DPFS Devolved Portfolio (Pilot)

Lead Research Organisation: University of Nottingham

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

This is an award of a devolved portfolio under a pilot phase, as part of the implementation of the Development Pathway Funding Scheme (DPFS). DPFS Devolved Portfolios are block awards for specific universities to support goal-orientated translational research projects. The award allows universities to allocate the money to different translational projects more responsively based on their relative progress. For example the university might decide to stop a particular project and recycle the money allocated to it into other proposals. All projects supported by the Portfolio fall within the remit of the Development Pathway Funding Scheme (DPFS).

Publications

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Ahmed MA (2012) A CD44?/CD24? phenotype is a poor prognostic marker in early invasive breast cancer. in Breast cancer research and treatment

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Conroy S (2010) Medulloblastoma in childhood: revisiting intrathecal therapy in infants and children. in Cancer chemotherapy and pharmacology

 
Description Breast Cancer Prognostic
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact Evaluation of Gene expression profiling and expanded immunohistochemistry tests to guide selection of chemotherapy regimes in breast cancer management.
 
Description Early Stage IP
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact Meetings with UK IPO to illustrate challenges and importance of patent applications in commercialisation of early stage medical devices.
 
Description InnovateUK/MRC Biomedical Catalyst
Amount £1,400,000 (GBP)
Funding ID HeartLight: Heart-Rate Monitoring for Neonatal Resuscitation 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 03/2015 
End 08/2017
 
Description Prof Brigitte Scammell: Innovate UK Award with Locate Therapeutics
Amount £1,392,904 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start  
 
Description Prof Brigitte Scammell: Wellcome Trust VIP Award
Amount £17,770 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Prof David Brook: Wellcome Trust Seeding Drug Discovery
Amount £3,120,000 (GBP)
Funding ID 107562/Z/15/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Prof David Walker: Brain Tumour UK
Amount £750,000 (GBP)
Organisation The Brain Tumour Charity 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Prof Jonathan Ball: FP7
Amount € 5,990,000 (EUR)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description Professor Barrie Hayes Gill - University of Nottingham Hermes
Amount £23,500 (GBP)
Organisation University of Nottingham 
Sector Academic/University
Country United Kingdom
Start  
 
Description SurePulse - University of Nottingham IAA
Amount £59,840 (GBP)
Organisation University of Nottingham 
Sector Academic/University
Country United Kingdom
Start  
 
Description UoN MRC CiC award to PI Sharkey and Hayes-Gill Round 8; Newborn resuscitation monitoring device
Amount £97,817 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2019 
End 03/2020
 
Title DM Cell Lines 
Description the group has established a series of cell lines from more than 20 DM patients. Four of these have been stably transfected with a telomerase-expressing plasmid to allow continued growth in culture. Two of the lines have also been infected with an inducible plasmid to express MyoD, which promotes differentiation into myoblasts and myotubes. 
Type Of Material Cell line 
Year Produced 2010 
Provided To Others? Yes  
Impact Identification of hit compounds for treatment of myotonic dystrophy 
 
Title NPI 
Description Use of fuzzy logic to define new patient classifications for breast cancer 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact Greater clarification of breast cancer classes allowing for clearer diagnosis, treatment and prognosis. 
 
Description Bone Scaffolds 
Organisation Biomet, Inc
Department Biomet UK
Country United Kingdom 
Sector Private 
PI Contribution The R&D team have supplied formulations of bone scaffold polymer to Biomet to test in a number of orthopaedic applications.
Collaborator Contribution Design and manufacture of unique bone scaffold polymers.
Impact Anticipated licensing agreement.
Start Year 2011
 
Description EU7 Platelets 
Organisation European Commission
Department Seventh Framework Programme (FP7)
Country European Union (EU) 
Sector Public 
PI Contribution Assistance in drafting the application and performance of comparative platelet activation assays.
Collaborator Contribution Will allow for a multi-centre trial of new platelet activation assays
Impact Outputs expected are publications resulting from the multi-centre testing of platelet activation kits.
Start Year 2011
 
Description Myotonic Dystrophy 
Organisation GlaxoSmithKline (GSK)
Department Discovery Partnerships with Academia
Country Global 
Sector Private 
PI Contribution The proprietorial cell based assay will be explored by GSK to screen a coumpound librsry
Collaborator Contribution Assistance with assay development
Impact Although a lead candidate was identified GSK chose not to continue with the development programme.
Start Year 2011
 
Description NPI 
Organisation University of Edinburgh
Department Division of Pathology
Country United Kingdom 
Sector Academic/University 
PI Contribution Breast tissue microarray samples were provided from a cohort of Edinburgh patients. These were subject to immunohistochemical staining for a panel of biomarkers.
Collaborator Contribution Nottingham Prognostics has performed all the histology and used its unique algorithms to assign breast cancer classes.
Impact Once the data has been validated and any IP position confirmed; the results will be published. This is not a mulit-disciplinary collaboration.
Start Year 2011
 
