ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C)
Lead Research Organisation:
University of Edinburgh
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
This award is being made in support of urgent research costs to enable sampling amongst UK COVID-19 cases. This is essential in developing diagnostics, therapeutics (monoclonal antibodies) and understanding the pathogen and the natural history of the disease, as well as developing rapid prognostic tools. This funding support will ensure samples are distributed safely to researchers. Research could change the course of the rapidly spreading outbreak.
Organisations
Publications
Adams E
(2020)
Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel
in Wellcome Open Research
Adler H
(2022)
Clinical features and management of human monkeypox: a retrospective observational study in the UK.
in The Lancet. Infectious diseases
Adler H
(2022)
Clinical features and management of human monkeypox: a retrospective observational study in the UK.
in The Lancet. Infectious diseases
Andersson M
(2020)
SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus
in Wellcome Open Research
Andersson MI
(2020)
SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus.
in Wellcome open research
Ansari M
(2021)
In vivo negative regulation of SARS-CoV-2 receptor, ACE2, by interferons and its genetic control
in Wellcome Open Research
Cho SM
(2023)
Neurological manifestations of COVID-19 in adults and children.
in Brain : a journal of neurology
| Title | Dawn, on the Morning After the Storm |
| Description | Dawn, on the Morning After the Storm, is a new work by composer Zakiya Leeming, who has been collaborating with health data researchers since 2018 to create music informed by their work. All performances were recorded independently in lockdown conditions and then compiled by the composer. The piece is a result of discussions with UK members of the global International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) and COVID-19 Clinical Information Network about their experiences working through the COVID-19 outbreak. ISARIC4C, led by investigators from the University of Edinburgh, University of Liverpool and Imperial College London, is recognised as the sovereign COVID-19 research programme to meet urgent public health needs for the UK. It is a collaboration of over 200 scientists from 11 institutions and NHS teams from 350 hospitals. Outputs from the project have informed the UK's response to the current pandemic, based on data and biological samples from patients in hospitals across the UK, and it is one of the largest COVID-19 projects in the world. When Leeming asked ISARIC4C Chief Investigator, Professor Calum Semple OBE, what a piece about his experience should describe, Semple replied, 'Like Dawn, on the morning after the storm'. For Semple, it was about coming together to play, in the same way the consortium came together to respond to the challenge of the virus. The performance was followed by a recorded discussion between the composer and ISARIC performers. |
| Type Of Art | Performance (Music, Dance, Drama, etc) |
| Year Produced | 2021 |
| Impact | 637 views and was streamed live from the Royal Northern College of Music on 17 Jun 2021 |
| URL | https://youtu.be/e0l3S04TfFY |
| Description | Contributed regularly to Scientific Advisory Group for Emergencies (SAGE) COVID-19 Response from meeting 20 in March 2020 to Meeting 105 in February 2022 |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Targeted improvements in Infection prevention control Optimised roll out of vaccination Identified people most at risk of severe disease, likely to deteriorate and die. Explored impact of co-morbidity. Studies associations between ethnicity and outcome. |
| URL | https://www.gov.uk/government/collections/scientific-evidence-supporting-the-government-response-to-... |
| Description | Member of NERVTAG |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Our analysis informed vaccine prioritisation schedules, with two citations in Chapter 14A of The Green Book "Coronavirus (COVID-19) vaccination information for public health professionals." See Docherty AB et al BMJ 2020 and Swann OV et BMJ 2020 We developed the most widely used risk stratification tool to better identify those people at risk of death and deterioration. We allowed target intervention at sites where nosocomial infection rates were high. |
| URL | https://www.gov.uk/government/publications/covid-19-the-green-book-chapter-14a |
| Description | Two of the research team are represented on two Department of Health Advisory groups. The New Emerging Respiratory Viral Threat Advisory Group (MGS on NERVTAG) and the Antimicrobial Resistance Modelling Group (MGS & PM) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Identification of risk groups and their prioritization for vaccination. |
| URL | https://www.gov.uk/government/publications/technical-report-on-the-covid-19-pandemic-in-the-uk |
| Description | A UK underpinning platform to study immunology and immunopathology of COVID-19:The UK Coronavirus Immunology Consortium |
