Statistical epidemiology in ageing research
Lead Research Organisation:
MRC Biostatistics Unit
Abstract
Understanding how health and ill health change with age is important for public health. The shape of the population is changing with more surviving into old age. Information on changes that occur with time is generally measured using longitudinal population based studies. Although these studies provide direct information on changes and the age at which they occur, they also suffer from potential problems due to dropout of respondents as a result of refusal, migration and death. If this is not taken into account reported results can seriously underestimate disease and disability in the population. This programme aims to investigate the health changes caused by ageing that take into account the difficulties of the studies that were used to derive them. In this way, proper public health statements can be made and used to develop policy for the future. The programme undertakes to improve both the methods and also provide applied papers that will focus on the implications of the changes.
Technical Summary
A programme of work that covers both the methodology and application of measures for changes associated with ageing. Modelling the ageing process to correctly investigate individual differences, missing data and the correct formulation of the time process requires both good data and improved methodology. The programme covers the improvement in methodology and the application within applied scientific papers.|1. Healthy life expectancy and multi-state modelling|A programme of research that involves improving measures of healthy life expectancy modelled using longitudinal data, including the modelling process, measuring model fit, relaxing some of the assumptions and the investigation of missing data, and then undertaking analyses of health life in a variety of settings.|2. Cognitive modelling and modelling through the life course|A programme of research involved in the investigation of cognition through time, over age and near death. The modelling involves a detailed investigation of the patterns of change, the relationship with covariates, the impact of missing data and the relationship with mortality. In addition the programme collaborates with other MRC units on a cross collaboration project of ageing through the lifecourse. This is investigating the methods of combining longitudinal investigations to enable understanding the entire age range.|3. MRC Collaborative Group for the Cognitive Function and Ageing Study I and II (CFAS) |Overall strategic control (planning, co-ordination, and development) of statistical analysis within this large, UK, multi-centre, epidemiological, cohort study of ageing, cognitive decline and dementia. A new cohort CFAS II is currently underway, our role includes sampling, data managament and statistical oversight. Sub-studies of blood and brain tissue elucidate the role of genetic factors within ageing, and of the neuropathological processes which characterise dementia in the community. Other sub-studies investigate the costs of continuing care and the burden on carers.|4. Applied research|A varied programme of investigations of application of the above methodology including mild cognitive impairment (the state between normal cognitive ageing and dementia), the relationship between ageing in life and pathology seen at death, autism in the UK and Netherlands, the investigation of disability its causes, incidence and recovery, and various aspects of healthy life expectancy (such as disability free life expectancy, cognitive impairment free life expectancy) and its causes and investigations of cognitive health. This all links to a focus on public health research and policy implications of the ageing population.||Key Words: healthy life expectancy, cognitive function, ageing and psychiatry
Organisations
- MRC Biostatistics Unit, United Kingdom (Lead Research Organisation)
- University College London, United Kingdom (Collaboration)
- University of Twente, Netherlands (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Luton and Dunstable University Hospital NHS Foundation Trust (Collaboration)
- University of Hertfordshire, United Kingdom (Collaboration)
- Deakin University (Collaboration)
- Newcastle University, United Kingdom (Collaboration)
- Bangor University, United Kingdom (Collaboration)
- University of East Anglia, United Kingdom (Collaboration)
- Medical Research Council (Collaboration)
- University of Exeter, United Kingdom (Collaboration)
- University of Cambridge (Collaboration)
- University of Victoria, Canada (Collaboration)
- Swansea University, United Kingdom (Collaboration)
- National Institute of Health and Medical Research (INSERM) (Collaboration)
- University of Sheffield, United Kingdom (Collaboration)
- University of New South Wales (Collaboration)
Publications
Aarsland D
(2011)
Nonlinear decline of mini-mental state examination in Parkinson's disease.
in Movement disorders : official journal of the Movement Disorder Society
Al-Mashhadi S
(2015)
Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain.
in Brain pathology (Zurich, Switzerland)
Anderson HR
(2008)
International correlations between indicators of prevalence, hospital admissions and mortality for asthma in children.
in International journal of epidemiology
Anderson HR
(2010)
Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC).
in Occupational and environmental medicine
Baron-Cohen S
(2009)
Prevalence of autism-spectrum conditions: UK school-based population study.
in The British journal of psychiatry : the journal of mental science
Basta NE
(2008)
Community-level socio-economic status and cognitive and functional impairment in the older population.
in European journal of public health
Bonnett L
(2018)
May the odds be ever in your favour May the odds be ever in your favour
in Teaching Statistics
Bonnett LJ
(2019)
Investigating populations via penguins and their poo!
in Teaching statistics
Brayne C
(2009)
Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study.
in Journal of Alzheimer's disease : JAD
| Description | Biomed central public access forum |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Description | CoDem report |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Cognitive modelling training |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Lectures on modelling of missing data and cognitive models. Resulted in changing researchers views on modelling cognition |
| Description | Delphi UK consensus for Alzheimer's disease |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in advisory committee |
| Impact | Figures used throughout the media to describe the dementia epidemic. |
| Description | Dementia Delphi expert |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a national consultation |
| Impact | Dementia UK reports defined the future needs for dementia in the UK and its being adopted worldwide. Second edition released 2014 |
| URL | http://www.alzheimers.org.uk/site/scripts/download_info.php?fileID=2323 |
| Description | Global burden in UK |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Input into new global burden of disease estimates for UK. Provide influcences that can be used both in policy and planning, together with knowledge about targetting the correct individuals with the right needs. |
| Description | HPE dementia prevalence |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Impact | The new prevalence estimates for all GPs in England (the dementia diagnosis targets) are defined with CFAS data from the 2013 paper. |
| Description | House of Commons Maths Education Parliamentary Reception |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Description | Lancet editorial consultant |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | As editorial consultant my work for the Lancet entails undertaking expert consultancy on the use of statistics within the journal which results in improvements in the quality of reporting in scientific papers |
| Description | Lancet paper 2013 |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Gave evidence to a government review |
| Description | Masterclass in longitudinal data analysis |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Teaching individuals on new methods of analysis |
| Description | NICE consultations on Alzheimer's disease treatment |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guidance committee |
| Impact | Undertook specialist validation of drug company submissions and a meta-analysis of aggregate data for the treatment of Alzheimers. Resulted in AD treatment decisions |
| Description | Postgraduate teaching |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Researchers go back to their host countries and implement evidence based Public Health interventions. |
| Description | Public Health England - Dementia Subgroup |
| Geographic Reach | National |
| Policy Influence Type | Participation in a national consultation |
| Description | Royal Statistical Society Science Journalism Programme |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The Royal Statistical Society aims to improve statistical literacy across the nation, from those in parliament to the children in our schools. But an important plank in this strategy is to also improve the understanding of those working in the media, who are often the brokers between the statisticians and the wider public. The RSS Science Journalism Programme was launched 2010. The aim of the project is to improve the scientific and statistical understanding of journalism professionals, and journalism students, through workshops given by science and statistics professionals themselves. The project has received funding from the Department for Business Innovation and Skills (BIS) to deliver the workshops at journalism schools and news organisations across the UK. The programme was originally established as a recommendation of the Science and the Media Expert Group's report Science and the Media: Securing the Future. The RSS agreed to host the programme on the principle that an understanding of statistics and science is fundamental to the needs of journalism training that were identified in the report. The programme has delivered training to journalists of all levels at multiple events and institutions nationally. |
| Description | Vascular dementia - new diagnostic criteria |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guidance committee |
| Description | DPUK |
| Amount | £350,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | DoH |
| Amount | £75,000 (GBP) |
| Organisation | NHS England |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2015 |
| End | 03/2016 |
| Description | ESRC |
| Amount | £135,876 (GBP) |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC Career Development Award (Biostatistics) |
| Amount | £100,400 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | PHE |
| Amount | £55,000 (GBP) |
| Organisation | Public Health England |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 04/2017 |
| Description | PHSRN |
| Amount | £128,240 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Title | Cognitive modelling techniques |
| Description | Cognitive modelling techniques that take into account missing data |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2008 |
| Provided To Others? | Yes |
| Impact | More accurate cognitive models |
| Title | ELECT |
| Description | Software toolkit for measurement of Healthy Active Life expectancy |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2011 |
| Provided To Others? | Yes |
| Impact | Usage has increased. New publications using the tool have started. |
| Title | MCI mapping |
| Description | Mild cognitive impairment review and description of clinical tools within the public health setting |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2007 |
