University of Southampton – Confidence in Concept

Lead Research Organisation: University of Southampton

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

10 25 50
 
Description Optically controlled fluid flow: enabling smart paper-based medical diagnostic devices
Amount £438,973 (GBP)
Funding ID EP/S003398/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 12/2018 
End 06/2021
 
Description Royal Blind, Royal College of Surgeons of Edinburgh Ophthalmology research grant
Amount £59,000 (GBP)
Organisation The Royal College of Surgeons of Edinburgh 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2019 
End 01/2020
 
Description Royal College of Surgeons of Edinburgh Ophthalmology Research Grants
Amount £11,000 (GBP)
Organisation The Royal College of Surgeons of Edinburgh 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 03/2018
 
Description Research collaboration with SME 
Organisation Renovo PLC
Country United Kingdom 
Sector Private 
PI Contribution Our research is centred around bone stem cells. We are working with Renovos through a an Innovate UK grant in which we are testing clay gels as a mechanism for supporting bone stem cells to improve bone healing.
Collaborator Contribution Renovos have been awarded a collaborative Innovate UK grant "Harnessing clay gels for bone tissue repair" to work with us in model systems to determine the efficacy fo this product. The aim is to improve bone healing int hese models and then move to human studies.
Impact none
Start Year 2017
 
Description Research collaboration with an industrial partner 
Organisation Bio Products Laboratory Ltd
Country United Kingdom 
Sector Private 
PI Contribution We are using this product to treat mice in a model of sub-arachnoid haemorrhage (SAH). The aim of this project is to determine if the haptoglobin can treat SAH, with a view to a subsequent clinical trial in patients with this condition.
Collaborator Contribution Bio Products Laboratory Ltd are supplying haptoglobin for use in the study. The estimated value of the product supplied is £60k.
Impact No outcomes at present
Start Year 2017
 
Title Haptoglobin for treatment of sub-arachnoid haemorrhage 
Description We have proven that haptoglobin as a treatment for brain haemorrhage is efficacious in a mouse model. The next stage is scaling up the lab method to pilot plant scale for commercial purification and then apply for funding for a phase I study. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2018
Development Status Under active development/distribution
Impact This provides a new method for scaling up production of haptoglobin 
 
Description Attitudes to genetic modification and the use of genetically-modified organisms in medicine 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This was a PPI group to garner opinion on the release of neisseria lactamica into the general population
Year(s) Of Engagement Activity 2017
 
Description Clinicians meet scientists networking events 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The first Southampton joint meeting between the University Hospital Southampton NHS Trust and The University of Southampton took place as an engagement event for the MRC CiC award. This enabled clinicians to meet with engineers to discuss opportunities for collaboration to address real world health problems. this has led to joint activities with the health technologies centre at University of Southampton.
Year(s) Of Engagement Activity 2018
 
Description GM-Neisseria Lactamica Press Release and FAQ meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This was a PPI activity to investigate attitudes to release of genetically modified Neisseria lactamica into the community
Year(s) Of Engagement Activity 2017
 
Description Global-NAMRIP Conference in Kampala, Uganda 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact This was a lecture given as part of the global NAMRIP conference. This is a research conference held at Makerere University, Kampala, Uganda and is part of The University of Southampton's strategic initiative on antimicrobial resistance and was co-funded by GCRF funds.
Year(s) Of Engagement Activity 2019
URL https://www.southampton.ac.uk/namrip/news/2019/02/uganda-conference.page
 
Description Included in a keynote presentation by TG Leighton at 2nd Global-NAMRIP conference (Kampala, Uganda, 3-7 March 2019) : https://www.southampton.ac.uk/namrip/news/2019/02/uganda-conference.page? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A presentation to an international conference on anti-micronbial resistance
Year(s) Of Engagement Activity 2019
 
Description Included in a presentation by TG Leighton at "Clinicians meet Engineers event" (9 November 2018) MRC Confidence in Concept 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact A talk at an internal meeting of clinicians and engineers that untied all faculties at the insitution
Year(s) Of Engagement Activity 2018
 
Description Included in an outreach presentation (open to members of the public) on 18 Sept 2018 that Professor Leighton gave to the local branch of the the Institute of Physics South West Branch and held at Sarum College, 19 The Close, Salisbury. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact The talk, entitled 'Climate Change, Dolphins and Antimicrobial Resistance - The Impact of Bubble Acoustics' was hosted by the Institute of Physics South West Branch. The talk was well received by the audience, who afterwards probed extensively on the issues around multidisciplinary teams that Prof Leighton had touched on, and which are so key to NAMRIP. They were particularly interested in how these teams address problems, the challenges associated with hiring across disciplines, and the personal qualities looked for when recruiting into a multidisciplinary team.
Year(s) Of Engagement Activity 2018
URL https://www.southampton.ac.uk/namrip/news/2018/09/leighton-inst-physics.page?
 
