MLC National Mouse Genetics Network
Lead Research Organisation:
MRC Harwell
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The MLC is the hub of the new National Mouse Genetics Network - NMGN and therefore is tasked with ensuring cohesion and sharing of mouse resources, technical skills, scientific data and training throughout the whole network. Working alongside the director, Owen Sansom, we will ensure that strategies and programmes of work at the MLC follow the vision and emphasis of the Network leader.
Organisations
- MRC Harwell (Collaboration, Lead Research Organisation)
- UNIVERSITY OF OXFORD (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- University College London (Collaboration)
- University of Iowa (Collaboration)
- University of York (Collaboration)
- University of Otago (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
People |
ORCID iD |
| Sara Wells (Principal Investigator) |
Publications
Bacman SR
(2024)
mitoTALEN reduces the mutant mtDNA load in neurons.
in Molecular therapy. Nucleic acids
Barrell WB
(2022)
Identification of a novel variant of the ciliopathic gene FUZZY associated with craniosynostosis.
in European journal of human genetics : EJHG
Dobson L
(2023)
GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration
in Cell Reports
Doro D
(2024)
Cranial suture lineage and contributions to repair of the mouse skull.
in Development (Cambridge, England)
Falabella M
(2022)
Gene therapy for primary mitochondrial diseases: experimental advances and clinical challenges.
in Nature reviews. Neurology
Lodge EJ
(2024)
The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development.
in Journal of anatomy
Lupo F
(2024)
Stressed out neutrophils drive metastasis.
in Immunity
Miller KA
(2024)
BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome.
in Journal of medical genetics
Molloy C
(2023)
Bridging the translational gap: what can synaptopathies tell us about autism?
in Frontiers in Molecular Neuroscience
Pratt JA
(2022)
BAP editorial: Improving the validity and translation of preclinical research.
in Journal of psychopharmacology (Oxford, England)
| Description | Consultant for the Science Media Centre |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://www.sciencemediacentre.org/ |
| Description | Alison Gifford (HLS Global Mobility Award) |
| Amount | £5,000 (GBP) |
| Organisation | University of Exeter |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 12/2023 |
| Description | Automated high sensitivity genetic assay for the screening of CRISPR modifications in early embryos |
| Amount | £79,993 (GBP) |
| Funding ID | P2023-0025 |
| Organisation | Francis Crick Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2024 |
| End | 12/2024 |
| Description | Haematopoiesis - Novel tools for modelling normal and perturbed haematopoiesis |
| Amount | £1,532,023 (GBP) |
| Funding ID | MC_PC_21043 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2027 |
| Description | Investigating immunological prevention strategies for precursor lesions of colon cancer |
| Amount | £517,141 (GBP) |
| Funding ID | PRCBTP-Nov23/100019 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2024 |
| End | 03/2027 |
| Description | MRC Centre for Neurodevelopmental Disorders |
| Amount | £1,911,031 (GBP) |
| Funding ID | MR/W006251/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2021 |
| End | 10/2026 |
| Description | MitoCluster: an integrated phenotyping and mouse model generation platform for mitochondrial disease and dysfunction |
| Amount | £2,933,088 (GBP) |
| Funding ID | MC_PC_21046 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2027 |
| Description | NIHR Biomedical Research Centre (BRC) Exeter |
| Amount | £15,000,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2022 |
| End | 12/2027 |
| Description | National Mouse Genetics Network - Grant award: Directorship Development Phase |
| Amount | £24,106 (GBP) |
| Funding ID | MC_PC_20025 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 03/2022 |
| Description | Nuclear mechanisms underpinning mitochondrial vulnerability in different cell-types |
| Amount | £4,376,805 (GBP) |
| Funding ID | 226653/Z/22/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2028 |
| Description | REMIT: Reconstructing the in vivo Evolution of mesothelioma for Improved Therapy |
| Amount | £2,121,000 (GBP) |
| Funding ID | DRCRPG-Jun22\100007 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2023 |
| End | 03/2028 |
| Description | Rescue of neuronal and behavioural deficits using a novel PAMs |
| Amount | £96,000 (GBP) |
| Funding ID | 524764 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2023 |
| End | 10/2024 |
| Description | Therapeutic Acceleration Support Fund |
| Amount | £69,927 (GBP) |
| Funding ID | MR/X502984 |
| Organisation | University College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2024 |
| End | 12/2024 |
| Description | antibody-based protein degraders to validate cell surface targets |
| Amount | £127,835 (GBP) |
| Funding ID | PHD-50695-2023 |
| Organisation | Medical Research Scotland |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2024 |
| End | 08/2028 |
| Title | Mouse models |
| Description | 1 x mouse strains carrying transgenes |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 2 x mouse strains generated by gene targeting events |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 3 x individual mouse strains carrying unique alleles |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 4 x mouse strains generated using CRISPR/Cas9 gene editing technology |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 5 x separate shipments of Degron10-B6J tissue samples |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | Congenital Anomalies Cluster Data Portal |