Title Heart rate monitor specifically designed for newborn babies requiring resuscitation at birth. 
Description "Approximately 70,000 newborns/yr in the UK (10% of births) require some form of resuscitation at birth. Many of these are premature or sick increasing their risk of morbidity and mortality. Newborns resuscitated but not admitted to the neonatal unit have an increased risk of poor cognitive function in later life. Heart rate (HR) is the best indicator of effective resuscitation and is currently assessed manually using a stethoscope. However, this is subject to human error, introduces delays, and may fail to detect a sudden deterioration. Hence, there is an urgent need for a HR monitor designed specifically for newborn delivery room resuscitation as current devices are unsuitable. This device aims to improve resuscitation practice, potentially improving outcomes and reducing time spent in intensive care. We have developed and patented a HR sensor specifically for this purpose. Preliminary work has demonstrated its use on babies in intensive care. DPFS funding is sought to further develop the technology for resuscitation in the delivery room and measure key performance parameters: namely accuracy, reliability and acquisition time. By placing this device in the hands of midwives and clinicians we aim to improve resuscitation in those infants at greatest risk of short and long term sequelae. Most recent work supported by DPFS Portfolio Award" 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2011
Development Status Under active development/distribution
Impact TBC 
 
Title Platelet function test to monitor effects of drug therapy 
Description "Blood platelets contribute to thrombus formation in veins and arteries and thrombi are the main cause of clinical events such as heart attack and stroke. Drugs that reduce platelet function are used to reduce the incidence of such events; however they can also increase risk of bleeding. We have an established track record in developing and using tests of platelet function in diagnosis and for monitoring effects of drug therapy, and as new anti-platelet drugs come on the market, there is a growing demand for such tests. Current tests are timeconsuming, technically demanding or use expensive equipment that is not readily available. Recent progress in our laboratory is such that we now have a simplified test that, with further development, could be used in a wide range of settings. The aim of this application is a) to simplify the test further in collaboration with an industrial collaborator; and b) set up clinical trials to assess its value in a range of different clinical scenarios. Most recent work supported by DPFS Portfolio Award" 
Type Support Tool - For Medical Intervention
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2011
Development Status Actively seeking support
Impact TBC 
 
Title The Greenbottle Pharmacy Project: Next Generation Wound Debridement Products 
Description "The Greenbottle Pharmacy Project sources wound care products from an organism, the greenbottle fly (Lucilla sericata), which is already used in the management of wounds. With Wellcome Trust, DSTL, EPSRC and TSB funding, we have identified a chymotrypsin from the secretions of L.sericata which completely digests eschar from human venous leg ulcers ex vivo and promotes alterations in fibroblast behaviour conducive to healing. This makes this particular chymotrypsin a prime candidate for development as a next generation wound debridement agent. Consequently, the enzyme has been cloned and expressed at a prototype level, and shown to mimic the effects of the whole organism in ex vivo debridement assays. Furthermore, we have incorporated the recombinant enzyme in a prototype formulation which clearly outperforms the leading competitor product Santyl. Confidence is high that the enzyme can now be developed through scale-up, formulation and toxicology to be ready for clinical evaluation within 2 years. The aim of the proposed project is to develop the product to a stage suitable for application ot wounds in patients. Most recent work supported by DPFS Portfolio Award" 
Type Therapeutic Intervention - Drug
Current Stage Of Development Initial development
Year Development Stage Completed 2011
Development Status On hold
Impact TBC 
 
Company Name HeartLight Systems Limited 
Description HeartLight Systems was set up as a joint venture between the University of Nottingham and Tioga Ltd to develop neonatal monitoring systems based on novel detection sensors. 
Year Established 2014 
Impact The company have recently received a TSB Biomedical Catalyst award to further develop the HeartLight monitors; the total project value is £1.74M. The Path to Market toolkit developed with support from EP/I500588/1 was critical in making the case for the Biomedical Catalyst Funding and also in securing initial pump priming investment for Heartlight Systems Ltd.
 
Company Name Platelet Solutions Limited 
Description Platelet Solutions Ltd aims to use novel technology to measure platelet function simply and accurately in any clinical setting. A particular aim is to use the technology to optimize treatment of patients at-risk of heart attack or stroke with the effects of improving health care and reducing health costs. The technology will also be of diagnostic and therapeutic value in other diseases and in drug development programs. 
Year Established 2011 
Impact The company has only been trading since 2011. Since January 2013 they have added two 0.5FTE posts and 1FTE
Website http://www.plateletsolutions.co.uk/
 
Company Name Nottingham Prognostics Limited 
Description The business concerns the development and launch of a second-opinion website for breast cancer patients and their clinicians. The need for second opinions is increasing as treatment options multiply and patient awareness increases. The site will offer paid-for consultations which will include a personalised prognosis (initially) relating to survival. 
Year Established 2012 
Impact No Scientific staff currently employed.