| Provided To Others? | Yes |
| Impact | Now expanding the areas to describe vascular differences too. |
| Title | Missing data description for the older population |
| Description | Missing data description for the older population |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Systematic review of the literature and method used throughout for many other cohort studies |
| Title | Multi-state models for the older population |
| Description | Multi-state models were developed that describe transitions between cognitive states. Death was included as an additional state. New methodology w.r.t. A. Possible misclassification of the states B. Estimation of healthy life expectancy C. Bayesian inference, e.g., w.r.t. unobserved heterogeneity (frailty) in mixed effect models |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2008 |
| Provided To Others? | Yes |
| Impact | - Citations. Buter et al. 2008 has already been cited several times (Google Scholar). - New collaborations. Started after presenting material at conferences. - Recent work that extends the methodology above has been accepted for publication in journals |
| Title | CFAS II |
| Description | The CFAS II database consists of a variety of data (on subsets of individuals) including quantitative information, interview information, medication information, death notification (including cause and place of death). |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Enable the data resource to be shared with other researchers |
| Description | Autism Research Centre |
| Organisation | University of Cambridge |
| Department | Autism Research Centre (ARC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide statistical study design and methodological input into their study designs |
| Collaborator Contribution | They provide the study |
| Impact | Numerous papers; PMid 25757721, 25952676, 24756542, 24522967, 24769432, 24331886, 23892873, 23570419, 23041658, 21681590,19478287, 18408991 |
| Start Year | 2006 |
| Description | Brain Mapping Unit, Dept of Psychiatry, University of Cambridge |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide statistical support and advice to researchers within the Brain Mapping Unit. |
| Collaborator Contribution | Provide expertise in neuroimaging and wider neuroscience to research on statistical neuroimaging within the MRC BSU. Collaboration supports statistical methodology research through access to imaging datasets. |
| Impact | None yet. |
| Start Year | 2016 |
| Description | CFAS II Wales |
| Organisation | Bangor University |
| Department | Institute of Medical and Social Care Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Interviewer training, participant sampling and allocation data cleaning and coding, quality control. |
| Collaborator Contribution | Contribution of interviews and data collection for the study. Contribution of interviews and data collection for the study. |
| Impact | Recruitment has not get started. |
| Start Year | 2009 |
| Description | CFAS II Wales |
| Organisation | Swansea University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Interviewer training, participant sampling and allocation data cleaning and coding, quality control. |
| Collaborator Contribution | Contribution of interviews and data collection for the study. Contribution of interviews and data collection for the study. |
| Impact | Recruitment has not get started. |
| Start Year | 2009 |
| Description | Cambridge Intellectual & Developmental Disabilities Research Group, Dept of Psychiatry, University of Cambridge |
| Organisation | University of Cambridge |
| Department | Department of Pathology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide statistical support and advice to researchers in the Cambridge Intellectual & Developmental Disabilities Research Group. |
| Collaborator Contribution | Bridging statistical approaches with subject specific applications in learning disability, an area with many research challenges which bring statistical analysis challenges. |
| Impact | None yet. |
| Start Year | 2015 |
| Description | Co-morbidity and dementia: improving healthcare for people with dementia |
| Organisation | Luton and Dunstable University Hospital NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Explore impact of comorbidities for people with dementia on access to non-dementia services, and identify ways of improving integration of services for this population, reducing fragmentation and inappropriate use of care |
| Collaborator Contribution | Explore impact of comorbidities for people with dementia on access to non-dementia services, and identify ways of improving integration of services for this population, reducing fragmentation and inappropriate use of care |
| Impact | One paper has been published - Comorbidity and dementia: a scoping review of the literature. Talks was given at conference and a few other papers are under preparation. |
| Start Year | 2012 |
| Description | Co-morbidity and dementia: improving healthcare for people with dementia |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Explore impact of comorbidities for people with dementia on access to non-dementia services, and identify ways of improving integration of services for this population, reducing fragmentation and inappropriate use of care |
| Collaborator Contribution | Explore impact of comorbidities for people with dementia on access to non-dementia services, and identify ways of improving integration of services for this population, reducing fragmentation and inappropriate use of care |
| Impact | One paper has been published - Comorbidity and dementia: a scoping review of the literature. Talks was given at conference and a few other papers are under preparation. |
| Start Year | 2012 |
| Description | Co-morbidity and dementia: improving healthcare for people with dementia |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Explore impact of comorbidities for people with dementia on access to non-dementia services, and identify ways of improving integration of services for this population, reducing fragmentation and inappropriate use of care |
| Collaborator Contribution | Explore impact of comorbidities for people with dementia on access to non-dementia services, and identify ways of improving integration of services for this population, reducing fragmentation and inappropriate use of care |
| Impact | One paper has been published - Comorbidity and dementia: a scoping review of the literature. Talks was given at conference and a few other papers are under preparation. |
| Start Year | 2012 |
| Description | Co-morbidity and dementia: improving healthcare for people with dementia |
| Organisation | University of Hertfordshire |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Explore impact of comorbidities for people with dementia on access to non-dementia services, and identify ways of improving integration of services for this population, reducing fragmentation and inappropriate use of care |
| Collaborator Contribution | Explore impact of comorbidities for people with dementia on access to non-dementia services, and identify ways of improving integration of services for this population, reducing fragmentation and inappropriate use of care |
| Impact | One paper has been published - Comorbidity and dementia: a scoping review of the literature. Talks was given at conference and a few other papers are under preparation. |
| Start Year | 2012 |
| Description | Cosmic consortium |
| Organisation | University of New South Wales |
| Department | Centre for Healthy Brain Ageing (CHeBA) |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Consortia of 24 ageing studies to investigate mild cognitive impairment |
| Collaborator Contribution | Data and analysis provided to the group |
| Impact | PMId: 26539987, 24195705 |
| Start Year | 2015 |
| Description | EPIC |
| Organisation | University of Cambridge |
| Department | Department of Public Health and Primary Care |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint grant application for new appointment providing advice |
| Collaborator Contribution | Joint grant application |
| Impact | Publications: 25527303, 22687394, 21411287 and successful grant |
| Start Year | 2009 |
| Description | INSERM Bordeaux |
| Organisation | National Institute of Health and Medical Research (INSERM) |
| Department | Bordeaux |
| Country | France |
| Sector | Public |
| PI Contribution | Developed joint fellowship |
| Collaborator Contribution | Research fellowship with joint placement |
| Impact | Joint publications published. PMid 26499254, 24577561 |
| Start Year | 2011 |
| Description | Institute for Physical Activity and Nutrition, Deakin University |
| Organisation | Deakin University |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Provide statistical support and advice to researchers within the institute. |
| Collaborator Contribution | Collaboration is through the institutes statistics team, with whom the MRC BSU collaborate on statistical challenges in physical activity - bridging statistical methodology and applied statistics. |
| Impact | Papers: DOI: http://dx.doi.org/10.1186/s12966-015-0181-9 |
| Start Year | 2014 |
| Description | MRC CFAS |
| Organisation | University of Cambridge |
| Department | Department of Public Health and Primary Care |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Developing methodology and software to MRC CFAS |
| Collaborator Contribution | Grant applications and papers jointly produced |
| Impact | Multidisciplinary team from across the UK, public health researchers, clinicians, statisticians, neuropathologists, epidemiologists 1: Wu YT, Prina AM, Jones A, Barnes LE, Matthews FE, Brayne C, Mrc Cfas. Land use mix and five-year mortality in later life: Results from the Cognitive Function and Ageing Study. Health Place. 2016 Mar;38:54-60. doi: 10.1016/j.healthplace.2015.12.002. Epub 2016 Feb 1. PubMed PMID: 26798962. 2: Jagger C, Matthews FE, Wohland P, Fouweather T, Stephan BC, Robinson L, Arthur A, Brayne C; Medical Research Council Cognitive Function and Ageing Collaboration. A comparison of health expectancies over two decades in England: results of the Cognitive Function and Ageing Study I and II. Lancet. 2016 Feb 20;387(10020):779-86. doi: 10.1016/S0140-6736(15)00947-2. Epub 2015 Dec 9. PubMed PMID: 26680218; PubMed Central PMCID: PMC4761658. 3: Wharton SB, Minett T, Drew D, Forster G, Matthews F, Brayne C, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study Group. Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study. Acta Neuropathol Commun. 2016 Feb 8;4(1):11. doi: 10.1186/s40478-016-0275-x. PubMed PMID: 26857919; PubMed Central PMCID: PMC4746919. 4: Simpson JE, Ince PG, Minett T, Matthews FE, Heath PR, Shaw PJ, Goodall E, Garwood CJ, Ratcliffe LE, Brayne C, Rattray M, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathol Appl Neurobiol. 2016 Feb;42(2):167-179. doi: 10.1111/nan.12252. Epub 2015 Jul 7. PubMed PMID: 26095650. 5: Newton JN, Briggs AD, Murray CJ, Dicker D, Foreman KJ, Wang H, Naghavi M, Forouzanfar MH, Ohno SL, Barber RM, Vos T, Stanaway JD, Schmidt JC, Hughes AJ, Fay DF, Ecob R, Gresser C, McKee M, Rutter H, Abubakar I, Ali R, Anderson HR, Banerjee A, Bennett DA, Bernabé E, Bhui KS, Biryukov SM, Bourne RR, Brayne CE, Bruce NG, Brugha TS, Burch M, Capewell S, Casey D, Chowdhury R, Coates MM, Cooper C, Critchley JA, Dargan PI, Dherani MK, Elliott P, Ezzati M, Fenton KA, Fraser MS, Fürst T, Greaves F, Green MA, Gunnell DJ, Hannigan BM, Hay RJ, Hay SI, Hemingway H, Larson HJ, Looker KJ, Lunevicius R, Lyons RA, Marcenes W, Mason-Jones AJ, Matthews FE, Moller H, Murdoch ME, Newton CR, Pearce N, Piel FB, Pope D, Rahimi K, Rodriguez A, Scarborough P, Schumacher AE, Shiue I, Smeeth L, Tedstone A, Valabhji J, Williams HC, Wolfe CD, Woolf AD, Davis AC. Changes in health in England, with analysis by English regions and areas of deprivation, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015 Dec 5;386(10010):2257-74. doi: 10.1016/S0140-6736(15)00195-6. Epub 2015 Sep 14. PubMed PMID: 26382241; PubMed Central PMCID: PMC4672153. 