Programme 3: Early development and risk of adult musculoskeletal disease

Lead Research Organisation: University of Southampton

Abstract

The aim of this programme is to integrate observational epidemiology and mechanistic understanding to inform novel interventions in early life to reduce the risk of later diseases such as osteoporosis and sarcopenia. Whilst our results have already informed national guidelines (DH, NICE, Public Health England and the Scientific Advisory Committee on Nutrition), the programme will advance this work by generating discovery science to delineate underlying mechanisms and to establish the wider relevance of the findings in order to inform the successful implementation of resulting public health strategies.

Technical Summary

Scientific abstract (around 400 words – max. 3,500 characters including spaces) Summary: This programme integrates observational epidemiology and mechanistic understanding to inform novel interventions in early life and thereby to reduce the risk of later diseases such as osteoporosis and sarcopenia.
Objectives: To (a) elucidate risk factors for reduced bone and muscle accrual during growth and development; (b) thus identify potential early interventions aimed at optimizing musculoskeletal development, so maximising peak bone and muscle mass, and; (c) test these
interventions, identifying mechanisms underlying, and markers of, factors which modify efficacy.
Research plan: Our future work will therefore focus on three key areas. First, study of Southampton Women’s Survey (SWS) children in late childhood/adolescence will enable us to characterise patterns of early nutrition and growth in relation to bone mass and body composition, and specifically the potential modifying effect on the pubertal transition of the earlier growth trajectory. Where potential interventions are identified and instruments are available, studies of causal inference may be undertaken using the UK Biobank cohort to inform new randomised controlled trials. We will use novel DXA image-derived phenotypes as part of our Wellcome Trust AUGMENT Award to investigate early life influences on novel indices of adult bone health in UK Biobank. With Programmes 1 and 2, this work will be complemented by novel intergenerational studies in the Hertfordshire Cohort and SWS, assessing phenotype and health across generations. Secondly, we will investigate the replication and persistence of the finding that maternal gestational vitamin D supplementation leads to improved offspring neonatal bone mass amongst winter births, using the SPRING trial (replication) and later childhood follow-up in MAVIDOS (persistence), together with adjunctive analyses in other populations, for example in novel trials such as NiPPeR and HeLTI trials in South Africa, India and China. Lastly, using experimental medicine approaches nested within our larger intervention studies, we will delineate mechanisms by which the impact of our interventions might be maximised, in a precision medicine approach, for example elucidating the influence of genetic polymorphisms on response to vitamin D supplementation and associated bone turnover, and markers of response using epigenetic profiles.
Impact: This programme will enable us to identify new public health approaches to optimise musculoskeletal development into adulthood, and characterise mechanisms underlying/modifying these early developmental influences, to ultimately reduce the burden of musculoskeletal diseases such as osteoporosis and sarcopenia in older age.

Publications

10 25 50

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Al-Daghri NM (2021) The application of FRAX in Saudi Arabia. in Archives of osteoporosis

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Beaudart C (2022) Patient preferences for lifestyle behaviours in osteoporotic fracture prevention: a cross-European discrete choice experiment. in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

 
Description Children's Alliance National Report on Physical Health of Children and Young People
Geographic Reach National 
Policy Influence Type Participation in a national consultation
URL https://www.activehealthykids.org/2021/12/16/childrens-alliance-report-physical-health-of-children-a...
 
Description Co-authorship of Royal Osteoporosis Society APPG enquiry into FLS (NCH) 2021
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description DHSC Women's Health Strategy
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Department for Education & Department for Health & Social Care national steering group for COVID testing for children with special educational needs and disabilities
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Safe school attendance and COVID-19 literacy/support materials during the pandemic for children with special educational needs and disabilities
 
Description European guidance on very high fracture risk (NCH, CC)
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
 
Description National Osteoporosis Guideline Group Advisory Committee (NCH, CC)
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description UKHSA and MHRA Oversight and Steering Group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Effective regulation of COVID testing during the pandemic
 
