DPFS Devolved Portfolio (Pilot)

Lead Research Organisation: University of Dundee

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

This is an award of a devolved portfolio under a pilot phase, as part of the implementation of the Development Pathway Funding Scheme (DPFS). DPFS Devolved Portfolios are block awards for specific universities to support goal-orientated translational research projects. The award allows universities to allocate the money to different translational projects more responsively based on their relative progress. For example the university might decide to stop a particular project and recycle the money allocated to it into other proposals. All projects supported by the Portfolio fall within the remit of the Development Pathway Funding Scheme (DPFS).

Publications

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Buciuc R (2014) P-018 MRI-based Endovascular Navigation in a Flow and Cadaveric Model; Feasibility Study in Journal of NeuroInterventional Surgery

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Cox B (2014) E-036 Cadaveric Flow Model for Endovascular Simulated Interventions in Journal of NeuroInterventional Surgery

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Cox B (2012) MR real-time tracking of hepatic motion during respiration in a Thiel Soft-fix cadaver in Biomedical Engineering / Biomedizinische Technik

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Eisma R (2013) Liver displacement during ventilation in Thiel embalmed human cadavers - a possible model for research and training in minimally invasive therapies. in Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy

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Gueorguieva MJ (2014) MRI of Thiel-embalmed human cadavers. in Journal of magnetic resonance imaging : JMRI

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Navratilova I (2011) Screening for GPCR Ligands Using Surface Plasmon Resonance. in ACS medicinal chemistry letters

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Pawellek A (2014) Identification of Small Molecule Inhibitors of Pre-mRNA Splicing in Journal of Biological Chemistry

 
Description MRI guided DBS and Targeted Drug Delivery (www.IGI-TDD.eu)
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
URL http://www.IGI-TDD.eu
 
Description CASE studentship
Amount £92,173 (GBP)
Funding ID BB/JO11770/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2013 
End 05/2017
 
Description CRUK programme grant
Amount £1,388,746 (GBP)
Funding ID C303/A14301 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2012 
End 09/2017
 
Description Chemistry Catalyst Fund
Amount £13,557 (GBP)
Organisation Scottish Universities Life Sciences Alliance 
Sector Academic/University
Country United Kingdom
Start 01/2012 
End 12/2012
 
Description Chemistry Catalyst Fund
Amount £18,000 (GBP)
Organisation Scottish Universities Life Sciences Alliance 
Sector Academic/University
Country United Kingdom
Start 01/2011 
End 12/2011
 
Description Chemistry Catalyst Fund
Amount £15,861 (GBP)
Organisation Scottish Universities Life Sciences Alliance 
Sector Academic/University
Country United Kingdom
Start 01/2012 
End 12/2012
 
Description Chemistry Catalyst Fund
Amount £18,897 (GBP)
Organisation Scottish Universities Life Sciences Alliance 
Sector Academic/University
Country United Kingdom
Start 11/2011 
End 06/2012
 
Description Confidence in Concept 2012
Amount £750,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2013 
End 06/2014
 
Description Confidence in Concept 2013
Amount £800,000 (GBP)
Funding ID MC_PC_13061 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2014 
End 08/2015
 
Description Confidence in Concept 2014
Amount £700,000 (GBP)
Funding ID MC_PC_14099 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2015 
End 08/2016
 
Description Darwin Trust bequest
Amount £100,000 (GBP)
Organisation British Society for the History of Science (BSHS) 
Department Darwin Trust of Edinburgh
Sector Academic/University
Country United Kingdom
Start 10/2015 
End 09/2016
 
Description Developmental Pathway Funding Scheme
Amount £282,826 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2011 
End 09/2013
 
Description Drug discovery
Amount £9,640 (GBP)
Organisation Tenovus 
Department Tenovus Scotland
Sector Charity/Non Profit
Country United Kingdom
Start 05/2012 
End 10/2012
 
Description EC FP7 Cooperation
Amount £614,248 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 03/2011 
End 02/2016
 
Description EC FP7 Cooperation
Amount £873,623 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2014 
End 12/2017
 
Description Healthcare Technology Challenges for Engineering
Amount £454,600 (GBP)
Funding ID EP/K020013/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 04/2013 
End 03/2016
 
Description Healthcare Technology Challenges for Engineering
Amount £924,870 (GBP)
Funding ID EP/K020250/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 07/2013 
End 12/2014
 
