MLC National Mouse Genetics Network
Lead Research Organisation:
MRC Harwell Institute
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The MLC is the hub of the new National Mouse Genetics Network - NMGN and therefore is tasked with ensuring cohesion and sharing of mouse resources, technical skills, scientific data and training throughout the whole network. Working alongside the director, Owen Sansom, we will ensure that strategies and programmes of work at the MLC follow the vision and emphasis of the Network leader.
People |
ORCID iD |
Publications
Falabella M
(2022)
Gene therapy for primary mitochondrial diseases: experimental advances and clinical challenges.
in Nature reviews. Neurology
| Description | Alison Gifford (HLS Global Mobility Award) |
| Amount | £5,000 (GBP) |
| Organisation | University of Exeter |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 12/2023 |
| Description | Haematopoiesis - Novel tools for modelling normal and perturbed haematopoiesis |
| Amount | £1,532,023 (GBP) |
| Funding ID | MC_PC_21043 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2022 |
| End | 03/2027 |
| Description | MLC National Mouse Genetics Network |
| Amount | £2,600,000 (GBP) |
| Funding ID | MC_PC_21047 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2022 |
| End | 03/2027 |
| Description | NIHR Biomedical Research Centre (BRC) Exeter |
| Amount | £15,000,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2022 |
| End | 12/2027 |
| Description | National Mouse Genetics Network - Grant award: Directorship Development Phase |
| Amount | £24,106 (GBP) |
| Funding ID | MC_PC_20025 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 03/2022 |
| Description | REMIT: Reconstructing the in vivo Evolution of mesothelioma for Improved Therapy |
| Amount | £2,121,000 (GBP) |
| Funding ID | DRCRPG-Jun22\100007 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2023 |
| End | 03/2028 |
| Description | National Mouse Genetics Network |
| Organisation | Medical Research Council (MRC) |
| Department | The Mary Lyon Centre |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I am leading on data for the National Mouse Genetics Network data platform. |
| Collaborator Contribution | This is a national network to bring together UK preclinical mouse modelling expertise across > 54 PIs |
| Impact | We are currently scoping an ambitious proposal to support a large national data platform, |
| Start Year | 2021 |
| Description | Precision control of protein dosage in vivo - MRC Mouse Genetics Network collaboration |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Human Genetics Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I was part of the grant application to the MRC Mouse Genetics Network Cluster application (led by Andrew Wood) to utilise targeted degradation systems in vivo. |
| Collaborator Contribution | I contributed with the design of the degron construct to be utilised for the transgene to be introduced in mice and helped shape the application. |
| Impact | In progress |
| Start Year | 2022 |
| Description | Ageing cluster workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | An online workshop to discuss the creation of a new cluster for the network focused on ageing in response to a UKRI strtegy policy and the availability of funding. Discussions on the definitions of ageing and the possible study avenues were very stimulating |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://nmgn.mrc.ukri.org/news/developing-an-ageing-cluster-for-the-national-mouse-genetics-network/ |
| Description | BNA Bulletin |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | BNA Bulletin article and interview promoting MURIDAE |
| Year(s) Of Engagement Activity | 2022 |
| Description | CRUK Lung Cancer Conference, Manchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentations of ongoing work in Mesothelioma and Lung cancer |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.cancerresearchuk.org/funding-for-researchers/research-events-and-conferences/the-lung-ca... |
| Description | Chairing a discussion group about "how to run a transgenic facility" |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Chaired at panel discussion at the International Society for Transgenic Technologies meeting in Helsinki in September 2022, entitled "How to run a transgenic facility" |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited lecture, MRC Toxicology Unit Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation of ongoing research on Mesothelioma |
| Year(s) Of Engagement Activity | 2022 |
| Description | LASA- National Mouse Genetics Network |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | LASA presentation introducing the Mouse Genetics Network |
| Year(s) Of Engagement Activity | 2022 |
| Description | Launch of MRC NMGN LinkedIn account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Launch of the LinkedIn account focused on amplifying the Network's activities and the work of the network associated scientists |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.linkedin.com/company/78765699/ |
| Description | Launch of the MRC NMGN Twitter account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Twitter account focused on providing information about the network activities and amplifying the work of the network associated institutions |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://twitter.com/MRCMouseNetwork |
| Description | Launch of the MRC NMGN website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The new MRC NMGN was launched in 2022 to provide information about the network, the network clusters and the work that will be carried out over the 5 years of the first round of funding. The website will also have news stories and job adverts linked to the network activities |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://nmgn.mrc.ukri.org/ |
| Description | MRC NMGN Associates meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | a two day meeting to take stock of the first few months of the network and stimulate discussion with external researchers and businesses and to invite them to associate with the network to benefit from work and data sharing |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://nmgn.mrc.ukri.org/news/expanding-and-establishing-the-network-with-growing-collaborations-as... |
| Description | MRC NMGN Launch event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The two day event was the chance to launch this £20m+ initiative and begin to define the work that woudl be carried out by the clusters. The first day was limited to network members, the second open to an invited selection of professionals. industry representatives and funders |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://nmgn.mrc.ukri.org/news/collaborate-to-translate-launching-the-new-network/ |
| Description | Marin lab twitter account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The Marin lab twitter account reports our research findings since 2012. The account has over 3500 followers. |
| Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016,2017,2018,2019,2020,2021 |
| URL | http://twitter.com/Marinlab |
| Description | Psychiatry Consortium targets workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Psychiatry Consortium organised a workshop to discuss possible therapeutic targets for neuropsychiatric disorders - Setd1a was one of the targets and I was invited because of my expertise in this area and in preclinical models more generally |
| Year(s) Of Engagement Activity | 2022 |
| Description | Scottish Clinical Trials "CACTUS" annual conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited oral presentation to the 6th annual CACTUS conference |
| Year(s) Of Engagement Activity | 2023 |
| Description | Short highlight talk at BNA Festive meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Mike Ashby spoke at the BNA Festive symposium ("Have your mental health a merry little Christmas") highlighting the work MURIDAE is hoping to do and the MRC NMGN more broadly |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.bna.org.uk/mediacentre/events/festive-symposium/ |