6: Fluteau A, Ince PG, Minett T, Matthews FE, Brayne C, Garwood CJ, Ratcliffe LE, Morgan S, Heath PR, Shaw PJ, Wharton SB, Simpson JE; MRC Cognitive Function Ageing Neuropathology Study Group. The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neurosci Lett. 2015 Nov 16;609:11-7. doi: 10.1016/j.neulet.2015.10.001. Epub 2015 Oct 8. PubMed PMID: 26455863; PubMed Central PMCID: PMC4674771. 7: Wu YT, Prina AM, Jones AP, Barnes LE, Matthews FE, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Community environment, cognitive impairment and dementia in later life: results from the Cognitive Function and Ageing Study. Age Ageing. 2015 Nov;44(6):1005-11. doi: 10.1093/ageing/afv137. Epub 2015 Oct 13. PubMed PMID: 26464419; PubMed Central PMCID: PMC4621236. 8: Yates JA, Clare L, Woods RT, Matthews FE; Cognitive Function and Ageing Study Wales. Subjective Memory Complaints are Involved in the Relationship between Mood and Mild Cognitive Impairment. J Alzheimers Dis. 2015 Sep 24;48 Suppl 1:S115-23. doi: 10.3233/JAD-150371. PubMed PMID: 26402102. 9: Wu YT, Prina AM, Jones A, Matthews FE, Brayne C; MRC CFAS. Older people, the natural environment and common mental disorders: cross-sectional results from the Cognitive Function and Ageing Study. BMJ Open. 2015 Sep 16;5(9):e007936. doi: 10.1136/bmjopen-2015-007936. PubMed PMID: 26377504; PubMed Central PMCID: PMC4577935. 10: Gao L, Green E, Barnes LE, Brayne C, Matthews FE, Robinson L, Arthur A; Medical Research Council Cognitive Function and Ageing Collaboration. Changing non-participation in epidemiological studies of older people: evidence from the Cognitive Function and Ageing Study I and II. Age Ageing. 2015 Sep;44(5):867-73. doi: 10.1093/ageing/afv101. Epub 2015 Aug 14. PubMed PMID: 26276156; PubMed Central PMCID: PMC4547929. 11: Al-Mashhadi S, Simpson JE, Heath PR, Dickman M, Forster G, Matthews FE, Brayne C, Ince PG, Wharton SB; Medical Research Council Cognitive Function and Ageing Study. Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain. Brain Pathol. 2015 Sep;25(5):565-74. doi: 10.1111/bpa.12216. Epub 2014 Nov 20. PubMed PMID: 25311358. 12: Wu YT, Prina AM, Barnes LE, Matthews FE, Brayne C; MRC CFAS. Relocation at older age: results from the Cognitive Function and Ageing Study. J Public Health (Oxf). 2015 Sep;37(3):480-7. doi: 10.1093/pubmed/fdv050. Epub 2015 Apr 28. PubMed PMID: 25922369; PubMed Central PMCID: PMC4552011. 13: Simpson JE, Ince PG, Matthews FE, Shaw PJ, Heath PR, Brayne C, Garwood C, Higginbottom A, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. Neuropathol Appl Neurobiol. 2015 Jun;41(4):483-96. doi: 10.1111/nan.12202. Epub 2015 Apr 23. PubMed PMID: 25443110. 14: Zaccai J, Brayne C, Matthews FE, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study. Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly. Alzheimers Res Ther. 2015 Apr 13;7(1):19. doi: 10.1186/s13195-015-0101-x. eCollection 2015. PubMed PMID: 25870655; PubMed Central PMCID: PMC4394405. 15: Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. A reduced astrocyte response to ß-amyloid plaques in the ageing brain associates with cognitive impairment. PLoS One. 2015 Feb 23;10(2):e0118463. doi: 10.1371/journal.pone.0118463. eCollection 2015. PubMed PMID: 25707004; PubMed Central PMCID: PMC4338046. 16: Garwood CJ, Simpson JE, Al Mashhadi S, Axe C, Wilson S, Heath PR, Shaw PJ, Matthews FE, Brayne C, Ince PG, Wharton SB; MRC Cognitive Function and Ageing Study. DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort. Neuropathol Appl Neurobiol. 2014 Dec;40(7):802-14. doi: 10.1111/nan.12156. PubMed PMID: 24861546. 17: Davis DH, Barnes LE, Stephan BC, MacLullich AM, Meagher D, Copeland J, Matthews FE, Brayne C; MRC Cognitive Function and Ageing Study. The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). BMC Geriatr. 2014 Jul 28;14:87. doi: 10.1186/1471-2318-14-87. PubMed PMID: 25066510; PubMed Central PMCID: PMC4126352. 18: van der Linde RM, Dening T, Matthews FE, Brayne C. Grouping of behavioural and psychological symptoms of dementia. Int J Geriatr Psychiatry. 2014 Jun;29(6):562-8. doi: 10.1002/gps.4037. Epub 2013 Oct 16. Review. PubMed PMID: 24677112; PubMed Central PMCID: PMC4255309. 19: Lima TA, Adler AL, Minett T, Matthews FE, Brayne C, Marioni RE; Medical Research Council Cognitive Function and Ageing Study. C-reactive protein, APOE genotype and longitudinal cognitive change in an older population. Age Ageing. 2014 Mar;43(2):289-92. doi: 10.1093/ageing/aft193. Epub 2013 Dec 3. PubMed PMID: 24305621; PubMed Central PMCID: PMC3927773. 20: Love S, Chalmers K, Ince P, Esiri M, Attems J, Jellinger K, Yamada M, McCarron M, Minett T, Matthews F, Greenberg S, Mann D, Kehoe PG. Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue. Am J Neurodegener Dis. 2014 Mar 28;3(1):19-32. eCollection 2014. Erratum in: Am J Neurodegener Dis. 2015;4(2):49. PubMed PMID: 24754000; PubMed Central PMCID: PMC3986608. 21: Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MW, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuiness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Deniz Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F; European Alzheimer's Disease Initiative (EADI); Genetic and Environmental Risk in Alzheimer's Disease; Alzheimer's Disease Genetic Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology, Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannefelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltuenen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013 Dec;45(12):1452-8. doi: 10.1038/ng.2802. Epub 2013 Oct 27. PubMed PMID: 24162737; PubMed Central PMCID: PMC3896259. 22: Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath PR, Shaw PJ, Baxter L, Gelsthorpe C, Forster G, Matthews FE, Brayne C, Simpson JE; MRC Cognitive Function and Ageing Neuropathology Study Group. Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol. 2013 Dec;39(7):788-99. doi: 10.1111/nan.12033. PubMed PMID: 23421725. 23: Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Rockwood K, Xiao S, Li J, Li X, Brayne C, Matthews FE, Stephan BC, Lipton RB, Katz MJ, Ritchie K, Carrière I, Ancelin ML, Seshadri S, Au R, Beiser AS, Lam LC, Wong CH, Fung AW, Kim KW, Han JW, Kim TH, Petersen RC, Roberts RO, Mielke MM, Ganguli M, Dodge HH, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Meguro K, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabárbara J; COSMIC. COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurol. 2013 Nov 6;13:165. doi: 10.1186/1471-2377-13-165. PubMed PMID: 24195705; PubMed Central PMCID: PMC3827845. 24: Matthews FE, Arthur A, Barnes LE, Bond J, Jagger C, Robinson L, Brayne C; Medical Research Council Cognitive Function and Ageing Collaboration. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II. Lancet. 2013 Oct 26;382(9902):1405-12. doi: 10.1016/S0140-6736(13)61570-6. Epub 2013 Jul 17. PubMed PMID: 23871492; PubMed Central PMCID: PMC3906607. 25: Restaino M, Matthews FE, Minett T, Albanese E, Brayne C, Stephan BC. Predicting risk of 2-year incident dementia using the CAMCOG total and subscale scores. Age Ageing. 2013 Sep;42(5):649-53. doi: 10.1093/ageing/aft082. Epub 2013 Jul 19. PubMed PMID: 23872637; PubMed Central PMCID: PMC3745089. 26: van der Linde RM, Stephan BC, Matthews FE, Brayne C, Savva GM; Medical Research Council Cognitive Function and Ageing Study. The presence of behavioural and psychological symptoms and progression to dementia in the cognitively impaired older population. Int J Geriatr Psychiatry. 2013 Jul;28(7):700-9. doi: 10.1002/gps.3873. Epub 2012 Aug 10. PubMed PMID: 22887592. 27: Köhler S, Allardyce J, Verhey FR, McKeith IG, Matthews F, Brayne C, Savva GM; Medical Research Council Cognitive Function and Ageing Study. Cognitive decline and dementia risk in older adults with psychotic symptoms: a prospective cohort study. Am J Geriatr Psychiatry. 2013 Feb;21(2):119-28. doi: 10.1016/j.jagp.2012.10.010. Epub 2013 Jan 22. PubMed PMID: 23343485. 28: Davis DH, Muniz Terrera G, Keage H, Rahkonen T, Oinas M, Matthews FE, Cunningham C, Polvikoski T, Sulkava R, MacLullich AM, Brayne C. Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study. Brain. 2012 Sep;135(Pt 9):2809-16. doi: 10.1093/brain/aws190. Epub 2012 Aug 9. PubMed PMID: 22879644; PubMed Central PMCID: PMC3437024. 29: Matthews F, Marioni R, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: a population-based prospective cohort study. BMC Geriatr. 2012 Aug 13;12:45. doi: 10.1186/1471-2318-12-45. PubMed PMID: 22889350; PubMed Central PMCID: PMC3542122. 30: Keage HA, Banks S, Yang KL, Morgan K, Brayne C, Matthews FE. What sleep characteristics predict cognitive decline in the elderly? Sleep Med. 2012 Aug;13(7):886-92. doi: 10.1016/j.sleep.2012.02.003. Epub 2012 May 5. PubMed PMID: 22560827. 31: Stephan BC, Matthews FE, Hunter S, Savva GM, Bond J, McKeith IG, Ince P, Brayne C; Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Neuropathological profile of mild cognitive impairment from a population perspective. Alzheimer Dis Assoc Disord. 2012 Jul-Sep;26(3):205-12. PubMed PMID: 21946014. 32: Richardson K, Stephan BC, Ince PG, Brayne C, Matthews FE, Esiri MM. The neuropathology of vascular disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Curr Alzheimer Res. 2012 Jul;9(6):687-96. PubMed PMID: 22471870. 33: Valenzuela MJ, Matthews FE, Brayne C, Ince P, Halliday G, Kril JJ, Dalton MA, Richardson K, Forster G, Sachdev PS; Medical Research Council Cognitive Function and Ageing Study. Multiple biological pathways link cognitive lifestyle to protection from dementia. Biol Psychiatry. 2012 May 1;71(9):783-91. doi: 10.1016/j.biopsych.2011.07.036. Epub 2011 Nov 4. PubMed PMID: 22055015. 34: Lace G, Ince PG, Brayne C, Savva GM, Matthews FE, de Silva R, Simpson JE, Wharton SB. Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort. Dement Geriatr Cogn Disord. 2012;34(1):15-24. doi: 10.1159/000341581. Epub 2012 Aug 3. PubMed PMID: 22868294. 35: Stephan BC, Matthews FE, Ma B, Muniz G, Hunter S, Davis D, McKeith IG, Foster G, Ince PG, Brayne C. Alzheimer and vascular neuropathological changes associated with different cognitive States in a non-demented sample. J Alzheimers Dis. 2012;29(2):309-18. doi: 10.3233/JAD-2011-110518. PubMed PMID: 22233761; PubMed Central PMCID: PMC3975483. 36: Keage HA, Ince PG, Matthews FE, Wharton SB, McKeith IG, Brayne C; MRC CFAS and CC75C. Impact of less common and "disregarded" neurodegenerative pathologies on dementia burden in a population-based cohort. J Alzheimers Dis. 2012;28(2):485-93. doi: 10.3233/JAD-2011-111268. PubMed PMID: 22045491. 37: Marioni RE, van den Hout A, Valenzuela MJ, Brayne C, Matthews FE; MRC Cognitive Function and Ageing Study. Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline. J Alzheimers Dis. 2012;28(1):223-30. doi: 10.3233/JAD-2011-110377. PubMed PMID: 21971400. 38: Marioni RE, Valenzuela MJ, van den Hout A, Brayne C, Matthews FE; MRC Cognitive Function and Ageing Study. Active cognitive lifestyle is associated with positive cognitive health transitions and compression of morbidity from age sixty-five. PLoS One. 2012;7(12):e50940. doi: 10.1371/journal.pone.0050940. Epub 2012 Dec 12. PubMed PMID: 23251404; PubMed Central PMCID: PMC3521012. 39: Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ, Ince PG. Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort. Neurosci Lett. 2011 Nov 7;505(1):25-30. doi: 10.1016/j.neulet.2011.09.049. Epub 2011 Sep 28. PubMed PMID: 21970975. 40: Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype. Neurobiol Aging. 2011 Oct;32(10):1795-807. doi: 10.1016/j.neurobiolaging.2011.04.013. Epub 2011 Jun 25. PubMed PMID: 21705112. 