Establishing MRC-NIHR Phenome Centre, a world leading high-throughput metabolic phenotyping centre for humanpopulation disease-risk biomarker discovery.

Lead Research Organisation: Imperial College London

Abstract

We are setting up a new national centre to examine tens of thousands of human blood, and urine samples for the huge variety of chemicals that are found in our bodies. Some of those chemicals are made by ourselves and others originate from our diet, medicines and even pollutants.

The purpose of doing this is to link the chemicals that we find in our bodies to different disease risk factors and to improve their prevention, diagnosis and treatment. This work will help us to understand the complexity of health and disease and will enhance our understanding of the interactions between peoples' genes, their lifestyle and their environment. This work will help us develop ways to make sure that everyone gets exactly the right treatment they need depending on their own genetics, lifestyle and other conditions they may have.

Measuring the tiny quantities of these compounds requires expert researchers and highly specialised equipment. It also requires sophisticated statistical and computer analysis to identify which of the many thousands chemicals are the most important predictors of disease. The Centre will build on existing expertise and infrastructure at Imperial and will enable us to make it available to others. We are working with other scientsits at King's College London, and experts from the equipment companies to set up the new centre, which will give all researchers in the UK access to these state-of-the-art facilities and expert scientists, and will train new researchers for the future.

This new centre is the first such facility in the world that can do parallel high throughput analysis of samples on this scale and will lead the way in setting standards for other countries that are setting up similar centres. The research that is undertaken in the centre will also help develop the technologies to be more cost effective and environmentally friendly.

By establishing this national centre, Imperial will be able to build on its world-leading expertise and work with other researchers to investigate a wider range of diseases and disease risks, and will speed up developments in their treatment, diagnosis and prevention.

Technical Summary

We are establishing the MRC-NIHR Phenome Centre, a world leading high-throughput metabolic phenotyping centre for human population disease-risk biomarker discovery. It will offer the scientific community a unique capability in targeted and exploratory metabolic phenotyping and assay development, as well as a computational medicine capability for the provision of data, models and physiological interpretation.

Metabolic phenotypes (metabotypes) are strongly influenced by both host genes and environment, and their interaction. A multitude of factors modify the metabotype of both individuals and populations. These include gender, age, diet, gut microbiome, physical activity, latent disease, hormone and stress levels, as well as xenobiotics, such as medications, plasticisers, food preservatives, pesticides, and plant secondary metabolites such as caffeine, flavinoids and phytoestrogens.

Biofluids, such as blood and urine, carry detailed metabolic and homeostatic information, providing a top-down 'systems biology' readout of the biochemical, physiological, dietary and environmental exposures of individuals. By taking advantage of the new -'omics' technologies, the end-products and consequences of these external challenges and internal responses ('the exposome') can be captured. Cross-integration of genetic and metabolic phenotype data will aid patient stratification through discovery of novel disease and prognostic biomarkers and better understanding of responses to treatment and novel therapies.

The MRC-NIHR National Phenome Centre will provide, at scale, the ability to analyse both patient- and population-based samples for biomarker discovery and validation, improved patient stratification through development of robust diagnostic and prognostic markers, and early identification of drug efficacy, safety and other responses to treatments. The Centre will provide a service to the scientific community providing high-throughput analysis of their samples, providing unprecedented scale, quality control and reproducibility and will also engage in academic collaboration for some of the projects requiring complex data analysis and interpretation.

The facility will comprise state-of-the-art Mass Spectrometry (MS) and high field Nuclear Magnetic Resonance (NMR) facilities at Imperial, and will be supported by strategic alliances with King's College London and major instrument suppliers of both MS (The Waters Corporation) and NMR (Bruker Biospin GmbH).

The establishment of the Phenome Centre will be one of the most important developments in applied analytical science in teh UK in a generation. It will be transformational in the scale of what can be achieved. It will create a template for international harmonisation of the approach to metabolic phenotyping and its methodologies, for the first time making data at this level comparable across institutions. Finally the R&D input from the Centre's technology partners will transform the instrumentation and methods for analytical chemistry by undertaking R&D to develop new analytical methods, establish novel approaches to computational multivariate analyses and to develop the technology, eg to increase the throughput and reduce environmental impact.

