UoNewcastle Confidence in Concept 2013
Lead Research Organisation:
Newcastle University
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
People |
ORCID iD |
Publications
Akin S
(2017)
Insight into Interface Engineering at TiO 2 /Dye through Molecularly Functionalized Caf1 Biopolymer
in ACS Sustainable Chemistry & Engineering
Amer A
(2019)
The association of pregnane X receptor activation with outcomes after liver transplantation-A retrospective study.
in Clinical transplantation
Baker MR
(2018)
Amyotrophic lateral sclerosis - Time for beta testing?
in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Bartsakoulia M
(2016)
Cysteine Supplementation May be Beneficial in a Subgroup of Mitochondrial Translation Deficiencies.
in Journal of neuromuscular diseases
Boczonadi V
(2015)
Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.
in The international journal of biochemistry & cell biology
Cocchiaro P
(2016)
Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury.
in Scientific reports
De Oliveira H
(2022)
Electrodiagnostic findings in facial onset sensory motor neuronopathy (FOSMN)
in Clinical Neurophysiology
| Description | A New Way to do Motor Neurone Disease Research |
| Amount | £1,011,726 (GBP) |
| Organisation | The William Leech Charity |
| Sector | Charity/Non Profit |
| Start | |
| Description | Abbvie 1Identification of liver fibrosis patients with NAFLD at high risk for fast disease progression |
| Amount | £597,701 (GBP) |
| Organisation | AbbVie Inc |
| Sector | Private |
| Country | United States |
| Start | 07/2016 |
| End | 06/2018 |
| Description | Advanced bioactive hydrogels for cell culture and wound care |
| Amount | £31,971 (GBP) |
| Organisation | United Kingdom Research and Innovation |
| Department | Northern Accelerator |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 02/2020 |
| Description | C1-3 - Translation package for fibrosis imaging |
| Amount | £118,062 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 01/2017 |
| End | 01/2019 |
| Description | Cell viability proposal OCATA |
| Amount | £35,140 (GBP) |
| Funding ID | 796 |
| Organisation | Astellas Pharma |
| Sector | Private |
| Country | Japan |
| Start | 08/2015 |
| End | 09/2016 |
| Description | Comparison of mitochondrial bioenergetic analysis techniques for Chronic Fatigue Syndrome / Myalgic Encephalomyelitis diagnosis |
| Amount | £21,305 (GBP) |
| Organisation | ME Association |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 09/2015 |
| Description | Confidence in Concept 2018: New tools to image pulmonary embolism without exposure to ionising radiation |
| Amount | £68,878 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2020 |
| End | 02/2021 |
| Description | DPFS - LIFT Non-invasive quantitative ventilation imaging by MRI of fluorocarbon gases |
| Amount | £673,681 (GBP) |
| Funding ID | MR/N018915/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 08/2019 |
| Description | Developing the Caf1 polymer technology into a commercial proposition |
| Amount | £190,399 (GBP) |
| Funding ID | BB/T017198/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 12/2021 |
| Description | Development and validation of novel platforms to address mechanisms of liver fibrosis |
| Amount | £594,195 (GBP) |
| Organisation | AbbVie Inc |
| Sector | Private |
| Country | United States |
| Start | 11/2015 |
| End | 06/2018 |
| Description | Dosing and Efficacy of Experimental Compounds Targeting TDP-43 Aggregation, Toxicity and Trans-synaptic Propagation in a Macaque Model of Amyotrophic Lateral Sclerosis |
| Amount | £753,487 (GBP) |
| Organisation | LifeArc |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2022 |
| Description | Establishment of improved cellular models for Alzheimer's and Parkinson's disease |
| Amount | £4,290 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Exosomal Protein Deficiencies: How Abnormal RNA Metabolism Results in Childhood-Onset Neurological Diseases |
| Amount | £558,443 (GBP) |
| Funding ID | MR/N025431/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2019 |
| Description | Exploring novel molecular targets and disease mechanisms in mitochondrial protein synthesis deficiencies to develop novel treatments in mitochondrial disease |
| Amount | £1,152,904 (GBP) |
| Funding ID | 109915/Z/15/Z |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Bloomsbury Centre |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 03/2021 |
| Description | HYDRO-FDG: Feasibility study of FDG PET-CT to evaluate muscle-invasive transitional cell carcinoma (TCC) |
| Amount | £16,186 (GBP) |
| Funding ID | BH165013 |
| Organisation | Newcastle upon Tyne Hospitals NHS Foundation Trust |
