University of Oxford Confidence in Concept – Round 7
Lead Research Organisation:
University of Oxford
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding
Organisations
People |
ORCID iD |
Matthew Wood (Principal Investigator) |
Publications
Brook M
(2019)
New frontiers: cellular immunotherapy beyond cancer
in Cell and Gene Therapy Insights
Alzhrani A
(2020)
Identification, selection, and expansion of non-gene modified alloantigen-reactive Tregs for clinical therapeutic use.
in Cellular immunology
Peddle CF
(2020)
CRISPR Interference-Potential Application in Retinal Disease.
in International journal of molecular sciences
Fry LE
(2020)
Promoter Orientation within an AAV-CRISPR Vector Affects Cas9 Expression and Gene Editing Efficiency.
in The CRISPR journal
Kantor A
(2020)
CRISPR-Cas9 DNA Base-Editing and Prime-Editing.
in International journal of molecular sciences
Kaiser D
(2021)
Freezing Medium Containing 5% DMSO Enhances the Cell Viability and Recovery Rate After Cryopreservation of Regulatory T Cell Products ex vivo and in vivo.
in Frontiers in cell and developmental biology
Mohseni YR
(2021)
Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive.
in European journal of immunology
Fry LE
(2021)
Analysis of Pathogenic Variants Correctable With CRISPR Base Editing Among Patients With Recessive Inherited Retinal Degeneration.
in JAMA ophthalmology
Kantor A
(2021)
CRISPR genome engineering for retinal diseases.
in Progress in molecular biology and translational science
Issa F
(2021)
The Fourth International Workshop on Clinical Transplant Tolerance.
in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hoogduijn MJ
(2021)
Cellular therapies in organ transplantation.
in Transplant international : official journal of the European Society for Organ Transplantation
Quinn J
(2021)
Genome-Editing Strategies for Treating Human Retinal Degenerations.
in Human gene therapy
Hennessy C
(2021)
Recent advances in our understanding of the allograft response.
in Faculty reviews
Stark HL
(2021)
Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?
in Frontiers in immunology
Adigbli G
(2021)
Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis In Vivo.
in Frontiers in immunology
Leng H
(2022)
Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease
in Nature Communications
Kaukonen M
(2022)
CRISPR DNA Base Editing Strategies for Treating Retinitis Pigmentosa Caused by Mutations in Rhodopsin
in Genes
Staurenghi F
(2022)
Minicircle Delivery to the Neural Retina as a Gene Therapy Approach.
in International journal of molecular sciences
Wing PAC
(2022)
Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model.
in PLoS pathogens
Bottomley MJ
(2022)
Towards regulatory cellular therapies in solid organ transplantation.
in Trends in immunology
Stevanovic M
(2022)
CRISPR Systems Suitable for Single AAV Vector Delivery.
in Current gene therapy
Zamora M
(2022)
DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy
in Experimental Neurology
Hansen S
(2023)
Future Perspectives of Prime Editing for the Treatment of Inherited Retinal Diseases
in Cells
Leng H
(2023)
Blocking glycosphingolipid production alters autophagy in osteoclasts and improves myeloma bone disease.
in Autophagy
Issa F
(2023)
IL-21-producing Alloreactive T Cells Expand in Parallel to Donor-specific Antibodies.
in Transplantation
Deli A
(2023)
The Design of Brainstem Interfaces: Characterisation of Physiological Artefacts and Implications for Closed-loop Algorithms.
in International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering
O'Neil A
(2023)
A GMP Protocol for the Manufacture of Tregs for Clinical Application.
in Methods in molecular biology (Clifton, N.J.)
Lim T
(2023)
Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans
in Journal of Hepatology
Cross A
(2023)
Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury
in JCI Insight
Hennessy C
(2023)
Barriers to Treg therapy in Europe: From production to regulation.
in Frontiers in medicine
Description | BRAINSTATE - To develop the DyNeuMo device for use in minimally conscious state (Alex Green) |
Amount | £697,119 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2022 |
End | 07/2025 |
Description | Developing CRISPR delivery strategies for the treatment of inherited retinal diseases |
Amount | £60,000 (GBP) |
Organisation | The Royal College of Surgeons of Edinburgh |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 10/2020 |
End | 09/2021 |
Description | ReSHAPE |
Amount | £151,875 (GBP) |
Funding ID | 825392 |
Organisation | European Commission H2020 |
Sector | Public |
Country | Belgium |
Start | 01/2019 |
End | 12/2023 |
Description | Experts in Residence meeting with Astra Zeneca |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Industry/Business |
Results and Impact | The purpose of the session was to discuss the longer term translational implications of the project via the experts in residence scheme. A wealth of information was transmitted to our research team on the validation routes for the project and how to consolidate the engagement and the collaboration prospects on this award. |
Year(s) Of Engagement Activity | 2020 |
Description | Industry engagement activities with Kymab / Sanofi |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | The project team has been discussing a collaboration project with Kymab / Sanofi. |
Year(s) Of Engagement Activity | 2020 |
Description | Industry engagement activities with UCB Pharma - (Alison Simmons) |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Industry/Business |
Results and Impact | Discussing potential licensing agreement, pending data from larger sets of efficacy studies and safety/toxicology profiling of our monoclonal antibodies. |
Year(s) Of Engagement Activity | 2021 |