UoC Confidence in Concept 2013
Lead Research Organisation:
University of Cambridge
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
People |
ORCID iD |
| Patrick Maxwell (Principal Investigator) |
Publications
Agboh K
(2018)
Powering the ABC multidrug exporter LmrA: How nucleotides embrace the ion-motive force.
in Science advances
Brame AL
(2015)
Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist.
in Hypertension (Dallas, Tex. : 1979)
Du D
(2015)
Structure, mechanism and cooperation of bacterial multidrug transporters.
in Current opinion in structural biology
Du D
(2018)
Multidrug efflux pumps: structure, function and regulation.
in Nature reviews. Microbiology
Harford-Wright E
(2017)
Pharmacological targeting of apelin impairs glioblastoma growth.
in Brain : a journal of neurology
Harford-Wright E
(2017)
Pharmacological targeting of apelin impairs glioblastoma growth
Hellmund C
(2016)
Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1.
in Viruses
Hurd CA
(2021)
Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.
in The Journal of biological chemistry
| Description | A Developmental Trial of Personalised Medicine for Repurposing Zibotentan, a Selective Endothelin A Receptor Blocker, in Microvascular Angina |
| Amount | £2,714,383 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | A video-rate near-infrared hyperspectral endoscope for early detection of oesophageal cancer |
| Amount | € 15,000 (EUR) |
| Organisation | Interuniversity Micro-Electronics Centre |
| Sector | Academic/University |
| Country | Belgium |
| Start | 03/2015 |
| Description | A video-rate near-infrared hyperspectral endoscope for early detection of oesophageal cancer |
| Amount | € 15,000 (EUR) |
| Organisation | XIMEA GmbH |
| Sector | Private |
| Country | Germany |
| Start | 08/2015 |
| Description | AZ Studentship |
| Amount | £128,000 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 05/2019 |
| Description | An advanced cryoEM instrument for the University of Cambridge |
| Amount | £3,000,000 (GBP) |
| Funding ID | 206171/Z/17/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 01/2022 |
| Description | An electron cryo-microscopy resource for macromolecular structure determination in the University of Cambridge |
| Amount | £1,000,000 (GBP) |
| Funding ID | 202905/Z/16/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2016 |
| End | 12/2021 |
| Description | CRUK Multidisciplinary Project Award |
| Amount | £475,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 04/2019 |
| Description | Churchill Scholarship, student joined for a one year MPhil. |
| Amount | £10,000 (GBP) |
| Organisation | University of Arizona |
| Sector | Academic/University |
| Country | United States |
| Start | |
| Description | Development and application of the hyperspectral endoscope |
| Amount | £150,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Discovery of altered binding and function in mutations in human apelin receptor identified from genomic sequencing of patients with rare diseases |
| Amount | £126,330 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 09/2020 |
| Description | Exploring how the C Terminus of RaIA regulates its structure and function |
| Amount | £96,690 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2020 |
| Description | Exploring how the C Terminus of RaIA regulates its structure and function |
| Amount | £44,348 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2020 |
| Description | Foundation Blanceflor - applied for a 4th year of PhD funding based on the results obtained from this project |
| Amount | £10,000 (GBP) |
| Organisation | Foundation Blanceflor Boncompagni Ludovisi, née Bildt |
| Sector | Academic/University |
| Country | Sweden |
| Start | 05/2016 |
| Description | Framework s'ship: structural and functional studies of the machinery of bacterial riboregulation |
| Amount | £122,390 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2020 |
| Description | Functional effects of apelin receptor mutations associated with pulmonary arterial hypertension in a human embryonic stem cell derived model |
| Amount | £116,124 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2021 |
| Description | GSK Fast track challenge |
| Amount | £500,000 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | |
| Description | GSK Innovation Funding Opportunity |
| Amount | £323,037 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 12/2014 |
| End | 12/2016 |
| Description | Hyperspectral Endoscopy for Early Detection of Precancerous Lesions in Normal and Inflammatory Bowel Disease Patients: Proof of Principle |
| Amount | £19,500 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 04/2020 |
| Description | Identification of 'hit to lead' small molecule 'biased' apelin receptor agonists for treating pulmonary arterial hypertension (PAH) using HTS and molecular modelling' |
| Amount | £140,392 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 09/2016 |
| Description | Maturation and characterization of stapled peptides for Ras-RalGEF-RalA/B inhibition |
| Amount | £62,000 (GBP) |
| Organisation | Cambridge Cancer Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2016 |
| Description | Molecular imaging of redox processes in cancer |
| Amount | £116,147 (GBP) |
| Organisation | European Union |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Molecular imaging of redox processes in cancer |
| Amount | £50,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Multidisciplinary Project award |
| Amount | £483,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| Description | Pioneer Award |
| Amount | £200,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2018 |
| Description | Pioneer Award |
| Amount | £175,806 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| Description | Programme grant |
| Amount | £1,000,000 (GBP) |
| Organisation | University of Cambridge |
| Department | MRC Cancer Unit |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 08/2019 |
| Description | Re-submission hit to lead small molecule biased apelin agonist |
| Amount | £297,464 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 08/2022 |
| Description | WD Armstrong Studentship |
| Amount | £63,000 (GBP) |
| Organisation | University of Cambridge |
| Department | WD Amstrong Trust |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 10/2018 |
| Description | WT Junior Fellowship |
