Proximity to Discovery - University of Oxford

Lead Research Organisation: University of Oxford

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The MRC Proximity to Discovery scheme awards universities funds to help develop new collaborations, and ways of exchanging knowledge and skills.  The awards can be used to support activities that promote the value of academic-industry partnership, and enhance academic and industry researchers’ understanding of each other’s needs and capabilities.  This may be through people exchanges, creation of technology demonstrators, showcase events, commercialisation workshops and ‘entrepreneurs in residence’ schemes.  Such exchanges of knowledge and skills will boost the most fruitful collaborations between UK universities and life science companies.

Publications

10 25 50
 
Description Longevity Forum
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
URL https://www.thelongevityforum.com
 
Description Longevity Leaders: advising/influencing investment by large companies including pension funds in ageing research - round table discussant
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
URL https://www.lsxleaders.com/longevity-leaders-congress
 
Description Master Investor: Investing in the age of longevity. Gave speech to financial leaders on emerging opportunities in ageing research
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Academic collaboration with commercial company
Amount $400,000 (USD)
Organisation Amway 
Sector Private
Country United States
Start 05/2017 
End 04/2018
 
Description Anaptysbio Research Grant
Amount £700,000 (GBP)
Organisation AnaptysBio 
Sector Private
Country United States
Start 02/2017 
End 01/2019
 
Description BBSRC case award with GSK
Amount £140,000 (GBP)
Funding ID BB/P504373/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 09/2020
 
Description British Medical Association
Amount £35,000 (GBP)
Organisation British Medical Association (BMA) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2012 
End 09/2014
 
Description British Skin Foundation Grant
Amount £62,000 (GBP)
Organisation British Skin Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2014 
End 12/2015
 
Description British Skin Foundation Large Research Awards
Amount £70,000 (GBP)
Organisation British Skin Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2008 
End 09/2011
 
Description Celgene Fellowship
Amount £500,000 (GBP)
Organisation Celgene 
Sector Private
Country United States
Start 01/2016 
End 01/2020
 
Description Comprehensive Research Network
Amount £1,700,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Clinical Research Network (CRN)
Sector Academic/University
Country United Kingdom
Start 04/2007 
End 03/2017
 
Description EXPLORATORY/DEVELOPMENT GRANT
Amount $137,000 (USD)
Funding ID 1R21AI125886-01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2016 
End 08/2018
 
Description Investigator Award
Amount £1,600,000 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Senior Investigator Award
Sector Charity/Non Profit
Country United Kingdom
Start 04/2016 
End 04/2021
 
Description Janssen collaborative research grant
Amount $1,600,000 (USD)
Organisation Johnson & Johnson 
Department Janssen Pharmaceuticals
Sector Private
Country United States
Start 10/2013 
End 09/2015
 
Description Johnson and Johnson collaborative research
Amount £100,000 (GBP)
Organisation Johnson & Johnson 
Sector Private
Country United States
Start 01/2015 
End 12/2015
 
Description MRC Experimental Medicine 2
Amount £380,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2009 
End 09/2012
 
Description MRC Proximity to Discovery Award
Amount £6,900 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2015 
End 11/2016
 
Description MRC/UCB Antibody Discovery Initiative
Amount £250,000 (GBP)
Funding ID MC_EX_MR/R022550/1 
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 02/2019 
End 12/2019
 
Description NIHR Senioe Investigator
Amount £60,000 (GBP)
Organisation University of Leicester 
Department NIHR Biomedical Research Centre
Sector Hospitals
Country United Kingdom
Start 04/2018 
End 03/2022
 
Description Oxford Biomedical Research Centre
Amount £1,000,000 (GBP)
Organisation Oxford University Hospitals NHS Foundation Trust 
Department NIHR Oxford Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2007 
End 03/2017
 
Description UCB Research grant
Amount £354,000 (GBP)
Organisation UCB Pharma 
Sector Private
Country United Kingdom
Start 09/2016 
End 08/2018
 
Description Wellcome Trust Collaboratiev Award
Amount £3,000,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2018 
End 04/2023
 
Description Abide Therapeutics - Oxford Collaboration 
Organisation Abide Therapeutics
Country United States 
Sector Private 
PI Contribution Expertise in innate immunology in relation to the gut and inflammatory bowel disease. Preclinical work with human primary dendritic cells and colon tissue examining roles for the endocannabinoid system.
Collaborator Contribution Processing of samples using activity-based protein profiling and lipidomics. Expertise in the pharmacology of the endocannabinoid system.
Impact No publications yet. No patents arising. There are other Abide - Oxford collaborations but these are separate to our own collaboration.
Start Year 2014
 
Description CN-Bio collaboration 
Organisation CN Bio Innovations Ltd
Country United Kingdom 
Sector Private 
PI Contribution Analysis of innate responses in an in vitro hepatocyte model
Collaborator Contribution Expertise and experiments in in vitro model
Impact Developing tools to study innate responses in the liver
Start Year 2016
 
Description License option taken by Roche ventana 
Organisation Ventana Systems Inc
Country United States 
Sector Private 
PI Contribution License option taken by Roche ventana to develop our technology to a diagnostic test.
Collaborator Contribution Roche Ventana will validate and obtain the necessary approvals to proceed towards a diagnostic test
Impact License option
Start Year 2017
 
