Efficacy and mechanism of thyroxine treatment on pregnancy and neonatal outcomes in women with thyroid antibodies:

Lead Research Organisation: Birmingham Women's Hospital

Abstract

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Technical Summary

Scientific Abstract|We conducted a systematic review exploring the association between thyroid antibodies and adverse pregnancy outcomes. For miscarriage, we identified 29 studies (9817 women), and 26 of these showed a positive association. Meta-analysis of the 29 studies showed more than doubling in the odds of miscarriage in the presence of thyroid antibodies (OR:2.4, 95% CI: 1.9, 3.1). For preterm birth, we identified 4 studies (2896 women). All studies showed a positive association and meta-analysis found more than doubling in the odds of preterm birth in the presence of thyroid antibodies (OR: 2.7, 95% CI: 1.9, 3.9). The two dominant hypotheses for these observations are that a) thyroid antibodies represent a state of global immune dysfunction and b) thyroid antibodies are associated with relative thyroid insufficiency. There is evidence that thyroxine treatment can alter global immune response directly, and it can also correct any relative thyroid insufficiency. We carried out another systematic review to identify studies of thyroxine replacement to improve pregnancy outcomes in women with thyroid antibodies: two randomised trials, including a total of 187 women, were identified; the studies showed a reduction in miscarriages (RR: 0.48, 95% CI:0.25, 0.92) and preterm birth (RR:0.31; 95% CI:0.11, 0.90) with levothyroxine treatment. However, our UK clinician survey (n=183) found that only 8% (15/183) of clinicians use or intend to use levothyroxine for the prevention of miscarriages in thyroid antibody positive women and that 85% (155/183) do not currently use levothyroxine, but would be willing to recruit into a randomised study.|We, therefore, propose a randomised, placebo-controlled, double-blind, multi-centre trial to test the hypothesis that in euthyroid women with thyroid peroxidase antibodies, levothyroxine (50mcg, oral, once daily), started pre-conceptually and continued to the end of pregnancy, compared with placebo, increases live births beyond 34 completed weeks of gestation by at least 10%. Nested within the trial, we will evaluate cytokine levels in the maternal circulation and decidua. We plan to randomise 900 women (450 participants in each arm): To detect a 10% difference in live birth beyond 34 weeks, for an alpha of 5% and power of 80%, 380 women will need to be randomised to each group. However, assuming and adjusting for a worst case scenario of a 15% attrition, the total number of participants required will be 900. The analysis will be by intention to treat, and according to a pre-specified analysis plan. The trial will be co-ordinated by an Accredited Clinical Trials Unit. Twenty one hospitals in the UK will participate in this trial, which will be led by a strong team of researchers with track record in conducting multicentre trials as well as miscarriage, preterm birth and thyroid research. The trial is supported by patients (78 interviewed), Miscarriage Association, British Thyroid Foundation, British Thyroid Association, the RCOG and others. If our study confirms the benefits shown in the existing trials, the NHS can save over £215 million/year.|

Organisations

 
Title Digital Awareness Raising Campaign for Miscarriage Research 
Description My team produced a series of videos, outdoor advertisements and digital promotions under the "Birmingham Heroes" brand, to raise awareness of our efforts to target the challenges and misconceptions of miscarriage research. 
Type Of Art Film/Video/Animation 
Year Produced 2016 
Impact Between April and June 2016, maternal health research became the highest scoring press theme of the academic year at the University of Birmingham. Overall, the campaign delivered approximately 1,200 website link clicks from 550,000 impressions. Facebook advertising was particularly effective, with over 600 link clinks generated from 50,000 impressions. On average people visited 2 webpages per session. The Twitter advertisement was retweeted 95 times. Our most popular advertisement strapline was "we are leading the largest early miscarriage centre in Europe." The campaign received praise and support on a variety of social media sites, from a variety of stakeholders including patients and families, students, academic peers, charities, professional practitioners and the Minister for Care Quality Ben Gummer. 
 