| Amount | £103,413 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2016 |
| Description | WT Pathfinder |
| Amount | £140,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 12/2015 |
| Description | Wellcome Trust Translation Award Concept |
| Amount | £140,392 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 09/2016 |
| Title | "NC-IUPHAR" is the International Union of Basic and Clinical Pharmacology Database; Anthony Davenport, UK - Executive Member of NC-IUPHAR - EAB Liaison with NC-IUPHAR |
| Description | "NC-IUPHAR" is the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification. The mission for NC-IUPHAR was initiated in 1987 at the Xth International Congress of Pharmacology. |
| Type Of Material | Database/Collection of data |
| Provided To Others? | Yes |
| Impact | The British Journal of Pharmacology and its publisher Wiley have been publishing articles for some time. You can see examples both in the CGTP 2013/14 series (https://www.ncbi.nlm.nih.gov/pubmed/?term=Concise%5bTitle%5d%20AND%20Guide%5bTitle%5d%20AND%20PHARMACOLOGY%5bTitle%5d&cmd=DetailsSearch) and recent NC-IUPHAR reviews (e.g. this 2014 one on epigenetic pathways) |
| URL | http://www.guidetopharmacology.org/ |
| Title | PATIENT-SPECIFIC ENDOVASCULAR DEVICES |
| Description | Methods for manufacturing a patient-specific endovascular device comprise creating a 3D model based on spatial dimensions relating to a section of a blood vessel and manufacturing the endovascular device using the 3D model to form a liner. In use the endovascular devices provide a liner which forms a seal against the inner blood vessel wall or the edge of the blood flow lumen. Corresponding patient-specific endovascular devices and methods for treating a patient by inserting an endovascular device are also provided. |
| IP Reference | WO2017187174 |
| Protection | Patent granted |
| Year Protection Granted | 2017 |
| Licensed | No |
| Impact | Not yet |
| Description | 'Infectious disease in the 21st Century' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Lever presented two public lectures in which the work was mentioned- 'Infectious disease in the 21st Century', at Addenbrookes Hospital and Peterhouse College |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cambridge News Articles |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | o "Cambridge University researchers developing tiny optical-fibre endoscope to aid doctors" o "New research programme in Cambridge could help detect cancer earlier" o "Scientists box clever, as 'Soapbox Science' roadshow comes to Cambridge" |
| Year(s) Of Engagement Activity | 2015,2016 |
| Description | Cambridge News article "Scientists box clever, as 'Soapbox Science' roadshow comes to Cambridge" |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | "Scientists box clever, as 'Soapbox Science' roadshow comes to Cambridge" |
| Year(s) Of Engagement Activity | 2016 |
| Description | Cambridge News article: "Cambridge University researchers developing tiny optical-fibre endoscope to aid doctors" |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | "Cambridge University researchers developing tiny optical-fibre endoscope to aid doctors" |
| Year(s) Of Engagement Activity | 2015 |
| Description | Cambridge News article: "New research programme in Cambridge could help detect cancer earlier" |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | "New research programme in Cambridge could help detect cancer earlier" |
| Year(s) Of Engagement Activity | 2015 |
| Description | Krishnaa Mahbubani participated as a week of outreach programmes and is currently a careers zone advisor on I'm an Engineer Get Me Out of Here, discussing the interesting facts and challenges faced in cryobiology and cryoengineering. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Krishnaa Mahbubani participated as a week of outreach programmes and is currently a careers zone advisor on I'm an Engineer Get Me Out of Here, discussing the interesting facts and challenges faced in cryobiology and cryoengineering. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Krishnaa Mahbubani: a Governor for the Society of Cryobiology |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Krishnaa Mahbubani has been nominated to stand as a Governor for the Society of Cryobiology as an outcome of research presentations and further discussions within the field. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Pint of Science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Delivered a lecture paired with optics demonstrations to illustrate novel endoscopic imaging to the public |
| Year(s) Of Engagement Activity | 2016 |
| Description | Publication of Waterhouse et al manuscript featured on BBC and Financial Times online, as well as numerous trade news outlets |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Publication of Waterhouse et al manuscript featured on BBC and Financial Times online, as well as numerous trade news outlets (2016) |
| Year(s) Of Engagement Activity | 2016 |
| Description | Soapbox Science - Stood on a soapbox in Cambridge Market Square |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | explaining the concepts of wavelength and polarization, illustrating how they might be used in diagnosis of cancer |
| Year(s) Of Engagement Activity | 2016 |
| Description | Structure-function of efflux systems and inhibitors |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The audience attended academic researchers including professors and postgraduate students. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Validation of genomic RNA packaging as a therapeutic target for HIV/AIDS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The work has also been presented by both Prof Lever and Dr Kenyon at a range of University outreach events to a total of around 350 sixth form students interested in studying science at University. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Validation of genomic RNA packaging as a therapeutic target for HIV/AIDS |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | The general work was presented to a lay audience via an article in 'the Homertonian' magazine, which is mailed in hard copy to 13,325 subscribers and publicly available online (https://issuu.com/homerton/docs/homertonian_2016_-_number_20 ). Many of the readers are current secondary school teachers. |
| Year(s) Of Engagement Activity | 2016 |