41: Marioni RE, Chatfield M, Brayne C, Matthews FE; Medical Research Council Cognitive Function and Ageing Study Group. The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: a population-based prospective cohort study. BMC Med Res Methodol. 2011 Sep 6;11:127. doi: 10.1186/1471-2288-11-127. PubMed PMID: 21896187; PubMed Central PMCID: PMC3175206. 42: Fox C, Richardson K, Maidment ID, Savva GM, Matthews FE, Smithard D, Coulton S, Katona C, Boustani MA, Brayne C. Anticholinergic medication use and cognitive impairment in the older population: the medical research council cognitive function and ageing study. J Am Geriatr Soc. 2011 Aug;59(8):1477-83. doi: 10.1111/j.1532-5415.2011.03491.x. Epub 2011 Jun 24. PubMed PMID: 21707557. 43: Stephan BC, Brayne C, Savva GM, Matthews FE; Medical Research Council Cognitive Function and Ageing Study. Occurrence of medical co-morbidity in mild cognitive impairment: implications for generalisation of MCI research. Age Ageing. 2011 Jul;40(4):501-7. doi: 10.1093/ageing/afr057. PubMed PMID: 21673136; PubMed Central PMCID: PMC3290328. 44: Richardson K, Ananou A, Lafortune L, Brayne C, Matthews FE. Variation over time in the association between polypharmacy and mortality in the older population. Drugs Aging. 2011 Jul 1;28(7):547-60. doi: 10.2165/11592000-000000000-00000. PubMed PMID: 21721599. 45: Valenzuela M, Brayne C, Sachdev P, Wilcock G, Matthews F; Medical Research Council Cognitive Function and Ageing Study. Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort. Am J Epidemiol. 2011 May 1;173(9):1004-12. doi: 10.1093/aje/kwq476. Epub 2011 Mar 4. PubMed PMID: 21378129. 46: Nicoll JA, Savva GM, Stewart J, Matthews FE, Brayne C, Ince P; Medical Research Council Cognitive Function and Ageing Study. Association between APOE genotype, neuropathology and dementia in the older population of England and Wales. Neuropathol Appl Neurobiol. 2011 Apr;37(3):285-94. doi: 10.1111/j.1365-2990.2010.01130.x. PubMed PMID: 20880354. 47: Marioni RE, Matthews FE, Brayne C; MRC Cognitive Function and Ageing Study. The association between late-life cognitive test scores and retrospective informant interview data. Int Psychogeriatr. 2011 Mar;23(2):274-9. doi: 10.1017/S1041610210001201. Epub 2010 Jul 19. PubMed PMID: 20637140. 48: Tsopelas C, Stewart R, Savva GM, Brayne C, Ince P, Thomas A, Matthews FE; Medical Research Council Cognitive Function and Ageing Study. Neuropathological correlates of late-life depression in older people. Br J Psychiatry. 2011 Feb;198(2):109-14. doi: 10.1192/bjp.bp.110.078816. PubMed PMID: 21282780. 49: Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG; Medical Research Council Cognitive Function and Aging Study. Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience. J Alzheimers Dis. 2011;25(2):359-72. doi: 10.3233/JAD-2011-091402. PubMed PMID: 21422529. 50: Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C, Ince PG. Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain. Neurosci Lett. 2010 Dec 17;486(3):246-51. doi: 10.1016/j.neulet.2010.09.063. Epub 2010 Sep 29. PubMed PMID: 20887772. 51: van der Linde R, Stephan BC, Matthews FE, Brayne C, Savva GM; Medical Research Council Cognitive Function and Ageing Study. Behavioural and psychological symptoms in the older population without dementia--relationship with socio-demographics, health and cognition. BMC Geriatr. 2010 Nov 30;10:87. doi: 10.1186/1471-2318-10-87. PubMed PMID: 21118498; PubMed Central PMCID: PMC3014957. 52: Hogervorst E, Matthews FE, Brayne C. Are optimal levels of testosterone associated with better cognitive function in healthy older women and men? Biochim Biophys Acta. 2010 Oct;1800(10):1145-52. doi: 10.1016/j.bbagen.2009.12.009. Epub 2010 Jan 7. PubMed PMID: 20060437. 53: Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, Frayling TM, Murray A, Melzer D. Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging. 2010 Sep;31(9):1563-8. doi: 10.1016/j.neurobiolaging.2008.08.020. Epub 2008 Oct 9. PubMed PMID: 18848371; PubMed Central PMCID: PMC2975102. 54: Stephan BC, Savva GM, Brayne C, Bond J, McKeith IG, Matthews FE; Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Optimizing mild cognitive impairment for discriminating dementia risk in the general older population. Am J Geriatr Psychiatry. 2010 Aug;18(8):662-73. PubMed PMID: 21491627. 55: EClipSE Collaborative Members, Brayne C, Ince PG, Keage HA, McKeith IG, Matthews FE, Polvikoski T, Sulkava R. Education, the brain and dementia: neuroprotection or compensation? Brain. 2010 Aug;133(Pt 8):2210-6. doi: 10.1093/brain/awq185. PubMed PMID: 20826429. 56: Matthews FE, Muniz-Terrera G, McKeith I, Brayne C; MRC CFAS. Who will be eligible? An investigation of the dementia population eligible for cholinesterase treatment following the change in NICE guidance. Int J Geriatr Psychiatry. 2010 Jul;25(7):719-24. doi: 10.1002/gps.2413. PubMed PMID: 19946863. 57: Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain. Neurobiol Aging. 2010 Apr;31(4):578-90. doi: 10.1016/j.neurobiolaging.2008.05.015. Epub 2008 Jun 30. PubMed PMID: 18586353. 58: Simpson JE, Ince PG, Haynes LJ, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE, Savva GM, Brayne C, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol. 2010 Feb;36(1):25-40. doi: 10.1111/j.1365-2990.2009.01030.x. Epub 2009 May 5. PubMed PMID: 19422529. 59: Keage HA, Matthews FE, Yip A, Gao L, McCracken C, McKeith IG, Rubinsztein DC, Brayne C; MRC Cognitive Function and Ageing Study. APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA Study. Age Ageing. 2010 Jan;39(1):104-11. doi: 10.1093/ageing/afp210. Epub 2009 Nov 24. PubMed PMID: 19939808; PubMed Central PMCID: PMC2794361. 60: Seidel D, Jagger C, Brayne C, Matthews FE, Cfas M. Recovery in instrumental activities of daily living (IADLs): findings from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Age Ageing. 2009 Nov;38(6):663-8. doi: 10.1093/ageing/afp128. Epub 2009 Jul 25. PubMed PMID: 19633320. 61: Matthews FE, Brayne C, Lowe J, McKeith I, Wharton SB, Ince P. Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study. PLoS Med. 2009 Nov;6(11):e1000180. doi: 10.1371/journal.pmed.1000180. Epub 2009 Nov 10. PubMed PMID: 19901977; PubMed Central PMCID: PMC2765638. 62: Seidel D, Crilly N, Matthews FE, Jagger C, Brayne C, Clarkson PJ; Medical Research Council Cognitive Function and Ageing Study. Patterns of functional loss among older people: a prospective analysis. Hum Factors. 2009 Oct;51(5):669-80. PubMed PMID: 20196292. 63: Llewellyn DJ, Matthews FE. Increasing levels of semantic verbal fluency in elderly English adults. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2009 Jul;16(4):433-45. doi: 10.1080/13825580902773867. Epub 2009 Mar 25. PubMed PMID: 19319746. 64: Byford M, Brayne C, McKeith I, Chatfield M, Ince P, Matthews F; MRC CFAS Neuropathology group. Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study. BMC Geriatr. 2009 Jun 15;9:22. doi: 10.1186/1471-2318-9-22. PubMed PMID: 19527486; PubMed Central PMCID: PMC2706837. 65: Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Age, neuropathology, and dementia. N Engl J Med. 2009 May 28;360(22):2302-9. doi: 10.1056/NEJMoa0806142. PubMed PMID: 19474427. 66: Lace G, Savva GM, Forster G, de Silva R, Brayne C, Matthews FE, Barclay JJ, Dakin L, Ince PG, Wharton SB; MRC-CFAS. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain. 2009 May;132(Pt 5):1324-34. doi: 10.1093/brain/awp059. Epub 2009 Mar 24. PubMed PMID: 19321462. 67: Savva GM, Zaccai J, Matthews FE, Davidson JE, McKeith I, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population. Br J Psychiatry. 2009 Mar;194(3):212-9. doi: 10.1192/bjp.bp.108.049619. PubMed PMID: 19252147. 68: Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Ince PG; Medical Research Council Cognitive Function and Ageing Study Neuropathology Group. Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways. Stroke. 2009 Feb;40(2):369-75. doi: 10.1161/STROKEAHA.108.529214. Epub 2008 Dec 24. PubMed PMID: 19109541. 69: Wharton SB, O'Callaghan JP, Savva GM, Nicoll JA, Matthews F, Simpson JE, Forster G, Shaw PJ, Brayne C, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study Group. Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia. Dement Geriatr Cogn Disord. 2009;27(5):465-73. doi: 10.1159/000217729. Epub 2009 May 7. PubMed PMID: 19420941. 70: Matthews FE, Jagger C, Miller LL, Brayne C; MRC CFAS. Education differences in life expectancy with cognitive impairment. J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):125-31. doi: 10.1093/gerona/gln003. Epub 2009 Jan 31. PubMed PMID: 19182231; PubMed Central PMCID: PMC2691183. 71: Stephan BC, Brayne C, McKeith IG, Bond J, Matthews FE; Medical Research Council Cognitive Function and Ageing Study. Mild cognitive impairment in the older population: Who is missed and does it matter? Int J Geriatr Psychiatry. 2008 Aug;23(8):863-71. doi: 10.1002/gps.2013. PubMed PMID: 18537198. 72: Matthews FE, Stephan BC, McKeith IG, Bond J, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree? J Am Geriatr Soc. 2008 Aug;56(8):1424-33. doi: 10.1111/j.1532-5415.2008.01820.x. Epub 2008 Jul 24. PubMed PMID: 18662209. 73: Hogervorst E, Huppert F, Matthews FE, Brayne C. Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study. Psychoneuroendocrinology. 2008 Aug;33(7):1013-22. doi: 10.1016/j.psyneuen.2008.05.008. Epub 2008 Jul 21. PubMed PMID: 18640783. 74: Xie J, Matthews FE, Jagger C, Bond J, Brayne C. The oldest old in England and Wales: a descriptive analysis based on the MRC Cognitive Function and Ageing Study. Age Ageing. 2008 Jul;37(4):396-402. doi: 10.1093/ageing/afn061. Epub 2008 Apr 18. PubMed PMID: 18424470; PubMed Central PMCID: PMC2441704. 75: Pérès K, Jagger C, Matthews FE; MRC CFAS. Impact of late-life self-reported emotional problems on Disability-Free Life Expectancy: results from the MRC Cognitive Function and Ageing Study. Int J Geriatr Psychiatry. 2008 Jun;23(6):643-9. PubMed PMID: 18044794. 76: Zaccai J, Brayne C, McKeith I, Matthews F, Ince PG; MRC Cognitive Function, Ageing Neuropathology Study. Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort. Neurology. 2008 Mar 25;70(13):1042-8. doi: 10.1212/01.wnl.0000306697.48738.b6. PubMed PMID: 18362284. 77: Kvaal K, McDougall FA, Brayne C, Matthews FE, Dewey ME; MRC CFAS. Co-occurrence of anxiety and depressive disorders in a community sample of older people: results from the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study). Int J Geriatr Psychiatry. 2008 Mar;23(3):229-37. PubMed PMID: 17631679. 78: Gao L, Matthews FE, Sargeant LA, Brayne C; MRC CFAS. An investigation of the population impact of variation in HbA1c levels in older people in England and Wales: from a population based multi-centre longitudinal study. BMC Public Health. 2008 Feb 11;8:54. doi: 10.1186/1471-2458-8-54. PubMed PMID: 18267013; PubMed Central PMCID: PMC2275259. 79: Xie J, Brayne C, Matthews FE; Medical Research Council Cognitive Function and Ageing Study collaborators. Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up. BMJ. 2008 Feb 2;336(7638):258-62. doi: 10.1136/bmj.39433.616678.25. Epub 2008 Jan 10. PubMed PMID: 18187696; PubMed Central PMCID: PMC2223023. 80: Basta NE, Matthews FE, Chatfield MD, Brayne C; MRC-CFAS. Community-level socio-economic status and cognitive and functional impairment in the older population. Eur J Public Health. 2008 Feb;18(1):48-54. Epub 2007 Jul 12. PubMed PMID: 17631489. 81: Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Stoeber K, Williams GH, Lewis CE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Microglial activation in white matter lesions and nonlesional white matter of ageing brains. Neuropathol Appl Neurobiol. 2007 Dec;33(6):670-83. PubMed PMID: 17990995. 