Establishment of a National Network on Musculoskeletal Ageing
Lead Research Organisation:
University of Southampton
Department Name: UNLISTED
Abstract
Our overall aim is to establish a new national network which will underpin a step change in musculoskeletal ageing research capacity and strategy, by identifying: key tractable research priorities; developing an integrated multi-disciplinary grouping to address the identified research gaps; providing a platform to disseminate best practice; supporting Early Career Researchers (ECRs) to build research capacity and ensure longevity to current UKRI investments; and coordinating an ongoing programme of innovative studies to identify, develop and translate findings from our discovery science to clinical impact. Crucially the network will contribute to delivering the government “Grand Challenge” target of 5 more years of independent living by 2035, by identifying approaches to maintain mobility in old age. The network will bring together the scientific excellence of the three principal applicants. Focusing on the leading chronic non-communicable disorders of bone, muscle and joint (osteoporosis, sarcopenia, rheumatoid arthritis and osteoarthritis), the integration of these groups will galvanize a truly bench to bedside approach to provide a strong evidence base for health policy, underpinning a step change in UK musculoskeletal ageing research capability/capacity, and promoting increased healthspan.
Technical Summary
Our overall aim is to establish a new national network which will underpin a step change in musculoskeletal ageing research capacity and strategy, by identifying: key tractable research priorities; developing an integrated multi-disciplinary grouping to address the identified research gaps; providing a platform to disseminate best practice; supporting Early Career Researchers (ECRs) to build research capacity and ensure longevity to current UKRI investments; and coordinating an ongoing programme of innovative studies to identify, develop and translate findings from our discovery science to clinical impact. Crucially the network will contribute to delivering the government “Grand Challenge” target of 5 more years of independent living by 2035, by identifying approaches to maintain mobility in old age. The network will bring together the scientific excellence of the three principal applicants. Focusing on the leading chronic non-communicable disorders of bone, muscle and joint (osteoporosis, sarcopenia, rheumatoid arthritis and osteoarthritis), the integration of these groups will galvanize a truly bench to bedside approach to provide a strong evidence base for health policy, underpinning a step change in UK musculoskeletal ageing research capability/capacity, and promoting increased healthspan.
People |
ORCID iD |
Publications
Abdulla N
(2022)
Epidemiology of hip fracture in Qatar and development of a country specific FRAX model.
in Archives of osteoporosis
Axelsson KF
(2022)
Analysis of Comorbidities, Clinical Outcomes, and Parathyroidectomy in Adults With Primary Hyperparathyroidism.
in JAMA network open
Beaudart C
(2022)
Patient preferences for lifestyle behaviours in osteoporotic fracture prevention: a cross-European discrete choice experiment
in Osteoporosis International
Bevilacqua G
(2022)
Medical history, medication use and physical activity in adults in their eighth and ninth decade of life in the Hertfordshire Cohort Study.
in EXCLI journal
Bevilacqua G
(2022)
What impact does osteoarthritis have on ability to self-care and receipt of care in older adults? Findings from the Hertfordshire Cohort Study.
in Osteoarthritis and cartilage open
Bevilacqua G
(2023)
Investigating the relationship between self-perception of fracture risk and prior fracture: findings from the Hertfordshire Cohort Study.
in Aging clinical and experimental research
Bloom I
(2022)
Nutritional risk and its relationship with physical function in community-dwelling older adults.
in Aging clinical and experimental research
Bountziouka V
(2022)
Association of shorter leucocyte telomere length with risk of frailty.
in Journal of cachexia, sarcopenia and muscle
Cawthon PM
(2022)
Defining terms commonly used in sarcopenia research: a glossary proposed by the Global Leadership in Sarcopenia (GLIS) Steering Committee.
