Zika: susceptibility of South American and European vectors to ZIKV infection, and influence of temperature

Lead Research Organisation: University of Liverpool

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

Zika virus (ZIKV) is transmitted by Aedes mosquitoes, primarily Ae. aegypti, a significant
virus vector in tropical regions worldwide. The highly invasive species, Ae. albopictus, can be
infected with ZIKV and may be an important vector too, especially as it occurs in temperate
regions, including mainland Europe, and threatens the UK. Mosquito species native to UK and
Europe, such as the human biting Aedes detritus and Ae. vexans, can support other
flaviviruses and may present an as yet unknown risk from ZIKV.
UoL/LSTM hold the UK’s first infection system for high-containment viruses in live
mosquitoes. Our main goal is to establish the first such system for ZIKV, and use it to answer
key questions regarding the vector competences of Ae aegypti and Ae albopictus, the
environmental temperature threshold required for transmission, and the risk presented by
indigenous UK or European Aedes mosquitoes, including Ae. detritus and Ae vexans. Such
data are essential to determine the risk of transmission of ZIKV in temperate zones of
western Europe and elsewhere.
The project has four complementary objectives:
1. Establish the UK’s first Zika virus – mosquito infection system
2. Compare vector competence of field-derived Ae. aegypti and Ae. albopictus.
3. Quantify the effect of temperature on the extrinsic incubation period of ZIKV in Ae. aegypti
and Ae. albopictus and determine temperature thresholds for transmission.
4. Assess the vector competence of UK and European mosquitoes for ZIKV.

Publications

10 25 50
 
Description Citation by French Ministry of Defence
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://www.defense.gouv.fr/content/download/495075/8442152/file/OBS_Climat%20et%20defense_201701-n1....
 
Description Citation by Human rights watch report on Zika in northeastern Brazil
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://www.hrw.org/sites/default/files/report_pdf/wrdzika0717_web_0.pdf
 
Description Citation by UN Adaptation Gap report 2018
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://www.unenvironment.org/resources/adaptation-gap-report
 
Description Citation by US National Academy of Sciences
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://www.nap.edu/catalog/24846/protecting-the-health-and-well-being-of-communities-in-a-changing-...
 
Description Citation by USAID - Climate Risk Profile Brazil
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://www.climatelinks.org/sites/default/files/asset/document/2018-April-30_USAID_CadmusCISF_Clima...
 
Description Citation by the Centre for Climate and Security
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://climateandsecurity.files.wordpress.com/2017/06/epicenters-of-climate-and-security_the-new-ge...
 
Description Zika: Predicted establishment of Aedes sp. in the UK
Geographic Reach Europe 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description A conflict of interests: How do viruses manipulate their mosquito-vector to increase their own transmission?
Amount £181,248 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2022 
End 09/2026
 
Description Do arboviruses manipulate their mosquito vectors' behaviour to increase transmission?
Amount £182,600 (GBP)
Organisation Majlis Amanah Rakyat (MARA) 
Sector Public
Country Malaysia
Start 11/2020 
End 10/2024
 
Description GCRF MRC Foundation Awards
Amount £400,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2017 
End 03/2019
 
Description Health Protection Research Unit (2) in Emerging Infections and Zoonoses
Amount £4,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2020 
End 03/2025
 
Description Usutu virus risk to the UK: Determining local vector competence and modelling climate suitability
Amount £468,971 (GBP)
Funding ID BB/W002906/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2022 
End 12/2024
 
Description VecPrime: immune priming to vaccinate vectors
Amount £97,302 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2018 
End 12/2019
 
Description Vector in the machine: How accurately can mosquito transmission of viruses be predicted by machine learning?
Amount £181,248 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2022 
End 09/2026
 
Description Collaboration with FIOCRUZ, Brazil 
Organisation Oswaldo Cruz Foundation (Fiocruz)
Country Brazil 
Sector Public 
PI Contribution none
Collaborator Contribution Partners in FIOCRUZ (Recife) have supplied Aedes aegypti mosquitoes for our experiments on Zika
Impact none yet
Start Year 2016
 
