ACA5: Decision making in dementia

Lead Research Organisation: MRC Cognition and Brain Sciences Unit

Abstract

How do you decide what to do, what action to take? Many patients with brain damage, Parkinson’s disease or dementia have difficulty making every day decisions about what to do, in the right place or at the right time. Patients may also have difficulty with mental flexibility, required to do different things when circumstances change, or to stop oneself when needed.

Our research group uses brain scanning and new methods in computer science and psychology to understand how healthy people and those with brain illnesses make decisions about what to do, and what not to do.

These decisions are made possible by the flow of information through brain networks. We use MRI and MEG type brain scanners to study these networks, in health, over the lifespan, and in people with emerging dementia.

Technical Summary

Advances in new treatments for dementia require a new mechanistic understanding of disease, linking changes in cognitive function to underlying neural systems and their pharmacology. They also require new tools to identify the signatures of nascent pathology in (as yet) asymptomatic patients that can be used to safely and reliably track the emergence of disease in the context of preventive and therapeutic clinical trials.

In the first part of this program, we develop new models of cognitive function, based neurophysiological models of decision making circuits. We examine decisions about behavioural control (including response inhibition), volition and the perception of environmental cues that guide actions. Using accumulation-to-threshold models of perception and behaviour, we will determine the processes by which sensory inputs are transformed to motor outputs, and the vulnerability of these processes to two different disorders: Parkinson’s disease and Alzheimer’s disease.

In the second part of the program, we will examine the problem that some people have increasingly poor cognitive function with age. This may be the presence of subclinical dementias, and we will compare neural signatures in healthy older adults to those with early dementia. However, unsuccessful cognitive ageing is not necessarily just a matter of early dementia.

Even those without emerging dementia will vary in their cognitive ageing profile, for reasons that we will elucidate. This builds on the CamCAN study of healthy ageing, bringing in for the first time those adults who performed poorly on screening tests. We will apply a tailored battery of imaging and psychological assessments, using MRI, fMRI and MEG, and use supervised machine earning methods to identify the neural factors that are associated with poor function. These will be compared with neural factors associated with early AD.

This program links directly to the Cambridge Centre for Ageing and Neuroscience (CamCAN) and the Dementias Platform UK, both in terms of the Synaptic Health Theme for Experimental Medicines, and the Deep and Frequent Phenotyping study of prodromal dementia. The MRC “ACA5. Decision making in dementia” provides vital links between normative studies, ageing and neurodegeneration. Through my Wellcome Trust Senior Research Fellowship and the NIHR Biomedical Research Centre’s Neurodegeneration and dementia theme we are developing pharmacological interventions to restore cognition, with direct translation from ACA5 innovations to clinical populations.

Publications

10 25 50
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Adams NE (2020) GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography. in The Journal of neuroscience : the official journal of the Society for Neuroscience

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Alexander SK (2014) Validation of the new consensus criteria for the diagnosis of corticobasal degeneration. in Journal of neurology, neurosurgery, and psychiatry

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Berry E (2009) The neural basis of effective memory therapy in a patient with limbic encephalitis. in Journal of neurology, neurosurgery, and psychiatry

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Bevan Jones WR (2016) [18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation. in Annals of clinical and translational neurology

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Bevan-Jones RW (2018) [18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion. in Annals of clinical and translational neurology

 
Title MEG & ME 
Description With ISSF funding, out team held a series of public open evenings to discuss research of interest to the public, to define a sho set of questions and design the experiments to answer them, and then carry it out using MEG. The project was filmed, and presented at a final public discussion meeting at the Cambridge Science Festival 
Type Of Art Film/Video/Animation 
Year Produced 2015 
Impact The project clearly caught he public's imagination, and over 100 members of the public took part across the weeks. https://vimeo.com/116423919 presents a final summary video 
URL https://vimeo.com/116423919
 
Title Misplaced in Space (September 2017) 
Description A collaboration with University of East Anglia, to portray the impact of Dementia 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2017 
Impact A film of the exhibition is available; 
URL https://vimeo.com/229381641
 
Title Pint of Science 
Description Pint of Science festival presentations in pubs, bringing research progress and ideas to the public. 
Type Of Art Performance (Music, Dance, Drama, etc) 
Year Produced 2018 
Impact Wide public interest -sell out events 
 
Description AI-MIND Consortium SAB
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact The AI-MIND Consortium is to delivery new artificial intelligence methods to improve diagnosis and prognosis in dementia
URL https://accelopment.com/projects/ai-mind/
 
Description Acadamey of Medical Sciences review of research governance
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact Description of experience of current unnecessary obstacles to safe clinical research and observations on practicable solutions.
 
Description Alzheimer Research UK Scientific Advisory Board Chair
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact To ensure the £30m annual investment in dementia research is most effective, for long term health, social and economic benefit
 
Description Cabinet briefing meeting - dementia
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact enhanced care and research progress on dementia
 
Description Cambridge Dementia Course
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL http://www.cambridgedementiacourse.com/index.html
 
Description Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria (May 2017).
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
URL https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.26987
 
Description DPUK2Associate Director
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact DPUK is leading academic-industrial partnerships for dementia research, and coordinating the 'ecosystem' for dementia research and care in the UK. As associate Director and lead for Experimental Medicine, my role is to accelerate early phase clinical trials though partnerships with industry, academic and third-sector stakeholder collaborations
URL https://www.dementiasplatform.uk/
 
Description Education - postdoctoral and graduate level
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Education of nationally distributed participants in conferences for "neurology for neuroscientists" and "advances in neuroscience", related to PD and other related neurodegenrative syndromes; Dementia care and management;
 
Description Memory Assessment Services
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact A discussion and proposal on adaptation of Memory Services to COVID, and the adoption of Telemedicine, with safety, equality of access, and forward planning for post COVID
URL http://www.yhscn.nhs.uk/media/PDFs/mhdn/Dementia/Covid%2019/MAS/MSA%20-%20A%20New%20Way%20of%20Worki...
 
Description Models and standards of Care (PSP)
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact New guidelines on standards of care, including opportunities to engage in research, for patients with PSP and CBD.
 
Description NIHT Translational Research Collaboration for dementia
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact To facilitate multilateral research across academic, healthcare and industrial partners in the UK, for better and faster dementia research. Reports to NIHR Office for Clinical Research Infrastructure (NOCRI)
URL https://www.nihr.ac.uk/partners-and-industry/industry/collaborate-with-us/dementia.htm
 
Description NMHB member
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact MRC Neuroscience and Mental Health Strategy review Oct 2012, Brain Banking Workshop 2013, Dementia Stigma 2014
 
Description PSP Criteria
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact The new evidence-based criteria include the importance of cognitive presentations in PSP, in part to improve access to trials, and in part to improve sensitivity and specificity of criteria. Much of the background work was undertaken at CBSU
 
Description Rowe - Masterclass (23rd March 2018). Danish Dementia Research Centre, Copenhagen, Denmark
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Masterclass in front of practitioners. Ad hoc patient review as training.
 
Description Trond Mohn Foundation
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Advisory committee for a major biomedical research foundation
 
Description UHF Research Review in Parkinsonism
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
 
Description US congressinal delegation
Geographic Reach North America 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description A new noradrenergic strategy for treatment of PSP
Amount £653,896 (GBP)
Funding ID MR/P01271X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2020
 
Description A standardized, multilingual, mini linguistic state examination (MLSE) for classifying and monitoring primary progressive aphasia.
Amount £358,924 (GBP)
Funding ID RG82683 
Organisation St George's University 
Sector Academic/University
Country Grenada
Start 01/2017 
End 12/2019
 
Description ABN Research Fellowship (Cope)
Amount £180,000 (GBP)
Funding ID RG78594 
Organisation Association of British Neurologists (ABN) 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2015 
End 11/2018
 
Description ABN fellowship to Thomas Cope
Amount £179,988 (GBP)
Organisation Association of British Neurologists (ABN) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2016 
End 12/2018
 
Description ARUK - Cambridge Network Centre
Amount £4,000 (GBP)
Funding ID RG86800 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 08/2017
 
Description Biomedical Research Centre Dementia Theme
Amount £118,000,000 (GBP)
Funding ID RG85367 
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description Bioresource
Amount £272,205 (GBP)
Funding ID RG85445 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2018
 
