Human infection challenge vaccine (HIC-vac) network
Lead Research Organisation:
Imperial College London
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Industrial Challenge Strategy Fund supplement is designed to bring diverse and flexible pump-priming activities to the Network with additional industrial involvement. This award will provide a support linkage, increasing UK Vaccine R&D activity around ‘proof of concept’ studies and can be used to support academic-industry partnerships and enhance academic and industry researchers' understanding of each other's needs and capabilities. This may be through people exchanges, creation of tecnology demonstrators, showcase events, workshops and pump-priming of grant activities.
Organisations
- Imperial College London (Lead Research Organisation)
- Liverpool School of Tropical Medicine (Collaboration)
- ST GEORGE'S UNIVERSITY OF LONDON (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Kenyan Institute for Medical Research (KEMRI) (Collaboration)
- Janssen Pharmaceutica NV (Collaboration)
- Leiden University Medical Center (Collaboration)
- University of Sheffield (Collaboration)
- Eijkman Institute (Collaboration)
- University of Bath (Collaboration)
- Sanofi (Collaboration)
- Centre for Infectious Disease Research in Zambia (Collaboration)
- Icahn School of Medicine at Mount Sinai (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- Translational Health Science and Technology Institute (Collaboration)
- Uganda Virus Research Institute (Collaboration)
- Kathmandu University (Collaboration)
- University of Bristol (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
- Central University of Rajasthan (Collaboration)
- NORTH BRISTOL NHS TRUST (Collaboration)
- University College London (Collaboration)
- University of Manchester (Collaboration)
- UNIVERSITY OF LEICESTER (Collaboration)
- PUBLIC HEALTH ENGLAND (Collaboration)
- Wellcome Trust (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- Tribhuvan University of Nepal (Collaboration)
- HUMABs Biomed, Bellinzona,Switzerland (Collaboration)
- SGS Life Sciences Ltd (Collaboration)
- London School of Hygiene and Tropical Medicine (LSHTM) (Collaboration)
- HVIVO PLC (Collaboration)
- Antigen Discovery Inc (Collaboration)
- UNIVERSITY OF KENT (Collaboration)
- Christian Medical College, Vellore (Collaboration)
People |
ORCID iD |
| Andrew Pollard (Co-Investigator) |
 http://orcid.org/0000-0001-7361-719X
|
Publications
Ascough S
(2019)
Local and Systemic Immunity against Respiratory Syncytial Virus Induced by a Novel Intranasal Vaccine. A Randomized, Double-Blind, Placebo-controlled Clinical Trial.
in American journal of respiratory and critical care medicine
Barclay W
(2018)
The 1918 Influenza Pandemic: one hundred years of progress, but where now?
in The Lancet. Respiratory medicine
Barnes MVC
(2023)
Human infection challenge in the pandemic era and beyond, HIC-Vac annual meeting report, 2022.
in Immunotherapy advances
Chilengi R
(2020)
A pilot study on use of live attenuated rotavirus vaccine (Rotarix™) as an infection challenge model.
in Vaccine
Mazur NI
(2018)
The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates.
in The Lancet. Infectious diseases
Petrarca L
(2018)
Vaccination policies in Europe: Common goals, diverse approaches and public doubts
in European Journal of Immunology
Pollard AJ
(2020)
Third human challenge trial conference, Oxford, United Kingdom, February 6-7, 2020, a meeting report.
in Biologicals : journal of the International Association of Biological Standardization
Schwarze J
(2018)
Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in asthma task force.
in Allergy
Shi T
(2020)
Global Disease Burden Estimates of Respiratory Syncytial Virus-Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis.
