Biomedical Catalyst – Demonstration of a low cost implantable blood pump
Lead Research Organisation:
Swansea University
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Chan CH
(2013)
The evaluation of leukocytes in response to the in vitro testing of ventricular assist devices.
in Artificial organs
Chan CH
(2014)
The effect of shear stress on the size, structure, and function of human von Willebrand factor.
in Artificial organs
Chan CHH
(2017)
Shear Stress-Induced Total Blood Trauma in Multiple Species.
in Artificial organs
Pieper IL
(2016)
Quantification methods for human and large animal leukocytes using DNA dyes by flow cytometry.
in Cytometry. Part A : the journal of the International Society for Analytical Cytology
Pieper IL
(2018)
Ovine Leukocyte Microparticles Generated by the CentriMag Ventricular Assist Device In Vitro.
in Artificial organs
Pieper IL
(2016)
Evaluation of Four Veterinary Hematology Analyzers for Bovine and Ovine Blood Counts for In Vitro Testing of Medical Devices.
in Artificial organs
Pieper IL
(2017)
Isolation of Mesenchymal Stromal Cells From Peripheral Blood of ST Elevation Myocardial Infarction Patients.
in Artificial organs
Radley G
(2018)
The effect of ventricular assist device-associated biomaterials on human blood leukocytes.
in Journal of biomedical materials research. Part B, Applied biomaterials
Radley G
(2019)
Artificial shear stress effects on leukocytes at a biomaterial interface
in Artificial Organs
| Title | Research as Art |
| Description | Public engagement activity with local primary school to create artwork entry for Research as Art at Swansea University |
| Type Of Art | Artwork |
| Year Produced | 2018 |
| Impact | Enthusiasm to engage in this type of activity again for myself and to encourage my research team to do so. |
| Description | HCRW pathway to portfolio |
| Amount | £19,540 (GBP) |
| Organisation | Health and Care Research Wales |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 10/2019 |
| Description | Impact Acceleration Account |
| Amount | £2,157 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 12/2016 |
| Description | Seed corn grants |
| Amount | £2,981 (GBP) |
| Organisation | St. David's Medical Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2015 |
| Title | Modeling shear and biomaterial exposures in humans |
| Description | In vitro model for exposing small volumes of human blood to different biomaterials and a fluid shear regime |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Invitation to join multi-national consortium developing a total artificial heart. |
| URL | https://onlinelibrary.wiley.com/doi/full/10.1111/aor.13409 |
| Description | Erasumus+ Staff Mobility |
| Organisation | Heart and Diabetes Centre North Rhine-Westphalia (HDZ NRW) |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | Dr Pieper, the post-doctoral researcher on the project has been awarded an Erasmus+ staff mobility award to travel to Professor Hendrik Milting's laboratory and undertake training as a prelude to exchange of samples and methodologies. |
| Collaborator Contribution | The partners will provide some training but also plasma samples from patients who have been implanted with ventricular assist devices, and explanted devices. |
| Impact | This collaboation is in its early stages but we are targeting Horizon 2020 submission in 2015. |
| Start Year | 2014 |
| Description | Hybrid Heart |
| Organisation | University of Amsterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Swansea University is a partner on a short-listed BHF Big Beat Challenge grant contributing to one work package related to in vitro testing with human blood. This involvement is a direct outcome of the Biomedical Catalyst award. |
| Collaborator Contribution | This multi-national consortium is led from Amsterdam University Medical Centre |
| Impact | This collaboration is in its early stages; unsuccessful application to BHF Big Beat Challenge but exploring other opportunities. |
| Start Year | 2019 |
| Description | Optimised assay development for blood health in transfusion settings |
| Organisation | Haemair Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have developed a red blood cell fragility assay for flow cytometry which is now in use by the company; we are progressing to cytokine assays of fluid phase. |
| Collaborator Contribution | The company provides the devices for testing, staff to run the assays once developed, and undertake all experimental work and data analysis |
| Impact | A grant application to SMARTExpertise, Welsh Government (SMARTBlood)is in preparation |
| Start Year | 2016 |
| Description | Scandinavian Real Heart |
| Organisation | Scandinavian Real Heart AB |
| Country | Sweden |
| Sector | Private |
| PI Contribution | Insight into mechanisms, implementation of rig tests, access to patients and their samples, laboratory analysis, publications, seeking grant funding |
| Collaborator Contribution | This is in preparation - specific testing rig and computational modelling insight. |
| Impact | Ww have submitted an outline project grant application to NC3Rs which as been invited to full application |
| Start Year | 2018 |
| Description | SoapBox Science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Participated in SoapBox Science, Swansea |
| Year(s) Of Engagement Activity | 2015 |