82: McDougall FA, Kvaal K, Matthews FE, Paykel E, Jones PB, Dewey ME, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Prevalence of depression in older people in England and Wales: the MRC CFA Study. Psychol Med. 2007 Dec;37(12):1787-95. Epub 2007 Apr 4. Erratum in: Psychol Med. 2007 Dec;37(12):1796. PubMed PMID: 17407617. 83: Stephan BC, Matthews FE, McKeith IG, Bond J, Brayne C; Medical Research Council Cognitive Function and Aging Study. Early cognitive change in the general population: how do different definitions work? J Am Geriatr Soc. 2007 Oct;55(10):1534-40. PubMed PMID: 17908056. 84: Matthews FE, Stephan BC, Bond J, McKeith I, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Operationalization of mild cognitive impairment: a graphical approach. PLoS Med. 2007 Oct;4(10):1615-9. Review. PubMed PMID: 17973571; PubMed Central PMCID: PMC2043006. 85: McDougall FA, Matthews FE, Kvaal K, Dewey ME, Brayne C. Prevalence and symptomatology of depression in older people living in institutions in England and Wales. Age Ageing. 2007 Sep;36(5):562-8. PubMed PMID: 17913759. 86: Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses. Neuropathol Appl Neurobiol. 2007 Aug;33(4):410-9. Epub 2007 Apr 18. PubMed PMID: 17442062. 87: Jagger C, Matthews RJ, Matthews FE, Spiers NA, Nickson J, Paykel ES, Huppert FA, Brayne C; Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS). Cohort differences in disease and disability in the young-old: findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS). BMC Public Health. 2007 Jul 13;7:156. PubMed PMID: 17629910; PubMed Central PMCID: PMC1947964. 88: Matthews FE, McKeith I, Bond J, Brayne C; MRC CFAS. Reaching the population with dementia drugs: what are the challenges? Int J Geriatr Psychiatry. 2007 Jul;22(7):627-31. PubMed PMID: 17136710. 89: Chatfield M, Matthews FE, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Using the Mini-Mental State Examination for tracking cognition in the older population based on longitudinal data. J Am Geriatr Soc. 2007 Jul;55(7):1066-71. PubMed PMID: 17608880. 90: Jagger C, Matthews R, Melzer D, Matthews F, Brayne C; MRC CFAS. Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS). Int J Epidemiol. 2007 Apr;36(2):358-65. Epub 2007 Jan 25. PubMed PMID: 17255347. 91: Jagger C, Matthews R, Matthews F, Robinson T, Robine JM, Brayne C; Medical Research Council Cognitive Function and Ageing Study Investigators. The burden of diseases on disability-free life expectancy in later life. J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):408-14. PubMed PMID: 17452735. 92: Brayne C, McCracken C, Matthews FE; Medical Research Council Coginitive Function and Ageing Study (CFAS). Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS). Int J Epidemiol. 2006 Oct;35(5):1140-5. Epub 2006 Sep 15. Review. PubMed PMID: 16980700. 93: Brayne C, Gao L, Dewey M, Matthews FE; Medical Research Council Cognitive Function and Ageing Study Investigators. Dementia before death in ageing societies--the promise of prevention and the reality. PLoS Med. 2006 Oct;3(10):e397. PubMed PMID: 17076551; PubMed Central PMCID: PMC1626550. 94: Foltynie T, Matthews FE, Ishihara L, Brayne C; MRC CFAS. The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort. BMC Neurol. 2006 Aug 22;6:29. PubMed PMID: 16925826; PubMed Central PMCID: PMC1569859. 95: Matthews FE, Chatfield M, Brayne C; Medical Research Council Cognitive Function and Ageing Study. An investigation of whether factors associated with short-term attrition change or persist over ten years: data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). BMC Public Health. 2006 Jul 18;6:185. PubMed PMID: 16848886; PubMed Central PMCID: PMC1538586. 96: Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB, Shaw PJ, O'Brien JT, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study Group. White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke. 2006 Jun;37(6):1391-8. Epub 2006 Apr 20. PubMed PMID: 16627790. 97: Matthews FE, Miller LL, Brayne C, Jagger C; Medical Research Council Cognitive Function and Aging Study (MRC CFAS). Regional differences in multidimensional aspects of health: findings from the MRC cognitive function and ageing study. BMC Public Health. 2006 Apr 6;6:90. PubMed PMID: 16600044; PubMed Central PMCID: PMC1475575. 98: Yip AG, Brayne C, Matthews FE; MRC Cognitive Function and Ageing Study. Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study. Age Ageing. 2006 Mar;35(2):154-60. Epub 2006 Jan 13. PubMed PMID: 16414964. 99: Brayne C, Gao L, Matthews F; MRC Cognitive Function and Ageing Study. Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression. Neurobiol Aging. 2005 Dec;26 Suppl 1:6-10. Epub 2005 Oct 24. Review. PubMed PMID: 16246462. 100: Barnes L, Matthews FE, Barber B, Davies L, Lloyd D, Brayne C, Parry B. Brain donation for research: consent and re-consent post Alder Hey. Bull Med Ethics. 2005 Oct-Nov;(211):17-21. PubMed PMID: 17139813. 101: Syed A, Chatfield M, Matthews F, Harrison P, Brayne C, Esiri MM. Depression in the elderly: pathological study of raphe and locus ceruleus. Neuropathol Appl Neurobiol. 2005 Aug;31(4):405-13. PubMed PMID: 16008824. 102: Matthews F, Brayne C; Medical Research Council Cognitive Function and Ageing Study Investigators. The incidence of dementia in England and Wales: findings from the five identical sites of the MRC CFA Study. PLoS Med. 2005 Aug;2(8):e193. Epub 2005 Aug 23. Erratum in: PLoS Med. 2005 Oct;2(10):e389. PubMed PMID: 16111436; PubMed Central PMCID: PMC1188245. 103: Spiers NA, Matthews RJ, Jagger C, Matthews FE, Boult C, Robinson TG, Brayne C. Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: findings from the Medical Research Council Cognitive Function and Ageing Study. J Gerontol A Biol Sci Med Sci. 2005 Feb;60(2):248-54. PubMed PMID: 15814870. 104: Fernando MS, O'Brien JT, Perry RH, English P, Forster G, McMeekin W, Slade JY, Golkhar A, Matthews FE, Barber R, Kalaria RN, Ince PG; Neuropathology Group of MRC CFAS. Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain. Neuropathol Appl Neurobiol. 2004 Aug;30(4):385-95. PubMed PMID: 15305984. 105: Matthews FE, Chatfield M, Freeman C, McCracken C, Brayne C; MRC CFAS. Attrition and bias in the MRC cognitive function and ageing study: an epidemiological investigation. BMC Public Health. 2004 Apr 27;4:12. PubMed PMID: 15113437; PubMed Central PMCID: PMC419705. 106: Williams JG, Huppert FA, Matthews FE, Nickson J; MRC Cognitive Function and Ageing Study (MRC CFAS). Performance and normative values of a concise neuropsychological test (CAMCOG) in an elderly population sample. Int J Geriatr Psychiatry. 2003 Jul;18(7):631-44. PubMed PMID: 12833308. 107: Matthews FE, Dening T; UK Medical Research Council Cognitive Function and Ageing Study. Prevalence of dementia in institutional care. Lancet. 2002 Jul 20;360(9328):225-6. PubMed PMID: 12133659. 108: Jagger C, Matthews F. Gender differences in life expectancy free of impairment at older ages. J Women Aging. 2002;14(1-2):85-97. PubMed PMID: 12537281. 109: Brayne C, Matthews FE, McGee MA, Jagger C. Health and ill-health in the older population in England and Wales. The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Age Ageing. 2001 Jan;30(1):53-62. PubMed PMID: 11322674. |
| Description | MRC Cognition and Brain Sciences Unit |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Cognition and Brain Sciences Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide statistical advice, support and contribute to statistics/methods training workshops at the MRC CBSU. |
| Collaborator Contribution | The MRC CBSU contributes experience in neuroimaging, as well as neuroscience more widely, to statistical neuroimaging research at the MRC BSU. |
| Impact | A joint PhD project between the MRC BSU and MRC CBSU (PhD is based at the MRC BSU). No papers yet (as of 2017/Mar). |
| Start Year | 2015 |
| Description | MRC Lifelong Health and Wellbeing Unit |
| Organisation | University College London |
| Department | MRC Unit for Lifelong Health and Ageing |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Consultant to HALCYon Grant. Discussions about future direction of ageing research. |
| Collaborator Contribution | The partners provided the interesting questions that needed answers. |
| Impact | Joint publications, talks and workshops |
| Start Year | 2010 |
| Description | Neuropathology |
| Organisation | University of Sheffield |
| Department | Sheffield Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Methodology, analytical support, study design, paper writing and grant writing |
| Collaborator Contribution | Undertaking new grant writing and paper writing and analysis methodologies |
| Impact | Numerous publications four succes, sful grants, . , PMid 26857919, 26095650, 24655863, 25311358, 25443110, 25870655, 263807344, 25707004, 24861546, 24927703, 23678850, 24754000, 25170584, 23421725, 21946014, 22471870, 22055015, 22868294, 22233761, 22045491, 21970975, 21705112, 20880354, 21282780, 21422529, 20887772, 18586353, 19422529, 19901977, 19527486, 19474427, 19321462, 19109541, 19420941, 18362284, 17990995, 17442062, 16627790, 15305984 |
| Description | Newcastle University |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on an ESRC grant with Professor Carol Jagger, workshop at conference for wider education and dissemination of results. We provided the workshop material and presentations. |
| Collaborator Contribution | Professor Jagger provided the conference facilities and organisation. |
| Impact | Publications Wohland P, Rees P, Gillies C, Alvanides S, Matthews FE, O'Neill V, Jagger C. Drivers of inequality in disability-free expectancy at birth and age 85 across space and time in Great Britain. Journal of Epidemiology & Community Health 2014, 68, 826-833. Open Access Wohland P, Rees P, Nazroo J, Jagger C. Inequalities in healthy life expectancy between ethnic groups in England and Wales in 2001. Ethnicity and Health 2014, DOI:10.1080/13557858.2014.921892, Open Access Presentations 2014 Pia Wohland, Carol Jagger, Fiona Matthews and Vikki O'Neill, Explaining health inequality at older ages in England and Wales, England and Wales, VID Conference, New Measures of Age and Ageing, 3 - 5 December 2014, poster presentation [Upcoming] Pia Wohland, Vikki O' Neill, Fiona Matthews and Carol Jagger, Explaining health inequality at older ages in England and Wales, Applied Epidemiology Research Day, 29th September 2014 [PDF] Pia Wohland, Carol Jagger, Fiona Matthes and Vikki O'Neill, Individual level socio economic factors explaining health inequality at older ages in England, oral presentation BSPS 2014, Winchester University [PDF] Pia Wohland, Clare Gillies, Seraphim Alvanides, Fiona Matthews and Vikki O'Neil, Where we live or how we live-Explaining regional health expectancy variations in England, REVES 2014 Edinburgh, 28 to 30 May 2014 [PDF] Fiona Matthews, Vikki O'Neill, Carol Jagger and Pia Wohland Comparison of methods and programs for calculating health life expectancies, REVES 2014 Edinburgh, 28 to 30 May 2014 [PDF] 2013 Pia Wohland, Fiona Matthews, Vikki O'Neill and Carol Jagger, "Explaining regional health expectancy variations: the relative contribution of socio-demographic, socio-economic and health behavioural factors", Workshop at 6th European Public Health Conference, Brussels, 13 - 16 November 2013 [PDF] Pia Wohland, Phil Rees and Carol Jagger for the InHALE project, "Explaining regional health variations - The relative contribution of socio-demographic, socio-economic and health behavioural factors", Poster presentation at BSPS 2013, Swansea University, 9 - 11 September 2013 [PDF] Pia Wohland, Phil Rees and Carol Jagger,"Health Inequalities across Great Britain", 7th International Conference on Population Geographies, Groningen 25.06.2013 - 28.06.2013 [PDF] Fiona Matthews, Vikki O'Neill and Carol Jagger, "Comparison of methods and programs for calculating health life expectancies", 25. REVES meeting, Austin, Texas May 