in The Journal of infectious diseases
Thwaites R
(2023)
Early mucosal events promote distinct mucosal and systemic antibody responses to live attenuated influenza vaccine
in Nature Communications
| Description | Developing ethical frameworks for human challenge studies |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Description | Vaccine Taskforce Human Challenge Board |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | A UK underpinning platform to study immunology and immunopathology of COVID-19:The UK Coronavirus Immunology Consortium |
| Amount | £6,552,119 (GBP) |
| Funding ID | MR/V028448/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 08/2022 |
| Description | A first-in-human open label wild-type SARS-CoV-2 dose-finding human infection challenge study |
| Amount | £817,899 (GBP) |
| Organisation | Department for Business, Energy & Industrial Strategy |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 10/2023 |
| Description | ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C) |
| Amount | £490,894,600 (GBP) |
| Funding ID | MC_PC_19059 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 09/2021 |
| Description | Senior Investigator Award |
| Amount | £60,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2021 |
| Title | Due diligence |
| Description | Due diligence processes initiated and implemented in accordance to GCRF's demands. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Due diligence processes in place and tested by audit by UKRI for future network awards. |
| Title | Finance systems to support pump-priming and training awards |
| Description | Template contracts, financial statements, and training award letters developed and approved by JRO. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Mechanisms established for awarding pump-priming awards from Imperial College's systems. |
| Title | System for robust investigator decision-making for pump-priming awards established at board level, linking with university research infrastructure |
| Description | The NMB and ISAB were responsible for completing the application review process, following a process defined by the HIC-Vac management office. The Network Manager and the Comms Lead performed initial eligibility checks on applications received, which covered: • whether lead applicants and co-applicants were HIC-Vac members (if not they were asked to become members, which boosted membership numbers in this period); • whether the £100,000 limit had been breached, • funding duration no more than 12 months; • at least two different institutions per application • assessment of conflict of interest for reviewers. The Network Manager and Comms Lead allocated 3 reviewers from the NMB and ISAB to each application, avoiding both personal and institutional conflict of interest and attempting an even burden of reviews per reviewer. These allocations were reviewed by the Network Director and Deputy Director. All reviewers were sent all applications received for context, though they only had to complete reviews for their nominated applications. Scoresheets were completed with marks out of 30 for: • Scientific merit (10 marks), • track record (5 marks), • facilitating cross-network collaborations (5 marks), • strategic impact for the network (5 marks) • route to further funding (5 marks). Outliers were assessed by Ops group but concluded that with only 3 reviewers per application, adjusting for generous or harsh marking made not material difference to final rankings. A maximum of 3 strategic points per application were awarded by the Director as follows: • LMIC (1 mark) • Lead = Early Career Researcher (1 mark) • Equality and Diversity (1 mark) Each application were ranked firstly by Mean Average Score and secondly by Mean Average plus Strategic score. NMB did not wish to re-rank or review the scores. They agreed to fund the top 9 as per Average+StrategicRank. NMB and funders were happy that the review procedure used was robust. The Director summarised reviewer comments from scoresheets which was included as constructive feedback for applicants on notification emails. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Guidelines are periodically published on the HIC-Vac website and templates available by request to the Network Manager for any other research groups wishing to set up a similar awarding process |
| URL | https://www.hic-vac.org/funding/pump-priming-funding |
| Description | Academic partnerships through funding |
| Organisation | Central University of Rajasthan |
| Country | India |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Centre for Infectious Disease Research in Zambia |
| Country | Zambia |
| Sector | Charity/Non Profit |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Christian Medical College, Vellore |
| Country | India |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Eijkman Institute |
| Country | Indonesia |
| Sector | Public |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Icahn School of Medicine at Mount Sinai |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Kathmandu University |
| Country | Nepal |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Kenyan Institute for Medical Research (KEMRI) |
| Country | Kenya |
| Sector | Public |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Leiden University Medical Center |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Liverpool School of Tropical Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Unit, The Gambia |
| Country | Gambia |
| Sector | Public |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Medical Research Council (MRC) |
| Department | MRC/UVRI and LSHTM Research Unit Uganda |
| Country | Uganda |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | North Bristol NHS Trust |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | St George's University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Translational Health Science And Technology Institute |
| Country | India |