Description Developmental origins of child neurodevelopment: Novel approaches to clinical risk prediction using an international metadataset.
Amount £364,324 (GBP)
Funding ID MR/V029169/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2021 
End 10/2027
 
Description Does maternal gestational vitamin D supplementation influence offspring DNA methylation in childhood?
Amount £29,984 (GBP)
Funding ID SGL023\1072 
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2020 
End 12/2021
 
Description MRC National Musculoskeletal Network
Amount £150,847 (GBP)
Funding ID MC_PC_21022 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2022 
End 02/2024
 
Description Nutritional determinants of skeletal development and bone loss: an investigation using a novel computer vision assessment of bone microarchitecture
Amount £36,000 (GBP)
Organisation University of Southampton 
Sector Academic/University
Country United Kingdom
Start 08/2022 
End 09/2025
 
Description Preventing broken bones in older people: from research to policy to practice
Amount £29,566 (GBP)
Funding ID MRF-145-0011-DG-HARV-C0913 
Organisation Medical Research Council (MRC) 
Department Medical Research Foundation
Sector Charity/Non Profit
Country United Kingdom
Start 03/2022 
End 09/2022
 
Title SPRING Trial 
Description SPRING Trial 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? No  
Impact SPRING Trial 
 
Description ALPHABET 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation National Institute of Health and Medical Research (INSERM)
Department Center for Epidemiological and Bio Statistics Research at Sorbonne
Country France 
Sector Public 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation University College Dublin
Department School of Physics
Country Ireland 
Sector Academic/University 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation University College Dublin
Country Ireland 
Sector Academic/University 
PI Contribution WP5, bone outcomes
Collaborator Contribution Consortium
Impact Ongoing
Start Year 2017
 
Description ALPHABET 
Organisation University of Bristol
Department Biomedical Research Unit in Nutrition, Diet and Lifestyle
Country United Kingdom 
Sector Hospitals 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description ALPHABET 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution WP5, bone outcomes
Collaborator Contribution Consortium
Impact Ongoing
Start Year 2017
 
Description ALPHABET 
Organisation University of South Carolina
Department Arnold School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Epigenetic determinants of bone development
Collaborator Contribution Epigenetic determinants of body composition and cognition
Impact N/A
Start Year 2016
 
Description AUGMENT UK Biobank collaboration 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution AUGMENT UK Biobank collaboration
Collaborator Contribution AUGMENT UK Biobank collaboration
Impact AUGMENT UK Biobank collaboration
Start Year 2017
 
Description AUGMENT UK Biobank collaboration 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution AUGMENT UK Biobank collaboration
Collaborator Contribution AUGMENT UK Biobank collaboration
Impact AUGMENT UK Biobank collaboration
Start Year 2017
 
Description Collaborative preconception research - HELMS 
Organisation KK Women and Childrens Hospital, Singapore
Country Singapore 
Sector Hospitals 
PI Contribution Collaboration to develop the study protocol for Healthy Early Life Moments in Singapore (HELMS), a single-arm pilot implementation model
Collaborator Contribution Collaboration to develop the study protocol for Healthy Early Life Moments in Singapore (HELMS), a single-arm pilot implementation model
Impact Multi-disciplinary obstetrics & public health
Start Year 2021
 
Description Collaborative research with the Singapore S-PRESTO study team 
Organisation Agency for Science, Technology and Research (A*STAR)
Department Singapore Institute for Clinical Sciences
Country Singapore 
Sector Academic/University 
PI Contribution Collaborative research within the Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO), a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including duration of gestation, fetal growth, metabolic and neural phenotypes in the offspring.
Collaborator Contribution Collaborative research within the Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO), a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including duration of gestation, fetal growth, metabolic and neural phenotypes in the offspring.
Impact Research publications
Start Year 2021
 
Description LifeLab Soweto 
Organisation University of the Witwatersrand
Department Wits Reproductive Health and HIV Institute
Country South Africa 
Sector Academic/University 
PI Contribution Collaboration to design, develop, deliver and evaluate an educational intervention in Soweto as part of a strategy to support the wellbeing of young people and their families.
Collaborator Contribution Collaboration to design, develop, deliver and evaluate an educational intervention in Soweto as part of a strategy to support the wellbeing of young people and their families.
Impact Multi-disciplinary health and education
Start Year 2021
 