| Description | Database of variants of uncertain significance (VUS) and associated clinical features that have been submitted by Clinicians/Researchers via the cluster data portal |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | VUS submitted via the portal will be assessed regularly for entry into the congenital anomalies cluster mouse modelling pipeline |
| URL | https://nmgn.mrc.ukri.org/clusters/congenital-anomalies/vus-submission-portal/ |
| Title | MGnify Super Study - National Mouse Genetics Network (NMGN) Microbiome Cluster |
| Description | The Microbiome Cluster of the National Mouse Genetics Network will achieve two complementary goals: it will develop an experimental pipeline for creating and studying mouse models of human genetic diseases involving barrier surfaces, with a focus on understanding the impact of the microbiome in these diseases and it will establish a national infrastructure for cutting edge mouse microbiome research that will be accessible to all UK researchers. This superstudy links NMGN-generated data analyses, as well as analyses of other publicly-available relevant datasets. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | None as yet |
| URL | https://www.ebi.ac.uk/metagenomics/super-studies/nmgn-microbiome |
| Title | Transcriptomic analysis of mouse mesothelioma tumours with or without CSF1R inhibition |
| Description | RNA-SEQ analysis of tumours in GM mice (genotype Cdkn2a-/-; Nf2fl/fl; Tp53fl/fl), induced by intrapleural installation with Lentiviral CRE + Asbestos and treated with Macrophage differentiation-linked CSF1R inhibitor, or vehicle control |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Data effectively rule out use of CSF1R inhibitor as potential single agent therapy to treat epithelioid mesothelioma |
| URL | https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-MTAB-12998?query=e-mtab-12998 |
| Description | Congenital Anomalies Cluster clinical partners - Centre for Human Genetics, Oxford University |
| Organisation | University of Oxford |
| Department | Wellcome Trust Centre for Human Genetics |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Collation and prioritisation of variants of uncertain significance (VUS) submitted by CHG team, VUS targetting design for modelling, mouse generation |
| Collaborator Contribution | Submission of VUS potentially causing a congenital disorder |
| Impact | Ongoing collaboration Multidiciplinary - clinicians, geneticists, developmental biologists |
| Start Year | 2023 |
| Description | Congenital Anomalies Cluster clinical partners - Otago University |
| Organisation | University of Otago |
| Department | Dunedin School of Medicine |
| Country | New Zealand |
| Sector | Academic/University |
| PI Contribution | Collation and prioritisation of variants of uncertain significance (VUS) submitted by University of Otago team, VUS targetting design for modelling, mouse generation |
| Collaborator Contribution | Submission of VUS potentially causing a congenital disorder |
| Impact | Ongoing collaboration Multidiciplinary - clinicians, geneticists, developmental biologists |
| Start Year | 2023 |
| Description | Congenital Anomalies Cluster clinical partners - University of Iowa |
| Organisation | University of Iowa |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Collation and prioritisation of variants of uncertain significance (VUS) submitted by Iowa team, VUS targetting design for modelling, mouse generation |
| Collaborator Contribution | Submission of VUS potentially causing cleft lip and palate |
| Impact | Ongoing collaboration Multidiciplinary - clinicians, geneticists, developmental biologists |
| Start Year | 2023 |
| Description | David Kent |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | co-leading the MRC mouse genetics network Haematopoiesis cluster theme 1b |
| Collaborator Contribution | intellectual contribution to grant proposals |
| Impact | new transgenic mouse lines being generated |
| Start Year | 2021 |
| Description | National Mouse Genetics Network |
| Organisation | Medical Research Council (MRC) |
| Department | The Mary Lyon Centre |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I am leading on data for the National Mouse Genetics Network data platform. |
| Collaborator Contribution | This is a national network to bring together UK preclinical mouse modelling expertise across > 54 PIs |
| Impact | We are currently scoping an ambitious proposal to support a large national data platform, |
| Start Year | 2021 |
| Description | National Mouse Genetics Network - Congenital Anomalies Cluster |
| Organisation | King's College London |
| Department | Dental Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team is a core member of the cluster whose goal is to make new improved mouse models of human congenital abnormalities |
| Collaborator Contribution | there are 5 cluster members, each makes a significant contribution to the |
| Impact | various mouse models are in production Cardiac geneborree - meeting in November 2023 |
| Start Year | 2021 |
| Description | National Mouse Genetics Network - Congenital Anomalies Cluster |
| Organisation | MRC Harwell |
| Department | MRC Mammalian Genetics Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team is a core member of the cluster whose goal is to make new improved mouse models of human congenital abnormalities |