Publications

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Chan Q (2017) Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview. in Hypertension research : official journal of the Japanese Society of Hypertension

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Elliott P (2015) Urinary metabolic signatures of human adiposity. in Science translational medicine

 
Description Big Data and Health Working Group 2013
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
URL http://www.wish-qatar.org/app/media/382
 
Description Imperial International Phenone Training Centre
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact The IIPTC has undertaken the training (both classroom-based and hands-on laboratory) of 150 trainees in its first year. Trainees have comes from all over the UK (from PhD students to clinicians), Europe and also Japan (Tohoku Megabank, Japan). This has resulted in an increase in the skill levels of the workforce.
URL http://www1.imperial.ac.uk/iiptc/about/
 
Description Dementia Research Institute Centres
Amount £10,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2017 
End 08/2022
 
Description Horizon 2020
Amount € 1,232,095 (EUR)
Funding ID 654241 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 09/2015 
End 08/2018
 
Description MICA: UK MEDical BIOinformatics partnership - aggregation, integration, visualisation and analysis of large, complex data (UK MED-BIO).
Amount £1,485,117 (GBP)
Funding ID MR/L01632X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 03/2019
 
Title Standards Database 
Description Known standards of common metabolites and chemicals have been run using the Centre's methods allowing a database of spectra to be created. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact The database is linked to the methods the Centre runs and is allowing the Centre to reanalyse all data generated with these methods to assist with the annotation of features of interest to the primary questions which have been posed for each of the studies. At least 2 pilot projects now have putative annotations for significant features which are being taken forward into validation studies and written up into research publications. 
 
Description AIRWAVES Project 
Organisation Imperial College London
Department School of Public Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Access granted to the National Phenome Centre by the Access Committee for the Centre to undertake metabolic profiling of 6000 samples. A Project Agreement has been drafted.
Collaborator Contribution Provision of samples (6000) plus associated data.
Impact Award by the National Phenome Centre Access Committee of access to the Centre for the AIRWAVES project. Agreement being drawn up.
Start Year 2013
 
Description Alzheimer's Biomarkers Pilot Project 
Organisation King's College London
Department Institute of Pharmaceutical Science
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £40,624 awarded to Dr Legido-Quigley/Prof Lovestone from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 672 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been drafted.
Collaborator Contribution Provision of samples (672) and associated data.
Impact Award of Pilot Project. Collaboration Agreement being drafted.
Start Year 2013
 
Description Asthma 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £25,232 awarded to Prof Howarth from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 389 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been signed.
Collaborator Contribution Provision of samples (389) plus associated data.
Impact Collaboration Agreement.
Start Year 2015
 
Description BGI MOU 
Organisation Beijing Genomics Institute
Country China 
Sector Academic/University 
PI Contribution Memorandum of Understanding for undertaking collaborative projects and the development of Phenome Centre for BGI.
Collaborator Contribution Knowledge and expertise linked to the creation of Phenome Centre.
Impact Memorandum of Understanding
Start Year 2013
 
Description Birmingham CDA 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Creation of a closer working relationship between the National Phenome Centre and the University of Birmingham as they obtain equipment as a result of MRC funding to allow them to harmonise to National Phenome Centre methods and standards as the first step on a UK-wide Phenome Centre Network. The Centre is providing Uni of Birmingham with specialist advice on how to create a Phenome Centre and how to implement National Phenome Centre methods.
Collaborator Contribution They have obtained MRC funding to purchase equipment to allow them to harmonise.
Impact The University of Birmingham secured funding from the MRC to purcahse equipment to allow them to harmonise with the MRC-NIHR National Phenome Centre.
Start Year 2014
 
Description Bruker 
Organisation Bruker Corporation
Department Bruker BioSpin
Country Germany 
Sector Private 
PI Contribution The research team and Imperial College London has created the laboratory facility into which the NMR equipment being leased from Bruker has been located. In addition staff have been employed to manage and run the facility (on the MRC-NIHR grant), and also on other funding to run the Training Centre.
Collaborator Contribution Bruker have committed to providing rapid engineer support to the NMR laboratories of the MRC-NIHR National Phenome Centre, along with assistance of method development. Bruker have also donated equipment to the Training Centre (which is led by Dr Elizabeth Want of Imperial College London).
Impact Donations of equipment have allowed the creation of the International Phenome Training Centre. This is a world-class facility which is enabling students, scientists and doctors from around the world to gain hands-on experience of using analytical technology to study the human phenome. One paper has been published in Analytical Chemistry.
Start Year 2012
 
