Imperial Confidence in Concept: ICiC5

Lead Research Organisation: Imperial College London

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

10 25 50
 
Description Schneider - ICiC 5 - Novel inhibitors
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
URL http://www.rcuk.ac.uk/media/news/150323/
 
Description Confidence in Concept
Amount £944,000 (GBP)
Funding ID MC_PC_17162 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2018 
End 02/2020
 
Description Foundation Fellow
Amount £1,055 (GBP)
Organisation UK Dementia Research Institute 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 09/2022
 
Description Pathfinder Award
Amount £126,000 (GBP)
Funding ID 204592/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Schneider - ICiC 5 - Novel inhibitors
Amount £4,500,000 (GBP)
Funding ID 205256/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2017 
End 11/2019
 
Description Schneider - ICiC 5 - Novel inhibitors
Amount £2,700,000 (GBP)
Funding ID 10638/Z/14/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2015 
End 05/2017
 
Description Bhide - ICiC 5 - BSUH NHS T 
Organisation Oncology; Brighton and Sussex University Hospitals NHS Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution We have set-up the pilot study investigating the role of circulating HPV DNA in anal cancer. We have helped the collaborating centres set the study up at their institutions. All the samples collected for the study are analysed by the team at ICR/RMH.
Collaborator Contribution The partners have recruited patients to this study and have also collected and provided samples for analysis.
Impact N/A
Start Year 2017
 
Description Bhide - ICiC 5 - ICH NHS T 
Organisation Imperial College Healthcare NHS Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution We have set-up the pilot study investigating the role of circulating HPV DNA in anal cancer. We have helped the collaborating centres set the study up at their institutions. All the samples collected for the study are analysed by the team at ICR/RMH.
Collaborator Contribution The partners have recruited patients to this study and have also collected and provided samples for analysis.
Impact N/A
Start Year 2017
 
Description Bhide - ICiC 5 - WTB DoCO 
Organisation Wales Cancer Bank
Country Unknown 
Sector Academic/University 
PI Contribution We have set-up the pilot study investigating the role of circulating HPV DNA in anal cancer. We have helped the collaborating centres set the study up at their institutions. All the samples collected for the study are analysed by the team at Institute of Cancer Research/Royal Marsden Hospital (ICR/RMH).
Collaborator Contribution The partners have recruited patients to this study and have also collected and provided samples for analysis.
Impact N/A
Start Year 2017
 
Description Drakakis - ICiC 5 - Design and Realisation of an Autonomic Stimulator - DT 
Organisation Derriford Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Our objective has been to develop a new, RoHS-compliant, customised, electronically-controlled and easily deployable stimulator prototype in order to detect reliably and fast which areas of the heart need ablation and thus develop, facilitate and validate an automated approach for GP localisation. The new stimulator has much superior control of the stimulation current and will help reduce GP ablation procedure time significantly. Such progress will allow for the broader investigation of the GP-based AF treatment by means of a multi-centre study we intend to lead.
Collaborator Contribution The Tau-20 prototype stimulator was tested in dry and wet-lab environment. A risk assessment regarding the use of the new device with the existing hospital setup has been drafted with the help of Dr Linton (Imperial) and Dr Kim (Royal Brompton). Such a step is crucial for further characterisation and documentation of the new device (ultimately aiming at contributing to the formation of the technical file needed for CE marking).
Impact None yet
Start Year 2017
 
Description Drakakis - ICiC 5 - Design and Realisation of an Autonomic Stimulator - Dr MYK 
Organisation Royal Brompton Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Our objective has been to develop a new, RoHS-compliant, customised, electronically-controlled and easily deployable stimulator prototype in order to detect reliably and fast which areas of the heart need ablation and thus develop, facilitate and validate an automated approach for GP localisation. The new stimulator has much superior control of the stimulation current and will help reduce GP ablation procedure time significantly. Such progress will allow for the broader investigation of the GP-based AF treatment by means of a multi-centre study we intend to lead.
Collaborator Contribution The Tau-20 prototype stimulator was tested in dry and wet-lab environment. A risk assessment regarding the use of the new device with the existing hospital setup has been drafted with the help of Dr Linton (Imperial) and Dr Kim (Royal Brompton). Such a step is crucial for further characterisation and documentation of the new device (ultimately aiming at contributing to the formation of the technical file needed for CE marking).
Impact NONE YET
Start Year 2017
 