Description Innovative Medicines Initiative (IMI)
Amount € 1,000,000 (EUR)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 01/2013 
End 12/2017
 
Description Innovative therapeutics
Amount £200,000 (GBP)
Organisation Charles Wolfson Charitable Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2012 
End 04/2014
 
Description Institutional Strategic Support Fund
Amount £275,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2011 
End 09/2012
 
Description Institutional Strategic Support Fund Y2
Amount £275,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2012 
End 09/2013
 
Description Institutional Strategic Support Fund Y3
Amount £275,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2013 
End 09/2014
 
Description Institutional Strategic Support Fund Y4-5
Amount £550,000 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start 10/2014 
End 09/2016
 
Description MRC Project Grant
Amount £418,900 (GBP)
Funding ID MR/K013343/1 
Organisation Medical Research Council (MRC) 
Department The Mary Lyon Centre
Sector Academic/University
Country United Kingdom
Start 04/2013 
End 03/2016
 
Description Medical device
Amount £130,000 (GBP)
Organisation Dr Hadwen Trust (DHT) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2011 
End 10/2014
 
Description NRS NHS Research Fellowh
Amount £148,000 (GBP)
Organisation NHS Research Scotland 
Sector Public
Country United Kingdom
Start 04/2013 
End 03/2016
 
Description Project grant
Amount £99,000 (GBP)
Organisation Tenovus 
Department Tenovus Scotland
Sector Charity/Non Profit
Country United Kingdom
Start 06/2014 
End 06/2016
 
Description Strategic Award (DGEM)
Amount £1,670,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2012 
End 06/2017
 
Title GPCR Ligand screen 
Description Use of established methodology for new use. 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Publication, new collaboration and funding leveraged. 
 
Title MR-guided procedure 
Description New tool for development of workflow of MR guided vascular interventons and validation of MRI guided Focused Ultrsound on moving organs in perfused Thiel embalmed cadavers. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2013 
Provided To Others? Yes  
Impact Better model for vascular interventions and Focused Ultrasound of Moving Organs provides an alternative to animal models. 
 
Title Madrasin 
Description Madrasin is a highly characterised small molecule modulator of alternative splicing. 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? Yes  
Impact The splicing field has been hapmered by the lack of a robust chemical tool to study the biology. Madrasin appears to fit the requirements of the community with multipe groups able to recapitulate its effects. The paper describing the discovery and characterisation of Madrasin has been cited 9 times to date. 
URL http://www.sigmaaldrich.com/catalog/product/sigma/sml1409?lang=en®ion=GB
 
Title Psoriasis cohort 
Description Cohort of psoriasis patients for genetic research 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Cohort under development . It will used to perform pharmacogenomic profiling for treatment effects. 
 
Description CRUK screen NRF2 
Organisation Cancer Research UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Expertise and specialist systems for the investigation of NRF2 biology
Collaborator Contribution Compound library screening and follow on drug discovery resource and expertise
Impact Too early
Start Year 2013
 
Description Cancer follow on study 
Organisation University of Alberta
Country Canada 
Sector Academic/University 
PI Contribution Supply of compounds and data.
Collaborator Contribution Broadening observations into other cancer types.
Impact Publications and two grant applications in progress.
Start Year 2012
 
Description Discovery Partnership ( RT) 
Organisation GlaxoSmithKline (GSK)
Department Discovery Partnerships with Academia
Country Global 
Sector Private 
PI Contribution University of Dundee licenced the IP around the chemistry and biology debveloped in under MRC-DPFS funding. The University of Dundee team (The Drug Discovery Unit and Prof Irwin McLean's group) are providing biology and chemistry expertise.
Collaborator Contribution GSK are leading the drug discovery project, providing funding (for both Dundee nad GSK activities), expertise and access to equipment and models.
Impact Project closed due to failure to meet key milestone. IP around lead compounds developed during the colaboration was assigned to Dundee along with associated data. Details are confidential. Project has become the subject of a second commercial partnership (with the company Pfizer in this case). Discussed as a separate output.
Start Year 2011
 
Description Discovery Partnership (HD) 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Provide biology and assay expertise for drug discovery.
Collaborator Contribution Drug discovery -compound design and screening.
Impact Milestones were all achieved. Lead optimisation halted due to lack of conclusive cellular data.
Start Year 2011
 
