UoBath Confidence in Concept 2013

Lead Research Organisation: University of Bath
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

People

ORCID iD

Publications

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Almansour K (2018) Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation in polarized intestinal epithelia. in Journal of controlled release : official journal of the Controlled Release Society

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Almansour K (2018) An intestinal paracellular pathway biased toward positively-charged macromolecules. in Journal of controlled release : official journal of the Controlled Release Society

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Goggins S (2017) Ratiometric electrochemical detection of hydrogen peroxide and glucose. in Organic & biomolecular chemistry

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Goggins S (2015) Ratiometric electrochemical detection of alkaline phosphatase in Chemical Communications

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Taverner A (2015) Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation. in Journal of controlled release : official journal of the Controlled Release Society

 
Description Developing vaccine applications for the Sbi-conjugate technology 
Organisation Porton Biopharma LTD
Country United Kingdom 
Sector Private 
PI Contribution Developing vaccine applications for the Sbi-conjugate technology
Collaborator Contribution Developing vaccine applications for the Sbi-conjugate technology
Impact Developing vaccine applications for the Sbi-conjugate technology
Start Year 2018
 
Title DRUG DELIVERY ENHANCEMENT AGENTS 
Description A peptide comprising a sequence for opening a tight junction of an epithelial surface and optionally a cell penetrating sequence; and related compositions, optionally comprising further pharmaceutical agents;and related methods. 
IP Reference WO2015189641 
Protection Patent granted
Year Protection Granted 2015
Licensed No
Impact The research has shown that it is possible to allow the controlled delivery of proteins via the oral route
 
Title IMMUNOGENIC COMPOSITIONS COMPRISING SBI PROTEIN AND USES THEREOF 
Description The invention relates to methods and compositions for use in stimulating an immune response against a target antigen. More specifically, it relates to use of domains III and IV of the Staphylococcal Sbi protein as an immunological adjuvant, for enhancing an immune response against a target antigen. 
IP Reference CA3044584 
Protection Patent application published
Year Protection Granted 2018
Licensed No
Impact Novel vaccine adjuvant technology based on Staphylococcus aureus immunomodulator Sbi
 
Description Article about paper in Global Medicine Discovery magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Global Medicine Discovery magazine contacted Prof Randy Mrsny to provide an article highlighting this technology (linked to the publication).

Regarding the "significant outcome" section below, this could be " more citations of the publication" (but there wasn't an option to add this in the list of options).
Year(s) Of Engagement Activity 2015
URL https://globalmedicaldiscovery.com/key-scientific-articles/enhanced-paracellular-transport-insulin-a...
 
Description Invited plenary talks on enhanced oral delivery of biopharmaceuticals 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited plenary talks in Shanghai and Dresden
Year(s) Of Engagement Activity 2015