| Collaborator Contribution | there are 5 cluster members, each makes a significant contribution to the |
| Impact | various mouse models are in production Cardiac geneborree - meeting in November 2023 |
| Start Year | 2021 |
| Description | National Mouse Genetics Network - Congenital Anomalies Cluster |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team is a core member of the cluster whose goal is to make new improved mouse models of human congenital abnormalities |
| Collaborator Contribution | there are 5 cluster members, each makes a significant contribution to the |
| Impact | various mouse models are in production Cardiac geneborree - meeting in November 2023 |
| Start Year | 2021 |
| Description | National Mouse Genetics Network - Congenital Anomalies Cluster |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team is a core member of the cluster whose goal is to make new improved mouse models of human congenital abnormalities |
| Collaborator Contribution | there are 5 cluster members, each makes a significant contribution to the |
| Impact | various mouse models are in production Cardiac geneborree - meeting in November 2023 |
| Start Year | 2021 |
| Description | Precision control of protein dosage in vivo - MRC Mouse Genetics Network collaboration |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Human Genetics Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I was part of the grant application to the MRC Mouse Genetics Network Cluster application (led by Andrew Wood) to utilise targeted degradation systems in vivo. |
| Collaborator Contribution | I contributed with the design of the degron construct to be utilised for the transgene to be introduced in mice and helped shape the application. |
| Impact | In progress |
| Start Year | 2022 |
| Description | 1st International Workshop on Innovative Models for Neuroblastoma Research |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Workshop focused on state of the art models of neuroblastoma research from international teams, which sparked questions and discussion. Long-term potential for exchange of resources and collaborations. |
| Year(s) Of Engagement Activity | 2023 |
| Description | AAIC 2023 Platform |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | AAIC 2023 oral platform presentation |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.alzint.org/news-events/events/alzheimers-association-international-conference/ |
| Description | Action on Asbestos talk to mark Mesothelioma victim's day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | I briefly described our work and recent advances in mesothelioma research to an audience of patients, relatives and carers for mesothelioma victims |
| Year(s) Of Engagement Activity | 2023 |
| Description | Ageing cluster workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | An online workshop to discuss the creation of a new cluster for the network focused on ageing in response to a UKRI strtegy policy and the availability of funding. Discussions on the definitions of ageing and the possible study avenues were very stimulating |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://nmgn.mrc.ukri.org/news/developing-an-ageing-cluster-for-the-national-mouse-genetics-network/ |
| Description | Article on research using mouse models of mesothelioma for Openaccess Govt |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Article title: The risk of Malignant Pleural Mesothelioma |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.openaccessgovernment.org/article/the-risk-of-malignant-pleural-mesothelioma/167083/ |
| Description | BNA Bulletin |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | BNA Bulletin article and interview promoting MURIDAE |
| Year(s) Of Engagement Activity | 2022 |
| Description | BNA Festival of Neuroscience |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented a poster describing the aims of MURIDAE at the Festival of Neuroscience, the British Neuroscience Association international biennial meeting. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://meetings.bna.org.uk/bna2023/ |
| Description | CRUK Lung Cancer Conference, Manchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentations of ongoing work in Mesothelioma and Lung cancer |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.cancerresearchuk.org/funding-for-researchers/research-events-and-conferences/the-lung-ca... |
| Description | CRUK Strategic Roundtable on Cancer Prevention |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participation in a discussion of priorities and strategies for funding cancer prevention research. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Cambridge Lung Cancer Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Conference Lecture: "GE mouse models for a better understanding of Mesothelioma: risk, mechanisms of progression, early detection & new treatments" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Cardiac Geneboree - From Cardiac Gene Variant to Mouse Model |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Meeting/workshop to discuss how to improve outcomes from genetic studies into congenital heart defects - engaged with developmental biology researchers, geneticists, cardiologists etc |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://nmgn.mrc.ukri.org/news/congenital-anomalies-cardiovascular-geneboree-23rd-and-24th-of-novemb... |