| Sector | Public |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Tribhuvan University of Nepal |
| Country | Nepal |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Tribhuvan University of Nepal |
| Country | Nepal |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Uganda Virus Research Institute |
| Country | Uganda |
| Sector | Public |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | University of Bath |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | University of Kent |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | University of Leicester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | University of Oxford |
| Department | Oxford University Clinical Research Unit Vietnam (OUCRU) |
| Country | Viet Nam |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | University of Sheffield |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | University of Southampton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Wellcome Trust |
| Department | Mahidol University-Oxford Tropical Medicine Research Programme |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Academic partnerships through funding |
| Organisation | Wellcome Trust |
| Department | Malawi-Liverpool Wellcome Trust Clinical Research Programme |
| Country | Malawi |
| Sector | Academic/University |
| PI Contribution | We have made financial contributions to these academic/publicly funded organisations via competitive applications for pump-priming or training funding awards, and a vaccine hesitancy project. |
| Collaborator Contribution | Academic and publicly funded organisations have brought research expertise to the the partnership, to allow us to achieve our goal of supporting and boosting HIC studies globally. |
| Impact | 24 pump-priming grants have been awarded and reported. 4 early career researchers/students from LMICs were funded to attend the IVVN vaccinology course. 9 training grants have been awarded with 3 having reported outcomes. 3 public engagement grants were awarded. |
| Start Year | 2017 |
| Description | Industry partnerships |
| Organisation | Antigen Discovery Inc |
| Country | United States |
| Sector | Private |
| PI Contribution | Partnerships with Antigen Discovery Inc and SGS Life Sciences are a direct funding relationship - both are collaborators on pump-priming grants. The other industry partners have attended HIC-Vac meetings (Kick-off meeting, innovation sandpit and first annual general meeting) contributing expertise and exploring potential new collaborations. |
| Collaborator Contribution | Industry expertise in collaboration with academic partners to achieve research outputs as defined in the pump-priming applications. Collaborators on further grants (ReSViTRAIN, GSK) |
| Impact | 2 pump priming awards, 1 further award resulting from Network activities. |
| Start Year | 2018 |
| Description | Industry partnerships |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | Partnerships with Antigen Discovery Inc and SGS Life Sciences are a direct funding relationship - both are collaborators on pump-priming grants. The other industry partners have attended HIC-Vac meetings (Kick-off meeting, innovation sandpit and first annual general meeting) contributing expertise and exploring potential new collaborations. |
| Collaborator Contribution | Industry expertise in collaboration with academic partners to achieve research outputs as defined in the pump-priming applications. Collaborators on further grants (ReSViTRAIN, GSK) |
| Impact | 2 pump priming awards, 1 further award resulting from Network activities. |
| Start Year | 2018 |
| Description | Industry partnerships |
| Organisation | HUMABs Biomed, Bellinzona,Switzerland |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | Partnerships with Antigen Discovery Inc and SGS Life Sciences are a direct funding relationship - both are collaborators on pump-priming grants. The other industry partners have attended HIC-Vac meetings (Kick-off meeting, innovation sandpit and first annual general meeting) contributing expertise and exploring potential new collaborations. |
| Collaborator Contribution | Industry expertise in collaboration with academic partners to achieve research outputs as defined in the pump-priming applications. Collaborators on further grants (ReSViTRAIN, GSK) |
| Impact | 2 pump priming awards, 1 further award resulting from Network activities. |
| Start Year | 2018 |
| Description | Industry partnerships |
| Organisation | Hvivo PLC |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Partnerships with Antigen Discovery Inc and SGS Life Sciences are a direct funding relationship - both are collaborators on pump-priming grants. The other industry partners have attended HIC-Vac meetings (Kick-off meeting, innovation sandpit and first annual general meeting) contributing expertise and exploring potential new collaborations. |
| Collaborator Contribution | Industry expertise in collaboration with academic partners to achieve research outputs as defined in the pump-priming applications. Collaborators on further grants (ReSViTRAIN, GSK) |
| Impact | 2 pump priming awards, 1 further award resulting from Network activities. |
| Start Year | 2018 |
| Description | Industry partnerships |
| Organisation | Janssen Pharmaceutica NV |
| Country | Belgium |
| Sector | Private |
| PI Contribution | Partnerships with Antigen Discovery Inc and SGS Life Sciences are a direct funding relationship - both are collaborators on pump-priming grants. The other industry partners have attended HIC-Vac meetings (Kick-off meeting, innovation sandpit and first annual general meeting) contributing expertise and exploring potential new collaborations. |
| Collaborator Contribution | Industry expertise in collaboration with academic partners to achieve research outputs as defined in the pump-priming applications. Collaborators on further grants (ReSViTRAIN, GSK) |
| Impact | 2 pump priming awards, 1 further award resulting from Network activities. |
| Start Year | 2018 |
