Promoting Innovation and Collaboration: Translational Medicine in Exeter 2 (PICTME2)

Lead Research Organisation: University of Exeter

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding.

Publications

10 25 50
 
Description Welcome Trust Strategic Award, seed-corn project (round 7): Estimation of volume and morphological abnormalities in larval zebrafish using machine learning
Amount £10,000 (GBP)
Organisation University of Exeter 
Sector Academic/University
Country United Kingdom
Start 01/2020 
End 06/2020
 
Title Estimation of volume and morphological abnormalities in larval zebrafish using machine learning 
Description We have integrated a Welcome Trust Strategic Award, seed-corn project (round 7): 'Estimation of volume and morphological abnormalities in larval zebrafish using machine learning' (Jan 2020 for 6 months). This utilises the combined expertise in zebrafish biology and programming skills and machine learning to develop software to create an automated approach to scoring some aspects of developmental phenotyping in zebrafish 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2020 
Provided To Others? No  
Impact We have integrated a Welcome Trust Strategic Award, seed-corn project (round 7): 'Estimation of volume and morphological abnormalities in larval zebrafish using machine learning' (Jan 2020 for 6 months). This utilises the combined expertise in zebrafish biology and programming skills and machine learning to develop software to create an automated approach to scoring some aspects of developmental phenotyping in zebrafish 
 
Description Determining tissue uptake and retention of lead compounds identified for improving organ / tissue preservation and transplantation 
Organisation Bridge to Life
Country United States 
Sector Private 
PI Contribution £44,952 in directly incurred costs for this project. Breakdown includes: -Synthesis of labelled compounds, throughout -CARS/spectroscopy reagents, microscopy consumables (filters, polarisers and a replacement objective) -Consumables/Animal costs (UoE)- husbandry contributions to Drs. Oltean and Koeners; use of their facilities to harvest organs, contribution to animal disposal/running costs etc -Consumables/animal cost- Prof. Alp Sener's group - surgical training in organ removal, preservation and transplantation -Cell culture (renal cell lines) and mitochondrial isolation from rat organs -Staff time for 6 months. F34 @ 1.0 FTE -Staff time for 6 months, F34 @ 0.2 FTE
Collaborator Contribution -B2L: UW fluid for organ preservation experiments will be provided gratis (In-kind) -B2L:Consultancy costs (in-kind) -B2L: cash contributions for travel and subsistence for training/upskilling -Training/upskilling: Travel to the Matthew Mailing Centre for Translational Transplant Studies, University of Western Ontario, Canada / Prof. Alp Sener's laboratory/group up to 2 weeks - economy airfare, hotel with breakfast, meals - to learn transplant procedure which will be modelled at UoE as well as watch human kidney transplant surgery (in-kind). Prof. Sener time in-kind:
Impact Project ongoing
Start Year 2019
 
Description Developing a 'from blood' T1D-GRS biochip 
Organisation Randox Laboratories
Country Global 
Sector Private 
PI Contribution £44,885 directly incurred costs: -10 months 100% FTE PDRA 1st Feb - 30th Nov 2020 -Commercially available 'from blood' T1D-GRS reagents and consumables -Travel budget for PDRA to work at Randox for a month
Collaborator Contribution £44,885 in kind contributions: -10 months salary for Randox employees working on 'from blood' T1D-GRS methods -Consumables: 'from blood' T1D-GRS reagents developed and manufactured by Randox
Impact Currently ongoing
Start Year 2020
 
Description Developing a novel genotyping tool to improve diagnosis and clinical management of inherited disease 
Organisation PlexSeq Diagnostics
Country United States 
Sector Private 
PI Contribution £22,000 directly incurred costs + in-kind contributions: -Consumables for test development in Exeter -30% Technician over 1 year
Collaborator Contribution £62,250 in kind contributions: -PlexSeq consultancy fees and staff costs for platform development -PlexSeq consumable and machine running costs for platform development
Impact Currently ongoing
Start Year 2020
 
Description Development of a novel assay for the early detection of drug induced limb malformation. 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution £24,656 directly incurred costs: -130 days staff time -60 days staff time -20 days staff time -Associated costs for travel/secondment
Collaborator Contribution £32,100 ($40,000) cash contributions for the following costs: -130 days staff time -60 days staff time -20 days staff time -qPCR consumables £10,000 in kind contributions: -Molecular biology reagents
Impact Currently ongoing
Start Year 2020
 
Description Identifying physical activity and physical function characteristics that are important to patient related outcomes following total knee replacement surgery based on wrist worn accelerometer data 
Organisation Activinsights
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Directly incurred costs (£43,334): -PDRA 12 Months 100% FTE -T&S and Accommodation for PDRA to Activinsights -T&S and Accommodation for Activinsights to Visit Exeter
Collaborator Contribution £34,608 in-kind contributions: -Equipment (20 devices for measurement) -Staff member 1 (Activinsights) 7.5%f te over 12 months -Staff member 2 (Activinsights) 3% fte over 12 months -Staff member 3 (Activinsights) 3%fte over 12 months -Staff member 4 (Activinsights) 5%f te over 12 months
Impact Project currently ongoing.
Start Year 2019
 
Description Chemicals and Environmental Health. Waking up to Planetary Health 2020. Royal Devon and Exeter Hospital and the University of Exeter Medical School. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Prof Tyler was invited to be a keynote speaker at Chemicals and Environmental Health. Waking up to Planetary Health 2020. Royal Devon and Exeter Hospital and the University of Exeter Medical School.
Year(s) Of Engagement Activity 2020
 
Description Endocrine Disrupting Chemicals and Chemicals of Environmental Concern. The 22nd UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Prof Tyler was invited to give the opening address at the Endocrine Disrupting Chemicals and Chemicals of Environmental Concern. The 22nd UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals.
Year(s) Of Engagement Activity 2020
 
Description South West Zebrafish Meeting University of Bristol (Tyler, Winter and Ball) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact A talk/presentation - South West Zebrafish Meeting University of Bristol (Tyler, Winter and Ball)
Year(s) Of Engagement Activity 2020