Newcastle Confidence in Concept 2017
Lead Research Organisation:
Newcastle University
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Al Alawi I
(2021)
Case Report: A Novel In-Frame Deletion of GLIS2 Leading to Nephronophthisis and Early Onset Kidney Failure.
in Frontiers in genetics
Barroso-Gil M
(2021)
Update of genetic variants in CEP120 and CC2D2A-With an emphasis on genotype-phenotype correlations, tissue specific transcripts and exploring mutation specific exon skipping therapies.
in Molecular genetics & genomic medicine
Cardenas-Rodriguez M
(2021)
Genetic compensation for cilia defects in cep290 mutants by upregulation of cilia-associated small GTPases.
in Journal of cell science
Choudhury S
(2019)
Slowed Movement Stopping in Parkinson's Disease and Focal Dystonia is Improved by Standard Treatment.
in Scientific reports
Lou Sutcliffe H L
(2022)
Surface electroencephalography (EEG) during the acute phase of stroke to assist with diagnosis and prediction of prognosis: a scoping review
in BMC Emergency Medicine
Molinari E
(2019)
Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts.
in Scientific reports
Olinger E
(2021)
A discarded synonymous variant in NPHP3 explains nephronophthisis and congenital hepatic fibrosis in several families.
in Human mutation
Rahman S
(2022)
Comparing Stop Signal Reaction Times in Alzheimer's and Parkinson's Disease.
in The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
| Description | A pilot study for a national screening programme of urothelial cancers in Lynch syndrome based on urine analysis using the Newcastle MSI-Plus assay |
| Amount | £50,467 (GBP) |
| Organisation | SBRI Healthcare |
| Sector | Private |
| Country | United Kingdom |
| Start | |
| Description | Developing chemical probes to distinguish CDK4-cyclin D |
| Amount | £122,979 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2024 |
| Description | Developing non-invasive methods for early detection of Lynch Syndrome cancers using liquid biopsy |
| Amount | £171,124 (GBP) |
| Organisation | Barbour Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Dissemination of the Newcastle MSI-PLUS assay for Lynch syndrome screening and therapeutic targetting. |
| Amount | £1,800,000 (GBP) |
| Organisation | SBRI Healthcare |
| Sector | Private |
| Country | United Kingdom |
| Start | |
| Description | Innate interferons in epithelial defence against respiratory viruses |
| Amount | £176,474,894 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2023 |
| Description | Novel MRI Biomarkers in Neuromuscular Disease |
| Amount | £117,300 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Pre-transplant microRNA blockade using direct Antisense Oligonucleotide delivery during Ex Vivo Normothermic machine Perfusion of kidneys |
| Amount | £140,193 (GBP) |
| Organisation | Kidney Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | SBRI 18 Phase 2 Stroke & Technology |
| Amount | £798,919 (GBP) |
| Organisation | SBRI Healthcare |
| Sector | Private |
| Country | United Kingdom |
| Start | 11/2022 |
| End | 11/2023 |
| Description | Using minimal Factor H therapy and normothermic conditions to prepare kidneys for transplantation |
| Amount | £897,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Using structural and chemical biology to understand the roles and mechanisms of CDKs: generating hypotheses for drug discovery |
| Amount | £1,914,754 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| End | 07/2026 |
| Title | METHOD OF IDENTIFYING COMPLEMENT MODULATORS (Amended) |
| Description | Aspects of the present invention relate to method and systems which provide extended capability, compared to the existing techniques, for the screening of epitopes associated with complement activation. Particularly, but not exclusively, certain embodiments of the present invention relate to a method for generating a complement panning surface. Certain embodiments involve the use of surface plasmon resonance, and/or phage display technology. Certain embodiments of the present invention may be advantageous over the prior art in the generation of new complement panning surfaces. These surfaces may enable the identification of neoepitopes associated with surface-bound activated complement components. Compared to previous 'homing' complement drugs, such as TT30 - which target epitopes found on both soluble and surface-bound, activated complement components - the selective binding of only surface-bound activated components may result in said compound eliciting a longer-lasting therapeutic effect. This could potentially improve the compound's efficacy as a complement-modulating drug by extending the therapeutic window. |
| IP Reference | PCT/GB2021/051359 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2022 |
| Licensed | No |
| Impact | Not known as yet |
| Description | Invited talk to a national specialist stroke meeting Prehospital selection and redirection in the NHS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delivered a talk on Pre- hospital selection and redirection in the NHS. Sparked questions and answers and general discussion. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited talk to the Welsh Stroke Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delivering efficient emergency prehospital stroke care. Generated Questions and answers from the audience and also discussion during the day. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://healthandcareresearchwales.org/about/events/welsh-stroke-conference |
| Description | Talk at American Society of Nephrology Annual Meeting Oct 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation and discussions at the event with networking opportunities during the event. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.asn-online.org/education/kidneyweek/2022/meeting-overview.aspx |
| Description | Talk at EMBO CILIA Cologne Oct 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 4 day event. Presentation given which generated question and answers and a great opportunity for networking |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.cilia2022.de/ |
| Description | Talk at RSM Nephrology London Dec 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation given which then generated question and answer session. Networking also took place during the event. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.rsm.ac.uk/events/nephrology/2022-23/ner03/ |