Description CSV 
Organisation University of Cambridge
Department Department of Clinical Neurosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £37,876 awarded to Professor Markus from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 622 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been signed.
Collaborator Contribution Provision of samples (622) plus associated data.
Impact Collaboration Agreement
Start Year 2015
 
Description DPUK_LBC1936 
Organisation University of Edinburgh
Department School of Philosophy, Psychology and Language Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution The National Phenome Centre will undertake the analysis of the Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been signed.
Collaborator Contribution Provision of samples (601) plus associated data.
Impact Collaboration Agreement.
Start Year 2015
 
Description EPIC HCC 
Organisation Imperial College London
Department Faculty of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £47,770 awarded to Dr Sharma from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 800 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee.
Collaborator Contribution Provision of samples (800) plus associated data.
Impact None to date
Start Year 2015
 
Description ERICCA Trial Pilot Project 
Organisation University College London
Department Hatter Cardiovascular Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £14,786 awarded to Dr Hausenloy from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 200 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been drafted.
Collaborator Contribution Provision of samples (200) and associated data
Impact Pilot Project awarded, Collaboration Agreement being drafted.
Start Year 2013
 
Description GRAPHIC Pilot Project 
Organisation University of Leicester
Department Department of Cardiovascular Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £236,522 awarded to Prof Samani from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 4000 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been signed and samples have been received and are currently being analysed.
Collaborator Contribution Provision of samples (4000), plus related associated data. They are actively involved in collaborative data analysis.
Impact Collaboration Agreement has been signed.
Start Year 2013
 
Description Kings 
Organisation Medical Research Council (MRC)
Department MRC-HPA Centre for Environment and Health
Country United Kingdom 
Sector Public 
PI Contribution The research team and Imperial College London has created the facility. In addition staff have been employed to manage and run the facility (on the MRC-NIHR grant), and also on other funding to run the Training Centre.
Collaborator Contribution KCL have provided people (Prof Frank Kelly) to provide their time and assistance on the MRC-NIHR National Phenome Centre Access Committee and Executive Board. In addition one post-doctoral position has been awarded to Dr Norman Smith's research group at KCL to assist with method development on the mass-spec platform.
Impact The input on the Access Committee and Executive Boards has been essential in ensuring the successful start to the MRC-NIHR National Phenome Centre to ensure a balanced portfolio. Prof Kelly has also assisted in raising the profile of the Centre within the UK research community.
Start Year 2012
 
Description LOLIPOP Pilot Project 
Organisation Imperial College London
Department National Heart & Lung Institute (NHLI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £189,384 awarded to Prof Kooner from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 3000 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been signed.
Collaborator Contribution Provision of samples (3000) plus associated data
Impact local Collaboration Agreement
Start Year 2013
 
Description MARS 
Organisation Institute of Cancer Research UK
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £34,577 awarded to Prof Dearnaley from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 900 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been signed.
Collaborator Contribution Provision of samples (560) plus associated data.
Impact Collaboration Agreement
Start Year 2015
 
Description MASALA Study 
Organisation University of California, San Francisco
Country United States 
Sector Academic/University 
PI Contribution Undertaking the full global profiling of 745 samples via NMR and UPLC-MS assays
Collaborator Contribution Provision of 745 samples and associated clincial data. They will undertake the analysis of the data in conjunction with their other omics data
Impact No outputs to date
Start Year 2017
 
Description Ovarian Cancer Pilot Project 
Organisation Imperial College London
Department Department of Surgery and Cancer
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £30,729 awarded to Prof Brown from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 487 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been drafted.
Collaborator Contribution Provision of samples (487) and associated data.
Impact Award of Pilot Project, local Collaboration Agreement being drawn up.
Start Year 2013
 
Description RAMS 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £15,886 awarded to Dr Barton from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 216 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been signed.
Collaborator Contribution Provision of samples (216) plus associated data.
Impact Collaboration agreement
Start Year 2015
 
Description Renal 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £36,776 awarded to Dr Martin from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 600 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been signed.
Collaborator Contribution Provision of samples (600) plus associated data.
Impact Collaboration Agreement.
Start Year 2015
 