Description Drug Discovery partnership (Pfizer-RT project) 
Organisation Pfizer Ltd
Department Orphan & Genetic Diseases Research Unit Pfizer
Country United Kingdom 
Sector Private 
PI Contribution The University of Dundee licenced the background IP around the projects chemical matter and biological model systems. The University of Dundee team are developing assays and support for high-throughput screening. The majority of the projects biology work is conducted by the Dundee team. The Dundee team are also providing Medicinal Chemistry and Project management expertise for the project.
Collaborator Contribution In addition to fully funding University of Dundee activities, Pfizer are providing access to compound libraries, models and drug discovery expertise. The project is part of the Pfizer-RDRU, with Pfizer staff members providing Project management and technical expertise to the project.
Impact Projects status is confidential
Start Year 2015
 
Description Fragment screening 
Organisation Duke University
Country United States 
Sector Academic/University 
PI Contribution Conducted screen.
Collaborator Contribution Provided target.
Impact Manuscript in preparation.
Start Year 2012
 
Description Imaging of echogenic microbubbles and liposomes 
Organisation European Commission
Department Seventh Framework Programme (FP7)
Country European Union (EU) 
Sector Public 
PI Contribution Development of equipment and imaging protocols
Collaborator Contribution Testing of equipment and development of software and hardware
Impact Results leading to possible future collaboration. Multidisciplinary-physics, chemistry, biology.
Start Year 2011
 
Description Open innovation (AZ-OGA) 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution The University of Dundee will use their OGA assay platform to screen the AZ compound libraries in order to identify new classes of OGA inhibitor. If suitable compounds are identified The University of Dundee will conduct structural biology, Medicinal chemistry and associated drug discovery activities to develop the hit compounds toward in vivo leads.
Collaborator Contribution AZ will provide access to AZ screening facilities and will provide access to proprietary compound libraries.
Impact Project in early stages and no outputs generated to date.
Start Year 2016
 
Title Modulators of cAMP-PDE 
Description Repositioning of known compounds and discovery of novel compounds for increasing sperm motility. 
IP Reference WO2013054111 
Protection Patent application published
Year Protection Granted 2013
Licensed No
Impact Ongoing drug discovery programmes.
 
Title NMT inhibitors 
Description Compounds with potential for therapy in neglected diseases and cancer. The MRC funded devolved portfolio funded a project in the cancer therapeutic area. 
IP Reference EP2323987 
Protection Patent application published
Year Protection Granted 2012
Licensed No
Impact Collaboration with an international group.
 
Title Surgical tissue anchor 
Description A means of displacing internal organs to prevent them from obstructing a minimal access surgical procedure. 
IP Reference GB1100902.4 
Protection Patent application published
Year Protection Granted 2012
Licensed Yes
Impact None other than licence
 
Description Conference proceedings (AM 2014) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Cox BF, Eisma R, Rube MA, Immel E, Gueorguieva M, McLeod H, Melzer A. Developing Thiel Soft-Fix Cadavers as a suitable model for iMRI training and research. Abstract, Presented at the 9th International Interventional MRI Symposium, September, 2012.

Pendleton M, Cox BF, Saliev T, Rube MA, McLeod H, Melzer A. Imaging of Vessel Patency in Thiel Embalmed Liver. Oral Presentation, Presented at Fifth Image Guided Therapy Workshop of the National Center for Image-Guided Therapy, September, 2012.

Cox BF, McLeod H, Rube MA, Vinnicombe S, Holbrook AB, Eisma R, Saliev T, Karakitsios I, Melzer A. MR real-time tracking of hepatic motion during respiration in a Thiel Soft-fix cadaver. Oral Presentation, Presented at the 46th Annual Conference of the Deutsche Gesellschaft für Biomedizinische Technik, September 2012.

Rube MA, Immel E, Cox B, Melzer A. Towards Interventional MRI: Semi-Active Device Localization in Phantom Experiments and in a Thiel Embalmed Human Cadaver Model. Oral Presentation, Presented at the 26th International Congress and Exhibition of Computer Assisted Radiology and Surgery, June 2012.

McLeod H, Cox B, Eisma R, Mathew S, Melzer A, Houston G. Thiel Embalmed Human Cadaver: Vascular Model Development for Teaching and Training. Poster session presented: College Research Symposium, University of Dundee, Crieff, Feb 20th - 21st 2014.

