Maximising patient benefit: Leeds’ Interdisciplinary approach to translation (CiC 2017)
Lead Research Organisation:
University of Leeds
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
People |
ORCID iD |
Publications
Allwardt V
(2020)
Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption.
in Bioengineering (Basel, Switzerland)
Bauer C
(2020)
Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels
in RSC Chemical Biology
Cheung SY
(2018)
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
in Oncotarget
Cragg J
(2021)
Surgical cognitive simulation improves real-world surgical performance: randomized study.
in BJS open
Giles OT
(2018)
Hitting the Target: Mathematical Attainment in Children Is Related to Interceptive-Timing Ability.
in Psychological science
Irvine SF
(2018)
Perineuronal Nets in Spinal Motoneurones: Chondroitin Sulphate Proteoglycan around Alpha Motoneurones.
in International journal of molecular sciences
Kearney KJ
(2021)
Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI.
in Proceedings of the National Academy of Sciences of the United States of America
Lepannetier S
(2018)
Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory.
in Frontiers in cellular neuroscience
Mancini V
(2021)
Probing morphological, genetic and metabolomic changes of in vitro embryo development in a microfluidic device.
in Biotechnology progress
| Description | Design, Fabrication and Testing of a Mouse Embryo Culture Chip |
| Amount | £150,000 (GBP) |
| Funding ID | NC/C016207/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 11/2019 |
| Description | Development of FXIIa Inhibitors to treat thrombosis |
| Amount | £300,000 (GBP) |
| Organisation | University of Leeds |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 02/2021 |
| Description | Development of First-In Class Small Molecule Preclinical Candidate Anticoagulant Targeting Activated Factor XII with Minimal Risk of Bleeding |
| Amount | £3,150,000 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 02/2021 |
| Description | Impact Accelerator award |
| Amount | £43,466 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 05/2020 |
| Description | Life Science Investor into LUNAC Therapeutics |
| Amount | £2,350,000 (GBP) |
| Organisation | Epidarex |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 02/2021 |
| Description | MRC CiC UoL funding |
| Amount | £83,904 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 03/2021 |
| Description | Proof of Concept |
| Amount | £79,785 (GBP) |
| Organisation | Grow MedTech |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 12/2019 |
| End | 11/2020 |
| Description | UKRI ICURe: Embryo culture device for successful IVF |
| Amount | £30,000 (GBP) |
| Organisation | Set Squared Partnership |
| Department | ICURe |
| Sector | Private |
| Start | 01/2021 |
| End | 03/2021 |
| Description | Understanding potent small-molecule inhibition of TRPC1/4/5 channels |
| Amount | £203,098 (GBP) |
| Funding ID | PG/19/2/34084 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 02/2022 |
| Description | Wellcome Trust iTPA: A microfluidic chip to improve human embryo culture and selection of best embryos in In Vitro Fertilization |
| Amount | £59,959 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 12/2021 |
| Description | The project is led to a CDT PhD studentship between University of Leeds, University of Oxford, and Nottingham Trent University |
| Organisation | Nottingham Trent University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We lead this work from Leeds with colleagues from Elec Eng, Mech Eng, and Biology. The PhD student started his project in October 2019 and is currenly finalising a review paper of the state of the art. We will design and fabricate a fully functioning prototype ready for cell culture experiments. The student will learn how to culture primary cells on soft material. Successful culture will be subjected to various degrees of stretching to investigate the effect of stretching to cell damage. |
| Collaborator Contribution | All finite element simulation of this technology will be performed by the student under direct supervision by NTU. The PhD student will evaluate the prototype system using tendon cells extracted from tissues (healthy and diseased) at Oxford. |
| Impact | No impact yet but we have successfully received IAA funding to pay for an external report to be performed by a consultant (Medilink North of England, Ltd) to assess the market for this technology. We would like to know the size of the market and whether there is a user pull for this technology. |
| Start Year | 2019 |
| Description | The project is led to a CDT PhD studentship between University of Leeds, University of Oxford, and Nottingham Trent University |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We lead this work from Leeds with colleagues from Elec Eng, Mech Eng, and Biology. The PhD student started his project in October 2019 and is currenly finalising a review paper of the state of the art. We will design and fabricate a fully functioning prototype ready for cell culture experiments. The student will learn how to culture primary cells on soft material. Successful culture will be subjected to various degrees of stretching to investigate the effect of stretching to cell damage. |
| Collaborator Contribution | All finite element simulation of this technology will be performed by the student under direct supervision by NTU. The PhD student will evaluate the prototype system using tendon cells extracted from tissues (healthy and diseased) at Oxford. |
| Impact | No impact yet but we have successfully received IAA funding to pay for an external report to be performed by a consultant (Medilink North of England, Ltd) to assess the market for this technology. We would like to know the size of the market and whether there is a user pull for this technology. |
| Start Year | 2019 |
| Title | DEVICE FOR SUPPORTING DEVELOPMENT OF A CELL OR TISSUE DERIVED FROM THE OVARY |
| Description | A device for supporting development of a cellular deposit comprising at least one of a cell or a tissue derived from an ovary. The device comprises an inlet well, an outlet well, and an enclosed culture chamber disposed between the inlet well and the outlet well. The device further comprises an inlet channel fluidly coupling the inlet well to the culture chamber and an outlet chamber and/or at least one outlet channel fluidly coupling the culture chamber to the outlet well. At least one of the outlet chamber and the at least one outlet channel is sized to prevent passage of the cellular deposit therethrough. |
| IP Reference | WO2019202334 |
| Protection | Patent application published |
| Year Protection Granted | 2019 |
| Licensed | Commercial In Confidence |
| Impact | - |
| Company Name | LUNAC THERAPEUTICS LIMITED |
| Description | A virtual company that is seeking investor funding to pursue development of our anticoagulant drug. |
| Year Established | 2018 |
| Impact | In early stages but soon will happen! |
| Description | Conference Oral Presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | n/a |
| Year(s) Of Engagement Activity | 2018,2020 |
| Description | Symposium Presentastion |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | n?a |
| Year(s) Of Engagement Activity | 2019 |