Description Waters 
Organisation Waters Corporation
Country United States 
Sector Public 
PI Contribution The research team and Imperial College London has created the laboratory facility into which the liquid chromatography and mass spectrometry equipment being leased from Waters has been located. In addition staff have been employed to manage and run the facility (on the MRC-NIHR grant), and also on other funding to run the Training Centre.
Collaborator Contribution Waters have committed to providing rapid engineer support to the mass-spec laboratories of the MRC-NIHR National Phenome Centre. Waters have also donated equipment and provided two members of staff (employed by Waters, but located at Imperial College London) to run the Centre (which is led by Dr Elizabeth Want of Imperial College London).
Impact Donations of equipment and provision of two funded staff members (employed by Waters, but located at Imperial College London) have allowed the creation of the International Phenome Training Centre. This is a world-class facility which is enabling students, scientists and doctors from around the world to gain hands-on experience of using analytical technology to study the human phenome. Over 7 courses have been run at the training centre in the last 12 months, resulting in the training of a significant number of students in metabolic phenotyping and is related activities.
Start Year 2012
 
Description Xtreme Everest Pilot Project 
Organisation University College London
Department Division of Surgery & Interventional Science
Country United Kingdom 
Sector Academic/University 
PI Contribution Pilot project of £76,156 awarded to Dr Martin from the NIHR awarded Pilot Project section of the National Phenome Centre grant to undertake metabolic profiling of 900 samples. The National Phenome Centre will undertake the analysis of the Pilot Project samples for the project as awarded by the National Phenome Centre Access Committee. A Collaboration Agreement has been signed.
Collaborator Contribution Provision of samples (900) plus associated data.
Impact Collaboration Agreement
Start Year 2013
 
Title nPYc-Toolbox 
Description The nPYc-Toolbox defines objects for representing, and implements functions to manipulate and display, metabolic profiling datasets. 
Type Of Technology Software 
Year Produced 2018 
Open Source License? Yes  
Impact A Python implementation of the NPC toolchain for the import, quality-control, and preprocessing of metabolic profiling datasets. This takes peak-picked LC-MS data, raw NMR spectra and targeted datasets and provides batch and drift correction, feature alignment, calculation of spectral line-width, PCA of datasets and visualisation of datasets. The toolbox creates a standardised way of dealing with the very large datasets which metabolic profiling creates and provides outputs needed to allow onward analysis of the datasets in standard statistical packages. 
URL https://github.com/phenomecentre/nPYc-Toolbox
 
Description 2016 Keystone Symposia (Rhode Island) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote address "Towards Personalized Medicine and Microbiome Regulation". This meeting discussed how the gut microbiome and its metabolites influence major molecular and physiological mechanisms responsible for man-made metabolic diseases. It incorporated investigators from diverse areas such as medicine, immunology, neurobiology, endocrinology, physiology, psychiatry, systems biology and microbiology. In addition, the nutritional, surgical and pharmacological aspects of innovative therapeutic strategies were discussed in dialogue with scientists from pharmaceutical/nutritional companies.
Year(s) Of Engagement Activity 2016
URL http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1417
 
Description ABPI Stratified Medicine Working Group meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Presentation made to Association of the British Pharmaceutical Industry's Stratified Medicine Working Group meeting in October 2013 to update on current programme or work in the National Phenome Centre and plans going forward in respect to industry collaboration.

Increased knowledge of ABPI members of the existence and capabilities of the National Phenome Centre.
Year(s) Of Engagement Activity 2013
 
Description Gave the Robert Stowell lecture: The Challenge of Implementing Systems Medicine Paradigms in a Changing World. University of California Davis Health System, Sacramento, California - 14 April 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk resulted in large number of questions. Also sparked interest in practitioners undertaking metabolic phenotyping work

Interest in practitioners undertaking metabolic phenotyping work
Year(s) Of Engagement Activity 2014
URL http://www.ucdmc.ucdavis.edu/publish/news/newsroom/8831
 
Description Imperial College London Data Science Institute 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The Research Board is formed of senior and active stakeholders of data science related research representative of the faculties of Engineering, Medicine, and Natural Sciences, and Imperial Business School. It's purpose is to set strategy and oversee strategic implementation to fulfil the objectives of the Institute, in particular to enhance communication between the Institute and the College.
Year(s) Of Engagement Activity 2015,2016,2017
URL https://www.imperial.ac.uk/data-science/about-the-institute/governance/
 
Description Industry Engagement Merck 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Global Head Translational and Biomarker Research for Merck visited. Resulted in increased awareness of potential areas of collaboration between the company and the Phenome Centre. Precipitated a further visit from another section of Merck (Business Development, Consumer Health Americas, Merck V) later on in the year where collaborative areas of working were discussed.
Year(s) Of Engagement Activity 2016
 