2013 [PDF] Pia Wohland, Phil Rees, James Nazroo and Carol Jagger, "Ethnicity and Inequalities in Health Expectancies", 25. REVES meeting, Austin, Texas May 2013 [PDF] Pia Wohland and Carol Jagger, InHALE- Inequalities in Healthy Active Life Expectancy - How to make the best use of census information, poster presented at the 2013 LARIA conference, Manchester, March 2013 [PDF] 2012 Pia Wohland, Phil Rees and Carol Jagger, "Explaining inequality in mortality and health across the UK between 1991 and 2001", poster presentation at the international conference on "Determinants of Unusual and Differential Longevity", Vienna, 21 Nov. - 23 Nov. 2012 [PDF] Pia Wohland "Explaining inequality in mortality and health across the UK", CCSR Seminar, 6th of November 2012, Manchester [PDF] Pia Wohland "How to Calculate Health Expectancies for Local Authorities" Training on local authority demography, workshop at BSPS 2012, University of Nottingham, UK [link] Pia Wohland, Phil Rees and Carol Jagger, "Inequalities in disability free life expectancy and healthy life expectancy between ethnic groups in England and Wales", BSPS 2012, University of Nottingham, UK [PDF] Carol Jagger and Pia Wohland, "Are we all living longer and healthier lives?", presented at the IAH institute seminar, 5 July 2012, Newcastle, Institute for Ageing and Health, UK Pia Wohland and Carol Jagger, "How have inequalities in LE and DFLE changed for local areas in England and Wales between 1991 and 2001?" presented at the 24th REVES meeting, 25-27 May 2012, Taichung, Taiwan "Inequalities in health by socio-economic status: Is it a universal fact?" [PDF] Pia Wohland, "The role of social factors in explaining variations in HLE and DFLE at different ages between geographic areas - Progress report on work package 1" presented at the first advisory board meeting, 5 April 2012, Newcastle, Institute for Ageing and Health, UK |
| Start Year | 2012 |
| Description | Newcastle University (IHS) |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Developing the ageing team within Newcastle University |
| Collaborator Contribution | Providing support for research posts |
| Impact | Publications now out: For example: PMid: 26680218, 24907279, 23871492, 26690191, 26377504, 24754000, 26276156 |
| Start Year | 2014 |
| Description | PSHRN |
| Organisation | University College London |
| Department | MRC Unit for Lifelong Health and Ageing |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint grants together with publications in process |
| Collaborator Contribution | Joint grant |
| Impact | Publications now out. PMiD 24770853, 22249241, 20843964 |
| Start Year | 2009 |
| Description | SAvva- U EA |
| Organisation | University of East Anglia |
| Department | School of Pharmacy |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Statistical methods analysis |
| Collaborator Contribution | Grant collaboration |
| Impact | Publications are now underway, public engagement workshop |
| Start Year | 2016 |
| Description | School of Public Health |
| Organisation | University of Cambridge |
| Department | Cambridge Institute of Public Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing methodological support |
| Collaborator Contribution | Input into research decisions and thoughts around the analysis |
| Impact | A number of publications have had indirect support from the school. PMid 2679862, 26680218, 26300044, 26464419, 26377504 |
| Start Year | 2013 |
| Description | Scott Hofer |
| Organisation | University of Victoria |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Cross visitations between UK and Canada, established joint working. |
| Collaborator Contribution | Publications jointly written Conference workshop together New grant application submitted |
| Impact | Joint workshop in Berlin, publications published. PMid 23276221, 23626569 |
| Start Year | 2008 |
| Description | UCL |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Statistical expertise |
| Collaborator Contribution | Publications and software improvement |
| Impact | Several publications |
| Start Year | 2009 |
| Description | University of Edinburgh |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration between FM and Graciela Muniz on modelling cognitive change over time. FM provides statistical questions and analytically ideas. |
| Collaborator Contribution | Collaboration between FM and Graciela Muniz on modelling cognitive change over time. GM provides data and analytically ideas. |
| Impact | Too early for outputs |
| Start Year | 2016 |
| Description | University of Exeter |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I provide statistical mentoring and direction to researchers in Exeter who are involved in the IDEAL study. |
| Collaborator Contribution | The IDEAL study is a multi-disciplinary group of researchers involved in a longitudinal study on dementia. |
| Impact | None yet |
| Start Year | 2016 |
| Description | University of Twente |
| Organisation | University of Twente |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Statistical expertise |
| Collaborator Contribution | Publications |
| Impact | Publication PMiD 22080595 |
| Start Year | 2009 |
| Title | Dementia prevalence estimates |
| Description | New dementia guidelines for all GPs are generated from dementia prevalence estimates produced. |
| Type | Management of Diseases and Conditions |
| Current Stage Of Development | Wide-scale adoption |
| Year Development Stage Completed | 2015 |
| Development Status | Under active development/distribution |
| Impact | The prevalence estimates for all GPs are more realistic to the actual amount of dementia in the population. They will be modified as new information is produced. |
| Title | Dementia public health advice |
| Description | Dementia and cholinesterase usage in the UK |
| Type | Management of Diseases and Conditions |
| Current Stage Of Development | Wide-scale adoption |
| Year Development Stage Completed | 2008 |
| Development Status | Under active development/distribution |
| Impact | The usage of these drugs are not reaching the population. Clinicians are now aware of the problem |
| Title | New VCI consensus definitions |
| Description | Part of the VCI consensus group for developing new guidelines |
| Type | Diagnostic Tool - Non-Imaging |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2011 |
| Development Status | Under active development/distribution |
| Impact | Published and incorporated into new guidelines for clinicians. |
| Title | Trachoma public health advice |
| Description | Sudan description of trachoma burden and potential impact of intervention |
| Type | Preventative Intervention - Behavioural risk modification |
| Current Stage Of Development | Wide-scale adoption |
| Year Development Stage Completed | 2006 |
| Development Status | Under active development/distribution |
| Impact | Full scale usage and understanding of the SAFE strategy for elimination of results |
| Description | 1st International Conference of Longevity, Ageing and Its Diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Two cohort studies in England and Wales. Audience consitituted from all fields within ageing research. Further impact of our results to a wider audience |
| Year(s) Of Engagement Activity | 2007 |
| Description | Aberdeen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Day long visit to Aberdeen with a keynote presentation to raise profile of new estimates of dementia prevalence. About 100 people attended the lunchtime lecture. Asked to collaborate more frequently in this area. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Armitage Lectures |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Annual workshop and lecture created and hosted by the MRC Biostatistics Unit, to honour the immense contributions of Professor Peter Armitage who was at the unit from 1947 to 1961, and whose work is recognised throughout the world as achieving a successful balance between methodological rigour and applied commonsense, to which all statisticians aspire. An eminent medical statistician visits for a week and works with members of the unit. The highlight is the Armitage Lecture, where more than 100 delegates attend. This event raises the unit research profile and creates new collaborations. |
| Year(s) Of Engagement Activity | Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017 |
| URL | https://www.mrc-bsu.cam.ac.uk/news-and-events/armitage-lectureships-and-workshops/ |
| Description | Attendance at 2019 MELODEM conference 21-22 July 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attendance at 2019 MELODEM conference 21-22 July 2019 This is an annual conference and international collaborative group that was set up to bring together the cohort studies in the world that have thought about the challenges of appropriate analysis of longitudinal data. These are fraught with challenges and I have been involved in these discussions since I started out in my career. This conference brings doctoral students, intermediate career scientists and senior leaders together. This means that the discussion is rich, with implicit teaching on new methods to address the challenges. I heard about new methods of analysis, seeing how methods that have been used in the MRC BSU with which I have collaborated for decades are being disseminated. It is interesting that these take just as long as the classical 17 years much quoted about clinical changes. The talks ranged across examination of the very old and whether the relationship between White Matter Lesions with neuropsychological tests holds for this population to whether patterns of work in women are associated with particular cognitive change in later life. How to estimate the prevalence of the suggested indicative biomarkers for Alzheimer's Disease, which reveals the real challenges in this. Chronic Traumatic Encephalopathy is another area. This new learning helps me keep up to date with my own research field. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Awarded Peter Holmes Prize for hands-on statistics activity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Senior Research Associate, Simon White, awarded Peter Holmes prize for best hands-on classroom activity published in Teaching Statistics. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://onlinelibrary.wiley.com/doi/10.1111/test.12217 |
| Description | BSU Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Unit held open day as part of MRC Festival of Medical Research. The aim of the open day was to welcome secondary school students and members of the general public to come to the unit, find out about the research the unit does, and to take part in activities that illustrate BSU research, with the overall theme being 'Fun with statistics'. An open day of this format was a first for the unit and overall it was a very successful event. There were 40 attendees over a 4 hour event. All attendees pre-booked and were split into 4 groups for a 1 hour session comprising of an introduction, participation in hands-on activities, and a brief careers talk. The small groups and length of session allowed for quality engagement between the scientists and the audience. Feedback from the attendees was very positive, and the wider MRC Festival activities that took place in Cambridge demonstrated the benefits in delivering these types of events. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.mrc-bsu.cam.ac.uk/bsu-open-day-2016-why-are-statistics-important/ |