Description Brain Network Analysis in Neurodegenerative Tauopathies
Amount £22,391 (GBP)
Funding ID RG89925 
Organisation The Evelyn Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 12/2019
 
Description Cam-Can
Amount £310,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2010 
End 10/2015
 
Description Clinical research infrastructure
Amount £6,995,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2015 
End 09/2020
 
Description Elucidating the mechanisms of psychosis in motor neuron disease - to Alicia Wilcox
Amount £108,693 (GBP)
Funding ID RG87714 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description GENetic Frontotemporal dementia Imaging - Second phase (GENFI-2)
Amount £2,613,582 (GBP)
Funding ID MR/M023664/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2015 
End 04/2020
 
Description JPND EUFIND
Amount £30,000 (GBP)
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND) 
Sector Public
Country European Union (EU)
Start 10/2016 
End 10/2017
 
Description Linking patient phenotype with cell and animal models of alpha-synucleinopathies and tauopathy to study disease pathogenesis and biomarker candidates
Amount £1,300,000 (GBP)
Funding ID RG75814 
Organisation AstraZeneca 
Department MedImmune
Sector Private
Country United Kingdom
Start 10/2014 
End 08/2018
 
Description MAPT-PSP: clinicopathological correlations and biomarker evaluation of a tau radioligand in progressive supranuclear palsy in preparation for clinical trials
Amount £93,105 (GBP)
Funding ID RG76137 
Organisation PSP Association 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2014 
End 12/2016
 
Description MRC Partnership grant for UK7T
Amount £220,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2016 
End 03/2019
 
Description MRC clinical training fellowship
Amount £272,739 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2007 
End 10/2010
 
Description MRC clinical training fellowship
Amount £275,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2011 
End 10/2014
 
Description Measuring microscopic changes at the macroscopic level in frontotemporal dementia - Fellowship to Sanne S. Kaalund
Amount kr 400,000 (DKK)
Funding ID R232-2016-2333 
Organisation Lundbeck Foundation 
Sector Charity/Non Profit
Country Denmark
Start 08/2017 
End 07/2019
 
Description Multi-scale network dynamics of the ageing brain: Modelling neurocognitive function and dysfunction - Fellowship to Kamen Tsvetanov
Amount £264,375 (GBP)
Funding ID RG84427 
Organisation The British Academy 
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 12/2019
 
Description NIHR BRU-dementia
Amount £600,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Cambridge Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2012 
End 03/2017
 
Description NIHR Biomedical Research Centre
Amount £250,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Cambridge Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2012 
End 03/2017
 
Description New Therapeutics in Alzheimer s Disease (NTAD) - ARUK
Amount £100,000 (GBP)
Funding ID RG89702 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 08/2020
 
Description PROSPECT-MR: magnetic resonance imaging in the longitudinal clinical and biomarker study of Progressive Supranuclear Palsy and corticobasal degeneration
Amount £299,995 (GBP)
Funding ID RG78738 
Organisation Progressive Supranuclear Palsy Association (PSPA) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 08/2019
 
Description PSP association
Amount £93,000 (GBP)
Organisation Progressive Supranuclear Palsy Association (PSPA) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 07/2016
 
Description Progress in understanding volition
Amount $600,000 (USD)
Funding ID RG63965 
Organisation James S. McDonnell Foundation 
Sector Charity/Non Profit
Country United States
Start 12/2011 
End 11/2019
 
Description Restoring noradrenergic function to improve apathy in Parkinson s disease to Claire O Callaghan
Amount £49,677 (GBP)
Funding ID RG90797 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2017 
End 07/2018
 
Description The physiology of dementia: magnetoencephalographic investigation of brain networks in frontotemporal lobar degeneration and Alzheimer's disease in preparation for experimental medicine studies.
Amount £49,592 (GBP)
Funding ID RG84879 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
End 09/2017
 
Description Wellcome Trust Senior Fellowship
Amount £1,200,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2009 
End 11/2014
 
Description Wellcome Trust Senior Fellowship - Restoring brain function: from cortisol microcircuits to complex behaviours in neurodegenerative disease
Amount £1,885,182 (GBP)
Funding ID RG73750 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2014 
End 11/2019
 
Title Accumulator models and brain imaging 
Description Demostrating and promoting the value of accumulator models in brain and behaviour analysis 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2011 
Provided To Others? Yes  
Impact Key papers and conference presentations in leading journals and reviews 
 
Title MEG-dementia platform 
Description MEG program for dementia and degeneration, based at CBSU Incorporated into DPUK programs 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2015 
Provided To Others? Yes  
Impact 1. innovations published in peer review journals 2. incorporated into national dementia study protocol 3. new drug discovery/evaluation program initiated 
 
Title iElectrodes toolbox: for invasive electroencephalography (EEG) recordings 
Description The localization of intracranial electrodes is a fundamental step in the analysis of invasive electroencephalography (EEG) recordings in research and clinical practice. The conclusions reached from the analysis of these recordings rely on the accuracy of electrode localization in relationship to brain anatomy. However, currently available techniques for localizing electrodes from magnetic resonance (MR) and/or computerized tomography (CT) images are time consuming and/or limited to particular electrode types or shapes. We present iElectrodes, an open-source toolbox that provides robust and accurate semi-automatic localization of both subdural grids and depth electrodes. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2017 
Provided To Others? Yes  
Impact The software project is made available to the scientific community in the form of an open-source MATLAB® toolbox that can be freely downloaded from https://sourceforge.net/projects/ielectrodes/ for research porpoises only under GNU General Public License. 
URL https://sourceforge.net/projects/ielectrodes/
 
Title network modeling of neuroimaging data 
Description Implementation of several methods to study brain network connectivity in humans, including patients, to understand the impact of disease and mechanism of effective therapies. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2010 
Provided To Others? Yes  
Impact Interest in adopting these methods to other projects at other sites, and invitiations to teach at several centres and to publish review articles on this topic. 
 
Title Cam-CAN 
Description Cam-CAN project extended to include subarm of "Cam-CAn Frail" and early dementia participants. 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact Extensive applications for data from CC700; Cam-CAN-Frail still in data acquisition phase. 
 
Title DPUK 7T data sharing 
Description Agreement on data sharing for 7T images using DPUK XNAT platform 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact pending 
 
Description ASAP SynTau: Alignment and Standardization of Neuroimaging Methods in Atypical Parkinsonism, specifically Synucleinopathies and Tauopathie 
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND)
Country European Union (EU) 
Sector Public 
PI Contribution This Working Group brings together neuroimaging experts from all over the world to develop a broad, community-based consensus on imaging protocols. These outcomes will help pave the way for the integration of neuroimaging in large and longitudinal multi-centre studies in AP, including therapeutic trials. Meetings, harmonisation of imaging data, workshops, and later data sharing.
Collaborator Contribution Meetings, harmonisation of imaging data, workshops, and later data sharing.
Impact A project initiation report is submitted to JPND. Data sharing agreements are in progress.
Start Year 2016
 
Description Bayesian integration of intentions, actions, and sensation. 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Framing the translational research question, training and supervising research students, organising and supervising the use of MRC panel members, occulography and behavioural testing.
Collaborator Contribution Expertise in Bayesian modeling of behaviour; Gates Scholarship student;
Impact Multiple abstracts to international meetings; Key papers published; This is an multi-disciplinary project, including Departments of Engineering (Cambridge) and Clinical Neurosciences; doi: 10.3389/fnins.2014.00069; doi: 10.3389/fnbeh.2014.00232; doi: 10.1523/JNEUROSCI.3093-13.2015; doi: 10.1523/JNEUROSCI.5095-14.2015; doi: 10.3389/fpsyg.2015.01514; doi: 10.1093/brain/awv331; doi: 10.1186/s12918-017-0484-3;
Start Year 2010
 
Description BioFIND - JPND 
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND)
Country European Union (EU) 
Sector Public 
PI Contribution We led the JPND award on the use of MEG in harmonisation and standarisation for Dementia research, bringing together Pharma and Academic partners from ten sites.
Collaborator Contribution Expertise, knowledge sharing, and scoping of future project needs.
Impact A project initiation report is submitted. A new data sharing project has begun across six sites.
Start Year 2016
 