Description Industry Visit - Biocrates 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact CEO and Business Director for Biocrates visited the Phenome Centre and met with Prof Nicholson to discuss potential future collaborations and joint ventures.
Year(s) Of Engagement Activity 2016
 
Description International Phenome Training Centre 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The Imperial International Phenome Training Centre has been established to provide hands-on training in metabolic profiling, mass spectrometry, NMR, informatics and chemometrics. Two courses with multinational representation have been run through the Training Centre. Involving members of the Centre in talks, practicals and also hosting visits to the National Phenome Centre labs.

Successful training of participants in understanding the background and practical application of work undertaken in the National Phenome Centre.
Year(s) Of Engagement Activity 2013
URL http://iptc@imperial.ac.uk
 
Description Invited Session (40th Annula Meeting of the Japanese Sociaty for Biomedical Mass Spectrometry) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Nicholson gave an invited session on Systems Medicine in a Changing World: The Challenge of Measuring and Visualising Personal and
Public Healthcare Data. Over 300 people attended the meeting.
Year(s) Of Engagement Activity 2015
URL http://www2.hama-med.ac.jp/w3a/photon/gakkai/The%2040th%20Annual%20Meeting%20of%20JSBMS.pdf
 
Description Keynote Lecture (EUROTOX 2015) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote Lecture: Systems Medicine, Microbiomes and Personalised Healthcare.
Year(s) Of Engagement Activity 2015
URL http://www.eurotox2015.com/dokumente/PROGRAMME_EUROTOX_2015.pdf
 
Description Keynote Speaker (China) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Jeremy Nicholson was the keynote speaker at the 2015 Beijing Fragrant Hill Conference on International Phenome Research, Beijing, China 4-6 May 2015.
Year(s) Of Engagement Activity 2015
 
Description Launch of International Phenone Centre Network at WISH Conference Nov 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Prof Nicholson joined Dame Sally Davies (Chief Medical Officer, UK Government), Professor the Lord Ara Darzi of Denham (Director of the Institute of Global Health Innovation at Imperial College London), Professor John Rudan (Head of Department of Surgery, Queen's University Kingston General and Hotel Dieu Hospitals, Canada) and Professor James Best (Dean, Lee Kong Chian School of Medicine, Singapore) in launching the International Phenome Centre Network at the World Innovation Summit for Health in Dohar. Significant press interest was created as well as a number of organisations making contact regarding potential collaborations or additional Phenome Centre development.
Year(s) Of Engagement Activity 2016
URL http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/medicine/departmentofsurgeryandcancer/...
 
Description Lecture (14th Mitchum E. Warren, Jr. Lecture in Chemistry, Vanderbuilt University Nashville) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Lecture: Implementing Molecular Phenotyping and Systems Medicine Approaches in Personal and Public Healthcare. 14th Mitchum E. Warren, Jr. Lecture in Chemistry, Vanderbilt University Nashville. The lecture was hosted by The Chemistry Graduate Association of Students (GSAC) and the Chemistry Department at Vanderbilt University and aimed to engage undergraduates and postgraduates in the potential for working in the area of metabolic phenotyping.
Year(s) Of Engagement Activity 2015
URL https://medschool.vanderbilt.edu/career-development/blog/event-chemistry-implementing-molecular-phen...
 
Description Lecture (ADME Analytics, University of Amsterdam) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Lecture (Systems Medicine and Molecular Phenomics: Meeting the challenges in 21st century personal and public healthcare) during mini-symposium which was open to public.
Year(s) Of Engagement Activity 2015
URL http://www.aimms.vu.nl/en/news-events/events/2015/2015-08-27-minisymposium-innovative-analytical-app...
 
Description Lecture (Epigenetics 2015 Annual International Conference) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Jeremy Nicholson was invited to close the conference with his talk "Systems Medicine: Facing Personalized and Public Healthcare Challenges in a Changing and Dangerous World."
Year(s) Of Engagement Activity 2015
URL https://www.functionalmedicine.org/files/library/aic-2015-schedule_002.pdf
 
Description Lecture (Singapore Phenome Centre) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Lecture at the opening of Singapore Phenome Centre, Singapore. This official opening event resulted in significant media coverage in Singapore and the wider world press (listing of media coverage of event please see http://media.ntu.edu.sg/MediaReports/Pages/newsdetail.aspx?news=6017b5e7-f322-402b-b7b5-8471319473c6)
Year(s) Of Engagement Activity 2015
URL http://enewsletter.ntu.edu.sg/thelkcmedicine/Issue%2020/Pages/Launch-of-the-Singapore-Phenome-Centre...
 