Description Hamburg University of Applied Sciences (HAW) 
Organisation Hamburg University of Applied Sciences
Country Germany 
Sector Academic/University 
PI Contribution Cyril Caminade (U. Liverpool) was contacted by Walter Leal (Hamburg University of Applied Sciences) who has a funded German project on Zika in the Fiji. Two members of Leal team (J. Boenecke and K. West) visited C. Caminade and M. Baylis in Liverpool on the 25-26 Oct 2017 to discuss their project, present preliminary results and discuss potential collaborations. C. Caminade was invited in Hamburg on the 4-5 Dec 2018 to meet all project partners (University of Fiji and HAW) and present his work on Zika (Caminade et al., PNAS 2017). HAW and Fiji partners are actually collecting zika samples in about 2000 patients and weather station data for the Fiji. Caminade agreed to run his R0 risk model based on weather station data for the Fiji (work in progress).
Collaborator Contribution HAW partners paid for their expenses when they came in Liverpool and they paid for Cyril Caminade expenses (contracted guest lecturer) when he visited all partners in Hamburg.
Impact none
Start Year 2017
 
Description Manipulating mosquito immune memory and fertility 
Organisation University of Liverpool
Department Institute of Integrative Biology
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributing mosquito experiments to larger projects on immune memory and fertility across a range of insect species important to health and agriculture (pollinators and pests), specifically: mosquitoes, bees, and drosophila
Collaborator Contribution Collaborators provide expertise in agricultural insects
Impact VecPrime grant (~£100k) Ongoing grant applications, including to the upcoming 'Bezos Earth Fund'
Start Year 2018
 
Description BBC World Service - Zika 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Live interview by Baylis on BBC World Service regarding the Zika - El Nino paper in PNAS
Year(s) Of Engagement Activity 2016
 
Description Big Bang Northwest 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact "Bug" stall at Big Bang North West event for regional schools
Year(s) Of Engagement Activity 2016
 
Description Climate change impacts on health presentation to Civil Service Environment Network 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Short presentation to the CSEN on the origins of pandemics, and how climate change is a driver of their emergence. The key message was that climate change is an important driver, but there are others and it cannot be considered in isolation
Year(s) Of Engagement Activity 2022
URL https://www.civilserviceenvironmentnetwork.org/
 
Description Comment for Nature Middle East News - "A 'perfect storm' for the future spread of the Zika virus" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Comment by Caminade on a recent study showing the potential impact of future El Nino on the risk of Zika in South America
Year(s) Of Engagement Activity 2018
URL https://www.natureasia.com/en/nmiddleeast/article/10.1038/nmiddleeast.2019.14
 
Description Interest from the mainstream press on our work on El Nino and the Zika outbreak in Latin America 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Caminade et al. 2017 PNAS made the headlines in the mainstream press (Washington Post - Scientific American - Yahoo news). The paper is in the top 5% of all research outputs scored by Altmetric. A summary of press releases, blogs and social media interest is available on Altmetric (see URL).
Year(s) Of Engagement Activity 2017
URL https://pnas.altmetric.com/details/14860002
 
Description Interview by Greenpeace (Unearthed group) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact C. Caminade was interviewed by a member of Greenpeace International, following the release of a report by Human rights watch about Zika in northeastern Brazil .
Year(s) Of Engagement Activity 2017
URL https://unearthed.greenpeace.org/2017/07/13/brazil-zika-virus-climate-change-human-rights-watch/
 
Description Interview for AFP "How climate change could expose new epidemics" by Amélie Bottollier-Depois 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview for AFP (Amélie Bottollier-Depois) leading to press article that was disseminated at global scale by other sources
Year(s) Of Engagement Activity 2020
URL https://phys.org/news/2020-08-climate-expose-epidemics.html
 
Description Interview for France Info "Le billet vert. Le moustique tigre de plus en plus contagieux à cause du réchauffement climatique" by Etienne Monin. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview for France info
Year(s) Of Engagement Activity 2020
URL https://www.francetvinfo.fr/replay-radio/le-billet-vert/le-billet-vert-le-moustique-tigre-de-plus-en...
 