Description CSF biomarkers 
Organisation Swedish Research Council
Country Sweden 
Sector Public 
PI Contribution A new collabortion for CSF biomarkers studies
Collaborator Contribution Biosamples and clinical metadata
Impact Interdisciplinary - dementia and biochemistry
Start Year 2015
 
Description Cam-CAN 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Design and analysis of response control and inhibition studies, for fMRI and MEG. Started a new arm in 2015 called the Cam-CAN Frail study.
Collaborator Contribution A strong collaboration for epidemiologically validated ageing research, across multiple modalities.
Impact doi: 10.1186/s12883-014-0204-1; doi: 10.1038/ncomms6658; doi: 10.1002/hbm.22768; doi: 10.1016/j.neurobiolaging.2015.07.028; doi: 10.3390/ijerph121215003; doi: 10.1523/JNEUROSCI.2733-15.2016; doi: 10.1016/j.cortex.2016.05.001; doi: 10.1038/srep32527; doi: 10.1038/ncomms13034; doi: 10.1038/ncomms14743; doi: 10.1038/ncomms15671; more publications to come;
Start Year 2010
 
Description Cambridge 7T consortium 
Organisation Medical Research Council (MRC)
Department MRC Cognition and Brain Sciences Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming the new University-MRC partnership and Cambridge 7T consortium. Full access to new facility for both partners.
Collaborator Contribution Staff allocation for physics support and adjunctive technologies for participant interaction.
Impact Multidisciplinary - dementia, neurology, psychiatry, development and ageing, cognitive neuroscience and physics. New head of 7T department has been recruited.
Start Year 2015
 
Description Cambridge Parkinson s Disease Consortium 
Organisation Addenbrooke's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Research design, recruitment, governance administration, data acquisition, analysis of behaviorual and imaging data, evaluation and publication of research.
Collaborator Contribution Planning of joint research projects, especially cognitive disorders in Parkinson's disease and related diseases, including several experimental medicine studies of new agents. Consolidation of collaborative partnerships, facilitating ACA5, and adding value through parallel research programs.
Impact Clinical and non-clinical scientists; abstracts and publications see separate entry;
Start Year 2009
 
Description Cambridge Parkinson s Disease Consortium 
Organisation University of Cambridge
Department Department of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Research design, recruitment, governance administration, data acquisition, analysis of behaviorual and imaging data, evaluation and publication of research.
Collaborator Contribution Planning of joint research projects, especially cognitive disorders in Parkinson's disease and related diseases, including several experimental medicine studies of new agents. Consolidation of collaborative partnerships, facilitating ACA5, and adding value through parallel research programs.
Impact Clinical and non-clinical scientists; abstracts and publications see separate entry;
Start Year 2009
 
Description Claire O Callaghan - Restoring noradrenergic function to improve apathy in Parkinson s disease 
Organisation University of Cambridge
Department Department of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution Input on study design
Collaborator Contribution Study design, will do data collection and analyses, publications pending
Impact publications still pending
Start Year 2017
 
Description Dementias Platform UK 
Organisation National Institute for Health Research
Department Biomedical Research Centre for Mental Health and Dementia Unit (BRC/U)
Country United Kingdom 
Sector Academic/University 
PI Contribution Deep and Frequent Phenotyping study site Synaptic Physiology Theme lead, linked to CBSU MEG and dementia programs Imaging Theme - linked to 7T and PET for dementia
Collaborator Contribution new deep phenotyping study - multiple modalities £1000000 offered by DPUK partners towards new collaborative award, Decision pending.
Impact commenced 2014
Start Year 2014
 
Description FTD neuroimaging 
Organisation University of Cambridge
Department Department of Clinical Neurosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Study design, data acquisition, and planned analyses.
Collaborator Contribution CBSU-based MEG facilities and expertise has greatly enhanced translational medicine of FTD, including new experimental medicine studies.
Impact abstracts published; papers submitted and published; new experimental studies begun;
Start Year 2009
 
Description GENFI-1 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution A new prevalence cohort of genetically detemined FTD or genetically at-risk relatives
Collaborator Contribution Coordination of a multicentre study imaging analysis genetics guardians
Impact Pilot data for strategic award; several publications; doi: 10.1016/S1474-4422(14)70324-2; doi: 10.1093/brain/awx103; doi: 10.1002/jmri.25751; doi: 10.1016/j.nicl.2017.04.015; 10.1016/j.neurobiolaging.2017.10.008;
Start Year 2011
 
Description ICICLE-PD study of Parkinsons disease cognition 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Characterise cohorts with parkinsonisms in Cambridgeshire. Identify and phenotype patients who develop PD dementia.
Collaborator Contribution Characterise cohorts with parkinsonisms in Cambridgeshire. Identify and phenotype patients who develop PD dementia.
Impact several publications; doi: 10.1212/WNL.0000000000000066; doi: 10.1093/brain/awu201; doi: 10.1093/brain/awv211; doi: 10.1002/mds.26563; doi: 10.1016/j.parkreldis.2016.04.009; doi: 10.1002/gps.4623; doi: 10.1016/j.parkreldis.2017.01.001; doi: 10.1136/jnnp-2016-315099;
Start Year 2010
 
Description JPND EUFIND - European Ultrahigh Field Imaging Biomarkers for Dementia 
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND)
Country European Union (EU) 
Sector Public 
PI Contribution An international consortium for harmonisation and standardisation of UHF-MRI for Dementia Research. We have contributed expertise, data, and engaged in a pilot study for feasibility and methods development
Collaborator Contribution An international consortium for harmonisation and standardisation of UHF-MRI for Dementia Research. Our partners from 20 EU sites have contributed expertise, data, and engaged in a pilot study for feasibility and methods development
Impact A project initiation report is submitted to JPND
Start Year 2016
 
Description Mechanisms of inhibition 
Organisation University of Cambridge
Department Department of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Framing clinical and non-clinical research questions about the dissociable mechanisms of inhibition in health and diease. Setting behavioural, pharmacological and imaging methods to answer these.
Collaborator Contribution Expertise in design and interpretation of experimental studies, and joint supervision of students
Impact several articles published; more to come; doi: 10.1093/cercor/bhs070; doi: 10.1016/j.neuroimage.2012.06.058; doi: 10.1038/npp.2012.264; doi: 10.1016/j.neuroimage.2013.10.012; doi: 10.1093/brain/awu032; doi: 10.1016/j.biopsych.2014.01.024; doi: 10.1093/brain/awu117; doi: 10.1523/JNEUROSCI.3093-13.2015; doi: 10.1093/brain/awv133; doi: 10.1093/brain/awv331; doi: 10.1002/hbm.23087; doi: 10.1038/npp.2016.18; doi: 10.1093/brain/aww138; doi: 10.1093/brain/awx101;
Start Year 2010
 
Description Misplaced in space 
Organisation University of East Anglia
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of PE concept, and data sharing.
Collaborator Contribution Artistic development of a Dementia outreach exhibition
Impact Exhibition in 2017 at the University of East Anglia
Start Year 2016
 
Description NIHR BRC 
Organisation National Institute for Health Research
Department NIHR Cambridge Biomedical Research Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution Biomarker development, including cognitive and imaging based deep phenotyping;
Collaborator Contribution Cellular, physiological, radio-chemistry, genetic and pharmaceutical innovations within a pipeline for novel drug discovery;
Impact several publications; more to come; 10.1017/S1041610216002143; 10.1016/j.arr.2017.03.002; 10.1016/j.neurobiolaging.2017.03.012; 10.1093/brain/awx101; 10.1016/j.nicl.2017.04.015; 10.3233/JAD-170129; 10.1016/j.neuropsychologia.2017.08.022; 10.1093/ijnp/pyx040; 10.1136/jnnp-2017-316402; 10.1007/s00415-017-8647-0; 10.3233/JAD-170344; 10.1016/j.neurobiol aging.2017.10.008; 10.1093/brain/awx347; 10.1136/jnnp-2016-314411; 10.1136/bmjopen-2016-013187; 10.1093/brain/aww340;
Start Year 2012
 
