MRC Lifecourse Epidemiology Centre - Core Support

Lead Research Organisation: University of Southampton
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

MRC Lifecourse Epidemiology Centre: Technical Summary

Overview
The MRC will use lifecourse epidemiological methods to reduce the population burden of chronic musculoskeletal disease and disability. These approaches will optimize musculoskeletal health (bone, muscle and joint) through the development and testing of lifestyle, behavioural and pharmacological interventions informed by a series of observational studies; and by using these findings to influence health policy.

The specific aims of the MRC Lifecourse Epidemiology Centre will be to:
• Delineate the environmental influences, throughout the lifecourse, of age-related musculoskeletal diseases (osteoporosis, osteoarthritis and sarcopenia).
• Use findings to develop and test population based and targeted interventions to improve musculoskeletal health throughout the lifecourse.
• Maintain and develop the long-term cohorts/trials assembled in Southampton as national and international resources to explore the mechanisms underlying the developmental origins and later causes of musculoskeletal and metabolic health and disease.
• Minimise the adverse impact of musculoskeletal disorders on ability to work, by undertaking a programme running alongside the Versus Arthritis-MRC Centre for Musculoskeletal Health and Work.
• Provide data management and statistical support for a series of preconceptual and pregnancy-based cardiometabolic intervention studies maintained at the fore-running MRC Lifecourse Epidemiology Unit (HeLTI, TALENT, NiPPeR, EACH-B and WRAPPED).
• Inform health policy and promote training, research capacity development, knowledge transfer and public engagement in lifecourse epidemiology.
The aims of the MRC Lifecourse Epidemiology Centre will be delivered through three linked scientific programmes:

1. Musculoskeletal health in later life (PI: Professor Cyrus Cooper)
2. Determinants of musculoskeletal health in the mid-lifecourse (PI: Professor Karen Walker-Bone)
3. Early development and risk of adult musculoskeletal disease (PI: Professor Nicholas Harvey)

People

ORCID iD

Publications

10 25 50

publication icon
Barnsley J (2021) Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people. in Aging clinical and experimental research

 
Description European guidance on very high fracture risk (NCH, CC)
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
 
Description National Osteoporosis Guideline Group Advisory Committee (NCH, CC)
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Nutritional determinants of skeletal development and bone loss: an investigation using a novel computer vision assessment of bone microarchitecture
Amount £36,000 (GBP)
Organisation University of Southampton 
Sector Academic/University
Country United Kingdom
Start 09/2022 
End 09/2025
 
Description Preventing broken bones in older people: from research to policy to practice
Amount £29,566 (GBP)
Funding ID MRF-145-0011-DG-HARV-C0913 
Organisation Medical Research Council (MRC) 
Department Medical Research Foundation
Sector Charity/Non Profit
Country United Kingdom
Start 03/2022 
End 09/2022
 
Description UKRI WCL Capital funding 2020 2021 DXA and MSK Scanning Suite
Amount £216,857 (GBP)
Funding ID 4050801857 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2020 
End 03/2021
 
Title Novel seasonal adjustment for vitamin D concentrations 
Description Novel method for adjusting the vitamin D concentrations for season, independent of assays used. 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Tracking of 25-hydroxyvitamin D status during pregnancy: the importance of vitamin D supplementation. Moon RJ, Crozier SR, Dennison EM, Davies JH, Robinson SM, Inskip HM, Godfrey KM, Cooper C, Harvey NC. Am J Clin Nutr. 2015 Nov;102(5):1081-7. doi: 10.3945/ajcn.115.115295. 
 
Description ALPHABET 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation National Institute of Health and Medical Research (INSERM)
Department Center for Epidemiological and Bio Statistics Research at Sorbonne
Country France 
Sector Public 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation University College Dublin
Department School of Physics
Country Ireland 
Sector Academic/University 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation University College Dublin
Country Ireland 
Sector Academic/University 
PI Contribution WP5, bone outcomes
Collaborator Contribution Consortium
Impact Ongoing
Start Year 2017
 
Description ALPHABET 
Organisation University of Bristol
Department Biomedical Research Unit in Nutrition, Diet and Lifestyle
Country United Kingdom 
Sector Hospitals 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution WP5, bone outcomes
Collaborator Contribution Consortium
Impact Ongoing
Start Year 2017
 
Description ALPHABET 
Organisation University of South Carolina
Department Arnold School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALSPAC placenta 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Placental determinants of bone mass
Collaborator Contribution Placental determinants of bone mass
Impact Ongoing
Start Year 2013
 
Description AUGMENT UK Biobank collaboration 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution AUGMENT UK Biobank collaboration
Collaborator Contribution AUGMENT UK Biobank collaboration
Impact AUGMENT UK Biobank collaboration
Start Year 2017
 