| Department | Newcastle Healthcare Charity |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 12/2019 |
| Description | Identification of novel inhibitory compounds targeting the master bacterial DNA replication |
| Amount | £3,000 (GBP) |
| Funding ID | BB/N011732/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 09/2016 |
| Description | Identification of novel inhibitory compounds targeting the master bacterial DNA replication initiation protein DnaA (RA 50%) |
| Amount | £16,038 (GBP) |
| Funding ID | BB/N011732/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 09/2016 |
| Description | Investigating an Innovative Self-Care Model for Patients with Prostate Cancer |
| Amount | £47,002 (GBP) |
| Organisation | Royal College of Surgeons of England |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 07/2017 |
| Description | Investigating the physiological DNA replication initiation reaction |
| Amount | £1,535,316 (GBP) |
| Funding ID | 204985/Z/16/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 01/2022 |
| Description | Manufacture of complex protein polymers for industry and medicine |
| Amount | £1,880,176 (GBP) |
| Funding ID | BB/M018318/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 04/2020 |
| Description | Mechanisms of tau degradation after telomerase activation in neurons |
| Amount | £4,950 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Personalising therapy for adults with acute lymphoblastic leukaemia |
| Amount | £229,807 (GBP) |
| Funding ID | 21019 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 05/2021 |
| Description | PhD Studentship to work on LifeArc project |
| Amount | £65,000 (GBP) |
| Organisation | The William Leech Charity |
| Sector | Charity/Non Profit |
| Start | 04/2022 |
| Description | Preclinical screening of novel cathepsin D inhibitors in kidney cells and tissue slices |
| Amount | £25,000 (GBP) |
| Organisation | Northern Counties Kidney Research Fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 12/2017 |
| Description | Prosperity Outcomes: Development of a home test for Prostate Specific Antigen |
| Amount | £34,909 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 03/2017 |
| Description | Real-time assessment and optimisation of livers for transplant during ex-vivo perfusion |
| Amount | £56,030 (GBP) |
| Organisation | Royal College of Surgeons of England |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Studying the development of a new natural product antibiotic for the treatment of ESKAPE infections |
| Amount | £54,171 (GBP) |
| Organisation | Rosetrees Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Telomerase activity and inflammation markers in Parkinson's disease (PD) patients from the ICICLE study |
| Amount | £80,321 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Newcastle Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Title | RECOMBINANT POLYPEPTIDE |
| Description | This will develop, fibronectin-like, non-animal, fully biodegradable, highly defined scaffolds with very low manufacturing costs. |
| IP Reference | EP2858675 |
| Protection | Patent application published |
| Year Protection Granted | 2015 |
| Licensed | No |
| Impact | Significant advantages in wound healing. |
| Title | Six gene signature in liver transplantation |
| Description | Aspects of the present invention relate to the assessment of explant organ viability prior to transplantation. Particularly, although not exclusively, aspects of the present invention relate to biomarkers which can be used to inform a decision as to whether an organ is suitable for transplantation into a recipient. In certain embodiments, the organ is undergoing hypothermic perfusion following retrieval from a donor. |
| IP Reference | PCT/GB2020/052397 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2021 |
| Licensed | Commercial In Confidence |
| Impact | No notable impact to report |
| Description | International meeting in Australia by the World Federation of Neurology and the International Federation of Clinical Neurophysiology |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International meeting in September 2019 in Australia by the World Federation of Neurology and the International Federation of Clinical Neurophysiology to discussed Updating International Diagnostic Criteria for ALS. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited speaker at Indian Academy of Neurosciences |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presenting Basic/translational work on MND/ALS to the audience. Question and Answer session and informal discussion afterwards by attendees. |
| Year(s) Of Engagement Activity | 2021 |