Integrating genetic, clinical and phenotypic data to advance stratification, prediction and treatment in mental health.
Lead Research Organisation:
Cardiff University
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Dennison CA
(2020)
Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective.
in Schizophrenia research
Dennison CA
(2021)
Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type.
in Schizophrenia bulletin
Dennison CA
(2021)
Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank.
in PloS one
Drakesmith M
(2019)
Genetic risk for schizophrenia and developmental delay is associated with shape and microstructure of midline white-matter structures.
in Translational psychiatry
Hubbard L
(2021)
Rare Copy Number Variants Are Associated With Poorer Cognition in Schizophrenia.
in Biological psychiatry
Jones HJ
(2019)
Association of Genetic Risk for Rheumatoid Arthritis With Cognitive and Psychiatric Phenotypes Across Childhood and Adolescence.
in JAMA network open
Legge SE
(2019)
Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits.
in JAMA psychiatry
Legge SE
(2021)
Associations Between Schizophrenia Polygenic Liability, Symptom Dimensions, and Cognitive Ability in Schizophrenia.
in JAMA psychiatry
Lynham AJ
(2023)
DRAGON-Data: a platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts.
in BJPsych open
Lynham AJ
(2022)
Web-Based Cognitive Testing in Psychiatric Research: Validation and Usability Study.
in Journal of medical Internet research
| Description | The phenotypic expression of autism spectrum disorder in adults |
| Amount | £29,984 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2018 |
| End | 01/2019 |
| Description | Wolfson Centre for Young People's Mental Health |
| Amount | £10,000,000 (GBP) |
| Organisation | The Wolfson Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2020 |
| End | 09/2025 |
| Title | Genetic sampling in schools |
| Description | Assessment of feasibility and acceptability of new classroom workshop for use in secondary schools to educate children around genetics and mental health, relevant consent processes, and collection of DNA saliva samples in schools |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | none as yet |
| Description | Schools Health Research Network |
| Organisation | School Health Research Network |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Integration of mental health measures in all-Wales biennial secondary school pupil assessments. Validation of existing mental health assessment using clinical interview Analysis of trends in youth depression in Wales Feasibility/acceptability pilot study of genetic sampling in classroom settings Integral part of new £10m Wolfson Centre for Young People's Mental Health and proposed 5 year research programmes |
| Collaborator Contribution | Access to SHRN survey data Facilitation of PPI work with youth, parents and teacher groups Integral part of new £10m Wolfson Centre for Young People's Mental Health and proposed 5 year research programmes |
| Impact | Melendez-Torres (2019) - paper on validation on wellbeing questionnaire Component of successful grant to Wolfson foundation for new £10m Centre for Young People's Mental Health |
| Start Year | 2018 |
| Description | Mental health resilience (School Ysgol Plasmawr) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Invited talk for school Inset day to train teachers in relation to youth mental health resilience |
| Year(s) Of Engagement Activity | 2018 |
| Description | Parents advisory group |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Parent advisory group to inform design and implementation of Mental Health Genes and Environment Study (MAGES) |
| Year(s) Of Engagement Activity | 2019 |
| Description | Schools advisory events |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | School leaders from 5 schools attended workshop and University facilities tour to advise on planned Mental Health in Adolescence Genes and Environment Study (MAGES). Discussion resulted in significant amendments to study research protocol. Three schools now agreed to take part in study. One school requested formal links with Cardiff University as 'twinned' school. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Scout evening - genetics workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Third sector organisations |
| Results and Impact | Educational workshop around genetics with scouts group comprising presentation and practical activities. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Understanding the crisis: young people's mental health (Digital Showcase event) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Supporters |
| Results and Impact | Raising awareness of priorities in young people's mental health research |
| Year(s) Of Engagement Activity | 2021 |
| Description | Youth advisory group |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Youth advisory group to inform design and implementation of MAGES schools study |
| Year(s) Of Engagement Activity | 2019 |