Edinburgh – Confidence in Concept 2019
Lead Research Organisation:
University of Edinburgh
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding.
People |
ORCID iD |
Publications
Ferreira-Gonzalez S
(2022)
Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage.
in Science translational medicine
| Description | Golem: A disruptive platform to access and interactively analyse genetic data |
| Amount | £288,694 (GBP) |
| Funding ID | 10001080 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2022 |
| Description | Grant for marketing content |
| Amount | £23,250 (GBP) |
| Organisation | Scottish Enterprise |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Metabolic photosensitizers for photodynamic therapy of brain cancer. |
| Amount | £600,137 (GBP) |
| Funding ID | EP/W015706/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 02/2025 |
| Description | Non-invasive monitoring of human pluripotent stem cell differentiation into midbrain dopaminergic neural cells |
| Amount | £633,616 (GBP) |
| Funding ID | MR/V00560X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 10/2023 |
| Description | Old College Capital (Canela Xandri) |
| Amount | £15,000 (GBP) |
| Organisation | University of Edinburgh |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | PhD studentship |
| Amount | € 55,000 (EUR) |
| Organisation | European Society for Organ Transplantation (ESOT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Research Excellence and Acceleration Award (REA) Institutional grant |
| Amount | £24,741 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2022 |
| End | 03/2023 |
| Description | Robertson Trust Fellowship |
| Amount | £60,000 (GBP) |
| Organisation | The Royal College of Surgeons of Edinburgh |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2022 |
| End | 03/2023 |
| Description | Scottish Enterprise funding |
| Amount | £75,000 (GBP) |
| Organisation | Scottish Enterprise |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Sequencing grant |
| Amount | £3,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Human Genetics Unit |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | iCURE phase 1 (Canela Xandri) |
| Amount | £29,022 (GBP) |
| Organisation | ICURE Pharm |
| Sector | Private |
| Country | Korea, Republic of |
| Start | |
| Description | iCURE phase 2 (Canela Xandri) |
| Amount | £20,000 (GBP) |
| Organisation | ICURE Pharm |
| Sector | Private |
| Country | Korea, Republic of |
| Start | |
| Title | OCT-based elastography method to measure differences between healthy and fibrotic tissue |
| Description | We have demonstrated the use of an OCT-based elastography method, developed in our lab, to measure differences between healthy and fibrotic tissue. This has open the path towards novel in vitro, ex-vivo applications, and pilot data to fund a device for in vivo measurements. |
| Type Of Material | Biological samples |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Nothing to report yet. |
| Description | Amazon (Canela Xandri) |
| Organisation | Amazon.com |
| Department | Amazon UK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Research and project idea |
| Collaborator Contribution | Unknown |
| Impact | No outcomes to date |
| Start Year | 2021 |
| Description | Epidarex Capital - Investment in Kynos Therapeutics |
| Organisation | Epidarex |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | UoE founders of Kynos Therapeutics - Damian Mole and Scott Webster |
| Collaborator Contribution | Investment into Kynos Therapeutics |
| Impact | Company is building executive and management team. |
| Start Year | 2022 |
| Description | Heriot Watt University |
| Organisation | Heriot-Watt University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research idea |
| Collaborator Contribution | Expertise |
| Impact | Nothing to report |
| Start Year | 2021 |
| Description | Innovate UK funding into Kynos |
| Organisation | Innovate UK |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Spin out company from UoE researchers/founders |
| Collaborator Contribution | Investment into spin out company, Kynos Therapeutics |
| Impact | Building executive and management team |
| Start Year | 2022 |
| Description | Roche Research Evaluation Agreement |
| Organisation | Roche Pharmaceuticals |
| Country | Global |
| Sector | Private |
| PI Contribution | CoDE-HF project |
| Collaborator Contribution | A Research Evaluation Agreement between UoE and Roche is set up to enable Roche Data Scientists to evaluate the potential of CoDE-HF as a companion AI clinical decision support tool to their NT-proBNP assay. This could represent a potential future licensing opportunity with Roche taking on regulatory approval and marketing of CoDE-HF. |
| Impact | No outcomes to date - agreement newly signed |
| Start Year | 2023 |
| Description | Torcis collaboration |
| Organisation | Bio-Techne Ltd |
| Department | Tocris |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Project idea/reagents |
| Collaborator Contribution | Tocris acquired non-exclusive license for commercialisation of lab reagents |
| Impact | No impact to date |
| Start Year | 2022 |
| Description | University of Bath |
| Organisation | University of Bath |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research project |
| Collaborator Contribution | Expertise |
| Impact | No outcomes to report as yet |
| Start Year | 2021 |
| Title | SMALL MOLECULE PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY |
| Description | The invention relates to small photosensitizers, their process of preparation and uses of the compounds in optical imaging and photodynamic therapy. The invention provides a compound of formula (I), a derivative or a salt thereof Wherein R1 is selected from the group consisting of amines, anilines, phenols, thiophenols, selenols and aryl groups; R2 and R3 independently are H or halogen; R4 is selected from the group consisting of H, nitre and cyano: and R5 and R6 independently are either absent or oxygen or methyl. |
| IP Reference | WO2020187913 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2020 |
| Licensed | No |
| Impact | Non exclusive license to Torcis for photosensitizers developed during this project to commerialise as research reagents Funding approved for filing in EU and US. |
| Company Name | Omecu Ltd |
| Description | Business and domestic software development Aims to democratise genetic data access and cut from days to minutes the time it takes to analyse millions of genetic records. Wide-ranging benefits in drug discovery and personalised medicine, while improving patient data security. |
| Year Established | 2021 |
| Impact | Company is new and no impacts to date |
| Company Name | KYNOS THERAPEUTICS LTD |
| Description | Research and experimental development on biotechnology |
| Year Established | 2020 |
| Impact | No impacts to date |
| Description | Invited lectures at Imperial College London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | 2022-2023. Invited lectures in 'IACE: Industrial Applications of Cellular Engineering'. Faculty of Engineering, Department of Bioengineering Imperial College London, UK |
| Year(s) Of Engagement Activity | 2022 |