Description Drakakis - ICiC 5 - Design and Realisation of an Autonomic Stimulator - Dr NWFL 
Organisation Imperial College Healthcare NHS Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution Our objective has been to develop a new, RoHS-compliant, customised, electronically-controlled and easily deployable stimulator prototype in order to detect reliably and fast which areas of the heart need ablation and thus develop, facilitate and validate an automated approach for GP localisation. The new stimulator has much superior control of the stimulation current and will help reduce GP ablation procedure time significantly. Such progress will allow for the broader investigation of the GP-based AF treatment by means of a multi-centre study we intend to lead.
Collaborator Contribution The Tau-20 prototype stimulator was tested in dry and wet-lab environment. A risk assessment regarding the use of the new device with the existing hospital setup has been drafted with the help of Dr Linton (Imperial) and Dr Kim (Royal Brompton). Such a step is crucial for further characterisation and documentation of the new device (ultimately aiming at contributing to the formation of the technical file needed for CE marking).
Impact None yet
Start Year 2017
 
Description Drakakis - ICiC 5 - Design and Realisation of an Autonomic Stimulator - MHT 
Organisation Leeds General Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution Our objective has been to develop a new, RoHS-compliant, customised, electronically-controlled and easily deployable stimulator prototype in order to detect reliably and fast which areas of the heart need ablation and thus develop, facilitate and validate an automated approach for GP localisation. The new stimulator has much superior control of the stimulation current and will help reduce GP ablation procedure time significantly. Such progress will allow for the broader investigation of the GP-based AF treatment by means of a multi-centre study we intend to lead.
Collaborator Contribution The Tau-20 prototype stimulator was tested in dry and wet-lab environment. A risk assessment regarding the use of the new device with the existing hospital setup has been drafted with the help of Dr Linton and Dr Kim (Imperial). Such a step is crucial for further characterisation and documentation of the new device (ultimately aiming at contributing to the formation of the technical file needed for CE marking).
Impact None yet
Start Year 2017
 
Description Drakakis - ICiC 5 - Design and Realisation of an Autonomic Stimulator - Prof PK 
Organisation Imperial College Healthcare NHS Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution Our objective has been to develop a new, RoHS-compliant, customised, electronically-controlled and easily deployable stimulator prototype in order to detect reliably and fast which areas of the heart need ablation and thus develop, facilitate and validate an automated approach for GP localisation. The new stimulator has much superior control of the stimulation current and will help reduce GP ablation procedure time significantly. Such progress will allow for the broader investigation of the GP-based AF treatment by means of a multi-centre study we intend to lead.
Collaborator Contribution The Tau-20 prototype stimulator was tested in dry and wet-lab environment. A risk assessment regarding the use of the new device with the existing hospital setup has been drafted with the help of Dr Linton (Imperial) and Dr Kim (Royal Brompton). Such a step is crucial for further characterisation and documentation of the new device (ultimately aiming at contributing to the formation of the technical file needed for CE marking).
Impact None yet
Start Year 2017
 
Description Drakakis - ICiC 5 - Design and Realisation of an Autonomic Stimulator - RH 
Organisation St Bartholomew's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Our objective has been to develop a new, RoHS-compliant, customised, electronically-controlled and easily deployable stimulator prototype in order to detect reliably and fast which areas of the heart need ablation and thus develop, facilitate and validate an automated approach for GP localisation. The new stimulator has much superior control of the stimulation current and will help reduce GP ablation procedure time significantly. Such progress will allow for the broader investigation of the GP-based AF treatment by means of a multi-centre study we intend to lead.
Collaborator Contribution The Tau-20 prototype stimulator was tested in dry and wet-lab environment. A risk assessment regarding the use of the new device with the existing hospital setup has been drafted with the help of Dr Linton (Imperial) and Dr Kim (Royal Brompton)). Such a step is crucial for further characterisation and documentation of the new device (ultimately aiming at contributing to the formation of the technical file needed for CE marking).
Impact None yet
Start Year 2017
 
Description Georgiou - ICiC 5 - Next generation diagnostics - Prof AH 
Organisation Imperial College London
Department Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution We are developing the molecular methods targeting the different pathogens of interest and transferring them to our microchips.
Collaborator Contribution Clinical advice and samples.
Impact • All collaborations are multidisciplinary. • As a results of this collaboration we got two BBSRC PhD scholarships (4 years) and one MSc student working with us.
Start Year 2012
 
Description Georgiou - ICiC 5 - Next generation diagnostics - Prof JB 
Organisation Imperial College London
Department Department of Life Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution We are developing the molecular methods targeting the different pathogens of interest and transferring them to our microchips.
Collaborator Contribution Clinical advice and samples.
Impact • All collaborations are multidisciplinary. • As a results of this collaboration we got two BBSRC PhD scholarships (4 years) and one MSc student working with us.
Start Year 2016
 