Description Included in the Royal Society Clifford Paterson Award Lecture (open to members of the public) given by Professor Leighton on receipt of the Royal Society Clifford Paterson Medal on 5 September 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professor Tim Leighton was awarded the Clifford Paterson Medal of the Royal Society, giving on the occasion a lecture entitled 'The acoustic bubble: climate change, spaceships, dolphins, and the antibiotic apocalypse'. The medal and lecture, given every 2 years to an outstanding researcher in the field of engineering, was presented by Vice-President Ulrike Tillmann. Professor Leighton's lecture covered the full range of his work suggested by the title, including fundamental research sponsored by NAMRIP, which was subsequently picked up for translation by the MRC Confidence in Concept award.
Year(s) Of Engagement Activity 2018
URL https://www.southampton.ac.uk/namrip/news/2018/09/leighton-paterson-medal.page
 
Description Investigation of the efficacy of a novel ultrasonically activated stream for removal of antimicrobial resistant biofilms Poster EP134 at 28TH CONFERENCE OF THE EUROPEAN WOUND MANAGEMENT ASSOCIATION (KRAKOW, POLAND 9 - 11 MAY 2018)http://ewma.org/fileadmin/user_upload/web_376227_EWMA2018_Programme_.pdf 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Conference talk
Year(s) Of Engagement Activity 2018
 
Description Presentation at New Forest show 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact A presentation on bone stem cells was given to the New forest Show in the Wessex Medical Research Tent. this invited questions and discussions from the audience
Year(s) Of Engagement Activity 2018
URL https://www.newforestshow.co.uk/
 
Description Presentation at Southampton mela festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact presentation on bone stem cells at the festival. An interview was given to Unity FM
Year(s) Of Engagement Activity 2018
URL http://www.southamptonmela.com/
 
Description Presentation at the Boone Research Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation: Application of 3D-printed patient-speci?c skeletal implants augmented with autologous skeletal stem cells given at the meeting of the Bone Reserach Society 2018
Year(s) Of Engagement Activity 2018
URL https://boneresearchsociety.org/meeting/winchester2018/
 
Description Presentation at the European Wound management Association 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This will be a research presentation at The European Wound Management Association in Krakow in May 2018. the paper will be entitiled "Investigation of a novel ultrasonically activated stream for removal of antimicrobial resistant biofilms.
Year(s) Of Engagement Activity 2018
URL http://ewma.org/ewma-conference/2018/
 
Description Professor Leighton was speaking to the 2018 Summer Conference of EPSRC's Special Interest Group on Fluid Mechanics of Cleaning and Decontamination. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Included in an multidisciplinary engagement presentation on Wednesday 29th August 2018, in a Plenary Lecture by Professor Leighton at Cambridge University's Isaac Newton Institute to a professional audience.
Year(s) Of Engagement Activity 2018
 
Description Stem cell mountain 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Stem cell mountain is now a permanent exhibit at The Winchester Science Centre. the centre is visited by members of the public and school children
Year(s) Of Engagement Activity 2018,2019
URL https://www.winchestersciencecentre.org/
 
Description lecture on clay nanogels at Termis world congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Jon Dawson gave a keynote lecture on clay nanongels at the Termis World congress. This is the biggest conference on tissue engineering worldwide.
Year(s) Of Engagement Activity 2018
URL https://www.termis.org/wc2018/
 
Description poster at international conference on sub-arachnoid haemorrhage 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A poster was presented at the international conference on sub-arachnoid haemorrhage: in Amsterdam to a scientific audience
Year(s) Of Engagement Activity 2018
URL https://www.isah-conference.org/
 
Description poster presentation at the Bone Research Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation: Bone induction in a murine subcutaneous model using nanoclay gel and bone morphogenic protein: an optimization study
Year(s) Of Engagement Activity 2018
URL https://boneresearchsociety.org/meeting/winchester2018/