Description LifeLab Soweto 
Organisation University of the Witwatersrand
Country South Africa 
Sector Academic/University 
PI Contribution Collaboration to design, develop, deliver and evaluate an educational intervention in Soweto as part of a strategy to support the wellbeing of young people and their families.
Collaborator Contribution Collaboration to design, develop, deliver and evaluate an educational intervention in Soweto as part of a strategy to support the wellbeing of young people and their families.
Impact Multi-disciplinary health and education
Start Year 2021
 
Description MAVIDOS Childhood Follow up 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Recruitment to MAVIDOS 6 year follow-up in Sheffield
Collaborator Contribution Recruitment to MAVIDOS six-year follow-up in Sheffield
Impact N/A
Start Year 2016
 
Description Microbial derived metabolomics collaboration 
Organisation Southampton NIHR Biomedical Research Centre in Nutrition
Country United Kingdom 
Sector Public 
PI Contribution Concept to measure microbial derived metabolomics and relate these to infantile atopic dermatitis
Collaborator Contribution Mass spectrometry and metabolomics expertise
Impact Application for an Academy of Medical Sciences Starter Grant for Clinical Lecturers
Start Year 2021
 
Description UKRI (BBSRC/MRC) UK Ageing Network 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC)
Country United Kingdom 
Sector Public 
PI Contribution MyAge (Muscle resilience across the life course: from cells to society) network - member of leadership team
Collaborator Contribution MyAge (Muscle resilience across the life course: from cells to society) network
Impact Media communication at launch: https://www.southampton.ac.uk/news/2022/03/muscle-resilience-research.page
Start Year 2022
 
Description UKRI (BBSRC/MRC) UK Ageing Network 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution MyAge (Muscle resilience across the life course: from cells to society) network - member of leadership team
Collaborator Contribution MyAge (Muscle resilience across the life course: from cells to society) network
Impact Media communication at launch: https://www.southampton.ac.uk/news/2022/03/muscle-resilience-research.page
Start Year 2022
 
Description UKRI (BBSRC/MRC) UK Ageing Network 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Public 
PI Contribution MyAge (Muscle resilience across the life course: from cells to society) network - member of leadership team
Collaborator Contribution MyAge (Muscle resilience across the life course: from cells to society) network
Impact Media communication at launch: https://www.southampton.ac.uk/news/2022/03/muscle-resilience-research.page
Start Year 2022
 
Description UKRI (BBSRC/MRC) UK Ageing Network 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution MyAge (Muscle resilience across the life course: from cells to society) network - member of leadership team
Collaborator Contribution MyAge (Muscle resilience across the life course: from cells to society) network
Impact Media communication at launch: https://www.southampton.ac.uk/news/2022/03/muscle-resilience-research.page
Start Year 2022
 
Description UKRI (BBSRC/MRC) UK Ageing Network 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution MyAge (Muscle resilience across the life course: from cells to society) network - member of leadership team
Collaborator Contribution MyAge (Muscle resilience across the life course: from cells to society) network
Impact Media communication at launch: https://www.southampton.ac.uk/news/2022/03/muscle-resilience-research.page
Start Year 2022
 
Title MAVIDOS trial vitamin D intervention 
Description Vitamin D supplementation 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Wide-scale adoption
Year Development Stage Completed 2021
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Maternal vitamin D supplementation led to greater bone mass in the offspring for winter births 
 
Title SPRING Pregnancy vitamin D supplementation trial 
Description Trial of vitamin D supplementation during pregnancy 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Wide-scale adoption
Year Development Stage Completed 2021
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Trial of vitamin D supplementation during pregnancy 
 
Description 114th Annual Meeting of the Association of Physicians 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this online meeting on 16th March 2021. This was a APAM online Inauguration. The meeting was hosted by University of Oxford.
Year(s) Of Engagement Activity 2021
URL https://aopgbi.org/
 