Description Lecture (Stanford Medicine) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Prof Nicholson presented a lecture on Systems Medicine Approaches in Personalised and Public Healthcare as part of the Biomedical Seminars Series.
Year(s) Of Engagement Activity 2015
URL http://med.stanford.edu/seminars/eventDetails.do?semid=118123
 
Description MRC-PHE Centre Training Programme AM, Oct 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Population-scale metabolic profiling in the MRC-NIHR Phenome Centre" presented at the MRC-PHE Centre Training Programme Annual Meeting

Increased knowledge and understanding of audience of metabolic phenotyping potential impact.
Year(s) Of Engagement Activity 2013
 
Description Metabolomics Society June 16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Nicholson gave the opening plenary session talk "Metabolic profiling in system medicine". The audience reported a raised awareness of the work of the National Phenome Centre and resulted in a number of visits to the information stand which the Centre had at the event allowing provision to people of further information about the field in general and the offering of the Centre in particular as well as the training centre.
Year(s) Of Engagement Activity 2016
URL http://metabolomics2016.org/images/Metabolomic-Conference-detailed-programme-6-20-16.pdf
 
Description NHS England Visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Visit of Sir Bruce Keogh and Sir David Nicholson to view the work and laboratories of the National Phenome Centre


Increased the knowledge of the visitors in relation to the work and scope of the Centre. Timely as discussion took place regarding the Personal Genome Project and potential links to metabolic phenotyping to aid understanding of Sir Bruce.
Year(s) Of Engagement Activity 2013
 
Description NIHR Workshop in Metabolic Profiling 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact NIHR held a workshop day on metabolic profiling to coincide with the launch of the National Phenome Centre-produced NIHR-hosted on-line e-learning course in Metabonomics. Nearly 100 delegates from clinical practice and charity funders joined for a day of presentations from NPC staff and other presenters from Prof Nicholson's department. At the end of the day delegates had a fuller understanding of the potential of metabolic profiling and had also undertaken a hands-on exercise led by NPC staff in how to design a study to have enough samples for powering a metabonomic study. There was a significant level in the knowledge of this work and an interest on the behlaf of a number of delegates to either undertake such work in the future with the NPC or to support grant applications seen by funders if it involved NPC work.
Year(s) Of Engagement Activity 2018
URL https://www.eventbrite.co.uk/e/nihr-workshop-on-metabolic-phenotyping-tickets-41454205645
 
Description Phenome Centre Birmingham keynote address May 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Nicholson gave the keynote address at the official opening ceremony and celebration for the University of Birmingham's Phenome Centre. This cemented the relationship between the National Phenome Centre and Phenome Centre Birmingham and engaged with policymakers and potential users of the Centre's as to the importance of metabolic phenotyping. A number of joint grant initiatives have resulted from the relationship.
Year(s) Of Engagement Activity 2016
URL http://www.birmingham.ac.uk/research/activity/phenome-centre/about/opening-ceremony.aspx
 
Description RSC Presentation, September 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Royal Society of Chemistry Joint Meeting: Separation Science Group and Chemometrics Special Interest Group Using predictive chromatographic methods to improve drug design, safety and reduce attrition

Increased understanding of metabolic phenotyping potential.
Year(s) Of Engagement Activity 2013
 
Description RSM Visit (Turkey) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Jeremy Nicholson was invited to join the Royal Society of Medicine Visit to Baskent University, Ankara Turkey - 7 - 9 January 2015.
Year(s) Of Engagement Activity 2015
 
Description Seminar (University of California) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Professor Nicholson gave a seminar entitled "Systems Medicine Approaches in Personalised and Public Healthcare." At the School of Pharmacy, University of California
Year(s) Of Engagement Activity 2015
URL https://pharmacy.ucsf.edu/events/2015/10/jeremy-nicholson-seminar
 
Description Support and guidance for grant application (Murdoch University, Australia) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Professor Jeremy Nicholson worked in collaboration with Dr Andrew Currie, Senior Lecturer in Immunology and Associate Professor Rob Trengove, Scientific Director of the Separation Science and Metabolomics Laboratory at Murdoch University with their successful application for $473,000 in funding from the WA Department of Health to establish the WA Phenome Centre, Australia's first centre for advanced metabolic phenotyping in infants and children.
Year(s) Of Engagement Activity 2014,2015
URL http://media.murdoch.edu.au/major-grant-to-build-worlds-first-precision-medicine-research-centre-for...
 
