Accelerating translational research through Cardiff University’s Clinical Innovation pipeline
Lead Research Organisation:
Cardiff University
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
People |
ORCID iD |
Publications
Castell OK
(2018)
Single molecule fluorescence for membrane proteins.
in Methods (San Diego, Calif.)
Hardinge P
(2020)
Bioluminescent detection of isothermal DNA amplification in microfluidic generated droplets and artificial cells.
in Scientific reports
Kandil S
(2019)
Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity.
in Bioorganic & medicinal chemistry letters
Lynham A
(2023)
Cardiff Online Cognitive Assessment in a National Sample: Cross-Sectional Web-Based Study
in Journal of Medical Internet Research
Lynham AJ
(2022)
Web-Based Cognitive Testing in Psychiatric Research: Validation and Usability Study.
in Journal of medical Internet research
Margrain TH
(2020)
Functional Imaging of the Outer Retinal Complex using High Fidelity Imaging Retinal Densitometry.
in Scientific reports
Wright BJ
(2020)
Real time monitoring of screw insertion using acoustic emission can predict screw stripping in human cancellous bone.
in Clinical biomechanics (Bristol, Avon)
Yarova PL
(2021)
Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma.
in The Journal of pharmacology and experimental therapeutics
| Description | National Centre for Mental Health |
| Geographic Reach | National |
| Policy Influence Type | Contribution to new or Improved professional practice |
| Description | (ACDC) - Artificial Cells with Distributed Cores to Decipher Protein Function |
| Amount | € 4,376,295 (EUR) |
| Funding ID | 824060 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2019 |
| End | 01/2023 |
| Description | Development of calcilytics for treating COPD in humans |
| Amount | £52,450 (GBP) |
| Organisation | European Social Fund (Welsh Government/ EU) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2021 |
| Description | Functional imaging of the outer retina using high fidelity imaging densitometry: exploring the relationship between visal pigment kinetics and AMD pathology |
| Amount | £40,445 (GBP) |
| Organisation | The College of Optometrists |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 03/2022 |
| Description | Targeting ERK signalling to ameliorate intellectual disability and autism spectrum disorder associated with chromosomal rearrangements at 16p11.2 |
| Amount | £1,204,625 (GBP) |
| Funding ID | MR/S037667/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 10/2023 |
| Description | Wellcome Trust ISSF |
| Amount | £99,666 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2018 |
| End | 09/2019 |
| Description | Wellcome Trust ITPA ToC |
| Amount | £20,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 10/2020 |
| Title | Cognitive Assessment Battery |
| Description | This project has created the first freely available, accessible, online cognitive assessment battery validated in those with a history of mental illness. People with lived experience of mental illness had input into the design, which is another innovative aspect of the battery. At present, there are no freely available online cognitive assessments that have been designed specifically for use with people with mental health disorders. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Initially the battery was hosted on a rudimentary website but the MRC-CiC funding allowed us to respond to participant feedback and upscale the project, creating a battery that is user-friendly and suitable for collecting very large datasets. The consultation and public/patient outreach work conducted as part of this project has generated ideas that will allow us to further develop the test as a clinical tool and has provided a foundation for future grant funding. |
| Description | Design, synthesis, biological screening and formulation studies of novel, small molecule-based therapeutics for the treatment of obstructive airways disorders |
| Organisation | King’s Health Partners |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | N/A |
| Collaborator Contribution | N/A |
| Impact | N/A |
| Start Year | 2022 |
| Description | TNA Therapeutics Identifying biomarkers for phase 1 clinical trials of CB1: a first in class anti-cancer agent targeting Bcl3 |
| Organisation | TnA Therapeutics LLC |
| Country | United States |
| Sector | Private |
| PI Contribution | N/A |
| Collaborator Contribution | N/A |
| Impact | N/A |
| Start Year | 2022 |
| Description | TnA Therapeutics |
| Organisation | TnA Therapeutics LLC |
| Country | United States |
| Sector | Private |
| PI Contribution | Lead candidate CB1 as a novel anti-metastatic agent |
| Collaborator Contribution | Commercial develoipment support |
| Impact | Joint collaborative application for funding |
| Start Year | 2020 |
| Title | ARTIFICIAL CELLS |
| Description | The invention relates to an artificial cell system comprising at least one droplet-interface bilayer (DIB) encased within a shell; a suspension comprising same; and a method and a device for the manufacture of same. |
| IP Reference | US2019255529 |
| Protection | Patent application published |
| Year Protection Granted | 2019 |
| Licensed | No |
| Impact | Initial discussions with industry |
| Title | NEUROPROTECTIVE PEPTIDE |
| Description | The invention relates to inhibitors of MAPK3(ERK1 MAP kinase), in particular to polypeptides having the ability to stimulate the global ERK signalling pathway in the brain and their use as neuroprotective and/or cognitive enhancing agents.The invention also concerns related polynucleotides, vectors, host cells and pharmaceutical compositions able to inhibit MAPK3, causing the stimulation of the global ERK signalling pathway.Additionally, use of the afore inhibitors or stimulators in the treatment of neurodegenerative or neuropsychiatric disorders and cognitive impairment is also disclosed. |
| IP Reference | WO2019102201 |
| Protection | Patent application published |
| Year Protection Granted | 2019 |
| Licensed | No |
| Impact | Discussions with industry |
| Title | MacuMap |
| Description | http://stfc.technologypublisher.com/tech?title=Imaging_Retinal_Densitometry%3A_MacuMap |
| Type | Diagnostic Tool - Imaging |
| Current Stage Of Development | Refinement. Clinical |
| Year Development Stage Completed | 2020 |
| Development Status | Under active development/distribution |
| Impact | n/a |
| URL | http://stfc.technologypublisher.com/tech?title=Imaging_Retinal_Densitometry%3A_MacuMap |
| Company Name | CARBON THERAPEUTICS LTD |
| Description | Therapeutic and medicine development |
| Year Established | 2020 |
| Impact | None as yet |
| Description | WCAE-2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Proceedings of the World Conference of Acoustic Emission |
| Year(s) Of Engagement Activity | 2019 |