| Description | Industry partnerships |
| Organisation | SGS Life Sciences Ltd |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | Partnerships with Antigen Discovery Inc and SGS Life Sciences are a direct funding relationship - both are collaborators on pump-priming grants. The other industry partners have attended HIC-Vac meetings (Kick-off meeting, innovation sandpit and first annual general meeting) contributing expertise and exploring potential new collaborations. |
| Collaborator Contribution | Industry expertise in collaboration with academic partners to achieve research outputs as defined in the pump-priming applications. Collaborators on further grants (ReSViTRAIN, GSK) |
| Impact | 2 pump priming awards, 1 further award resulting from Network activities. |
| Start Year | 2018 |
| Description | Industry partnerships |
| Organisation | Sanofi |
| Department | Sanofi Research Division |
| Country | France |
| Sector | Private |
| PI Contribution | Partnerships with Antigen Discovery Inc and SGS Life Sciences are a direct funding relationship - both are collaborators on pump-priming grants. The other industry partners have attended HIC-Vac meetings (Kick-off meeting, innovation sandpit and first annual general meeting) contributing expertise and exploring potential new collaborations. |
| Collaborator Contribution | Industry expertise in collaboration with academic partners to achieve research outputs as defined in the pump-priming applications. Collaborators on further grants (ReSViTRAIN, GSK) |
| Impact | 2 pump priming awards, 1 further award resulting from Network activities. |
| Start Year | 2018 |
| Description | Feature in the FT |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A feature in the FT discussing the ethics of human challenge studies. Article behind a paywall https://www.ft.com/content/1f8ad850-037b-11e9-99df-6183d3002ee1 |
| Year(s) Of Engagement Activity | 2018 |
| Description | HIC VAC Video in conjunction with Luke Hanrahan |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | HIC Vac Video (more information to be added) |
| Year(s) Of Engagement Activity | 2023 |
| Description | HIC-Vac Independent Scientific Advisory Board (ISAB) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | - Established the HIC-Vac ISAB, with formal Terms of Reference. - Membership is Fred Hayden (US, Chair), Camille LOCHT (France) and Richard Moxon (UK). - ISAB members participated in scoring process for first pump-priming awards round and will meet by teleconference on 1st April, subsequently producing a short report for MRC on scientific and management progress of the HIC-Vac Network. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.hic-vac.org/members/network-management-board/scientific-advisory-board |
| Description | HIC-Vac Twitter channel |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Creation of a Twitter feed to share information including funding calls and publications with our Network. Now 410 followers. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://twitter.com/hic_vac |
| Description | HIC-Vac member conferences and events |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Six events have taken place to engage HIC-Vac members and encourage networking and collaborations: the Kickoff meeting (Nov 2017), the Innovation Sandpit (June 2018), the Annual General Meetings (Nov 2018 (Liverpool), 2019 (Windsor), 2021 (Chalfont), 2022 (Guidlford)). |
| Year(s) Of Engagement Activity | 2017,2018,2019,2021,2022 |
| Description | HIC-Vac website creation and development |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Creation and development of an independent HIC-Vac website. Audience is primarily researchers, but also inclusive of a section for public information. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.hic-vac.org/ |
| Description | Imperial Science Festival |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | HIC-Vac ran a stall at the Imperial Science Festival to discuss human infection studies with the public and run some engagement activities. Also an activity about vaccines for children. |
| Year(s) Of Engagement Activity | 2018 |
| Description | MRC press release to announce HIC-Vac first funding round |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The MRC (our primary funder) wrote a press release describing our activities and our first round of funding announcement. The story was covered by the Telegraph https://www.telegraph.co.uk/science/2018/07/02/volunteers-infected-deadly-strain-flu-make-vaccine-better/ and Daily Mail https://www.dailymail.co.uk/health/article-5913445/Would-flu-science-10-volunteers-given-deadly-H3N2-strain-summer.html. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://mrc.ukri.org/news/browse/funding-boost-for-volunteer-infection-studies-to-help-combat-infect... |
| Description | Participant videos |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Creation of short videos featuring volunteers who have taken part in human infection studies for the website and social media channels. The videos have also been shared by the institutes who ran the studies. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.hic-vac.org/public-information/participants-stories |
| Description | Telegraph feature |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Feature in the Telegraph naming HIC-Vac and quotes from Co-Director Prof Pollard and member Dr Andrea Collins. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.telegraph.co.uk/news/0/students-paid-3500-catch-potentially-deadly-diseases-science/ |
| Description | The Global Health Network Platform |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Development of a platform to share resources, information and best practice linked to human challenge studies internationally, with a particular focus on supporting LMICs setting up new challenge studies. Site still being developed. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://humaninfectionstudies.tghn.org/ |