| Description | Cardiovascular Geneboree - from Cardiac Gene Variant to Mouse Model |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The meeting title 'From Cardiac Gene Variant to Mouse Model' is a good summary of the aims of this informal meeting which are to: Create a framework for accurately modelling and phenotyping human congenital heart defects in mouse. Link human and mouse phenotyping. The target audience is varied and expected to comprise clinicians, clinical geneticists and developmental biologists interested in finding new genes for congenital heart defects and validating them in mouse models. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://nmgn.mrc.ukri.org/news/congenital-anomalies-cardiovascular-geneboree-23rd-and-24th-of-novemb... |
| Description | Chairing a discussion group about "how to run a transgenic facility" |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Chaired at panel discussion at the International Society for Transgenic Technologies meeting in Helsinki in September 2022, entitled "How to run a transgenic facility" |
| Year(s) Of Engagement Activity | 2022 |
| Description | Chilean Society for Biochemistry & Molecular Biology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote Conference Lecture: "Of mouse and man: what can GEMMs teach us about thoracic Cancer?" |
| Year(s) Of Engagement Activity | 2023 |
| Description | DevNeuro Academy |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The DevNeuro Academy Widening Participation project consists of a regular programme of activities designed to improve the progression and success of students currently under-represented at our university and other institutes of higher education. The project combines a series of four in-school interactive 'Discovery workshops' with a two-week laboratory summer research work experience in our Centre. At the end of the work experience there will be a graduation ceremony here at Guy's campus. The students' families, class-mates and teachers will be invited and the students will be presented with a certificate. |
| Year(s) Of Engagement Activity | 2021,2022,2023,2024 |
| URL | https://devneuro.org/cdn/public-engagement-dna.php |
| Description | European Human Genetics Conference exhibitor stand |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | exhibitor stand at this international conference to promote the Network's activities |
| Year(s) Of Engagement Activity | 2023 |
| Description | Family/Patient group conference - Joseph's Goal |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Online family conference co-organised by my team (hosted at UCL) and Jospeh's Goal focussing on rare metabolic disease, involving several talks from group members and Q&A session |
| Year(s) Of Engagement Activity | 2023 |
| Description | Festival of Genomics |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | exhibitor stand at the Festival of Genomics, London to promote MLC and NMGN activities |
| Year(s) Of Engagement Activity | 2024 |
| Description | Indonesian Ministry of Health delegation |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Visit by a delegation from the Indonesian Ministry of health to the CRUK Scotland Institute to discuss dangers of Asbestos and link to Mesothelioma |
| Year(s) Of Engagement Activity | 2023 |
| Description | International Conference on Cancer Biology: Molecular Mechanisms, Genomics & Novel Therapeutics, Chennai, India. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote Conference Lecture: "Of mouse and man: what can GEMMs teach us about Cancer?" Keynote Speaker |
| Year(s) Of Engagement Activity | 2023 |
| Description | Interview for national news |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | I was interview by BBC Radio Scotland about our research study. This prompted requests by the public to enroll in clinical trials. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.bbc.co.uk/news/uk-scotland-glasgow-west-65960708 |
| Description | Invited lecture, MRC Toxicology Unit Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation of ongoing research on Mesothelioma |
| Year(s) Of Engagement Activity | 2022 |
| Description | LASA Council Meeting (Face-to-face) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | LASA council member |
| Year(s) Of Engagement Activity | 2023 |
| Description | LASA Plenary |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Key note at National Conference, audience including leaders in animal work legislation (ARSU/Home office), NGOs (NC3R) and related business (Charles River, Agenda) |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.lasa.co.uk/ |
| Description | LASA- National Mouse Genetics Network |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | LASA presentation introducing the Mouse Genetics Network |
| Year(s) Of Engagement Activity | 2022 |
| Description | Launch of MRC NMGN LinkedIn account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Launch of the LinkedIn account focused on amplifying the Network's activities and the work of the network associated scientists |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.linkedin.com/company/78765699/ |
| Description | Launch of the Congenital Anomalies Cluster web portal |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online advertising of the launch of the congenital anomalies cluster web portal |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://thenode.biologists.com/understanding-variants-of-uncertain-significance-in-congenital-anomal... |
| Description | Launch of the MRC NMGN Twitter account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Twitter account focused on providing information about the network activities and amplifying the work of the network associated institutions |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://twitter.com/MRCMouseNetwork |