in European geriatric medicine
| Description | European guidance on very high fracture risk (NCH, CC) |
| Geographic Reach | Europe |
| Policy Influence Type | Membership of a guideline committee |
| Description | National Osteoporosis Guideline Group Advisory Committee (NCH, CC) |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | Nutritional determinants of skeletal development and bone loss: an investigation using a novel computer vision assessment of bone microarchitecture |
| Amount | £36,000 (GBP) |
| Organisation | University of Southampton |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2025 |
| Description | Preventing broken bones in older people: from research to policy to practice |
| Amount | £29,566 (GBP) |
| Funding ID | MRF-145-0011-DG-HARV-C0913 |
| Organisation | Medical Research Council (MRC) |
| Department | Medical Research Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 09/2022 |
| Description | AUGMENT UK Biobank collaboration |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | AUGMENT UK Biobank collaboration |
| Collaborator Contribution | AUGMENT UK Biobank collaboration |
| Impact | AUGMENT UK Biobank collaboration |
| Start Year | 2017 |
| Description | AUGMENT UK Biobank collaboration |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | AUGMENT UK Biobank collaboration |
| Collaborator Contribution | AUGMENT UK Biobank collaboration |
| Impact | AUGMENT UK Biobank collaboration |
| Start Year | 2017 |
| Description | Abstract Writing Masterclass |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Nick Harvey presented the MRC National Musculoskeletal Ageing Network abstract writing seminar, which took place on December 13th 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Article written by Nick Harvey in UoS Enews |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Nick Harvey wrote an article for the University of Southampton Enews in which he wrote about the welcome return to face-face- meetings; the opportunity for in-person participation in the American Society for Bone and Mineral Research Annual Scientific Conference in Austin, Texas and to be able to catch up with colleagues and friends from all over the world. He also mentioned that the new term brings progression of a major initiative in UK musculoskeletal science with the consolidation of the strategic framework for our UKRI MRC National Musculoskeletal Ageing Network. The network will be led by the University of Southampton. He also added that it was great to see the exciting news of the UK Biobank Repeat Imaging Study recently made public. |
| Year(s) Of Engagement Activity | 2022 |
| Description | ESCEO Working Group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Cyrus Cooper attended the ESCEO Working Group on September 9th 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Gestational vitamin D supplementation: observation mechanism and intervention in the MAVIDOS trial. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Nick Harvey gave a talk at the BSR Science Forum on 18th February 2022. Up to 50 people attended. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Launch of the MRC Lifecourse Epidemiology Centre & MRC National Musculoskeletal Group |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The launch of the MRC Lifecourse Epidemiology Centre and the MRC National Musculoskeletal Ageing Network was an online event. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://us06web.zoom.us/rec/play |
| Description | Lay presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Nick Harvey delivered a lay presentation on Osteoporosis to the Patient Partner Group at the St Francis Surgery in Hedge End, Southampton. Around 100 people attended. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation given at ESCEO Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Cyrus gave a presentation entitled "Optamising the prescription of oral Bisphosphonates" |
| Year(s) Of Engagement Activity | 2022 |
| Description | Press Release and publication of paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Press release for the paper entitled "Is the skull responsive to bone mineralisation stimuli in children? published in the journal Bone. There was some media attention following the publication of this paper. The press release was entitled "Skulls stay strong despite worse diets" |
| Year(s) Of Engagement Activity | 2022 |
| Description | Press Release of published paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | There were a number of online citings following a press release entitled "Three coffees a day could help keep the doctor away." This was to do with an article published in European Journal of Preventive Cardiology entitled: Light to moderated coffee consumption is associated with lower risk of death: UK Biobank Study. Simon J, Fung K, et al. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Preventing broken bones in older people: from research to policy to practice |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | The University Faculty of Medicine print a Research Roundup Newsletter. These newsletters aim to celebrate success, provide research updates and give information on upcoming opportunities. The second of these newsletters was written by Professor Nick Harvey. |
| Year(s) Of Engagement Activity | 2022 |
| Description | REF 2021 University Results Presentation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Cyrus attended the REF2021 University Results Presentation meeting on 9th May 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Southampton Women's Survey Celebration Event |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | As part of the 50th Anniversary of the NIHR BRC, the Southampton Women's Survey were chosen to represent some of the research that has taken place in Southampton. The BRC funded an evening at the City Art Gallery in Southampton for 50 SWS participants and their family or friends. The speakers who talked about the study findings were Prof. Cyrus Copper, Prof Keith Godfrey, Prof Janis Baird and Prof Hazel Inskip who wrote and sang a song at the end of the presentation whilst playing her ukulele. SWS staff in attendance and who organised the logistics for the event were research nurses, Julia Hammond, Nicole Minette, Karen McGill and Tina Horsfall. They received requests about further participation or involvement, the audience reported change in views, opinions or behaviours, requests for further information. Children were also recruited for PPI for the BRC. |
| Year(s) Of Engagement Activity | 2022 |
| Description | University of Southampton Science and Engineering Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Nick Harvey was part of a team from the MRC LEU that took part in this event. The event was well attended with members of the public showing great interest. |
| Year(s) Of Engagement Activity | 2022 |
| Description | WCO-IOF-ESCEO Conference - Virtual |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Nick Harvey, Deputy Director of MRC LEU gave the Plenary Lecture 2 entitled 'Update of the management of patients at imminent fracture risk at the WCO-IOF-ESCEO conference on 24th March 2022, which was held virtually. This was attended by over 1,000 people. |
| Year(s) Of Engagement Activity | 2022 |