Title Forget Me Not campaign item 1 
Description In 2017 my team collaborated with colleagues at the University of Birmingham to coordinate a campaign to raise more than £70,000 in support of miscarriage studies. The campaign included personalised electronic and hard copy letters to alumni all over the world, three videos (hundreds of views) and specially produced seed papers to grow forget-me-not flowers in honour of pregnancies ended too soon. 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact Many alumni responded by sending in letters of appreciation or writing about their own stories. We not only achieved more than £70,000 income to pursue more life-changing research that could not otherwise be realised: the team also brought hope to thousands of families affected by the heartache of pregnancy loss and demonstrated our commitment to challenge the social stigma of miscarriage. One of the couples who participated in the project said "knowing there are people out there researching early miscarriage gives couples hope and belief when sometimes there are no answers available." One of the alumni who donated to the project said "I am full of admiration for their work and wish them continued success." 
URL http://www.birmingham.ac.uk/alumni/Giving/Health-and-medical-research/Miscarriage.aspx
 
Title Forget Me Not campaign item 2 
Description In 2017 my team collaborated with colleagues at the University of Birmingham to coordinate a campaign to raise more than £70,000 in support of miscarriage studies. The campaign included personalised electronic and hard copy letters to alumni all over the world, three videos (hundreds of views) and specially produced seed papers to grow forget-me-not flowers in honour of pregnancies ended too soon. 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact Many alumni responded by sending in letters of appreciation or writing about their own stories. We not only achieved more than £70,000 income to pursue more life-changing research that could not otherwise be realised: the team also brought hope to thousands of families affected by the heartache of pregnancy loss and demonstrated our commitment to challenge the social stigma of miscarriage. One of the couples who participated in the project said "knowing there are people out there researching early miscarriage gives couples hope and belief when sometimes there are no answers available." One of the alumni who donated to the project said "I am full of admiration for their work and wish them continued success." 
URL https://www.youtube.com/watch?v=vqg0gv-8XlA
 
Title Forget Me Not campaign item 3 
Description In 2017 my team collaborated with colleagues at the University of Birmingham to coordinate a campaign to raise more than £70,000 in support of miscarriage studies. The campaign included personalised electronic and hard copy letters to alumni all over the world, three videos (hundreds of views) and specially produced seed papers to grow forget-me-not flowers in honour of pregnancies ended too soon. 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact Many alumni responded by sending in letters of appreciation or writing about their own stories. We not only achieved more than £70,000 income to pursue more life-changing research that could not otherwise be realised: the team also brought hope to thousands of families affected by the heartache of pregnancy loss and demonstrated our commitment to challenge the social stigma of miscarriage. One of the couples who participated in the project said "knowing there are people out there researching early miscarriage gives couples hope and belief when sometimes there are no answers available." One of the alumni who donated to the project said "I am full of admiration for their work and wish them continued success." 
URL https://www.youtube.com/watch?v=ooDv-yojo2E
 
Title Tommys National Centre for Miscarriage Research 
Description We created a film, animation and soundtrack to explain the key questions asked by women and couples who experience a miscarriage: Why did it happen? Will it happen again? Can we prevent it happening again? How can we come to terms with this? 
Type Of Art Film/Video/Animation 
Year Produced 2015 
Impact This video contributed to the successful application of my team to lead Tommy's National Centre for Miscarriage Research. 
 
Description DARO Forget-Me-Not
Amount £72,000 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start 08/2017 
 
Title Miscarriage PSP 
Description I was involved in the Miscarriage Priority Setting Partnership (PSP). This project aimed to establish what miscarriage research topics are important to women and those affected by miscarriage, as well as what miscarriage research topics are important to professionals. 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact The results of the project are shaping the miscarriage research agenda and acting as a catalyst for more funding opportunities for research in this area. 
URL http://miscarriagepsp.org/
 
Description Miscarriage PSP 
Organisation Association of Early Pregnancy Units
Country United Kingdom 
Sector Learned Society 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Birthrights
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Ectopic Pregnancy Trust
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Heart of England NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation International Society of Ultrasound in Obstetrics and Gynecology
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation James Lind Alliance
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Miscarriage Association
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Mumsnet
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Netmums Ltd
Country United Kingdom 
Sector Private 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Nurture Fertility
Country United Kingdom 
Sector Hospitals 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Royal College of General Practitioners
Country United Kingdom 
Sector Academic/University 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Royal College of Nursing
Country United Kingdom 
Sector Learned Society 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Royal College of Obstetricians and Gynaecologists (RCOG)
Country United Kingdom 
Sector Academic/University 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Scottish Care & Information On Miscarriage
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation St Mary's Hospital, London
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Sunderland Royal Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Tommy's
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation University of Birmingham
Department Department of Finance
Country United Kingdom 
Sector Academic/University 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description Miscarriage PSP 
Organisation Wellbeing of Women
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage.
Collaborator Contribution The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research.
Impact The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571.
Start Year 2016
 