| Description | Launch of the MRC NMGN website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The new MRC NMGN was launched in 2022 to provide information about the network, the network clusters and the work that will be carried out over the 5 years of the first round of funding. The website will also have news stories and job adverts linked to the network activities |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://nmgn.mrc.ukri.org/ |
| Description | MRC Hub meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | okioll |
| Year(s) Of Engagement Activity | 2024 |
| Description | MRC NMGN Associates meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | a two day meeting to take stock of the first few months of the network and stimulate discussion with external researchers and businesses and to invite them to associate with the network to benefit from work and data sharing |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://nmgn.mrc.ukri.org/news/expanding-and-establishing-the-network-with-growing-collaborations-as... |
| Description | MRC NMGN Industry day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Presented at and participated in the MRC National Mouse Genetics Network Industry Day at the Royal Society of Medicine, London. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://nmgn.mrc.ukri.org/news/launching-our-business-engagement-fund-whilst-talking-to-industry/ |
| Description | MRC NMGN Industry day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Meeting to engage the industry in the work of the MRC NMGN and launch the Business Engagement fund |
| Year(s) Of Engagement Activity | 2023 |
| Description | MRC NMGN Launch event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The two day event was the chance to launch this £20m+ initiative and begin to define the work that woudl be carried out by the clusters. The first day was limited to network members, the second open to an invited selection of professionals. industry representatives and funders |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://nmgn.mrc.ukri.org/news/collaborate-to-translate-launching-the-new-network/ |
| Description | MRC NMGN Science meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk: Mouse models for rare disease - KCTD15 |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://nmgn.mrc.ukri.org/news/york-7th-9th-of-february-2024-mrc-national-mouse-genetics-network-mee... |
| Description | MRC NMGN Science meeting - Network's associates day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk promoting the congenital anomalies cluster data portal |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://nmgn.mrc.ukri.org/news/york-7th-9th-of-february-2024-mrc-national-mouse-genetics-network-mee... |
| Description | MRC NMGN science meeting: Setd1a mutant mice reveal novel physiological and molecular pathways underpinning schizophrenia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk entitled "Setd1a mutant mice reveal novel physiological and molecular pathways underpinning schizophrenia" at the MRC NMGN science day in York |
| Year(s) Of Engagement Activity | 2024 |
| Description | MRC National Mouse Genetics Network Ageing Cluster press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A press release on UKRI investment in the MRC NMGN that was amplified from the UKRI website to social media channels by many followers and organisations interested in the work |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.ukri.org/news/new-mouse-genetics-funding-to-tackle-human-ageing-dementia-and-diseases/ |
| Description | MRC National Mouse Genetics Network Research Event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | MRC National Mouse Genetics Network attended a 3-day event in York in February 2024, where we shared research, training activities, networking and welcomed external participation. |
| Year(s) Of Engagement Activity | 2024 |
| Description | MSKCC Invited Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Memorial Sloan Kettering Cancer Centre, New York USA. "Next generation GE mouse models as tools for discovery in Lung Cancer & Mesothelioma" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Marin lab twitter account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The Marin lab twitter account reports our research findings since 2012. The account has over 3500 followers. |
| Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016,2017,2018,2019,2020,2021 |
| URL | http://twitter.com/Marinlab |
| Description | Member of the MRC Centre for Neurodevelopmental Disorders (CNDD) Public Engagement Committee |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Member of the MRC Centre for Neurodevelopmental Disorders (CNDD) Public Engagement Committee - current campaigns include raising awareness of CNDD research via Instagram |
| Year(s) Of Engagement Activity | 2021,2022,2023,2024 |
| Description | NYU Invited Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | New York University, New York USA. "Developing the next generation of cancer mouse models" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Neural Crest development and disorders: From patient to model system and back again |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Over the course of 2.5 intense days, attendees can expect exciting sessions and discussions exploring all facets of Neural Crest development, covering the initial phases of NC induction and specification over to NC cell differentiation, and Neurocristopathies. To include a patient perspective to the ongoing research, this conference also invited a speaker, living with a Neurocristopathy to share her experience and her view of the expectations from public and patients for current research. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://neucrestfinalconference.org |