Description AUGMENT UK Biobank collaboration 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution AUGMENT UK Biobank collaboration
Collaborator Contribution AUGMENT UK Biobank collaboration
Impact AUGMENT UK Biobank collaboration
Start Year 2017
 
Description MAVIDOS Childhood Follow up 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Recruitment to MAVIDOS 6 year follow-up in Sheffield
Collaborator Contribution Recruitment to MAVIDOS six-year follow-up in Sheffield
Impact N/A
Start Year 2016
 
Description MAVIDOS Childhood Follow-up Oxford 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Recruitment of children to MAVIDOS six-year follow-up in Oxford
Collaborator Contribution Recruitment of children to MAVIDOS six-year follow-up in Oxford
Impact N/A
Start Year 2016
 
Description MAVIDOS Oxford CVD 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Vitamin D in pregnancy and offspring cardiac structure and function
Collaborator Contribution Vitamin D in pregnancy and offspring cardiac structure and function
Impact Ongoing
Start Year 2015
 
Description SARCOFRAX 
Organisation University of Gothenburg
Country Sweden 
Sector Academic/University 
PI Contribution Developing sarcopenia outcome risk calculator
Collaborator Contribution Developing sarcopenia outcome risk calculator
Impact ongoing
Start Year 2020
 
Description SARCOFRAX 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Developing sarcopenia outcome risk calculator
Collaborator Contribution Developing sarcopenia outcome risk calculator
Impact ongoing
Start Year 2020
 
Description WHO Clinical Consortium on Health Ageing 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Contribution to World Report on Ageing and Health, and project to operationalise concept of intrinsic capacity
Collaborator Contribution Organisation of WHO workshop on intrinsic capacity
Impact WHO Global Report on Ageing and Health
Start Year 2016
 
Title PHENOTYPE PREDICTION BY DETERMINING THE METHYLATION STATUS OF GENES 
Description Phenotypic characteristics selected from obesity and/or adiposity, bone health, and cardiovascular disease, may be predicted by determining the methylation status of one or more CpG dinucleotides of the, SLC6A4, CDKN2A, FEN1 and BACH1 genes. 
IP Reference WO2015067952 
Protection Patent application published
Year Protection Granted 2015
Licensed No
Impact EpiGen Consortium
 
Title PREDICTIVE USE OF CPG METHYLATION 
Description RXRA for obesity or adiposity, body mass index and limb fat as an indicator of body fat distribution 
IP Reference EP2391730 
Protection Patent application published
Year Protection Granted 2011
Licensed No
Impact EpiGen Consortium
 
Title Phenotype prediction 
Description Detection of epigenetic alteration, especially methylation, of a gene or a combination of genes, preferably in a perinatal tissue sample such as umbilical cord, for predicting diverse phenotypic characteristics such as propensity for obesity, altered body composition, impaired cognition, low bone mineral content, neuro-behavioural problems and altered cardiovascular structure and function occurring in an individual. 
IP Reference EP2194143 
Protection Patent application published
Year Protection Granted 2010
Licensed No
Impact EpiGen Consortium
 
Description ESCEO Working Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended the ESCEO Working Group on September 9th 2022.
Year(s) Of Engagement Activity 2022
 
Description Launch of the MRC Lifecourse Epidemiology Centre & MRC National Musculoskeletal Group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact The launch of the MRC Lifecourse Epidemiology Centre and the MRC National Musculoskeletal Ageing Network was an online event.
Year(s) Of Engagement Activity 2022
URL https://us06web.zoom.us/rec/play
 
Description Presentation given at ESCEO Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus gave a presentation entitled "Optamising the prescription of oral Bisphosphonates"
Year(s) Of Engagement Activity 2022
 
Description REF 2021 University Results Presentation 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Cyrus attended the REF2021 University Results Presentation meeting on 9th May 2022.
Year(s) Of Engagement Activity 2022
 
Description Southampton Women's Survey Celebration Event 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact As part of the 50th Anniversary of the NIHR BRC, the
Southampton Women's Survey were chosen to represent
some of the research that has taken place in
Southampton. The BRC funded an evening at the City
Art Gallery in Southampton for 50 SWS participants and
their family or friends. The speakers who talked about
the study findings were Prof. Cyrus Copper, Prof Keith
Godfrey, Prof Janis Baird and Prof Hazel Inskip who
wrote and sang a song at the end of the presentation
whilst playing her ukulele. SWS staff in attendance and
who organised the logistics for the event were research
nurses, Julia Hammond, Nicole Minette, Karen McGill
and Tina Horsfall. They received requests about further
participation or involvement, the audience reported
change in views, opinions or behaviours, requests for
further information. Children were also recruited for PPI
for the BRC.
Year(s) Of Engagement Activity 2022