MRC Pandemic Preparedness Funding – The Francis Crick Institute
Lead Research Organisation:
The Francis Crick Institute
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
This funding will enable the Institute to address two major aims:
i) understanding the coronavirus pathogen, including viral assembly, host factors and exploitation of structural components for the development of therapeutic targets; and
ii) understanding the features of host response to infection that shape protective or pathological responses and defining correlates of immunity and immune pathology.
i) understanding the coronavirus pathogen, including viral assembly, host factors and exploitation of structural components for the development of therapeutic targets; and
ii) understanding the features of host response to infection that shape protective or pathological responses and defining correlates of immunity and immune pathology.
People |
ORCID iD |
| Stephane Maikovsky (Principal Investigator) |
Publications
Alrubayyi A
(2021)
Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV.
in Nature communications
Arulkumaran N
(2021)
Influence of IL-6 levels on patient survival in COVID-19.
in Journal of critical care
Arulkumaran N
(2021)
Defining Potential Therapeutic Targets in Coronavirus Disease 2019: A Cross-Sectional Analysis of a Single-Center Cohort.
in Critical care explorations
Arulkumaran N
(2021)
Sex differences in immunological responses to COVID-19: a cross-sectional analysis of a single-centre cohort
in British Journal of Anaesthesia
Au L
(2021)
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2.
in Nature medicine
Basu S
(2021)
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase.
in The Biochemical journal
Benton DJ
(2021)
The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2.
in Proceedings of the National Academy of Sciences of the United States of America
Bertolin AP
(2021)
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase.
in The Biochemical journal
Buck MD
(2021)
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay.
in Wellcome open research
Canal B
(2021)
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease.
in The Biochemical journal
| Description | COVID 2019 consortium |
| Organisation | University College London Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Funding supported work of the consortium of University College London Hospitals, Health Services Laboratory (HSL), the Institute of Cancer Research and the Francis Crick Institute to research on COVID-19. |
| Collaborator Contribution | It allow for research on the effect of vaccines and testing. |
| Impact | Has resulted in 39 paper which are listed in this award. Has formed closer bonds between academics and clinicians. |
| Start Year | 2020 |