| Description | Oxford Cancer Prevention Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Conference Lecture: "Improving GE mouse models of Thoracic Cancers: Mechanisms of cancer progression; Opportunities & challenges for modelling prevention" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster: The role of the placenta in PWS: mapping the expression of PWS genes |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation at the Wellcome connecting science conference on "Genomic Imprinting - from Biology to Disease" |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://coursesandconferences.wellcomeconnectingscience.org/event/genomic-imprinting-from-biology-to... |
| Description | Presentation at Barts Cancer Institute seminar series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | About 40 scientists attended my presentation at the research organization which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Dutch Society for Immunology Annual Symposium, Tiel, Netherlands |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | About 200 scientists attended my presentation at the research organization which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at European Society for Medical Oncology (ESMO), Paris, France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | About 300 scientists attended my presentation at the research organization which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Fox Chase Cancer Center |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | About 40 scientists attended my presentation at the research organization which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Indian Institute of Technology, Madras, Chennai, India |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | About 300 scientists attended my presentation at the research organization which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Linkoping University, Sweden |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | About 40 scientists attended my presentation at the research organization which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at London Pancreas Workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | About 200 scientists attended my presentation at the research organization which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Mahidol University, Thailand |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | About 100 scientists attended my presentation at the research organization which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Tubingen University, Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | About 50 scientists attended my presentation at the research organization which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at gamma delta T cell Twitter forum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | About 150 scientists attended my presentation at the research organization which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2023 |
| Description | Psychiatry Consortium targets workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Psychiatry Consortium organised a workshop to discuss possible therapeutic targets for neuropsychiatric disorders - Setd1a was one of the targets and I was invited because of my expertise in this area and in preclinical models more generally |
| Year(s) Of Engagement Activity | 2022 |
| Description | Roles for Neural Crest Cells and Cranial Placodes in Vertebrate Development, Evolution and Disease |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Neural Crest and Cranial Placodes GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.grc.org/neural-crest-and-cranial-placodes-conference/2023/ |
| Description | Scottish Clinical Trials "CACTUS" annual conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited oral presentation to the 6th annual CACTUS conference |
| Year(s) Of Engagement Activity | 2023 |
| Description | Second MRC NMGN Associates Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attended and Chaired a session at the second MRC NMGN Associates day in York |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://nmgn.mrc.ukri.org/news/join-us-for-our-second-network-associates-day/ |
| Description | Short highlight talk at BNA Festive meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Mike Ashby spoke at the BNA Festive symposium ("Have your mental health a merry little Christmas") highlighting the work MURIDAE is hoping to do and the MRC NMGN more broadly |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.bna.org.uk/mediacentre/events/festive-symposium/ |
| Description | Spatial Biology presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of research findings using RNAscope technology at a "Spatial Biology" workshop organised by two companies (biotechne & Nanostring) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Talk at an EU Summer School for Kidney researchers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk about method development for the generation of genetically altered rodents |
| Year(s) Of Engagement Activity | 2023 |
| Description | University of Bath AWERB Annual Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | University of Bath - Cross Faculty annual AWERB lecture |
| Year(s) Of Engagement Activity | 2023 |