| Description | Bassingbourn Village College Statistics Workshop, STEM Ambassador |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | STEM Statistics Workshop was developed, supported by a Public Engagement Seed Fund (awarded by the University of Cambridge). The workshop was designed to engage Year 10 and Year 11 students in statistical thinking and present interesting problems in biostatistics. The workshop consisted for three interactive activities, with a significant focus on working in groups to investigate and talk about the activities. This prompted many questions and discussions as the students worked through the activities. Bassingbourn Village College reported students were very engaged with the activities, and it was very helpful to see a different context for the statistical ideas taught as part of the curriculum. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Big Biology Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Participation in Big Biology Day, organised by Hills Road Sixth Form College in Cambridge - a one day annual 'science festival' event open to memebers of the general public to participate in a range of biology based hands-on activities for all ages. BSU presented a stand with three hands-on, interactive activities, each communicating a simple statistical method or idea, linked to the unit's research themes. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.hillsroad.ac.uk/college-life/events/2016/10/15/default-calendar/big-biology-day |
| Description | CSaP talk - How to stop bad data driving out the good in an age of misuse, misleadingness and misinformation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | CSaP talk - How to stop bad data driving out the good in an age of misuse, misleadingness and misinformation 4 March 2019 Ed Humpherson is the CEO of the Office of Statistics Regulation. He gave an elegant talk about how numbers can be used poorly - The Number, misleading and too much unsignposted data. He talked about creating standards and reporting on these, how his office has interacted with government departments to call such practice out and how they have responded. He also talked about responsible media. I gained insight into how such a government function can operate to hold government to account. It highlighted the fact that this is possible to do within a (relatively) stable governmental/public domain structure but that it would be unlikely professional integrity heading for CPD. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Each year BSU participate in Cambridge Science Festival - members of the general public explore and discuss issues of scientific interest and concern, through a series of different events. The event also aims to raise aspirations by encouraging young people to consider a career in science, technology, engineering or mathematics. BSU take part over two full days - 'Science Saturday' and the 'Cambridge Biomedical Campus' day. The unit presents a stand with 4 - 5 interactive activities that each communicate a basic statistical method or idea, representing one of the four research themes in the unit. Each year a new activity is developed and delivered requiring scientific input from staff across the unit. Over the two days, BSU engage with approximately 500 adults and children who visit the festival. Senior Investigator Statistician, Simon White, has played a significant role in developing activities for Cambridge Science Festival. He is now Public Engagement Champion for the unit. Raised the profile of the Unit in the region Audience asked for more opportunities for communication and interaction with the public health researchers Contributed to raise the profile of Biostatistics in medical research Contributed to enhance the methodological quality of medical research developed by BSU staff Contributed to enable Best Research for Best Health |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017 |
| URL | http://www.cam.ac.uk/science-festival |
| Description | Cambridge Science Festival Co-ordinator |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Audience asked for more opportunities for communication and interaction with the public health researchers Raised the profile of the Biostatistics Unit in the region Contributed to raise the profile of Biostatistics in medical research Contributed to enhance the methodological quality of medical research developed by BSU staff Cambridge Science Festival receives extensive national and local media coverage |
| Year(s) Of Engagement Activity | 2011,2012,2013,2014 |
| URL | http://www.cam.ac.uk/science-festival |
| Description | Careers talk at Cambourne Village College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Talk to secondary scholl students on how to pursue career as a biostatistician and scientist - encouraging and enthusing young students about the highlights of being a scientist. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Contemporary populations and dementia, what have we learnt and where are we headed |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A talk was given at Fourth Annual NHMRC National Institute for Dementia Research Australian Disease Forum 2019 at Hobart, Tasmania Keynote Address: Contemporary populations and dementia, what have we learnt and where are we headed? |
| Year(s) Of Engagement Activity | 2019 |
| Description | Dementia Advisory Group Meeting International Health Metrics/GBD |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dementia Advisory Group Meeting International Health Metrics/GBD (funded by Gates) 19 July 2019 This was the second DAG that I have attended. The first was by phone. This was in person in Los Angeles. The programme contained updates on how the GBD team at the University of Washington are synthesising evidence on dementia and creating Global metrics. The advisory panel includes individuals with very different experiences and expertise, including health economics and those who are pure epidemiologists. This meant the discussion was very rich and stimulating, and that although we are advisors we are also learning. It provided insights into the synthesis of evidence, the approaches this team teak to doing this There was lively discussion about the challenges - with aspects ranging from sociocultural context of dementia, changes across time, evidence from different fields of non communicable diseases, how to incorporate dementia associated with other conditions that are already exercises in GBD and incorporate dementia into their own outcomes (ie. Danger of double counting). The health economics remains a crude science relative to the epidemiology and for both there is a great challenge of absence of data or data that are not population representative where they do exist. I will continue to be part of this DAG, but the discussions are relevant to work for PHE and also at the national level in my work with FPH and RCP. Continue to engage where possible with these kinds of meetings where there is much mutual learning, as expressed by one of the other attendees. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Dementia Research Knowledge into Care |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk on 26th September Dementia Research Knowledge into Care Mixed audience mainly carers about 100 people Title "Long-term research across the population: looking to the future " None as yet |
| Year(s) Of Engagement Activity | 2011 |
| Description | Dementia and brain ageing in populations |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Invited speak for Cambridge University Biological Society March 2019. Title is Dementia and brain ageing in populations. . |
| Year(s) Of Engagement Activity | 2019 |
| Description | Dementias 2020 - What can epidemiology tell us about dementia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | For health practitioners to keep their professional certification. Lots of discussion about dementia and how the population health is influenced. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Dendron East |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Around 250 charity workers, patient representatives and professionals allied to medicine attended Raised profile of epidemiology to wider audience |
| Year(s) Of Engagement Activity | 2010 |
| Description | FameLab 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | FameLab is for scientists, mathematicians and engineers across the globe to take part in its flagship science communications competition. SW took part in FameLab 2016 heats. Gave three minute talk to panel of judges and general public on statistics topic, with no presentation slides and minimal props. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.cheltenhamfestivals.com/about/famelab/ |
| Description | FameLab 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Simon White, Senior Investigator Statistician, took part in international science communications competition - FameLab. Gave 3 minute presentation to general public/lay audience communicating a statistical concept. Simon was successful in reaching regional finals in Cambridge. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.cheltenhamfestivals.com/about/famelab/ |
| Description | Feature Article in The Pharmaceutical Journal |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Feature Article in The Pharmaceutical Journal on 'How lifestyle changes could reduce the risk of developing Dementia' (December 2015) |
| Year(s) Of Engagement Activity | 2015 |
| Description | Festival of Neuroscience |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Presentation at the Festival of Neuroscience. A conference that is open to the public and all audiences. 10th April 2013. Barbican Conference facilities. London Raised the profile of Epidemiology within Neuroscience and the public |
| Year(s) Of Engagement Activity | 2013 |
| Description | Healthy brain ageing in the 21st Century |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | An audience of nearly 120 members of the public and members of the CAMCAN study listened to an evening of presentations (me as Keynote) on healthy brain ageing. The discussion was stimulating and interesting. People wanted to take part in more research and learnt a great deal from attending. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Healthy brain ageing, what can we do? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | 70 alumni of Newcastle University and members of the public attended a presentation and discussion session. The alumni association said it was the most popular activity of the entire weekend. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Horizon seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | How long is healthy life in old age? Horizon Seminar, Cambridge Public health advice about the status of healthy ageing in the growing epidemic |
| Year(s) Of Engagement Activity | 2007 |
| Description | IPH Open Day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Health professionals |
| Results and Impact | 100 people attended the talk I was asked to give more presentations to various audiences |
| Year(s) Of Engagement Activity | 2009 |
| Description | IPH open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | IPH open day. Showcases best science from the Institute. Aimed at the general public. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Institute of Actuaries, Sessional meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 50 people attended 'What longevity predictors should be allowed for when valuing pension scheme liabilities?' Institute of Actuaries, Sessional meeting (read paper). London. Networking |
| Year(s) Of Engagement Activity | 2009 |