Description Interviews and articles for New Scientist and The Independent 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interviews with reporters from New Scientist and The Independent, articles were written in both and further media sources wrote articles based on these.
Year(s) Of Engagement Activity 2020
URL https://www.newscientist.com/article/2248273-climate-change-may-push-zika-virus-into-southern-and-ea...
 
Description Invited keynote presentation - "Maladies infectieuses vectorielles et changement climatique", French Academy of Medicine, Paris, France 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Caminade was invited to give a prestigious keynote presentation (Maladies infectieuses vectorielles et changement climatique) by a working group commissioned by the French academy of Medicine (Commission XIV), lead B. Swynghedauw. Contribution to a report titled "Impacts of climate change on human and animal health", involving world leading French scientists in several fields, biodiversity, air pollution, vector-borne diseases, heat mortality... (7 May 2019).

Associated website:
https://www.academie-medecine.fr/consequences-du-changement-climatique-sur-la-sante-humaine-et-animale-2/?lang=en

Associated publication:
https://doi.org/10.1016/j.banm.2021.01.009
Year(s) Of Engagement Activity 2019
 
Description Invited keynote presentation - British Association for Veterinary Parasitology, University of Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Caminade was invited to give a keynote presentation (Impact of climate change on vector-borne diseases, past, recent and future trends) for BAVP, winter meeting 2018, in Cambridge, UK (10-11 Dec 2018).
Year(s) Of Engagement Activity 2018
URL http://bavp.org.uk/meeting-news/bavp-winter-meeting-cambridge-10-11th-december-2018/
 
Description Invited keynote presentation - EUPHA pre-conference "Public health: how to deal with climate change?", Parc Chanot, Marseille, France 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Caminade was invited to give a keynote presentation (Vector-borne diseases and climate change) by GREC-SUD at the pre EUPHA conference "Public health: how to deal with climate change?" in Marseille, France (20 Nov 2019). Interview by journalists and public health experts - associated press release (in French) at https://jne-asso.org/blogjne/2019/12/21/climat-et-sante-des-changements-impossibles-a-ignorer/
Year(s) Of Engagement Activity 2019
URL https://eupha.org/repository/conference/2019/Preconferences/Progr_pre-conf_EN_13112019.pdf
 
Description Invited presentation "Climate Change and Vector-Borne Diseases". Symposium 9, "Beyond Temperature: Assessing the Global Burden of Disease From Climate Change", ISEE 2020 virtual conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to present at ISEE2020, Symposium 9 "Beyond Temperature: Assessing the Global Burden of Disease From Climate Change" (lead Susan Anenberg, Washington university) with Sari Kovatz (LSHTM)
Year(s) Of Engagement Activity 2020
URL https://isee2020virtual.org/scientific-program/#1596023318685-bae4e530-0d8d
 
Description Invited presentation "Modelling the impact of climate change on human health, lessons learnt, open questions and perspectives" for Virtual International workshop "Advancing Research for Regional Climate Information" 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Workshop connected to IPCC WGI and WGII
Year(s) Of Engagement Activity 2020
URL https://homepage.uni-graz.at/en/douglas.maraun/regional-climate-information/
 
Description Invited presentation "The impact of climate change on pests", for UK APSE 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker for APSE conference, with prestigious speakers like Dr Andrew Kemp and MP Sharon Hodgson

Associated youtube presentation video
https://www.youtube.com/watch?v=2qidnapH1aw&feature=emb_logo
Year(s) Of Engagement Activity 2021
URL https://www.apse.org.uk/apse/index.cfm/events/previous-seminars/2021/apse-facilities-catering-and-cl...
 
Description Invited speaker, "The impact of climate change on pests", by CIEH, Pest Control Conference: Safeguarding Public Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker for a short conference about pests in the UK for UK pest control officers
Year(s) Of Engagement Activity 2020
URL https://bpca.org.uk/CPD-Articles/cieh-conference-discount-for-bpca-members/245295
 
Description Opinion piece for Infectious Disease Hub - "Climate change and pestilence: vector-borne diseases in a changing world" 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Caminade was invited to write an opinion article for Infectious Diseases Hub
Year(s) Of Engagement Activity 2019
URL https://www.id-hub.com/2019/09/10/climate-change-pestilence-vector-borne-diseases-changing-world/?fb...
 