Description 8th IOF Asia Pacific Regional Conference Programme, IOF Regional Bangkok 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this conference, and gave a talk entitled 'Osteoporosis Management in 2021: South Asia meets Europe'.
This took place on 1st December 2021.
Year(s) Of Engagement Activity 2021
URL http://www.iof-regional.org
 
Description ASBMR online (EC) 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at ASBMR, USA
Year(s) Of Engagement Activity 2021
 
Description ASBMR-ECTS debate EC 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ASBMR-ECTS debate EC 2021
Year(s) Of Engagement Activity 2021
 
Description Academy Advisory Committee Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 21st April 2021. The meeting was attended by over 10 people.
Year(s) Of Engagement Activity 2021
URL http://www.theros.org.uk
 
Description Association for the Study of Obesity national webinar 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact "Maternal obesity and the health of the next generation", invited keynote speaker
Year(s) Of Engagement Activity 2021
 
Description BRC Science Forum Friday 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact During the current pandemic, NIHR Southampton Biomedical Research Centre hold a weekly forum to discuss the latest research. All staff with a University of Southampton login to Teams can access the recordings of these talks. Cyrus Cooper gave his talk on Lifecourse Epidemiology of Musculoskeletal Disorders on 12th January 2021.
Year(s) Of Engagement Activity 2021
URL https://web.microsoftstream.com/video/0cd14716-d313-4398-b541-52df9e72aa54?referrer=https:%2F%2Fwww....
 
Description BRC Science Forum Friday KMG 2021 - KMG 2022 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact At the BRC Science Forum Friday Professor Keith Godfrey gave a presentation from 1.30 - 2.00 p.m. This presentation was an idea for the proposed BRC Research themes for the next BRC application 2022 - 2027.
Year(s) Of Engagement Activity 2021
 
Description Blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Professor Cyrus Cooper discussed how and why we should preserve creativity in times of crisis on both a personal and professional level. Blog attached.
Blog was called Medically speaking.
Year(s) Of Engagement Activity 2021
 
Description Chair ASBMR IOF joint session at ASBMR 2021 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chair ASBMR IOF joint session at ASBMR 2021 (NCH)
Year(s) Of Engagement Activity 2021
 
Description EAG teleconference: Osteoporosis and Fragility Fractures Policy Network 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 16th September. The meeting was called 'ASBMR Secondary Fracture Prevention Initiative, Full Coalition Call'
Year(s) Of Engagement Activity 2021
URL https://www.osteopolicynetwork.org
 
Description ECTS 2021 Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper gave a presentation entitled: 'Building Bones in Young Individuals' at the ECTS 2021 Congress.
This was attended by over 100 people.
Year(s) Of Engagement Activity 2021
URL http://www.ects2021.org
 
Description Evaluation of the expanded Southampton pilot study (Phase 2) for use of saliva-based lamp testing in asymptomatic populations KMG 2021 - KMG 2022 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact The University News wrote about the report published on the evaluation of the expanded Southampton pilot study (Phase 2) for use of saliva-based lamp testing in asymptomatic populations. Final report 16th November 2020. The lead author of this report was Professor Keith Godfrey, Professor Janis Baird and Professor Mary Barker were also authors. The title of the article was "Southampton pilot demonstrates effective COVID-19 testing in school and University settings.
Year(s) Of Engagement Activity 2021
URL https://doi.org/10.5258/SOTON/P0045
 
Description FRAX Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attending a FRAX meeting, held by University of Sheffield on 4th March 2021
Year(s) Of Engagement Activity 2021
 
Description Fellowship Committee Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus attended this meeting on 10th May 2021.
There were over 100 people in attendance.
Year(s) Of Engagement Activity 2021
URL http://www.acmedsci.ac.uk
 