Description MedImmune Collaboration 
Organisation MedImmune
Department MedImmune Cambridge
Country United Kingdom 
Sector Private 
PI Contribution Scientific collaboration with MedImmune
Collaborator Contribution Analysis of samples, data to be analysed and reported in publication
Impact Data generation
Start Year 2016
 
Description UCB collaboration with Sansom & Stansfeld 
Organisation UCB Pharma
Country United Kingdom 
Sector Private 
PI Contribution Dr Zara Sands (UCB) spent time in my lab and worked alongside students & postdocs to familiarize herself with our methods for simulation of complex cell membranes
Collaborator Contribution Dr Zara Sands (UCB) spent time in my lab and worked alongside students & postdocs to familiarize herself with our methods for simulation of complex cell membranes
Impact This has resulted in UCB supporting an additional iCASE studentship in my group.
Start Year 2016
 
Title Development of a test for T celllymphoma/leukaemia 
Description We have developed a potential test for T cell lymphoma which may have future theraeutic relevance. 
IP Reference WO2016051205 
Protection Patent application published
Year Protection Granted 2014
Licensed Commercial In Confidence
Impact Academic work continues in order to validate the technology. Commercial interactions currently under negotiation.
 
Description "Cut & Paste" - genome editing (Royal Institution Family Fun day) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact "Cut & Paste" - genome editing activities at the Royal Institution Family Fun day on 22nd February 2019. It comprised three activities explaining genome editing and its utilisation as a research tool
Year(s) Of Engagement Activity 2019
 
Description "Understanding allergy - Itching, sneezing, wheezing" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Two 30 minute talks to 9/10 year students explaining the immune system and allergy. The talks were part of Wadham College Aspiration day 4th March 2019 - Academic taster session.
Year(s) Of Engagement Activity 2019
 
Description Establishment of Oxford-wide ageing hub 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The workshop brought together researchers from across the academic divisions of the university (medical sciences, maths, physical and life sciences, social sciences and humanities) to establish an Oxford ageing hub - this also included NHS representatives, public attendees and 3rd sector organisations with an interest in ageing and later life health.
Year(s) Of Engagement Activity 2019
 
Description Invited keynote at Biopharma meeting, UCL 23rd Feb 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact I gave a 1 hour invited presentation on prospects for developing new medicines for age-related diseases through understanding cellular senescence, and then sat on a discussion panel (with 2 other scientists) to take audience questions on the entire workshop.
Year(s) Of Engagement Activity 2019
 
Description Molecular Haematology Unit seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact A talk regarding the work on single-cell systems biology carried out by the company to date. This sparked a good debate between the presenter and the audience.
Year(s) Of Engagement Activity 2016,2017,2018,2019
 
Description OxAgeN - establishment of the Oxford Aging Network (L. Cox) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Established a network of scientists and clinicians with an interest in ageing (research and clinical practice) to foster closer collaboration and accelerate discoveries from bench to clinic. Representatives from commercial organisations and third sector (U3A, Age UK) are also members.
Impact: decision to hold scientific conference on ageing in Oxford.
Year(s) Of Engagement Activity 2015
URL http://www.imm.ox.ac.uk/ageing
 
Description Oxford Science Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Oxford Science Festival
Year(s) Of Engagement Activity 2016
 
Description Public Engagement (Pint of Science) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Pint of Science talks aim to deliver the most recent/exciting scientific advances to the general public in a relaxed and informal setting. It is a platform for the general public to ask questions about scientific research, to the researchers carrying out the experiments! The aim is to broaden public interest in- and access to- scientific discoveries and data. Date of event: May 17th 2017.
Year(s) Of Engagement Activity 2017
URL https://pintofscience.co.uk/events/oxford
 
Description Science Career Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact A career talk to students and post-docs involving working in the USA
Year(s) Of Engagement Activity 2016
 
Description Science club at Freeland Primary School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Visit to Freeland Primary School on 14th January 2020 to carry out a 1h session comprising three activities with primary school students to explain DNA and genome editing.
Year(s) Of Engagement Activity 2020
 
Description T cell differentation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact 1h session during Biology Summer School which took place at Wadham College on 21st August 2019. The activity looked at how naïve T cells differentiate into T cell subsets in vitro.
Year(s) Of Engagement Activity 2019
 
Description Talk, OxAgeN meeting July 2015 (L. Cox) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Scientific presentation at Oxford Ageing Network meeting; outcome = agreed several collaborations and in discussion with possible industrial funders
Year(s) Of Engagement Activity 2015
 
Description The Immune Cell Highway 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact The Immune Cell Highway was a session organised for Superdads Playgroup at Northway Church, Oxford on 8th February 2020. The activities were aimed at explaining how immune cells move around the body via two pathways - the blood & the lymphatics - and how this travelling is essential for clearing infections in the skin.
Year(s) Of Engagement Activity 2020
 
Description The Immune Cell Highway (Swindon Science Festival) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The Immune Cell Highway activity links the work being done in the Dong, Ogg and Jackson labs in the WIMM. They have created a stand explaining how immune cells move around the body via two pathways: the blood & the lymphatics. This activity was part of Swindon Science Festival on 21st and 22nd February 2020.
Year(s) Of Engagement Activity 2020
 
Description Understanding allergy - Itching, sneezing, wheezing 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Two 30 minute sessions doing an "allergy testing" experiment with 9/10 year students. These sessions were part of Wadham College Aspiration Day - Academic taster session on 10th May 2019.
Year(s) Of Engagement Activity 2019