Description NIHR BRC 
Organisation National Institute for Health Research
Department NIHR Cambridge Biomedical Research Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution Biomarker development, including cognitive and imaging based deep phenotyping;
Collaborator Contribution Cellular, physiological, radio-chemistry, genetic and pharmaceutical innovations within a pipeline for novel drug discovery;
Impact Adams, N. E., Hughes, L. E., Phillips, H. N., Shaw, A. D., Murley, A. G., Nesbit, D., Cope, T. E., Bevan-Jones, W. R., Passamonti, L., Rowe, J. B. (2020). GABA-ergic dynamics in human frontotemporal networks confirmed by pharmaco magnetoencephalography, Journal of Neuroscience, https://doi.org/10.1523/JNEUROSCI.1689-19.2019. Lewis-Smith, D. J., Wolpe, N., Ghosh, B. C. P., Rowe, J. B. (2020). Alien limb in the corticobasal syndrome: phenomenological characteristics and relationship to apraxia, Journal of Neurology, https://doi.org/10.1007/s00415-019-09672-8. Jabbari, E., Chelban, V., Holland, N., Jones, P. S., Lamb, R., Rawlinson, C., Guo, T., Costantini, A. A., Tan, M. M. X., Heslegrave, A. J., Roncaroli, F., Klein, j. C., Ansorge, O., Allinson, K. S. J., Jaunmuktane, Z., Holton, J. L., Revesz, T., Warner, T. T., Lees, A. J., Zetterberg, H., Russell, L. L., Bocchetta, M., Rohrer, J. D., Williams, N. M., Grosset, D. G., Burn, D. J., Pavese, N., Gerhard, A., Kobylecki, C., Leigh, P. G., Church, A., Hu, M. T. M., Woodside, J., Houlden, H., Rowe, J. B., Morris, H. R. (2020). Diagnosis across the spectrum of progressive supranuclear palsy and corticobasal syndrome, JAMA Neurology, doi:10.1001/jamaneurol.2019.4347. van der Ende, E. L,, Meeter, L. H., Poos, J. M., Panman, J. L., Jiskoot, L. C., Dopper, E. G. P., Papma, J. M., de Jong, F. J., Verberk, I., Teunissen, C. E., Rizopoulos, D., Heller, C., Convery, R. S., Moore, K. M., Bocchetta, M., Neason, M., Cash, D. M., Borroni, B., Galimberti, D., Sanchez-Valle, R., Laforce, Jr R., Moreno, F., Synofzik, M., Graff, C., Masellis, M., Tartaglia, M. C., Rowe, J. B., Vandenberghe, R., Finger, E., Tagliavini, F., de Mendonça, A., Santana, I., Butler, C., Ducharme, S., Gerhard, A., Danek, A., Levin, J., Otto, M., Frisoni, G. B., Cappa, S., Pijnenburg, Y. A. L., on behalf of the GENetic Frontotemporal Dementia Initiative (GENFI), Rohrer, J. D., van Swieten, J. C. (2019). Longitudinal serum neurofilament light chain in genetic frontotemporal dementia: a multicentre cohort study. Lancet Neurology, 18: 1103-1111, https://doi.org/10.1016/S1474-4422(19)30354-0. Shafto, M. A., Henson, R. N., Matthews, F. E., Taylor, J. R., Emery, T., Erzinclioglu, S., Hanley, C., Rowe, J. B., Cusack, R., Calder, A. J., Marslen-Wilson, W. D., Duncan, J., Dalgleish, T., Brayne, C., Cam-CAN, Tyler, L. K. (2019). Cognitive Diversity in a Healthy Aging Cohort: Cross-Domain Cognition in the Cam-CAN Project, Journal of Aging and Health, doi: 10.1177/0898264319878095 [ahead of print], PMID: 31592706 Lansdall, C. J., Coyle-Gilchrist, I. T. S., Vázquez Rodríguez, P., Wilcox, A., Wehmann, E., Robbins, T. W., Rowe, J. B. (2019). Prognostic importance of apathy in syndromes associated with Frontotemporal lobar Degeneration, Neurology, 92(14):e1547-e1557. doi: 10.1212/WNL.0000000000007249, PMID: 30842292, PMC: 6448451. Borchert, B. J., Rittman, T., Rae, C. L., Passamonti, L., Jones, P. S., Vatansever, D., Vazquez-Rodriguez, P., Ye, Z., Nombela, C., Hughes, L. E., Robbins, T. W., Rowe, J. B. (2019). Atomoxetine and citalopram alter brain network organization in Parkinson's disease, Brain Communications, 1:1 fcz013, https://doi.org/10.1093/braincomms/fcz013. PMID: [pending], PMC: [pending]. Nicastro, N., Surendranathan, A., Mak, E., Rowe, J. B.*, O'Brien, J. T.* (2019). 11C-PK11195 PET imaging and white matter changes in Parkinson's disease dementia, Annals of Clinical and Translational Neurology, doi: 10.1002/acn3.50877, PMID: 31507085, PMC: [pending]. Low, A., Mak, E., Malpetti, M., Chouliaras, L., Nicastro, N., Su, L., Holland, N., Rittman, T., Vázquez Rodríguez, P., Passamonti, L., Bevan-Jones, W. R., Jones, P. S., Rowe, J. B.*, O'Brien, J. T.* (2019). Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid-positive mild cognitive impairment is associated with key clinical features, Alzheimer's & Dementia: Diagnosis, Assessment, & Disease Monitoring, 11: 690-699, DOI: https://doi.org/10.1016/j.dadm.2019.08.001, PMID: 31667328, PMC: 6811895. Tavares, T. P., Mitchell, D. G. V., Coleman, K., Shoesmith, C., Bartha, R., Cash, D. M., Moore, K. M., van Swieten, J. C., Borroni, B., Galimberti, D., Tartaglia, M. C., Rowe, J. B., Graff, C., Tagliavini, F., Frisoni, G., Cappa, S., Laforce, R. Jr, de Mendonça, A., Sorbi, S., Wallstrom, G., Masellis, M., Rohrer, J. D., Finger, E. C., GENetic Frontotemporal Dementia Initiative (GENFI) (2019). Ventricular volume expansion in presymptomatic genetic frontotemporal dementia, Neurology, doi: 10.1212/WNL.0000000000008386, PMID: 31578297, PMC: [pending]. Passamonti, L., Tsvetanov, K. A., Jones, P. S., Bevan-Jones, W. R., Arnold, R., Borchert, R. J., Mak, E., Su, L., O'Brien, J. T.*, Rowe, J. B.* (2019). Neuroinflammation and functional connectivity in Alzheimer's disease: interactive influences on cognitive performance, Journal of Neuroscience, doi: 10.1523/JNEUROSCI.2574-18.2019. PMID: 31320450, PMC: 6733539. Jabbari, E., Woodside, J., Guo, T., Magdalinou, N. K., Chelban, V., Athauda, D., Lees, A. J., Foltynie, T., Houlden, H., Church, A., Hu, M. T., Rowe, J. B., Zetterberg, H., Morris, H. R. (2019). Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes, Journal of Neurology, Neurosurgery and Psychiatry, 90(7):768-773. doi: 10.1136/jnnp-2018-320151. PMID: 30867224, PMC: 6585258. Hughes, L. E., Henson, R. N., Pereda, E., Bruña, R., López-Sanz, D., Quinn, A. J., Woolrich, M. W., Nobre, A. C., Rowe, J. B., Maestú, F., BioFIND Working Group (2019). Biomagnetic biomarkers for dementia: A pilot multicentre study with a recommended methodological framework for magnetoencephalography, Alzheimers & Dementia (Amsterdam, Netherlands), 11:450-462. doi: 10.1016/j.dadm.2019.04.009. PMID: 31431918, PMC: 6579903. Shaw, A. D., Hughes, L. E., Moran, R., Coyle-Gilchrist, I., Rittman, T., Rowe, J. B. (2019). In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies. Cerebral Cortex. 2019. doi: 10.1093/cercor/bhz024. PMID: 31216360. van Eimeren, T., Antonini, A., Berg, D., Bohnen, N., Ceravolo, R., Drzezga, A., Höglinger, G. U., Higuchi, M., Lehericy, S., Lewis, S., Monchi, O., Nestor, P., Ondrus, M., Pavese, N., Peralta, M.C., Piccini, P., Pineda-Pardo, J. Á., Rektorová, I., Rodríguez-Oroz, M., Rominger, A., Seppi, K., Stoessl, A. J., Tessitore, A., Thobois, S., Kaasinen, V., Wenning, G., Siebner, H. R., Strafella, A. P., Rowe, J. B. (2019). Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System. Alzheimers & Dementia (Amsterdam, Netherlands). 11:301-309. doi: 10.1016/j.dadm.2019.01.011. PMID: 30984816, PMC: 6446052. Rittman, T., Borchert, R., Jones, P. S., van Swieten, J., Borroni, B., Galimberti, D., Masellis, M., Tartaglia, M. C., Graff, C., Tagliavini, F., Frisoni, G. B., Laforce, R. Jr, Finger, E., Mendonça, A., Sorbi, S., Rohrer, J. D., Rowe, J. B., GENetic Frontotemporal Dementia Initiative (GENFI) (2019). Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia, Neurobioly of Aging, 77:169-177. doi: 10.1016/j.neurobiolaging.2018.12.009, PMID: 30831384; PMC: 6491498. Bevan-Jones, W. R., Cope, T. E., Jones, P. S., Passamonti, L., Hong, Y. T., Fryer, T., Arnold, R., Coles, J. P., Aigbirhio, F. I., O'Brien, J. T., Rowe, J. B. (2019). In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier. Annals of Clinical Translational Neurology, 6(2):373-378. doi: 10.1002/acn3.683. PMID: 30847369; PMC: 6389753.
Start Year 2017
 
