Visit: Hayden Bridge |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Led problem based learning workshops on obesity and the role of physical activity. 6th form pupils. Improved awareness of the clinical impact of obesity and the potential role of physical activity. |
| Year(s) Of Engagement Activity | 2009 |
| Description | School visit: Haydon Bridge |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Open day on physiological measurement in obesity and metabolism; pupils got hands on experience of techniques discussed in their A-levels. Improved knowledge of techniques: de-geeking science. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Science on a Plate 2013 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Schools open day of lectures and interactive tasks Links with schools and motivating the next generation of scientists. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Science on a Plate workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Two researchers from Newcastle MoveLab led a workshop for young people entitled, "which is more important - fitness or fatness?". They provided thought provoking information, such as, "why watching television can cause diabetes," and "why bus driving is bad for your heart." The workshop participants helped with a fully monitored exercise test, ECG monitoring and real time analysis of respiraiton. not yet known |
| Year(s) Of Engagement Activity | 2012 |
| Description | Society for Endocrinology conference 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at the annual Society for Endocrinology Conference in Cologne,Germany. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://Cecad.uni-koeln.de |
| Description | Which is more important - fitness or fatness? |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Children from three local secondary schools attended the workshop and participated fully in the discussions. They also helped with a fully monitored exercise test, ECG monitoring and real time analysis of respiration. not yet known |
| Year(s) Of Engagement Activity | 2013 |
| Description | institute of Education London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at the Institute of Education London on 10 September 2015 |
| Year(s) Of Engagement Activity | 2015 |
| Description | mHealth Cycle Grand Tour Demonstration |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The MoveLab team set up a cycle demonstration in the student forum at Newcastle University and linked to a screen to stream coverage from the mHealth Cycle Grand Tour. Raised awareness of diabetes and the potential power of mHealth solutions. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.ncl.ac.uk/press.office/press.release/item/pedalling-towards-better-diabetes-management#hp... |
| Description | mHealth lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | keynote lecture on mHealth solutions and data from recent mHealth tour Connections with policymakers and healthcare providers. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.idf.org/worlddiabetescongress |