Description TABLET 
Organisation Ashford and St. Peter's Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Barts Health NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Barts Health NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Barts Health NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Barts Health NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Basildon University Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Birmingham City Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Birmingham Heartlands Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Birmingham Women's and Children's NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Bolton NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Bradford Teaching Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Burnley General Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Colchester Hospital University NHS Foundation Trust
Department Colchester General Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Countess of Chester Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation County Durham and Darlington NHS Foundation Trust
Department University Hospital of North Durham
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Crosshouse Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Derriford Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Ealing Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Frimley Park Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Furness General Hospital
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Guy's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Imperial College Healthcare NHS Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation James Cook University Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation King's College Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Liverpool Womens NHS Foundation Trust
Department Liverpool Women's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation New Cross Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation North Cumbria University Hospitals NHS Trust
Department Cumberland Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation North Manchester General Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Princess Royal Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Queen's Medical Centre
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Royal Cornwall Hospitals NHS Trust
Department Royal Cornwall Hospital (Treliske)
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Royal Derby Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Royal Devon and Exeter Hospital
Country United Kingdom 
Sector Academic/University 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Royal United Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Royal Victoria Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Saint Mary's Hospital, Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation St James's University Hospital (Jimmy's)
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation St Mary's Hospital, London
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation St Michael's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation St Thomas' Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
Department Royal Bournemouth Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Tommy's
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation University College London Hospital
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation University Hospital Coventry
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Warrington and Halton Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Watford General Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation West Middlesex University Hospital
Country United Kingdom 
Sector Academic/University 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Wirral University Teaching Hospital NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description TABLET 
Organisation Wrightington, Wigan and Leigh NHS Foundation Trust
Department Wrightington Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance.
Collaborator Contribution Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination.
Impact In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years.
Start Year 2011
 
Description Tommys 
Organisation Birmingham Women's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here?
Collaborator Contribution Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies.
Impact Outputs are listed in other sections of the form.
Start Year 2015
 
Description Tommys 
Organisation Imperial College London
Department Department of Earth Science & Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here?
Collaborator Contribution Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies.
Impact Outputs are listed in other sections of the form.
Start Year 2015
 
Description Tommys 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here?
Collaborator Contribution Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies.
Impact Outputs are listed in other sections of the form.
Start Year 2015
 
Description Tommys 
Organisation Queen Charlotte's and Chelsea Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here?
Collaborator Contribution Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies.
Impact Outputs are listed in other sections of the form.
Start Year 2015
 
Description Tommys 
Organisation Tommy's
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here?
Collaborator Contribution Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies.
Impact Outputs are listed in other sections of the form.
Start Year 2015
 
Description Tommys 
Organisation University Hospitals Coventry and Warwickshire NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here?
Collaborator Contribution Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies.
Impact Outputs are listed in other sections of the form.
Start Year 2015
 
Description Tommys 
Organisation University of Warwick
Department Warwick Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here?
Collaborator Contribution Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies.
Impact Outputs are listed in other sections of the form.
Start Year 2015
 
Title Levothyroxine to reduce miscarriage risk in euthyroid women with thyroid auto-antibodies 
Description Financially supported by the NIHR EME competition, the TABLET trial (ISRCTN 15948785, EudraCT 2011-000719-19) sought to evaluate the effects of thyroxine to prevent miscarriage in women with thyroid antibodies but normal thyroid function. The trial was carried out at more than 30 centres across the UK. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2011
Development Status Under active development/distribution
Impact Please refer to other sections of the portfolio for further details. 
URL http://www.birmingham.ac.uk/research/activity/mds/trials/bctu/trials/womens/tablet/index
 
Description AEPU 2015 - TABLET 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The AEPU conference is an annual event that brings together hundreds of researchers, healthcare practitioners and policy makers to build collaborations and raise the profile of early pregnancy care. In 2015 I presented the work of my team to conference delegates, and other team members operated a stall to promote the TABLET trial.
Year(s) Of Engagement Activity 2015
 
Description AEPU 2016 - TABLET 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The AEPU conference is an annual event that brings together hundreds of researchers, healthcare practitioners and policy makers to build collaborations and raise the profile of early pregnancy care. In 2016 my team presented TABLET news to conference delegates and operated a stall to promote the trial.
Year(s) Of Engagement Activity 2016
 
Description AEPU 2017 - Miscarriage Trials 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The AEPU conference is an annual event that brings together hundreds of researchers, healthcare practitioners and policy makers to build collaborations and raise the profile of early pregnancy care. In 2017 my team presented news of all our active clinical trials (in the United Kingdom) to conference delegates, and operated a stall to promote the studies.
Year(s) Of Engagement Activity 2017
 
Description BBC Yorkshire interview about miscarriage 2018 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Steve Bailey, BBC Journalist for Radio Yorkshire, interviewed Professor Coomarasamy for a feature about miscarriage experiences and management.
Year(s) Of Engagement Activity 2018
 
Description British Thyroid Foundation - TABLET 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact News of the TABLET trial was reported via the British Thyroid Foundation website.

