Integrating genetic, clinical and phenotypic data to advance stratification, prediction and treatment in mental health.

Lead Research Organisation: Cardiff University

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

Mental ill health has a major impact on patients, their carers and the wider community. Psychiatric
disorders are estimated to cost the UK economy £70-100 Bn per year. Recently, large scale data sharing has allowed major progress to bemade in understanding the genetic basis of many major psychiatric disorders. The MRC Centre for Neuropsychiatric Genetics and Genomics (MRC CNGG) in Cardiff has played a leading role in driving this genomic progress. Key insights that have emerged include the polygenic nature of these conditions, the extensive overlap of risk across current diagnostic categories, and the convergence of risk factors onto specific biological processes. These advances in genetics offer major opportunities for improving stratification and treatment responses in mental disorders, as well as for the development of new biomarkers and biological models. However, to capitalise on this progress there is now a need to extend this large-scale data-driven approach forward by integrating genetic information with clinical, environmental, developmental and biological data at scale in mental health to transform the management of psychiatric disorders.
Our overall vision is to build key components of a platform that will enable the extension of the
collaborative efforts seen in psychiatric genetics into the clinical and biological platforms required for fundamental progress in psychiatric disorders. Our proposed programme comprises 4 Workstreams to achieve these aims:
Workstream (WS) 1. Development of a platform for integrating genomic and phenotypic data across large patient cohorts, including with electronic health records.
WS 2. Development of a school-based adolescent cohort for identifying the antecedents of early-onset psychiatric disorder.
WS 3. Developing a platform for advancing electrophysiological imaging biomarkers in mental
health disorders.
WS 4. Establishing methodologies for data sharing and standardisation in neuronal cellular model systems.

Publications

10 25 50
 
Description The phenotypic expression of autism spectrum disorder in adults
Amount £29,984 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2018 
End 01/2019
 
Description Mental health resilience (School Ysgol Plasmawr) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Invited talk for school Inset day to train teachers in relation to youth mental health resilience
Year(s) Of Engagement Activity 2018
 
Description Parents advisory group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Parent advisory group to inform design and implementation of Mental Health Genes and Environment Study (MAGES)
Year(s) Of Engagement Activity 2019
 
Description Schools advisory events 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact School leaders from 5 schools attended workshop and University facilities tour to advise on planned Mental Health in Adolescence Genes and Environment Study (MAGES). Discussion resulted in significant amendments to study research protocol. Three schools now agreed to take part in study. One school requested formal links with Cardiff University as 'twinned' school.
Year(s) Of Engagement Activity 2018
 
Description Scout evening - genetics workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Third sector organisations
Results and Impact Educational workshop around genetics with scouts group comprising presentation and practical activities.
Year(s) Of Engagement Activity 2019
 
Description Youth advisory group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Youth advisory group to inform design and implementation of MAGES schools study
Year(s) Of Engagement Activity 2019