Description Georgiou - ICiC 5 - Next generation diagnostics - Prof MF 
Organisation Imperial College London
Department School of Public Health
Country United Kingdom 
Sector Academic/University 
PI Contribution We are developing the molecular methods targeting the different pathogens of interest and transferring them to our microchips
Collaborator Contribution Clinical advice and samples.
Impact • All collaborations are multidisciplinary. • As a results of this collaboration we got two BBSRC PhD scholarships (4 years) and one MSc student working with us.
Start Year 2017
 
Description Georgiou - ICiC 5 - Next generation diagnostics - Prof ML 
Organisation Imperial College London
Department Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution We are developing the molecular methods targeting the different pathogens of interest and transferring them to our microchips.
Collaborator Contribution Clinical advice and samples
Impact • All collaborations are multidisciplinary. • As a results of this collaboration we got two BBSRC PhD scholarships (4 years) and one MSc student working with us.
Start Year 2014
 
Description Georgiou - ICiC 5 - Next generation diagnostics - Prof PL 
Organisation Imperial College London
Department Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution We are developing the molecular methods targeting the different pathogens of interest and transferring them to our microchips.
Collaborator Contribution Clinical advice and samples.
Impact • All collaborations are multidisciplinary. • As a results of this collaboration we got two BBSRC PhD scholarships (4 years) and one MSc student working with us.
Start Year 2016
 
Description Grossman - ICiC 5 - Non-invasive, low-cost electrical stimulation - Harvard 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution Our team developed the Temporal Interfering (TI) stimulation for Proof of Concept Testing
Collaborator Contribution Harvard: Pay for a post-doc scientist to conduct proof-of-concept testing in humans of the TI stimulation that I developed.
Impact Prof Alvaro Pascual-Leone (Harvard), clinical neuroscience
Start Year 2012
 
Description Grossman - ICiC 5 - Non-invasive, low-cost electrical stimulation - MIT 
Organisation Massachusetts Institute of Technology
Country United States 
Sector Academic/University 
PI Contribution Grossman collaborate's with Prof Ed Boyden (MIT) Grossman sent a PhD student to Prof Ed Boyden (MIT) and co-fund a postdoc at Boyden's lab who carry key experiments in animals for him.
Collaborator Contribution Prof Ed Boyden (MIT) raised funding, via donation, to support the joint development work of the technology and the dissemination of the technology to labs around the world. Prof Boyden hosts a PhD from my lab (for 2 terms) and recruited a postdoc scientists to carry key experiments for us.
Impact Publication (https://www.ncbi.nlm.nih.gov/pubmed/28575667); Funding (donation to MIT, NIH grant under review); IP; Dr Nir Grossman, biophysics; Prof Ed Boyden (MIT), preclinical electrophys and neurotech
Start Year 2012
 
Description Guerra - ICiC 5 - Collaboration with AstraZeneca 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution My research team perform experiments and generate data
Collaborator Contribution Intellectual contribution via discussion
Impact Seminar I gave to medimmune
Start Year 2017
 
Description Maitland - ICiC 5 - Development of a therapeutic 
Organisation Campden BRI
Country United Kingdom 
Sector Private 
PI Contribution We are formally developing a prototype legume-based nutritional feeding product with a future potential to be used commercially.
Collaborator Contribution Campden BRI are contracted as a collaborative partner to develop the feed. Campden BRI offers a research led development of food programme which ensures safety of the final product.
Impact None
Start Year 2017
 
Description Schneider - ICiC 5 - Novel inhibitors of Nemo-like kinase (NLK 
Organisation Domainex
Country United Kingdom 
Sector Private 
PI Contribution Target validation by RNA interference in human pluripotent stem cell-derived cardiomyocytes, assay development, mouse microsurgery and physiology, phosphoproteomics, 3D engineered heart tissue
Collaborator Contribution Medicinal chemistry, structural biology, computer-aided drug design
Impact UK composition of matter patent application, submitted October 2017. Cell Stem Cell manuscript, in revision.
Start Year 2013
 
Description Tate - ICiC 5 - Disarming the Hedgehog - Dundee 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution I/Imperial have led the collaboration, initiated the proposal to undertake and HTS, and bring most of the technologies required (assay, reagents).
Collaborator Contribution Provided the screening platform and access to 80,000 compounds for screening
Impact N/A
Start Year 2018
 
Description Tate - ICiC 5 - Disarming the Hedgehog - ICR 
Organisation Institute of Cancer Research UK
Country United Kingdom 
Sector Academic/University 
PI Contribution I/Imperial have led the collaboration, initiated the proposal to undertake and HTS, and bring most of the technologies required (assay, reagents)
Collaborator Contribution Involved in screening co-culture and spheroid models of PDAC and other cancers of severe unmet need.
Impact N/A
Start Year 2017
 