| Description | LSHTM's 23rd Austin Bradford Hill Memorial Lecture, and Clinical Trials: Past, Present and Glorious Future meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | For the LSHTM's 23rd Austin Bradford Hill Memorial Lecture, and Clinical Trials: Past, Present and Glorious Future meeting, more than two hundred guests gathered at the John Snow Lecture Theatre, London School of Hygiene and Tropical Medicine (LSHTM), and dedicated an afternoon to celebrating the history, achievements and challenges of randomized controlled trials, as part of the joint-history of the MRC Biostatistics Unit and Professors of Medical Statistics at the LSHTM. Raising the profile of the Unit nationally. Facilitated communication, interaction and collaboration between scientists. Contributed to enhance the methodological quality of medical research developed by BSU staff. Contributed to enable Best Research for Best Health. The London School of Hygiene and Tropical Medicine filmed various of the talks and published the videos online through the LSHTM Plus Vimeo channel. See http://vimeo.com/channels/760568 |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.mrc-bsu.cam.ac.uk/bradford-hill-memorial-lecture/ |
| Description | MCI Tool |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | Tool for researchers in MCI to investigate the impact of different MCI definitions in the literature. PloS Medicine paper and press release to launch tool |
| Year(s) Of Engagement Activity | 2007,2008,2009 |
| URL | http://gtr.rcuk.ac.uk/project/F30FB0E8-62BC-4175-9430-226059292F91 |
| Description | MRC BSU Armitage Lecture and Workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Attendees' reactions to the lectures and workshops were very positive. Raised the profile of the Unit and strenghted its links with international institutions. BSU strengthened its reputation as a major centre for knowledge transfer. Attendees' reactions to the lectureships and worshops have been overwhelmingly positive. |
| Year(s) Of Engagement Activity | 2009,2010,2011,2012,2013,2014 |
| URL | http://www.mrc-bsu.cam.ac.uk/training/workshops/armitage-lectureships-and-workshops/ |
| Description | MRC Centenary Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | 50 + people attended an exhibition about the history, pioneers and discoveries of the MRC Biostatistics Unit, and a series of talks/discussions series of talks and lectures as part of the BSU contribution to MRC Centenary Open Days. Invited speaker (Dr Fiona Matthews). Talk entitled: Cognition: A matter of life and death. Raised the profile of the Unit in the local region |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.mrc-bsu.cam.ac.uk/NewsandEvents/mrccentenary.html |
| Description | Media advice |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Dementia and the media. Royal Statistical Society, media and statisticians: myths and memoranda Educating the press into the difficulties of explaining dementia public health advice to the public |
| Year(s) Of Engagement Activity | 2007 |
| Description | Media enquiries - Drop in dementia rates (CFAS) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release and a number of reactive media enquiries on new dementia research from CFAS project - statistical analysis showing that dementia rates are dropping. Fiona Matthews, Programme Leader, provided quotes for various press articles including; The Telegraph, The Sun, Daily Mail, Evening Standard, BBC News at Six, ITV News, BBC News, Sky News, BuzzFeed News, The Guardian |
| Year(s) Of Engagement Activity | 2016 |
| Description | Media enquiry - Article for The Independent |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Simon White, Senior Investigator Statistician, provided background research for article in The Independent on inaccurate and misleading statistics in the press, article called 'Lies, Damn Lies and Statistics' |
| Year(s) Of Engagement Activity | 2016 |
| Description | Media enquiry - Article for The Times |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Simon White, Senior Investigator Statistician, provided background research for artilce in The Times, on use of statistics in the press |
| Year(s) Of Engagement Activity | 2017 |
| Description | Media enquiry - BBC World News |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Fiona Matthews, Programme Leader, gave television interview for BBC World News about fall in dementia rates, from CFAS study work |
| Year(s) Of Engagement Activity | 2016 |
| Description | Media enquiry - Carers World Radio |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Simon White, Senior Investigator Statistician, gave radio interview for Carers World Radio for series of features on dementia research and carers. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Media enquiry - Essential statistics skills for journalists |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Simon White, Senior Investigator Statistician, provided background research on essential statistics skills for science journalists. Contributions to be included in textbook on science journalism. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Media enquiry - Forensic Factors TV |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Simon White, Senior Investigator Statistician, provided background research on statistical analysis of dementia and ageing work, for television feature on dementia. Enquiry received via RSS Ambassador programme. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://forensicfactors.tv/ |
| Description | Misleading statistics in the media (The Mail on Sunday) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Senior Investigator Statistician provided background research and expert statistical opinion to journalist on misleading graphs. |
| Year(s) Of Engagement Activity | 2017 |
| Description | New prevalence estimates for the UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release, paper and talk at international conference to launch new prevalence estimates of dementia. Invitation to new policy committee for Public Health England. Much international coverage of the estimates and press interest. |
| Year(s) Of Engagement Activity | 2013,2014 |
| Description | Nuffield Placement Student |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Sixth form student completed 4 week work placement at the Unit in 2015 & 2016. Over the 4 week period student learnt to manage and process data from the cognitive test - coming across the important issues of data security, anonymity and research ethics. He also learnt to use new software (GNU R statistical software) to analyse the outcomes. Student reported the findings to the wider Cam-CAN research group. The project was a great success, furthering understanding of the spot-the-word test across all ages and the issues of incomplete data. More importantly, feeding this research back into the wider Cam-CAN research community helps to ensure the test is used appropriately in other research questions. As a result of the student's work, a group of Cam-CAN researchers are writing a research paper to publish the findings. Student developed interest and knoweldge of statistical research and learnt about what it might like to become a research scientist in a biostatistics research unit. |
| Year(s) Of Engagement Activity | 2015,2016,2017 |
| URL | http://www.mrc-bsu.cam.ac.uk/developing-and-inspiring-our-future-biostatisticians/ |
| Description | Oral health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Intended to reach dementia research to dentists. Raised interesting questions about the extent and need for these patients. |
| Year(s) Of Engagement Activity | 2015 |
| Description | PHE Dementia |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Dementia subgroup for Public Health England. Presentation of dementi results and discussion about policy implications of results. New dementia prevalence estimates needed for policy makers expert panel set up. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Quintessential 'Counting for Health' |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Quintessential 'Counting for Health', smart PQs, and statistical surgery - Parliamentary Office of Science and Technology (POST) and APPG on Medical Research together with Medical Research Council's Biostatistics Unit, 6 May 2009 Policy relevant topical examples in 'Counting for Health' were used to illustrate key epidemiological questions and how to answer them. Raised awareness of the work of the Unit. This event contributed to enhance the methodological quality of medical research developed by BSU staff. This event contributed to enable Best Research for Best Health. |
| Year(s) Of Engagement Activity | 2009 |
| URL | http://www.cfas.ac.uk/pages/ppresentation/index.html |
| Description | REVES |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | workshop facilitator |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | 70 people attended talk 'The shape of total and healthy life expectancies'. REVES (the Network on Health Expectancies and the Disablement Process), Copenhagen, Denmark. 120 attended talk at REVES 2013 in Texas. 70 people attended workshop in Edinburgh in 2014, followed by 120 at the conference later Networking and possibilities for intellectual collaboration Workshop has educated new methods for others |
| Year(s) Of Engagement Activity | 2009,2013,2014 |
| Description | STEM Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Participation in STEM Fair at Duxford Imperial War Museum - an enrichment day for secondary school students in the region to learn and be inspired by the various scientific organisations in the area. BSU presented a workshop to 2x sets of 20 Year 10 students, leading 2 interactive activities, analysing and investigating hyperthetical data from human related studies, answering a series of questions about the data. Both workshops were very successful, inspiring students and nurturung a future generation of statisticians. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.mrc-bsu.cam.ac.uk/inspiring-with-statistics-at-stem-fair-2016/ |
| Description | Statistics Meets Public Health talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Programme Leader, Fiona Matthews, gave talk as part of 'Statistics Meets Public Health' seminar series - a series of non-technical talks, aiming to illustrate the links between statistical research and public health, targetted to lay audiences and free to attend. Fiona gave talk on 'Using statistics to estimate the extent of dementia in the population' to approximately 40 audience members. Further interest in the talk has been sought and video of talk circulated online. Future talks in seminar series arranged. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://sms.cam.ac.uk/media/2395374 |
| Description | Systems of Mild Cognitive Impairment and Longitudinal Course |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The 5th Annual Mild Cognitive Impairment (MCI) Symposium; Miami Beach, Florida. Presentation to the experts in the world of Mild Cognitive Impairment. See http://www.mcisymposium.org/html/mci_brochure2007.pdf Increase in interest in the population aspect of Mild cognitive impairment. |
| Year(s) Of Engagement Activity | 2007 |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/18525280 |
| Description | UK Media coverage on Dementia Research |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Article across UK press (including print, television and radio) on dementia figures platoing due to middle-aged living healthier lives Research from paper in Lancet - F Matthews co-author |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.telegraph.co.uk/news/science/science-news/11815699/Middle-aged-winning-battle-against-dem... |
| Description | WHO Bulletin Interview with Carol |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with Carol Brayne: a life-course approach to prevent dementia https://apps.who.int/iris/handle/10665/272247 WHO Bulletin Interview with Carol |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://apps.who.int/iris/handle/10665/272247 |
| Description | What do we know about health brain ageiing |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Over in Sydney Australia, showing the UK research into brain ageing into a public lecture with debate. |
| Year(s) Of Engagement Activity | 2019 |