The British Thyroid Foundation website brings news of the TABLET Trial to patient groups and the public.
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015
URL http://www.btf-thyroid.org/
 
Description CRNs - TABLET 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact My research team engages with CRNs across the UK.

CLRNs are providing support to the TABLET Trial. Many CLRNs are contributing to the costs of clinical testing, and some CLRNs are contributing nursing support, and/or assisting my research team to identify appropriate healthcare staff to work with us.
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015
 
Description Clinical Trials Presentation at IMSR Away Day 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact I was invited to deliver a presentation entitled "Translating Science into Health - Clinical Trials" to the Institute of Metabolism and Systems Research (IMSR) at the University of Birmingham. Questions and discussions increased awareness and interest in the subject.
Year(s) Of Engagement Activity 2016
 
Description Debate for British Thyroid Association - TABLET 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact In October 2010 at the Annual Meeting of the British Thyroid Association in London, Professor Mark Kilby took part in a national debate to contest whether the reproductive health of women with anti-TPO antibodies may be improved by treatment with thyroxine prior and during pregnancy. Professor Mark Kilby argued for this motion, and Professor Tony Weetman argued against it. The debate sparked audience participation and discussion afterwards.

The debate stimulated thinking and active consideration of the hypothesis among professional practitioners.
Year(s) Of Engagement Activity 2010
 
Description Early Pregnancy Research Presentation to the Gynaecology Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The Gynaecology Club hosts a series of events and meetings attended by consultants, junior doctors and researchers from across the Midlands. I was invited to deliver a presentation about early pregnancy research.
Year(s) Of Engagement Activity 2016
 
Description Facebook - TABLET 1 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact News of the TABLET trial was reported via facebook during the early period of the study. The study gained hundreds of 'likes' from assorted participants in the research and other supporters.

The TABLET Trial has gained 59 'Likes' from assorted participants in the research and other supporters.
Year(s) Of Engagement Activity 2011,2012,2013,2014
URL https://www.facebook.com/TabletTrial?ref=stream
 
Description Facebook - TABLET 2 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Between October and November 2015 we harnessed facebook to increase participant recruitment (using a web platform www.tabletstudy.co.uk as a screening tool) nationwide.
Year(s) Of Engagement Activity 2015
URL https://www.tabletstudy.co.uk
 
Description Infertility UK - TABLET 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact News of the TABLET trial was reported via the Infertility UK website.

The Infertility UK website brings news of the TABLET Trial to patient groups and the public.
Year(s) Of Engagement Activity 2006,2011,2012,2013,2014
URL http://www.infertilitynetworkuk.com/
 
Description Meeting of Collaborators - TABLET 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact The TABLET Collaborators' Meeting in 2015 brought together researchers from across the UK to share news and ideas, and gain inspiration to reach the culmination of the study.
Year(s) Of Engagement Activity 2015
 
Description Miscarriage Association - TABLET 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A representative of the Miscarriage Association - who participates in meetings of the TABLET Trial Steering Committee - regularly reports our news of the project via the Miscarriage Association website and meetings of this organisation.

The Miscarriage Association brings news of the TABLET Trial to patient groups and the public.
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015
URL http://www.miscarriageassociation.org.uk/
 
Description Miscarriage presentation to the RCOG World Congress in Obstetrics and Gynaecology 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The RCOG World Congress welcomes scientific and healthcare practitioners from the UK and overseas with a programme of lectures, lively debates and networking opportunities. I was invited to deliver a presentation about the "Mechanisms and Trials of Recurrent Miscarriage" within the early pregnancy workstream.
Year(s) Of Engagement Activity 2016
 
Description Newsletters - TABLET 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Newsletters were issued regularly to TABLET researchers, to keep everybody abreast of progress and build staff morale.

