UoBath Confidence in Concept 2013
Lead Research Organisation:
University of Bath
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
People |
ORCID iD |
Publications
Almansour K
(2018)
An intestinal paracellular pathway biased toward positively-charged macromolecules.
in Journal of controlled release : official journal of the Controlled Release Society
Almansour K
(2018)
Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation in polarized intestinal epithelia.
in Journal of controlled release : official journal of the Controlled Release Society
Goggins S
(2015)
Ratiometric electrochemical detection of alkaline phosphatase
in Chemical Communications
Goggins S
(2017)
Ratiometric electrochemical detection of hydrogen peroxide and glucose.
in Organic & biomolecular chemistry
Goggins S
(2017)
Ratiometric electrochemical detection of Pd•••p interactions: application towards electrochemical molecular logic gates
in Supramolecular Chemistry
Goggins S
(2015)
Signal transduction and amplification through enzyme-triggered ligand release and accelerated catalysis.
in Chemical science
Laabei M
(2016)
Using functional genomics to decipher the complexity of microbial pathogenicity.
in Current genetics
Laabei M
(2015)
Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus.
in PLoS biology
Taverner A
(2015)
Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation.
in Journal of controlled release : official journal of the Controlled Release Society
| Description | Developing vaccine applications for the Sbi-conjugate technology |
| Organisation | Porton Biopharma LTD |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Developing vaccine applications for the Sbi-conjugate technology |
| Collaborator Contribution | Developing vaccine applications for the Sbi-conjugate technology |
| Impact | Developing vaccine applications for the Sbi-conjugate technology |
| Start Year | 2018 |
| Title | DRUG DELIVERY ENHANCEMENT AGENTS |
| Description | A peptide comprising a sequence for opening a tight junction of an epithelial surface and optionally a cell penetrating sequence; and related compositions, optionally comprising further pharmaceutical agents;and related methods. |
| IP Reference | WO2015189641 |
| Protection | Patent granted |
| Year Protection Granted | 2015 |
| Licensed | No |
| Impact | The research has shown that it is possible to allow the controlled delivery of proteins via the oral route |
| Title | IMMUNOGENIC COMPOSITIONS COMPRISING SBI PROTEIN AND USES THEREOF |
| Description | The invention relates to methods and compositions for use in stimulating an immune response against a target antigen. More specifically, it relates to use of domains III and IV of the Staphylococcal Sbi protein as an immunological adjuvant, for enhancing an immune response against a target antigen. |
| IP Reference | CA3044584 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | Novel vaccine adjuvant technology based on Staphylococcus aureus immunomodulator Sbi |
| Description | Article about paper in Global Medicine Discovery magazine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Global Medicine Discovery magazine contacted Prof Randy Mrsny to provide an article highlighting this technology (linked to the publication). Regarding the "significant outcome" section below, this could be " more citations of the publication" (but there wasn't an option to add this in the list of options). |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://globalmedicaldiscovery.com/key-scientific-articles/enhanced-paracellular-transport-insulin-a... |
| Description | Invited plenary talks on enhanced oral delivery of biopharmaceuticals |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited plenary talks in Shanghai and Dresden |
| Year(s) Of Engagement Activity | 2015 |