Description Tate - ICiC 5 - Disarming the Hedghog - Oxford 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution I/Imperial have led the collaboration, initiated the proposal to undertake and HTS, and bring most of the technologies required (assay, reagents).
Collaborator Contribution Oxford University provided the protein for the assay
Impact N/A
Start Year 2016
 
Description Vaidyanathan - ICiC 5 - HCI 
Organisation HCI International Medical Centre
PI Contribution Our team will be traveling to HCI (in Glasgow)
Collaborator Contribution In addition to equipment and funds, HCI have lent their expertise in their domain of assistive technology.
Impact None yet
Start Year 2017
 
Description Vaidyanathan - ICiC 5 - Ossur 
Organisation Ossur
Country Iceland 
Sector Private 
PI Contribution Our team will be traveling to Ossur (in Iceland) to test our robotic system
Collaborator Contribution In addition to equipment and funds, Ossur have lent their expertise in the domain of assistive technology.
Impact None yet
Start Year 2017
 
Description Wigneshweraraj - ICiC 5 - Prof Jaramillo - University of Warwick 
Organisation University of Warwick
Country United Kingdom 
Sector Academic/University 
PI Contribution The phage-derived toxic payloads and their bacterial target are well characterised by Prof Wigneshweraraj and his team at Imperial
Collaborator Contribution Prof Jaramillo is providing expert advice on the biology of the P2 phage used for making synthetic viruses. Prof Wigneshweraraj provides expert advice on bacteriology, antibacterials and phage biology.
Impact N/A - Too early
Start Year 2017
 
Description Hanna - ICiC 5 - Imperial Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Participation in the Imperial Festival
Year(s) Of Engagement Activity 2017
 
Description Miguel Aliaga, ICiC 5 - The use of innovative spectroscopy technologies (i-Knife and DESI) - George Freeman 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact Hosted Minister for Life Sciences George Freeman during his visit to LMS. In the lab, we showed him how flies can be used to study obesity and cancer and discussed the importance of model organisms for biomedical research.
Year(s) Of Engagement Activity 2016
 
Description Miguel-Aliaga - ICiC 5 - GF 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact Hosted Minister for Life Sciences George Freeman during his visit to LMS. In the lab, we showed him how flies can be used to study obesity and cancer and discussed the importance of model organisms for biomedical research.
Year(s) Of Engagement Activity 2016
URL https://lms.mrc.ac.uk/ministerial-visit-gets-hearts-racing/
 
Description Miguel-Aliaga, ICiC 5 - The use of innovative spectroscopy technologies (i-Knife and DESI) - BBC Radio 4 interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact I contributed to BBC Radio 4's "Inside Science" series
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b0713p30
 
Description Miguel-Aliaga, ICiC 5 - The use of innovative spectroscopy technologies (i-Knife and DESI) - Brainy Tongue 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact 1. Neurogastronomy workshop with world-renowned chefs and neurobiologists. This has resulted in a network of collaborators, with whom I will continue to develop initiatives e.g. a follow up event based on our current dialogue with Heston Blumenthal and his team on the links between the intestine and emotion.
Year(s) Of Engagement Activity 2014,2016
URL http://www.bbc.co.uk/news/business-37800097
 
Description Miguel-Aliaga, ICiC 5 - The use of innovative spectroscopy technologies (i-Knife and DESI) - IF: Food of Tomorrow 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact My lab had a stand at the Imperial Fringe. This event was about the future of food and how we will feed the next generation. We will continue to participate in similar events.
Year(s) Of Engagement Activity 2006,2016
 
Description Miguel-Aliaga, ICiC 5 - The use of innovative spectroscopy technologies (i-Knife and DESI) - Social Media (Twitter) 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact I regularly liaise with our Institute's press office and use social media (>780 followers)
Year(s) Of Engagement Activity 2016,2017,2018
URL https://twitter.com/flygutlab?lang=en
 
Description Vaidyanathan - ICiC 5 - Interview for National Film 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Royal Academy of Engineering has made a film "This is Engineering" to promote interest in children to consider engineering as a career. The film featured 5 engineers in the country selected whose work would be highlighted. Mr Chris Caulcrick, a student working on the project "Mechanomyography control of lower limb prosthetics" was selected as one of the featured engineers. A range of film clips of him working are shown on the RAEng site along with interviews discussing the project.
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=DlwHeT-Cutk&feature=youtu.be