Liverpool – Confidence in Concept 2019

Lead Research Organisation: University of Liverpool
Department Name: UNLISTED


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Technical Summary

The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding.
Description Biochemical Toolkit for Discovery and Optimisation of Fungal Thioredoxin Reductase Inhibitors (University of Liverpool - University of Exeter) 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Tao You will construct an in vitro PK/PD model to recapitulate the relationships among PK - target engagement - disease modulation (cell cycle distribution / apoptosis biomarkers). Tao You will qualify and refine PK/PD modelling. Based on the PK/PD modelling work, Xiao-Ling Cockcroft and Tao You will optimise. Tao You will perform PK/PD modelling to support human dose selection.
Collaborator Contribution Steven Bates will help produce and purify thioredoxin reductase protein (Trr1 protein) from medically important fungal pathogens, including Aspergillus fumigatus, Candida auris, Candida albicans and Candida glabrata.
Impact To follow when outputs and outcomes of the work have been reported on.
Start Year 2022