Description International Venice Forum: Why investing in Maternal, Newborn and Child Health (MNCH) is critical for sustainable recovery after COVID-19 - KMG 2022 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keith Godfrey gave a presentation during Theme E entitled "Test, Trace and Learn - Lessons from the COVID 19 pandemic that will guide further public health preparedness and inform health policy research going forward. there were over 100 paticipants from 40 countries taking part in this International Venice Forum: Why investing in Maternal, Newborn and Child Health (MNCH) is critical for sustainable recovery after COVID-19
Year(s) Of Engagement Activity 2021
URL https://www.fisv.org/wp-content/uploads/2021/03/Draft-Programme-Venice-MNCH-Forum.pdf
 
Description Interview Rosemary Lobley of HEQ 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper gave an interview to Rosemary Lobley of HEQ about Osteoporosis, diagnosis, prevention, and treatment. The article is from issue 16 of Health Europa.
The date of the interview was 17th February 2021.
Year(s) Of Engagement Activity 2021
URL https://www.healtheuropa.eu/osteoporosis-diagnosis-prevention-and-treatment/105953/
 
Description Invited Chair joint IOF SIBOMM session (NCH) 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Chair joint IOF SIBOMM session (NCH) 2021
Year(s) Of Engagement Activity 2021
 
Description Invited presentation BRADOO 2021 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation BRADOO 2021 (NCH)
Year(s) Of Engagement Activity 2021
 
Description Invited presentation at Belgian Bone Club 2022 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation at Belgian Bone Club 2022 (NCH)
Year(s) Of Engagement Activity 2022
 
Description Invited presentation at SICOT (NCH) 21 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation at SICOT (NCH) 21
Year(s) Of Engagement Activity 2021
 
Description Lecture at BRS Conference Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper gave a lecture entitled 'Fracture Epidemiology Across the Globe'.
This took place on 28th June 2021. Over 100 people attended.
Year(s) Of Engagement Activity 2021
URL http://www.boneresearchsociety.org
 
Description LifeLab Online 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Development of online scientific literacy & engagement resources, including relating to COVID-19 testing and transmission
Year(s) Of Engagement Activity 2021
 
Description Lister Prize Interviews 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attending this event on 19th May 2021.
Year(s) Of Engagement Activity 2021
 
Description MTP WCO (EC) 2021 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Meet The Expert session at World Congress and Osteoporosis
Year(s) Of Engagement Activity 2021
 
Description MTP WCO 2021 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Meet The Professor session at World Congress in Osteoporosis 2021
Year(s) Of Engagement Activity 2021
 
Description NIH Strategic Workshop, Preconceptional Origins of Child Health Outcomes 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact "Preconception nutrition to optimise offspring life chances", Invited Keynote Speaker
Year(s) Of Engagement Activity 2021
 
Description Nutrition Society Summer Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited keynote speaker "Maternal preconception nutrition and the life chances of the next generation"
Year(s) Of Engagement Activity 2021
 
Description Pagets Information Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper gave the Introduction speech at the Pagets Information day on 8th October 2021.
Year(s) Of Engagement Activity 2021
 
Description Presentation at 3rd World Congress on Maternal Neonatal Medicine - KMG 2022 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keith Godfrey gave a presentation entitled Periconceptional stressors at the 3rd World Congress on Maternal Neonatal Medicine. There were 1640 participants from 88 countries at this event.
Year(s) Of Engagement Activity 2021
URL https://www.mcascientificevents.eu/worldmfnm/
 
Description Presentation at BSR (EC) 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation at British Society for Rheumatology
Year(s) Of Engagement Activity 2021
 
Description Presentation at WCO 2021 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at World Congress in Osteoporosis 2021
Year(s) Of Engagement Activity 2021
 
Description Presentations at WCO (EC) 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at World Congress in osteoporosis
Year(s) Of Engagement Activity 2021
 