Description Symposium (Phenomics and Phenome Networks) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Nicholson and his team and the MRC-NIHR National Phenome Centre organised and ran the 1st Phenomics and Phenome Networks Symposium, a one-day event at Imperial College London. Large-scale phenotyping studies have generated a tremendous amount of multi-platform 'omics data. As such there is a need to bring together like-minded individuals to facilitate deeper integration of phenomics into the wider 'omics community, and work towards developing a Phenomic Network in the UK. The one-day symposium focused on integrating phenomics. Symposium speakers will delivered presentations on their work and how it integrates with phenomics and the epidemiology and stratified medicine communities. Speakers included Prof Dame Carol Robinson (University of Oxford); Prof Tony Whetton (University of Manchester); Dr Christoph Steinbeck (European Bioinformatics Institute); Prof Mark Viant (University of Birmingham); Dr Julian Griffin (University of Cambridge); Prof Jeremy Nicholson (Imperial College London). Attended by over 100 people it was a seel-out event and attracted students, potential users of the National Phenome Centre and also members of the International Scientific Advisory Board for the National Phenome Centre, many of which flew in the the US to attend the symposium.
Year(s) Of Engagement Activity 2015
URL http://www.eventbrite.co.uk/e/phenomics-and-phenome-networks-symposium-registration-16038502593
 
Description Third meeting of the Societe de Nephrologie, UK Renal Association and Nephrology Section of the Royal Society of Medicine. Jan 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Spectroscopic methods, phenotyping and genomics. Third meeting of the Societe de Nephrologie, UK Renal Association and Nephrology Section of the Royal Society of Medicine. Jan 2014

After talk significant questions were asked by attendees resulting in an increase in their understanding
Year(s) Of Engagement Activity 2014
URL https://www.rsm.ac.uk/events/events-listing/2013-2014/sections/nephrology-section/nee02-entente-cord...
 
Description Thought Leaders Series Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact News Medical is an online, open-access medical information provider for healthcare professionals, medical researchers and engaged consumers. This interview was part of News Medical's "Thought Leaders" series which is a selection of articles written by national and international experts and trusted advisers in health and medicine. All the articles are written by experts who have been invited as recognised leaders in their fields to provide a "state of the art" contribution. As an open access website this broad interview written in a format suitable for both practitioners and the general public engaged with people from a wide background to open up metabolic phenotyping, the concept of the gut microbiombe and antimicrobial resistance to a wide audience to raise awareness.
Year(s) Of Engagement Activity 2016
URL http://www.news-medical.net/news/20160610/Tackling-healthcare-challenges-in-a-changing-world-an-inte...
 
Description Visit by Japan Agency for Medical Research and Development (AMED) June 16 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Professor Kato (Head of Japan Agency for Medical Research and Development (AMED) ) attended a visit to the National Phenome Centre. Potential for significant collaboration in the sphere of metabolic phenotyping was discussed, having raised the profile of this sector as an area of potential funding by AMED.
Year(s) Of Engagement Activity 2016
 
Description Visit of Leiden University Jan 17 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Visit by senior researchers to National Phenome Centre. Precipitated involvement in a H2020 application.
Year(s) Of Engagement Activity 2017
 
Description Wellcome Trust visit, Oct 2013 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Dr Alison Cave (Head of Cellular Developmental and Physiological Sciences, Science Funding Division, Wellcome Trust) visited the Centre to understand how the Centre works and how this fits with future applications the Wellcome Trust may see.

Improved understanding of the potential of the National Phenome Centre and how this might impact the future decision-making of the Welcome Trust in terms of grant awarding.
Year(s) Of Engagement Activity 2013
 
Description World Economic Forum Annual Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Prof Nicholson led on an Ideas Lab session entitled 'Life Enhancing Technologies within Imperial College London. Significant discussion was sparked both during and after the session.

After meeting, discussions with policymakers in international context.
Year(s) Of Engagement Activity 2014