McLeod H, Cox B, Eisma R, Immel E, Roberston J, Melzer A, Houston G. Thiel Embalmed Human Cadaver: Venous Modeling. Poster Session presented at 26th Society for Medical Innovaton and Technology, Shanghai, 18- 21st Sept 2014.

McLeod H, Cox B, Eisma R, Immel E, Pendleton M, Melzer A, Houston G. Thiel Embalmed Human Cadaver: Extracorporeal Central Arterial Circulatory Model Development. Oral Presentation presented at 26th Society for Medical Innovaton and Technology, Shanghai, 18- 21st Sept 2014.


Continuation of the demonstration of the strengths of this relatively new technology area amongst the academic community and those responsible for future clinical training and practice.
Year(s) Of Engagement Activity 2012,2014
 
Description Conference proceedings (AM group) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Gueorguieva M., Yeo D., Eisma R. and Melzer A., (2012). MR Imaging of Thiel embalmed human cadavers. 20th Annual meeting of the International Society for Magnetic Resonance in Medicine, ISMRM, Melbourne, Australia
• Rube M., Kokkalis E., Immel E., Gueorguieva M., Eisma R. And Melzer A., (2012). Training and Testing Environment for MR-guided Vascular Interventions. 20th Annual meeting of the International Society for Magnetic Resonance in Medicine, ISMRM, Melbourne, Australia
• Eisma R., Gueorguieva M., Immel E., Toomey R., Soames R., and Melzer A., (2012). Thiel embalmed cadavers as a model for research and training in minimally invasive therapies - a study of respiratory liver displacement. Joint Winter Meeting of Anatomical Societies, Dec. 2011 , Cardiff, UK. To be published in Journal of Anatomy.
• Toomey R.J., Gueorguieva M, Immel E, Houston J.G., McLeod G.A., Eisma R., Melzer A. (2011). Value and Techniques of Multi-Modality Imaging of Thiel Soft-Embalmed Cadavers for Research, Training and Device Development (Educational Exhibit). 97th Annual Meeting of the Radiological Society of North America, RSNA, Chicago, Illinois, USA
• Gueorguieva M. J., Immel E, Eisma R, and Melzer A., (2010). Improvement of MR Imaging of Thiel Embalmed Human Cadavers (Abstract). Minimally Invasive Therapy & Allied Technologies, MITAT, Vol. 19, Supplement 1: 40-41
• Immel E., Eisma R., Gueorguieva M., Fernandez-Gutierrez F., Houston G., and Melzer A., (2010). Comparison of X-Ray and MRI guided Implantation of a Resonant Balloon Expandable Stent in a Thiel Embalmed Cadaver (Abstract). Minimally Invasive Therapy & Allied Technologies, MITAT, Vol. 19, Supplement 1: 22-23
• Immel E., Eisma R., Gueorguieva M., Fernandez F., Houston G., and Melzer A., (2010). MRI guided Implantation of a Resonant Vena Cava Filter in a Thiel Embalmed Cadaver (Abstract). Minimally Invasive Therapy & Allied Technologies, MITAT, Vol. 19, Supplement 1: 50-51
" Thiel soft-fix embalming: the new face of anatomy in Dundee" Roos Eisma, presented at the Institute for Anatomical Sciences Autumn Scientific Meeting, St Andrews, 31 August 2012 and at the Association of Anatomical Pathology Technicians Conference, Bristol, 22 September 2012


Demonstrate utility of this relatively new technology area amongst the academic community.This will lead to increased collaborative opportunities and uptake of the technology that will impact on future clinical training and practice.
Year(s) Of Engagement Activity 2010,2011,2012
 
Description Conference proceedings (AM/2013) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited session and Chair at CARS 2013
Organised the 2nd Eurpoean FUS Therapy Symposium Rome 10-11th October 2013

Demonstration that this relatively newtechnology has lead to increased collbaorative opportunities and uptake of the technology that will impact on future clinical training and practice.
Year(s) Of Engagement Activity 2013
 
Description Lecture to GP's 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Talk sparked questions and discussion.

It is anticipated that there will be better informed treatment decisions as a result of the talk . The talk was only delivered on 28th October 2014 and as such feedback is expected over the next few months.
Year(s) Of Engagement Activity 2014
 
Description Open Doors Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact General public attended .

Raise awareness of science being done at College of Life Sciences, University of Dundee via exhibits and workshops.
Year(s) Of Engagement Activity 2011,2012