Description Outreach event - The Emergence of an Environmental Citizenship - "Night of Ideas" at the Alliance Française in Manchester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Caminade was invited to give a public/outreach presentation (climate change and health) at the Alliance francaise in Manchester for the night of Ideas event organised by the French Institute (31 Jan 2019)
Year(s) Of Engagement Activity 2019
URL http://nightofideas.co.uk/uk-wide/
 
Description Panellist, BBSRC webinar for COP26. Climate change bites; & associated blog post 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact As part of its contribution to COP26, BBSRC organised an online panel event, chaired by BBC's Victoria Gill. I was an invited panellist, taking part in the Q&A. There was also a blogged Q&A
Year(s) Of Engagement Activity 2022
URL https://medium.com/@UKRI/biting-bugs-are-set-to-benefit-from-climate-change-heres-why-that-s-a-probl...
 
Description Public engagement talk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk on ZIka virus to members of the pubic in an informal (pub) setting.
Year(s) Of Engagement Activity 2017
 
Description Radio Interview for RFI (Radio France International) 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Phone interview with a journalist working for RFI in Brazil. Questions related to the yellow fever epidemic in Brazil in 2017-18 and climatic conditions.
Year(s) Of Engagement Activity 2018
URL http://m.br.rfi.fr/brasil/20180201-desequilibrios-ecologicos-podem-levar-febre-amarela-de-volta-cida...
 
Description Radio Interview for Yale Climate Connections 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact C. Caminade was interviewed by a journalist from Yale Climate Connections. The interview was broadcast to over 200 radios in the US and available online on the Yale Climate connections website.
Year(s) Of Engagement Activity 2017
URL https://www.yaleclimateconnections.org/2017/06/zikas-link-to-climate-change/
 
Description School visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Evening presentation to the school children, and parents, on Zika
Year(s) Of Engagement Activity 2016
 
Description TV Interview for NTN24 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact C. Caminade was interviewed by NTN24 to discuss the link between El Nino, climate and the Zika outbreak in Latin America.
Year(s) Of Engagement Activity 2017
URL http://www.ntn24.com/video/zika-129198
 
Description Talk on emerging equid diseases at Newmarket 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Presentation on emerging vector-borne diseases of horses to an audience at Newmarket. Done as part of an HBLB-funded workshop. Audience mainly concerned about risks to racehorses.
Year(s) Of Engagement Activity 2019
 
Description Talk to civil service environment network 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Talk to civil service environment network, titled "exploring the relationship between climate change and pandemics", By Matthew Baylis and Marcus Blagrove. Will be avaliable online
Year(s) Of Engagement Activity 2022
URL https://www.civilserviceenvironmentnetwork.org/
 
Description Talk/Workshop to local school children as part of 'National Science Week' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Workshop including mosquito talks and microscopy. Also a DNA extraction exercise
Year(s) Of Engagement Activity 2017
 
Description Webinar "AJE, 3 7 20 Zoonoses peut-on prévenir les prochaines pandémies ?", FR 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Caminade gave a live webinar "Climate Change and Infectious Diseases" organised by AEJ (press conference event for journalists working on environmental issues)
Related video on youtube: https://www.youtube.com/watch?v=FYdEpac0kYA
This intervention led to a mainstream press article by AFP - https://phys.org/news/2020-08-climate-expose-epidemics.html
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?v=FYdEpac0kYA
 
Description Webinar "Climate Change and Infectious Diseases" organised by "Collaborative on Health and the Environment (CHE)", USA 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Caminade gave a live webinar "Climate Change and Infectious Diseases" organised by CEH - with interactive questions from the public (USA participants mostly).
Related video on youtube: https://youtu.be/Ij_tNphdRTs
Year(s) Of Engagement Activity 2019
URL https://www.healthandenvironment.org/webinars/96503?fbclid=IwAR3PkddpzJZ0E2q2ZkV_fG3B6laG81q564leSKE...