PREVALENCE, CHARACTERISATION AND RESPONSE TO CHRONIC KIDNEY DISEASE IN SOUTH AFRICA
Lead Research Organisation:
University of the Witwatersrand
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Chronic Kidney Disease (CKD) is an emerging public health challenge globally and treatment is largely unaffordable in poorer settings. Those from low to middle income countries are particularly vulnerable because of the increased burden of non-communicable diseases within ageing societies that are undergoing rapid epidemiological and social transitions. In addition, although not well understood, CKD in Africans appears to be different from that seen in other ethnic groups. Thus, there are major gaps in understanding the risk factors, presentation and scope of the burden of CKD in South and sub-Saharan Africa. This prevents development of evidence-based health policy, suited to local contexts, that addresses effective strategies for prevention, early detection and treatment. In this study we will:
? Determine the prevalence of CKD in a rural South African cohort
? Establish an accurate method for estimating kidney function at community level in the South African population and regionally, in conjunction with collaborating sister studies
? Investigate the risk factors, including novel gene loci, for incident and progressive CKD in an urban and rural South African cohorts
We will deepen our understanding of CKD in South Africa and considerably enhance it. It will contribute critical evidence to accurately inform an effective health systems response to CKD in a rapidly transitioning setting. A priority is to identify modifiable risk factors for CKD that can be targeted in the development of cost-effective screening and prevention strategies at primary health care level. This is critical as resources available for the treatment of end stage kidney disease with chronic dialysis and transplantation are severely restricted, and will remain so in the current health care setting.
? Determine the prevalence of CKD in a rural South African cohort
? Establish an accurate method for estimating kidney function at community level in the South African population and regionally, in conjunction with collaborating sister studies
? Investigate the risk factors, including novel gene loci, for incident and progressive CKD in an urban and rural South African cohorts
We will deepen our understanding of CKD in South Africa and considerably enhance it. It will contribute critical evidence to accurately inform an effective health systems response to CKD in a rapidly transitioning setting. A priority is to identify modifiable risk factors for CKD that can be targeted in the development of cost-effective screening and prevention strategies at primary health care level. This is critical as resources available for the treatment of end stage kidney disease with chronic dialysis and transplantation are severely restricted, and will remain so in the current health care setting.
Publications
Harris DCH
(2020)
Strategic plan for integrated care of patients with kidney failure.
in Kidney international
Hassan MO
(2020)
Design and methods of the prevalence and pharmacogenomics of tenofovir nephrotoxicity in HIV-positive adults in south-western Nigeria study.
in BMC nephrology
Kalyesubula R
(2020)
How to estimate glomerular filtration rate in sub-Saharan Africa: design and methods of the African Research into Kidney Diseases (ARK) study.
in BMC nephrology
Naicker S
(2020)
The Novel Coronavirus 2019 epidemic and kidneys.
in Kidney international
Naidoo S
(2019)
Early Life Factors and Longitudinal Blood Pressure Trajectories Are Associated With Elevated Blood Pressure in Early Adulthood.
in Hypertension (Dallas, Tex. : 1979)
Naidoo S
(2019)
Early Life Factors and Longitudinal Blood Pressure Trajectories Are Associated With Elevated Blood Pressure in Early Adulthood.
in Hypertension (Dallas, Tex. : 1979)
Naidoo S
(2023)
Prevalence and associated risk factors for elevated blood pressure in young adults in South Africa.
in Cardiovascular journal of Africa
Seeley J
(2020)
Understanding kidney disease in rural central Uganda - Findings from a qualitative study.
in Global public health
Description | The current equations that estimate kidney function, especially the use of the ethnicity correction factor, overestimate kidney function. This has adverse implications for individuals of black ethnicity in that the diagnosis of chronic kidney disease is delayed and delays their access to treatment and listing for kidney transplantation. Furthermore serum creatinine is not the ideal substance for estimation of kidney function an d research is required to identify a substance that would more accurately estimate kidney function. |
Exploitation Route | Studies into molecules that would enable more accurate estimation of kidney function are required. |
Sectors | Healthcare |
Title | blood and urine samples for chronic kidney disease cohort |
Description | Study population is well characterised and biological samples stored for future research. |
Type Of Material | Biological samples |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | Two Masters projects based on this cohort were completed in 2021. A PhD project is underway at present. |
Description | Collaborating group: ARK (Africa Research on Kidneys) including Drs Robert Kaylesubula (Uganda), Mia Crampin (Malawi), Laurie Tomlinson and Liam Smeeth (London School of Hygiene and Tropical Medicine) |
Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Harmonised protocols; provision of measurement of serum iohexol and cystitis C to develop a common equation to estimate GFR. Published 2 joint papers, with a third manuscript being finalized. |
Collaborator Contribution | MONTHLY CONFERENCES TO UPDATE PROGRESS, HARMONISATION OF PROTOCOLS, SET UP WEBSITE FOR ARK RESEARCH GROUP, JOINT PUBLICATIONS PLANNED |
Impact | 2 papers published, and are listed in the Publications section |
Start Year | 2017 |
Description | Collaborating group: ARK (Africa Research on Kidneys) including Drs Robert Kaylesubula (Uganda), Mia Crampin (Malawi), Laurie Tomlinson and Liam Smeeth (London School of Hygiene and Tropical Medicine) |
Organisation | Makerere University |
Country | Uganda |
Sector | Academic/University |
PI Contribution | Harmonised protocols; provision of measurement of serum iohexol and cystitis C to develop a common equation to estimate GFR. Published 2 joint papers, with a third manuscript being finalized. |
Collaborator Contribution | MONTHLY CONFERENCES TO UPDATE PROGRESS, HARMONISATION OF PROTOCOLS, SET UP WEBSITE FOR ARK RESEARCH GROUP, JOINT PUBLICATIONS PLANNED |
Impact | 2 papers published, and are listed in the Publications section |
Start Year | 2017 |
Description | patient group workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Initial event was to explain the research project to the community. Subsequent activity was to communicate results to the participants and explain their significance. Final activity was to explain the measurement of GFR and the requirements (time commitments, need for injection/infusion, blood sampling). |
Year(s) Of Engagement Activity | 2017,2018,2019 |