Description PSP network 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution A new netwrok to coordinate clinical and genetic and imaging research of this severe neurodegenerative disorder
Collaborator Contribution 1. coordinated recruitment 2. biomarker development
Impact PPI acivities; Papers pending;
Start Year 2015
 
Description PSP network 
Organisation Progressive Supranuclear Palsy Association (PSPA)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution A new netwrok to coordinate clinical and genetic and imaging research of this severe neurodegenerative disorder
Collaborator Contribution 1. coordinated recruitment 2. biomarker development
Impact PPI acivities; Papers pending;
Start Year 2015
 
Description PSP network 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution A new netwrok to coordinate clinical and genetic and imaging research of this severe neurodegenerative disorder
Collaborator Contribution 1. coordinated recruitment 2. biomarker development
Impact PPI acivities; Papers pending;
Start Year 2015
 
Description PSP network 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution A new netwrok to coordinate clinical and genetic and imaging research of this severe neurodegenerative disorder
Collaborator Contribution 1. coordinated recruitment 2. biomarker development
Impact PPI acivities; Papers pending;
Start Year 2015
 
Description PSP network 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution A new netwrok to coordinate clinical and genetic and imaging research of this severe neurodegenerative disorder
Collaborator Contribution 1. coordinated recruitment 2. biomarker development
Impact PPI acivities; Papers pending;
Start Year 2015
 
Description Siemens collaboration 
Organisation Siemens Healthcare
Country Germany 
Sector Private 
PI Contribution In establishing the new 7T MRI Research Facility, we have actively enganged with Siemens to revise and optimise the facility on an accelarated timescale. We will be the first non-Germany site to test their new Terra System, and to apply Terra to dementia and neuroscience disciplines.
Collaborator Contribution ?810,000 budgetary revision and 'no-cost' like-for-like upgrade of core technologies of circa ?750,000. Fellowship, on-site engineer for 12months and Scientist for 18 months circa ?260,000. So, total Siemens contribution ~?1,820,000. Subsequent substantial in kind contribution negotiated
Impact Delivery on time and on budget of new facility in 2016. Since 2017: Standard sequences are in in place with good QC/QA, and the scanner is in use for several research studies in clinical populations, ageing and development. The scanner is booked >80% now for clinical and cognitive neuroscience studies. We have negotiated research agreements with Siemens for 4 areas of collaborative development in MRI physics at 7T with the 7T physics group. These include developments in parallel transmit methods in the brain and body; developments in MR spectroscopy; and developments in whole-body metabolic imaging at 7T.
Start Year 2015
 
Description Synaptic Health 
Organisation Alzheimer's Research UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation AstraZeneca
Department MedImmune
Country United Kingdom 
Sector Private 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Eli Lilly & Company Ltd
Country United Kingdom 
Sector Private 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Janssen Biotech, Inc.
Country United States 
Sector Private 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation MRC Dementias Platform UK
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Tau biology in vivo 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution establishing a new biomedical research platform
Collaborator Contribution funding and provision of research materials
Impact pending
Start Year 2014
 
Description UK 7T MRI network 
Organisation Cardiff University
Department Brain Research Imaging Centre (CUBRIC)
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards.
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Description UK 7T MRI network 
Organisation University of Glasgow
Department Institute of Neuroscience and Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards.
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Description UK 7T MRI network 
Organisation University of Nottingham
Department School of Biomedical Sciences Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards.
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Description UK 7T MRI network 
Organisation University of Oxford
Department Oxford Centre for Functional MRI of the Brain (FMRIB)
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards.
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Title Atomoxetine in PD 
Description new drug strategy for impulsivity in PD tested for first time in two complementary studies 
Type Therapeutic Intervention - Drug
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2013
Development Status Closed
Impact reduced impulsivity in selected patients 
 
Title Citalopram 
Description SSRI assessment for FTD impulsivity and netwrok reorganisation 
Type Therapeutic Intervention - Drug
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2013
Development Status Under active development/distribution
Impact New experimental medicine trials planned 
 
Title Tiagabine in FTLD 
Description New drug strategy for impulsivity in FTLD tested for first time. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2021
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Reduced impulsivity in selected patients. 
 
Title iElectrodes toolbox 
Description iElectrodes is an opensource Matlab toolbox for intracranial electrode (SEEG and ECoG) localization and labeling. 
Type Of Technology Webtool/Application 
Year Produced 2016 
Impact None to date 
URL https://sourceforge.net/p/ielectrodes/wiki/Home/
 
Description BBC Newsnight documentary 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Cogntiive enhancement and psychology testing demonstrated and discussed as part of feature within Newsnight program

Greater awareness in the public of both the medical and ethical issues of cognitive enhancement, and also the process of research
Year(s) Of Engagement Activity 2011
 
Description BBC Science Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Discussion of memory inhibition, with Dr Anderson and presented Jessica Hynes, BBC2

pending
Year(s) Of Engagement Activity 2012
 
Description Brain and Mind Open day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Open lectures in CBU science, including work on music and PD, led by Dr Grahn and Dr Hughes, Mr Wolpe and other group members

"the dementia challenge" 2013

Highly popular annual event
Year(s) Of Engagement Activity 2007,2009,2013,2015
 
Description Conversion dystonia 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact New research results into 'hysterical' or conversion disorders, using brain imaging

High media interest in the UK and abroad.
Year(s) Of Engagement Activity 2013
 
Description Cope/Rowe - Alzheimer's breakthrough? Scientists show how toxic protein rips through the brain (2018). 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Article on Cope et al., Brain. By Giles Sheldrick. Express - online. www.express.co.uk/life-style/health/900212/Alzheimer-s-disease-toxic-protein-rips-through-brain-scientists-reveal
Year(s) Of Engagement Activity 2018
URL http://www.express.co.uk/life-style/health/900212/Alzheimer-s-disease-toxic-protein-rips-through-bra...
 
Description Cope/Rowe - Alzheimer's protein may spread like an infection, human brain scans suggest (2018). 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on Cope et al., 2018 in Brain. By Meredith Wadman. Science Magazine www.sciencemag.org
http://www.sciencemag.org/news/2018/01/alzheimer-s-protein-may-spread-infection-human-brain-scans-suggest
Year(s) Of Engagement Activity 2018
URL http://www.sciencemag.org/news/2018/01/alzheimer-s-protein-may-spread-infection-human-brain-scans-su...
 