Participants have expressed appreciation of newsletters and researchers have engaged in friendly competition in rates of recruitment between sites (performance in the TABLET Olympics reported in each issue), boosting our overall rate of progress.
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015
 
Description Participant Contact - TABLET 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact I telephoned ladies who have declined to participate in the TABLET trial, to gain an understanding of the reasons.

Our improved understanding of the reasons for potential participants to decline to join the TABLET Trial is enabling us to better address and overcome these issues, to improve our recruitment rates.
Year(s) Of Engagement Activity 2012,2013,2014,2015
 
Description Patient Information Sheet - TABLET 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact A lay representative of the Miscarriage Association assisted the design and contents of our Patient Information Sheets.

The feedback of a lay representative of the Miscarriage Association has improved the design and contents of our Patient Information Sheets, to enable participants to better understand the TABLET Trial.
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015
 
Description Prediction and Prevention of Miscarriage Presentation to the British Fertility Society (BFS), Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Organised by the Association of Clinical Embryologists (ACE), the British Fertility Society (BFS) and the Society for Reproduction and Fertility (SRF), this fertility conference drew an audience of scientists, clinicians, embryologists, nurses and counsellors. The conference encouraged networking, collaboration and discussion. I presented a keynote speech entitled "Prediction and Prevention of Miscarriage" to conference delegates.
Year(s) Of Engagement Activity 2017
 
Description Presentation to GVS - TABLET 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 40 members of the Gynaecological Visiting Society attended a talk about the prevalence of thyroid antibodies and thyroid dysfunction of women of reproductive age in the UK.

Conference delegates congratulated the TABLET team for determination, positivity and persistance in the face of practical challenges to meet recruitment targets.
Year(s) Of Engagement Activity 2014
 
Description Presentations to the Specialists in Sharing Expertise, Education and Data (SEED) Conference, Australia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact SEED is a highly respected symposium for fertility doctors. I presented "Recurrent Miscarriage: Definitions and Management" and "Progesterone in the Management of Miscarriage" at the annual meeting in Sydney, Australia.
Year(s) Of Engagement Activity 2017
 
Description Press activities surrounding miscarriage research 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Tommy's Centre for Miscarriage Research has achieved considerable local, national and international press coverage to raise awareness and engagement in miscarriage research. Examples of media exposure include: BBC Breakfast; BBC Radio 4; BBC Five Live; Articles in the Daily Mail Newspaper and The Daily Mirror Newspaper.
Year(s) Of Engagement Activity 2016,2017,2018
 
Description REACH Newsletters - TABLET 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact The TABLET trial was regularly mentioned in REACH newsletters. The REACH network also provided leadership and support in engaging with CRNs.

Health professionals across the region are aware of the TABLET Trial, and several new healthcare institutions have volunteered to become involved in the study.
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015
URL http://www.crncc.nihr.ac.uk/about_us/ccrn/bbc/lsg/reproductive_health
 
Description Scientific meeting of Tommys National Centre for Miscarriage Research, February 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact My team hosted a scientific meeting for early pregnancy researchers from Tommy's sites around the country. The event enabled junior and senior colleagues in disparate locations to share knowledge, ideas and peer support.
Year(s) Of Engagement Activity 2017
 
Description Tommys National Centre for Miscarriage Research Launch 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact In April 2016 we launched Tommy's National Centre for Miscarriage Research. Events in London and Coventry were spearheaded by academic team leaders, celebrity guest speakers and patrons of Tommy's charity. We gained tremendous national media exposure and raised awareness of our efforts to understand miscarriage.
Year(s) Of Engagement Activity 2016
 
Description Tommys misCOURAGE campaign 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Despite one in four pregnancies ending in miscarriage, the silence around the subject means that many couples who have lost babies harbour unexpressed feelings of failure, isolation and guilt. This campaign seeks to tell the stories of all those who have experienced miscarriage.
Year(s) Of Engagement Activity 2015,2016,2017,2018
URL https://www.tommys.org/miscourage
 
Description Twitter - TABLET 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Regular tweets - whenever a new patient was randomised - kept our study participants abreast of progress.

This engagement builds staff morale and helps to maintain recruitment momentum.
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015
 
Description Website - TABLET 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The TABLET trial maintains an active website.

Participants in the TABLET Trial and any other interested members of the public are able to verify the details of the project easily at any time.
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015
URL http://www.birmingham.ac.uk/research/activity/mds/trials/bctu/trials/womens/tablet/index.aspx