PREVALENCE, CHARACTERISATION AND RESPONSE TO CHRONIC KIDNEY DISEASE IN SOUTH AFRICA

Lead Research Organisation: University of the Witwatersrand

Abstract

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Technical Summary

Chronic Kidney Disease (CKD) is an emerging public health challenge globally and treatment is largely unaffordable in poorer settings. Those from low to middle income countries are particularly vulnerable because of the increased burden of non-communicable diseases within ageing societies that are undergoing rapid epidemiological and social transitions. In addition, although not well understood, CKD in Africans appears to be different from that seen in other ethnic groups. Thus, there are major gaps in understanding the risk factors, presentation and scope of the burden of CKD in South and sub-Saharan Africa. This prevents development of evidence-based health policy, suited to local contexts, that addresses effective strategies for prevention, early detection and treatment. In this study we will:
? Determine the prevalence of CKD in a rural South African cohort
? Establish an accurate method for estimating kidney function at community level in the South African population and regionally, in conjunction with collaborating sister studies
? Investigate the risk factors, including novel gene loci, for incident and progressive CKD in an urban and rural South African cohorts
We will deepen our understanding of CKD in South Africa and considerably enhance it. It will contribute critical evidence to accurately inform an effective health systems response to CKD in a rapidly transitioning setting. A priority is to identify modifiable risk factors for CKD that can be targeted in the development of cost-effective screening and prevention strategies at primary health care level. This is critical as resources available for the treatment of end stage kidney disease with chronic dialysis and transplantation are severely restricted, and will remain so in the current health care setting.

Publications

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Bamgboye EL (2021) COVID-19 Pandemic: Is Africa Different? in Journal of the National Medical Association

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Banda J (2020) Biomarkers for Diagnosis and Prediction of Outcomes in Contrast-Induced Nephropathy. in International journal of nephrology

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Baumgart A (2020) Meaning of empowerment in peritoneal dialysis: focus groups with patients and caregivers. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

 
Description Collaborating group: ARK (Africa Research on Kidneys) including Drs Robert Kaylesubula (Uganda), Mia Crampin (Malawi), Laurie Tomlinson and Liam Smeeth (London School of Hygiene and Tropical Medicine) 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Harmonised protocols; provision of measurement of serum iohexol and cystitis C to develop a common equation to estimate GFR. Published 2 joint papers, with a third manuscript being finalized.
Collaborator Contribution MONTHLY CONFERENCES TO UPDATE PROGRESS, HARMONISATION OF PROTOCOLS, SET UP WEBSITE FOR ARK RESEARCH GROUP, JOINT PUBLICATIONS PLANNED
Impact 2 papers published, and are listed in the Publications section
Start Year 2017
 
Description Collaborating group: ARK (Africa Research on Kidneys) including Drs Robert Kaylesubula (Uganda), Mia Crampin (Malawi), Laurie Tomlinson and Liam Smeeth (London School of Hygiene and Tropical Medicine) 
Organisation Makerere University
Country Uganda 
Sector Academic/University 
PI Contribution Harmonised protocols; provision of measurement of serum iohexol and cystitis C to develop a common equation to estimate GFR. Published 2 joint papers, with a third manuscript being finalized.
Collaborator Contribution MONTHLY CONFERENCES TO UPDATE PROGRESS, HARMONISATION OF PROTOCOLS, SET UP WEBSITE FOR ARK RESEARCH GROUP, JOINT PUBLICATIONS PLANNED
Impact 2 papers published, and are listed in the Publications section
Start Year 2017
 
Description patient group workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Initial event was to explain the research project to the community.
Subsequent activity was to communicate results to the participants and explain their significance.
Final activity was to explain the measurement of GFR and the requirements (time commitments, need for injection/infusion, blood sampling).
Year(s) Of Engagement Activity 2017,2018,2019