Description Cope/Rowe - How Alzheimer's disease spreads throughout the brain - new study. The Conversation (2018). 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Media article on Cope et al., Brain in "The Conversation".
Year(s) Of Engagement Activity 2018
URL http://theconversation.com/how-alzheimers-disease-spreads-throughout-the-brain-new-study-89692
 
Description Cope/Rowe - Recent advances in brain imaging have enabled scientists to show for the first time that a key protein which causes nerve cell death spreads throughout the brain in Alzheimer's disease - and hence that blocking its spread may prevent the disease from taking hold (2018). 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release by the Cambridge University regarding new article published by Cope et al., in Brain.
Year(s) Of Engagement Activity 2018
 
Description FTD carers group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 45 people, moslty fmailies, some allied professionals, regarding current research and activity, and practical management of symptoms


new audit of care
new direct input from DWP to clinic education
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015,2016
 
Description Hughes - CBU Open Science Workshop 2016, Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK (2016) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Hughes, L. (22nd November 2016). CBU Open Science Workshop 2016, Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
Year(s) Of Engagement Activity 2016
 
Description Inernational symposium on PSP/CBD 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact International symposium, including talk and posters from our group, on progress in PSP and CBD reesarch
Engagement with Pharma
Year(s) Of Engagement Activity 2018
 
Description MRC CBU Science Night - Cambridge Science Festival 2019 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Demonstrations of research studies, including VR game
Year(s) Of Engagement Activity 2019
URL http://www.mrc-cbu.cam.ac.uk/blog/2019/01/mrc-cbu-science-night-cambridge-science-festival-2019/
 
Description Nesbit - Talk presented at the meeting on "Your ageing brain. Use it or loose it". Meeting by Sevenoaks and Knole U3A Science Groups (2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Nesbit, D. (7th June, 2016). Talk presented at the meeting on "Your ageing brain. Use it or loose it". Meeting by Sevenoaks and Knole U3A Science Groups
Year(s) Of Engagement Activity 2016
 
Description Nesbitt - Q A with Dr David Nesbitt. The London Brain Project. Special Edition on Beyond Memories (2017) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Nesbitt, D. (28th September 2017). Q&A with Dr David Nesbitt. The London Brain Project. Special Edition on "Beyond Memories".
Year(s) Of Engagement Activity 2017
 
Description PD newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact feedback on research projects on PD to the PD research database panel, and PSP association newsletter

increased engagement in research particpation, by pateitns and their healthy contacts
Year(s) Of Engagement Activity 2007,2008,2009,2010,2014,2015
 
Description PD nurses 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 100 nurse specialsits and allied professionals to learn about dementia and neurodegeneration, including research perspectives.
CDC professionals Q&A
Clinic based teaching

tbc
Year(s) Of Engagement Activity 2013,2014,2015,2016
 
Description PPE - Cambridge university Hospitals Trust members 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact An evening event for the members of the Trust (patients, and local public) to discuss advances in dementia research and care, including the insights from new technologies
Year(s) Of Engagement Activity 2019
 
Description PSPA - health and social care professionals 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact challenges of PSP and its research

.
Year(s) Of Engagement Activity 2012,2013,2014,2015
 
Description PSPA guidelines 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Health professionals
Results and Impact A working party to develop new national guidelines


Published guidelines
Year(s) Of Engagement Activity 2012
 
Description Rowe - 11th Cambridge Dementia Course. Oliver Cousins for Advances in Clinical Neuroscience and Rehabilitation (ACNR), (2017). 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Rowe, J. B. (11th April 2017). 11th Cambridge Dementia Course. Oliver Cousins for Advances in Clinical Neuroscience and Rehabilitation (ACNR).
Year(s) Of Engagement Activity 2017
URL http://www.acnr.co.uk/2017/04/11th-cambridge-dementia-course/
 
Description Rowe - BBC Look East (2016) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 7T for dementia research
Year(s) Of Engagement Activity 2016
 
Description Rowe - Brain training app found to improve memory in people with mild cognitive impairment. University of Cambridge for Science Daily (2017) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (3rd July 2017). 'Brain training' app found to improve memory in people with mild cognitive impairment. University of Cambridge for Science Daily.
www.sciencedaily.com/releases/2017/07/170703083310.htm
Year(s) Of Engagement Activity 2017
URL http://www.sciencedaily.com/releases/2017/07/170703083310.htm
 
Description Rowe - Cambridge Neuroscientists involved in large multi-centre Alzheimer's study. Cambridge Neuroscience News, UK (2016) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (22th August 2016). Cambridge Neuroscientists involved in large multi-centre Alzheimer's study. Cambridge Neuroscience News, UK.
http://www.neuroscience.cam.ac.uk/news/article.php?permalink=886b81aa3d
Year(s) Of Engagement Activity 2016
URL http://www.neuroscience.cam.ac.uk/news/article.php?permalink=886b81aa3d
 
Description Rowe - Cambridge Science Festival (2017) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Lecture at Cambridge Science Festival
Year(s) Of Engagement Activity 2017
 
Description Rowe - Cambridge extends world leading role for medical imaging with powerful new brain and body scanners. Cambridge Neuroscience News, UK (2016). 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact • Rowe, J. B. (25th October 2016). Cambridge extends world leading role for medical imaging with powerful new brain and body scanners. Cambridge Neuroscience News, UK. http://www.neuroscience.cam.ac.uk/news/article.php?permalink=fe046fcc97
Year(s) Of Engagement Activity 2016
 
Description Rowe - Cambridge extends world leading role for medical imaging with powerful new brain and body scanners. University of Cambridge News for Medical Design Technology (2016) 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (24th October 2016). Cambridge extends world leading role for medical imaging with powerful new brain and body scanners. University of Cambridge News for Medical Design Technology. http://www.cam.ac.uk/research/news/cambridge-extends-world-leading-role-for-medical-imaging-with-powerful-new-brain-and-body-scanners
Year(s) Of Engagement Activity 2016
URL http://www.cam.ac.uk/research/news/cambridge-extends-world-leading-role-for-medical-imaging-with-pow...
 
Description Rowe - Existing drugs step up in battle against neurodegenerative disease. Magazine of the PSP Association (2017) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Rowe, J. B. (9th October 2017). Existing drugs step up in battle against neurodegenerative disease. Magazine of the PSP Association.
Year(s) Of Engagement Activity 2017
 
Description Rowe - FTD Carers' Meeting, Department of Clinical Neurosciences, University of Cambridge, UK (2014) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Rowe, J. B. (24th March 2014). FTD Carers' Meeting, Department of Clinical Neurosciences, University of Cambridge, UK.
Year(s) Of Engagement Activity 2014
 
Description Rowe - FTD Carers' Meeting, Department of Clinical Neurosciences, University of Cambridge, UK (2015). 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Rowe, J. B. (30th March 2015). FTD Carers' Meeting, Department of Clinical Neurosciences, University of Cambridge, UK.
Year(s) Of Engagement Activity 2015
 
Description Rowe - FTD Carers' Meeting. Department of Clinical Neurosciences, University of Cambridge (2017). 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Rowe, J. B. (13th September 2017). FTD Carers' Meeting. Department of Clinical Neurosciences, University of Cambridge; give feedback to carers and also get feedback from them.
Year(s) Of Engagement Activity 2017
 
Description Rowe - FTD Carers' Meeting. Department of Clinical Neurosciences, University of Cambridge (PPE) (2016). 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Rowe, J. B. (8th February 2016). FTD Carers' Meeting. Department of Clinical Neurosciences, University of Cambridge (PPE).
Year(s) Of Engagement Activity 2016
 
Description Rowe - FTD-UK Annual Meeting (2017) - Debate 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A discussion of imaging's contribution to FTD diagnosis, prognosis and stratification
Year(s) Of Engagement Activity 2017
 
Description Rowe - First dementia patient is scanned. BRC Communications, R D Newsletter, Cambridge Biomedical Research Centre (2017) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Rowe, J. B. (6th October 2017). First dementia patient is scanned. BRC Communications, R&D Newsletter, Cambridge Biomedical Research Centre.
Year(s) Of Engagement Activity 2017
 
Description Rowe - For the Dementia Awareness Week: Professor James Rowe of @CamNeuro on Cambridge s role in dementia research. University of Cambridge, (2017). 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (17th May 2017). For the Dementia Awareness Week: Professor James Rowe of @CamNeuro on #Cambridge's role in dementia research. University of Cambridge, Cambridge TV @cambridgetvnews (Twitter Video).
https://twitter.com/cambridgetvnews/status/864790164861800448; awareness for dementia
Year(s) Of Engagement Activity 2017
URL http://twitter.com/cambridgetvnews/status/864790164861800448
 