| Amount | £6,552,119 (GBP) |
| Funding ID | MR/V028448/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 12/2022 |
| Description | Clinical Characterisation of COVID-19 admitted to hospitals in the United Kingdom |
| Amount | £8,948,758 (GBP) |
| Funding ID | CO-CIN-01 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 11/2023 |
| Description | ISARIC Clinical Characterisation Protocol UK (CCP-UK) - a companion study for patients with Cancer and COVID-19 (CCP-CANCER-UK) |
| Amount | £344,930 (GBP) |
| Funding ID | MR/V028979/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 03/2022 |
| Description | Non-hospitalised Children & young people (CYP) with Long Covid (The CLoCk Study) |
| Amount | £680,000 (GBP) |
| Funding ID | MC_PC_20052 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 02/2024 |
| Description | OpenSAFELY, ISARIC, PHOSP: tracking consequences of COVID-19 infection across UK primary and secondary care. |
| Amount | £613,528 (GBP) |
| Funding ID | MR/W016729/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 08/2023 |
| Description | PHOSP-COVID Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes |
| Amount | £8,532,684 (GBP) |
| Funding ID | MR/V027859/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 08/2026 |
| Description | The UK Interstitial Lung Disease Long-COVID19 study (UKILD-Long COVID): understanding the burden of Interstitial Lung Disease in Long COVID. |
| Amount | £2,014,983 (GBP) |
| Funding ID | MR/W006111/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 08/2023 |
| Title | GenOMICC sample repository |
| Description | A sample repository comprising DNA from GenOMICC cases |
| Type Of Material | Biological samples |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Discovery of 41 genetic associations with critical Covid-19. Prediction of therapeutic efficacy for barcitinib. Inclusion of baricitinib in RECOVERY trial, leading to new effective therapy for Covid-19 |
| URL | http://genomicc.org/data |
| Title | Outbreak data analysis platform (ODAP) |
| Description | Scope: The purpose of the ODAP is to facilitate biomedical research to advance understanding of disease caused by emerging or re-emerging pathogens* or other exposures** of public health interest. Research within the ODAP is strictly limited to this purpose. *Emerging or re-emerging pathogens of public health interest: this term describes new infectious agents, and new, re-emerging or therapy-resistant forms of existing infectious agents. **Other exposures of public health interest: this term describes new or unexplained poisoning, or exposure to harmful energy sources such as electromagnetic radiation. What it is: The purpose of the outbreak data analysis platform is to provide an accessible, usable data resource to enable research relevant to COVID-19 and future outbreaks. This will accelerate scientific understanding of new outbreaks for the benefit of patients and the protection of the public. It will create a UK-wide capability by curating and linking outbreak relevant data from clinical records, research studies and audit data. It brings together key initiatives and leadership across the UK including ISARIC, COG-UK, MRC CLIMB and GenOMICC. The platform combines a national Trusted Research Environment (TRE) infrastructure collocated with >£100M of world-class computational and data science capacity including the UK National Supercomputer, with a UK-wide governance framework. |
| Type Of Material | Data handling & control |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | We have served 138 data access requests, resulting in secondary use, multiple following grant awards and collaborations including pharma some of which have already been published |
| URL | https://docs.google.com/spreadsheets/d/1EFmp9HEKyZiaJXb1YbW4lXvsuu8wQe9F7_CzUK12eA4/edit#gid=0 |
| Title | Clinical Guidelines Browser |
| Description | This is a web interface to be able to browse clinical hospital guidelines in the UK. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2020 |
| Impact | This document browsing system was initially developed as part of Work Package 8 (Facilitating translation to local clinical guidelines) of the ISARIC4C consortium, with the intention of creating a searchable collection of clinical guidelines.. Building on this work, a new version of this tool but applied to SAGE and NERVTAG meeting minutes has been made available. |
| URL | https://clinicalguidelines.net |
| Description | Alastair Stewart & Friends; Guest Interview on |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Discussion on COVID-19 impact on society |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.imdb.com/title/tt14844278/?ref_=nm_flmg_slf_1 |
| Description | Kay Burley Sky News: Interview |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Updates on science of COVID-19 and impact of medicines, vaccinations, behavioural change |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| URL | https://www.imdb.com/name/nm11426855/?ref_=nv_sr_srsg_1 |