Description Press Release and Publicity - findings from the NIPPER study - SB & KMG 2021 - KMG 2022 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact This publication (Godfrey K, Barton SJ, El-Heis S, Kenealy T, Nield H, Baker PN, Chon YS, Cutfield W, Chan S-Y, Nipper Study Group. Myo-Inositol,probioticsand microntrient supplementation from preconception for glycemia in pregnancy: NiPPeR International Multicenter Double-Blind Ramdomised Controlled Trial. Diabetes Care published online 29 March 2021 doi;.org/10.2337/dc20-2515.) of the findings from the NiPPeR study in this paper received some publicity from both Nestle and Food in Progress as well as being reported by the University of Southampton. The findings show that a mother's diet before and during pregnancy is important for herself and gives her baby the best start in life. The supplementation given to the women taking part in the NiPPeR study was linked to reduced risk of pre-term birth. The publication can be found at: https://www.foodinprogress.com/study-links-nutritional-supplementation-taken-preconception-and-in-pregnancy-to-a-reduced-risk-of-preterm-birth/;
Year(s) Of Engagement Activity 2021
URL https://www.southampton.ac.uk/news/2021/03/nipper-trial-reduced-preterm-birth.page
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 21st October 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 1st September 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 18th June 2021.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 28th April 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on May 4th 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 21st October 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 21st September 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 28th January 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 16th July 2021.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 19th May 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 31st August 2021, as a Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 19th April 2021, as an Impact Assessor
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 13th May 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 18th & 19th August 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attending a REF meeting on 17th March 2021, as an Impact Assesor
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 19th November 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description REF Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 23rd December 2021, as an Impact Assessor.
Year(s) Of Engagement Activity 2021
 
Description Royal Osteoporosis Society public event 2021 (NCH) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Working group vitamin D ESCEO 21 (NCH)
Year(s) Of Engagement Activity 2021
 
Description Speaker at ArLAR Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper was a speaker at the ArLAR Conference.
He gave a talk entitled 'Nutritional Approach of Osteoporosis and Fracture Prevention'. This took place on 5th March 2021
Year(s) Of Engagement Activity 2021
URL https://www.arabrheumatology.org
 
Description Speaker at BRADOO - ABRASSO Congress (Brazilian Association of Bone Assessment and Osteometabolism. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper gave a talk at this conference entitled 'Closing the treatment gap: An urgent Priority is Osteoporosis Care Worldwide'.
This took place on 24th April 2021.
Year(s) Of Engagement Activity 2021
 
Description Speaker at Polish Osteoarthrology Society 8th Central European Congress on Osteoporosis and Osteoarthritis. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attending this congress meeting, and gave a talk entitled 'Management of patients with low, high, and very high risk of osteoporotic fractures'. The meeting was held on 22nd October 2021.
Year(s) Of Engagement Activity 2021
 
Description Speaker at WCO-IOF ESCEO Congress (virtual). 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper was a Speaker at this online conference.
His talk was entitled 'Management of musculoskeletal disease from cradle to grave.'
This took place between 26-27th August 2021, and was attended by over 100 people.
Year(s) Of Engagement Activity 2021
URL https://virtual.wco-iof-esceo.org
 
Description Speaker at e-ECE2021 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper gave a talk entitled '1 year in Bone'. The event took place on 24th May 2021.
Year(s) Of Engagement Activity 2021
 
Description Starter Grants for Clinical Lecturers Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 3rd June 2021.
Year(s) Of Engagement Activity 2021
 
Description The 11th ICFSR Conference ASBMR 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this conference on 1st October 2021, and gave a talk entitled 'IOF Capture the Fracture Partnership'.
Year(s) Of Engagement Activity 2021
 
Description UKHSA/NHS-England COVID Testing Roadshow 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation "Overview of LAMP technology development and asymptomatic NHS staff testing for COVID-19"
Year(s) Of Engagement Activity 2021
 
Description Versus Arthritis RISAPS Supplement Review Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper attended this meeting on 7th May 2021.
Year(s) Of Engagement Activity 2021
URL https://versusarthritis.org
 
Description Working group on phosphate disorders ES CEO 2021 (NCH) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Working group vitamin D ESCEO 21 (NCH)
Year(s) Of Engagement Activity 2021
 
Description Working group vitamin D ESCEO 21 (NCH) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Working group vitamin D ESCEO 21 (NCH)
Year(s) Of Engagement Activity 2021