Description Rowe - He couldn t believe there was no cure: Husband of ski instructor, 32, struck down by rare dementia shortly after their wedding has shed so many tears since her diagnosis, her father reveals. Andrew Young for Daily Mail Online (2017) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Rowe, J. B. (4th September 2017). He couldn't believe there was no cure': Husband of ski instructor, 32, struck down by rare dementia shortly after their wedding has shed 'so many tears' since her diagnosis, her father reveals. Andrew Young for Daily Mail Online. http://www.dailymail.co.uk/news/article-4851272/Husband-couldn-t-believe-no-cure.html; mentions only James Rowe
Year(s) Of Engagement Activity 2017
URL http://www.dailymail.co.uk/news/article-4851272/Husband-couldn-t-believe-no-cure.html
 
Description Rowe - Her tester programleder Emma <>. Kristin Granbo for NRK News (2016). 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Rowe, J. B. (14th May 2016). Her tester programleder Emma <>. Kristin Granbo for NRK News.
Year(s) Of Engagement Activity 2016
URL https://www.nrk.no/dokumentar/xl/her-tester-programleder-emma-_smart-drug_-1.12916450
 
Description Rowe - How a blood test could save you from infertility: Women could be spared surgery which risks their ability to have children. Carol Davis for Daily Mail Online (2016) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Rowe, J. B. (19th November 2016). How a blood test could save you from infertility: Women could be spared surgery which risks their ability to have children. Carol Davis for Daily Mail Online. http://www.dailymail.co.uk/health/article-3952546/How-blood-test-save-infertility-Women-spared-surgery-risks-ability-children.html
Year(s) Of Engagement Activity 2016
URL http://www.dailymail.co.uk/health/article-3952546/How-blood-test-save-infertility-Women-spared-surge...
 
Description Rowe - James Rowe appointed as Professor in Department of Clinical Neurosciences. Cambridge Neuroscience News, UK (2015) 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (22th June 2015). James Rowe appointed as Professor in Department of Clinical Neurosciences. Cambridge Neuroscience News, UK.
http://www.neuroscience.cam.ac.uk/news/article.php?permalink=4cf805cac3
Year(s) Of Engagement Activity 2015
URL http://www.neuroscience.cam.ac.uk/news/article.php?permalink=4cf805cac3
 
Description Rowe - Look East. The latest news, sport and weather for the East of England. BBC One. (Feature about PSP Association) (2017) 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Rowe, J. B. (16th May 2017). Look East. The latest news, sport and weather for the East of England. BBC One. (Feature about PSP Association).
Year(s) Of Engagement Activity 2017
 
Description Rowe - Meeting the Scientist. Cambridge Science Festival, Cambridge, UK (25th March 2018) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Increase public awareness for rare dementia types (PSP, SD, frontotemporal dementia).
Year(s) Of Engagement Activity 2018
 
Description Rowe - Misplace in Space (2016-2017) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Rowe, J. B. (1st-6th September 2017). Misplaced in Space. Emily Fisher, Work by MA students shown in the MA Degree Show 2017 with work related to individual's experience to live with dementia. Norwich University of the Arts, UK. http://www.nua.ac.uk/ma-degree-show-catalogue-2017/emily-fisher/; An interactive exhibition about living with Dementia,
Year(s) Of Engagement Activity 2017
URL http://www.nua.ac.uk/ma-degree-show-catalogue-2017/emily-fisher/
 
Description Rowe - NIHR Westminster: Dementia meeting the challenge (2012) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presenting the case for cognitive phenotyping and imaging endpoints in magement and drug innovation,
including new cognitive technologies

new NDA with pharma, discussions ongoing
Year(s) Of Engagement Activity 2012
 
Description Rowe - NIMROD study. BRC Communications, R D Newsletter, Cambridge Biomedical Research Centre (2017) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Rowe, J. B. (6th October 2017). NIMROD study. BRC Communications, R&D Newsletter, Cambridge Biomedical Research Centre.
Year(s) Of Engagement Activity 2017
 
Description Rowe - Norwegian TV - Modafinil test by programme leader Emma Claire (2017) 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact On cognitive enhancement
Year(s) Of Engagement Activity 2017
 
Description Rowe - Opening the black box. Research Horizons - Pioneering research from the University of Cambridge, Issue 29 (2016). 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (29th February 2016). Opening the black box. Research Horizons - Pioneering research from the University of Cambridge, Issue 29.
Year(s) Of Engagement Activity 2016
 
Description Rowe - PCA support group (2015) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact PCA group - discussion of clicnial and reseaerch topics
Year(s) Of Engagement Activity 2015,2016
 
Description Rowe - PSP Matters (2017) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Research update and progress for PSPA
Year(s) Of Engagement Activity 2016,2017
 
Description Rowe - Patients recovering from depression show improvements in memory from the drug modafinil. Cambridge Neuroscience News, UK (2017) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (19th January 2017). Patients recovering from depression show improvements in memory from the drug modafinil. Cambridge Neuroscience News, UK. http://www.neuroscience.cam.ac.uk/news/article.php?permalink=d6523fd0d6
Year(s) Of Engagement Activity 2017
URL http://www.neuroscience.cam.ac.uk/news/article.php?permalink=d6523fd0d6
 
Description Rowe - Report on a very successful Imaging the Nervous System Symposium. Cambridge Neuroscience News, UK (2015). 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (8th October 2015). Report on a very successful 'Imaging the Nervous System' Symposium. Cambridge Neuroscience News, UK.
http://www.neuroscience.cam.ac.uk/news/article.php?permalink=19657b8d6b
Year(s) Of Engagement Activity 2015
URL http://www.neuroscience.cam.ac.uk/news/article.php?permalink=19657b8d6b
 
Description Rowe - Schizophrenia and the teenage brain: How can imaging help? The University of Cambridge for Medical Design Technology (2016). 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (22nd February 2016). Schizophrenia and the teenage brain: How can imaging help? The University of Cambridge for Medical Design Technology.
https://www.mdtmag.com/news/2016/02/schizophrenia-and-teenage-brain-how-can-imaging-help
Year(s) Of Engagement Activity 2016
URL https://www.mdtmag.com/news/2016/02/schizophrenia-and-teenage-brain-how-can-imaging-help
 
Description Rowe - She used to light up a room - but now 'beautiful' Becky from Suffolk finds it hard to speak after crushing dementia diagnosis. Emily Townsend for East Anglian Daily Times (2017) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Rowe, J. B. (11th September 2017). She used to light up a room - but now 'beautiful' Becky from Suffolk finds it hard to speak after crushing dementia diagnosis. Emily Townsend for East Anglian Daily Times. http://www.eadt.co.uk/news/she-used-to-light-up-a-room-but-now-beautiful-becky-from-suffolk-finds-it-hard-to-speak-after-crushing-dementia-diagnosis-1-5189016; mentions James Rowe
Year(s) Of Engagement Activity 2017
URL http://www.eadt.co.uk/news/she-used-to-light-up-a-room-but-now-beautiful-becky-from-suffolk-finds-it...
 
Description Rowe - The new scanners that can really get inside your head. Robin McKie for the Guardian (2016). 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Rowe, J. B. (23rd October 2016). The new scanners that can really get inside your head. Robin McKie for the Guardian.
https://www.theguardian.com/science/2016/oct/23/powerful-brain-scanners-cambridge-neuroscience
Year(s) Of Engagement Activity 2016
URL https://www.theguardian.com/science/2016/oct/23/powerful-brain-scanners-cambridge-neuroscience
 
Description Rowe - Video abstract: Study suggests new treatment for impulsivity in some dementia patients. Cambridge Neuroscience News, UK (2015) 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (25th June 2015). Video abstract: Study suggests new treatment for impulsivity in some dementia patients. Cambridge Neuroscience News, UK. http://www.neuroscience.cam.ac.uk/news/article.php?permalink=86cc5c6e76
Year(s) Of Engagement Activity 2015
URL http://www.neuroscience.cam.ac.uk/news/article.php?permalink=86cc5c6e76
 
Description Rowe, 'Brain training' app found to improve memory in people with mild cognitive impairment. Cambridge Neuroscience News, UK (2017) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (18th July 2017). 'Brain training' app found to improve memory in people with mild cognitive impairment. Cambridge Neuroscience News, UK.
http://www.neuroscience.cam.ac.uk/news/article.php?permalink=349646f424
Year(s) Of Engagement Activity 2017
URL http://www.neuroscience.cam.ac.uk/news/article.php?permalink=349646f424
 
Description Rowe, J. B. (11th October 2016). As fake 'study pills' become a staple of University life we speak to two students who reveal the horrifying consequences of brain boosting drugs. Matt Quinton for the Sun. 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Rowe, J. B. (11th October 2016). As fake 'study pills' become a staple of University life we speak to two students who reveal the horrifying consequences of brain boosting drugs. Matt Quinton for the Sun. https://www.thesun.co.uk/living/1949817/as-fake-study-pills-become-a-staple-of-university-life-we-speak-to-two-students-who-reveal-the-horrifying-consequences-of-brain-boosting-drugs/
Year(s) Of Engagement Activity 2016
URL https://www.thesun.co.uk/living/1949817/as-fake-study-pills-become-a-staple-of-university-life-we-sp...
 
Description Rowe, J. B. (28th September 2017) Understanding frontotemporal dementia: an interview with Professor James Rowe - Interview for the National Institute for Health Research (NIHR) (2017) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Rowe, J. B. (28th September 2017) Understanding frontotemporal dementia: an interview with Professor James Rowe. Interview for the National Institute for Health Research (NIHR). https://www.nihr.ac.uk/news-and-events/features/behind-the-research/Understanding-frontotemporal-dementia.htm
Year(s) Of Engagement Activity 2017
URL http://www.nihr.ac.uk/news-and-events/features/behind-the-research/Understanding-frontotemporal-deme...
 
Description Rowe/Team - Cambridge Science Festival (2017) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact A lecture on the challenge of dementia as part of the Cambridge Science Festival
Year(s) Of Engagement Activity 2017
 
Description Rowe/Team - MEG and Me (2015) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact ISSF grant awarded for public engagement with scientific experiment, design, execution and intepretation, filmed by Cambridge TV. (22nd March 2015). IFFS sponsored study of "MEG and ME - Design your own brain experiment" with public meetings to design a MEG experiment, take part in it, and be part of the interpretation of result. Presentation at the Cambridge Science Festival 2015. https://vimeo.com/122974384; https://timrittman.wordpress.com/2014/11/01/meg-and-me-design-your-own-brain-experiment/
Year(s) Of Engagement Activity 2015
 
Description Rowe/Team - Pint of Science (2015 and 2016) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Several team members in highly popular PoS events within Cambridge Science Festival
Year(s) Of Engagement Activity 2015,2016
 
Description Rowe/Team - The University of the third age (U3A) (2016) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The CamCAN project including CC-Frail from ACA5, was the focus of a special day event organised by the U3A
Year(s) Of Engagement Activity 2016
 
Description Rowe: FTD carers meeting (2017) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Research discussion to regional carers
Year(s) Of Engagement Activity 2017
 
Description School visits years 2-4 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact discussion of brains, their funciton and protection, with models and animal brains, and exercises. 70 children,

Has become a regular and highly popular activity.
Increased awareness of the amazing functions of the brain, and the need to look after it - linked to road safety, exercise and education.
Year(s) Of Engagement Activity 2010,2011,2014
 
Description Seven lab members (22nd March 2018). 5k for the PSP Association to raise money to support people affected by CBD & PSP, Cambridge, UK. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Run for PSP and CBD to increase awareness. https://www.pspassociation.org.uk/fundraising/5kforpspa/; promoted on twitter
Year(s) Of Engagement Activity 2018
 
Description Tomassini - Tutor for hands-on sessions for pupils on the use of magnetoencephalography and electroencephalography in neuroscience. Villiers Park Educational Trust, Cambridge, UK (2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Tomassini, A. (2016). Tutor for hands-on sessions for pupils on the use of magnetoencephalography and electroencephalography in neuroscience. Villiers Park Educational Trust, Cambridge, UK.
Year(s) Of Engagement Activity 2016
 
Description Tsvetanov - A well-connected brain is the key to healthy mental ageing. BBSRC news stories and features (2016). 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Tsvetanov, K. A. (18th March 2016). A well-connected brain is the key to healthy mental ageing. BBSRC news stories and features. http://www.bbsrc.ac.uk/news/health/2016/160318-pr-well-connected-brain-key-healthy-mental-ageing/
Year(s) Of Engagement Activity 2016
URL http://www.bbsrc.ac.uk/news/health/2016/160318-pr-well-connected-brain-key-healthy-mental-ageing/
 
Description Tsvetanov - Human brains age less than previously thought Interview with MedicalResearch.com (2015) 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Tsvetanov, K. A. (20th March 2015). Human brains age less than previously thought Interview with MedicalResearch.com. https://medicalresearch.com/author-interviews/human-brains-age-less-than-previously-thought/12840/
Year(s) Of Engagement Activity 2015
URL https://medicalresearch.com/author-interviews/human-brains-age-less-than-previously-thought/12840/
 
Description Tsvetanov - Human brains age less than previously thought. BBSRC news stories and features (2015) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Tsvetanov, K. A. (5th March 2015). Human brains age less than previously thought. BBSRC news stories and features. http://www.bbsrc.ac.uk/news/health/2015/150305-pr-human-brains-age-less-than-thought/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+bbsrc+%28BBSRC+-+News+stories+and+features%29
Year(s) Of Engagement Activity 2015
URL http://www.bbsrc.ac.uk/news/health/2015/150305-pr-human-brains-age-less-than-thought/?utm_source=fee...
 
Description Tsvetanov - Human brains age less than previously thought. CamCAN Newsletter (2015) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Tsvetanov, K. A. (2015). Human brains age less than previously thought. CamCAN Newsletter.
Year(s) Of Engagement Activity 2015
 
Description Tsvetanov - Journal cover image of Human Brain Mapping, Issue 6 (2015) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Tsvetanov, K. A. (2015). Journal cover image of Human Brain Mapping, Issue 6.
Year(s) Of Engagement Activity 2015
 
Description Tsvetanov - Talk presented at the meeting on "Your ageing brain. Use it or loose it". Meeting by Sevenoaks and Knole U3A Science Groups (2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Tsvetanov, K. (7th June, 2016). Talk presented at the meeting on "Your ageing brain. Use it or loose it". Meeting by Sevenoaks and Knole U3A Science Groups
Year(s) Of Engagement Activity 2016
 
Description Tsvetanov - Your brain might not be as "old" as you think. University of Cambridge Research Features (2015). 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Tsvetanov, K. A. (9th March 2015). Your brain might not be as "old" as you think. University of Cambridge Research Features. http://www.cam.ac.uk/research/discussion/your-brain-might-not-be-as-old-as-you-think
Year(s) Of Engagement Activity 2015
URL http://www.cam.ac.uk/research/discussion/your-brain-might-not-be-as-old-as-you-think
 
Description US congressional delegation 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact For UK-US policy review

Enhanced UK-US joint research funding
Dialogue on new care models
Year(s) Of Engagement Activity 2014
 
Description Vazquez/Rowe - Fighting PSP both in and outside the lab. PSP Association Magazine (2017) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Vazquez Rodriguez, P. (September 2017). Fighting PSP both in and outside the lab. PSP Association Magazine; raise awareness for PSP
Year(s) Of Engagement Activity 2017
 
Description WIRED magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Session with WIRED magazine journalists, on cognitive enhancement

Education of the public about the ethics, efficacy and evidence for cognitive enhancement
Year(s) Of Engagement Activity 2013
 
Description Wellcome Collection 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact An open evening in central london, with three speakers and audience particpation

very positive feedback
Year(s) Of Engagement Activity 2012
 
Description Wolpe - How does the motor system compensate for age-related decline in sensory processing? Cambridge Neuroscience News, UK (2016) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Wolpe N. (17th October 2016). How does the motor system compensate for age-related decline in sensory processing? Cambridge Neuroscience News, UK.
http://www.neuroscience.cam.ac.uk/news/article.php?permalink=bcd0bb401e
Year(s) Of Engagement Activity 2016
URL http://www.neuroscience.cam.ac.uk/news/article.php?permalink=bcd0bb401e