Aetiology of type 2 diabetes and obesity and related metabolic disorders

Lead Research Organisation: MRC Epidemiology Unit

Abstract

The pattern of the occurrence of type 2 diabetes suggests that this disorder arises from a complex interaction between genetic factors, obesity and lifestyle factors such as dietary behaviour and physical activity. Although this overall model of how diabetes develops explains differences in disease risk between and within populations, the detailed mechanisms underlying these interactions have not been fully identified. This programme of research aims to study the genetic factors, the lifestyle factors and finally the interaction between these factors using a range of different epidemiological study designs.||The study of the genetic basis of type 2 diabetes uses population cohorts and case-control studies which compare the frequency of genetic variants in people with the condition to that in people free of disease. These genetic variants are either selected on the basis of established biological knowledge or more recently from large scale genotyping studies in which a very large number of variants across the whole genome are studied without any reference to prior knowledge.|The investigation of the non-genetic determinants of diabetes is undertaken in population-based cohort studies in which key factors such as dietary behaviour and physical activity are characterised in large groups of people. These are then followed up over time to determine will develop obesity or type 2 diabetes. A key example of this is the EPIC-Norfolk study in which 25,000 people have been followed up for 10 years, with 900 developing type 2 diabetes.||The same general approach is taken to the study of the interaction between genetic and lifestyle factors but requires even larger studies. For reasons of efficiency one does not measure the genetic factors in all the individuals but only in the newly developed cases and a random subset of those who remain free of disease. This study design is being used in the InterAct project which has identified and confirmed over 12,000 incident cases of type 2 diabetes from an initial study population of 350,000 people who have been followed up for 7 years. The InterAct project will show how genetic and lifestyle factors lead to type 2 diabetes and will have important implications for the design of new therapies, the development of approaches to the identification of at-risk individuals and the personalisation of prevention.

Technical Summary

Type 2 diabetes is a growing public health problem which arises from complex interactions between genetic and lifestyle behavioural factors. This programme aims to investigate the basis of these interactions by studying the genetic aetiology of obesity and type 2 diabetes, the association between lifestyle factors such as diet, nutrition and physical activity, and lastly to study how the interaction between these various factors leads to disease. These goals are studied using a range of different epidemiological study designs.||Our programme on the genetics of type 2 diabetes and related disorders is a collaborative endeavour as part of the Genetics of Energy Metabolism (GEM) consortium which includes our key partners in the Wellcome Trust Sanger Institute (Dr Ines Barroso) and University of Cambridge (Professor Steve O Rahilly). Our approach combines candidate gene studies and genome wide association studies using large case-control studies (e.g. Norfolk Diabetes Study) and population-based cohorts with detailed metabolic characterisation (e.g. the Ely and Fenland studies). Together with colleagues in Lausanne and GSK, we are undertaking analyses of genomewide association data on key quantitative metabolic traits related to diabetes including glucose and insulin levels, anthropometry, blood pressure and blood lipids.||Our programme on non-genetic determinants of diabetes is based on large population cohort studies in which dietary and nutritional factors and physical activity have been carefully characterised (e.g. the EPIC-Norfolk study on 25,000 people in which we have identified 900 incident cases of type 2 diabetes). Our objectives are to study the association of food intake and nutritional content with the risk for diabetes and related endpoints using dietary assessment instruments with greater precision as well as using biomarkers of dietary intake. The same approach is taken for physical activity using cohorts in whom detailed questionnaires have been used (e.g. EPAQ2) or in whom physical activity energy expenditure has been assessed objectively (e.g. by combined heart rate and movement sensing). This element of the programme involves close collaboration with the Units Physical Activity Epidemiology programme.||The study of gene-lifestyle interaction requires a synthesis of data from a range of different studies. We have established large prospective case-control studies nested within existing cohorts (EPIC-Europe study), detailed metabolic phenotype cohorts with objective assessment of key lifestyle behaviours (Fenland study) and a biobank of individuals who can be recruited to physiological and clinical investigation studies on the basis of genotype (the Cambridge BioResource). The largest of these studies is the InterAct project funded by the European Commission under Framework 6. This project will study gene-lifestyle interaction in a nested case-control study within the total EPIC-Europe population of more than 350,000 people. A total of 12,403 verified incident cases of type 2 diabetes have been identified and together with a randomly selected control cohort this will enable sufficiently powered studies of gene-lifestyle interaction on the development of diabetes.

Publications

10 25 50
 
Description ADA/EASD/IDF Committee on the diagnosis of diabetes
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
 
Description An Investment Framework for Nutrition : Reaching the Global Targets for Stunting, Anemia, Breastfeeding and Wasting; Cited by World Bank on 30 Sep 2016
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://openknowledge.worldbank.org/bitstream/10986/25292/1/108645-v2-PUBLIC-Investment-Framework-fo...
 
Description Baker IDI Directorship Appointment Panel
Geographic Reach Australia 
Policy Influence Type Participation in a advisory committee
 
Description Breakthrough Generations Study Strategic Review
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description CESP Directorship Appointment Panel
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description CMO guidance on physical activity
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description CRUK, BHF, WT Population Health Working Group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Co-Laus International Scientific Advisory Board
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description DH: Use of HbA1c in the diagnosis of diabetes
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description Department of Health "Small changes big differences" campaign
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guidance committee
 
Description DoH Visit - Obesity strategy
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description EFSA - Vitamin A
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL http://www.efsa.europa.eu/sites/default/files/scientific_output/files/main_documents/4028.pdf
 
Description EU Diabetes Mapping Project (DiaMap)
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
 
Description Establishing Precompetitive Collaborations to Stimulate Genomics-Driven Product Development: Workshop Summary, Cited by National Academies Press on 24 Dec 2016
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in systematic reviews
URL http://www.nature.com/ng/journal/v42/n7/full/ng.609.html
 
Description Expert Group of NHS Diabetes Prevention Programme
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Foresight Obesity Review
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Gave evidence to a government review
 
Description Früherkennung, Diagnose, Therapie und Nachsorge des Harnblasenkarzinoms, Cited by The Association of the Scientific Medical Societies in Germany on 01 Nov 2016
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in other policy documents
URL http://www.awmf.org/uploads/tx_szleitlinien/032-038ol_m_S3_Harnblasenkarzinom_2016-12.pdf
 
Description Global Innovation Initiative - British Council and the Institute of International Education
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Gov Office for Science discussion on Population Science and Public Health
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description House of Commons Health Committee inquiry - oral evidence
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL http://www.parliament.uk/business/committees/committees-a-z/commons-select/health-committee/news/29-...
 
Description House of Lords Science & Technology Inquiry on Sports & Exercise (RCUK Evidence)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description IDF Diabetes Atlas 2011
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
 
Description IDF Global Diabetes Plan 2011-21
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
 
Description Implementation of Lung Cancer Screening: Proceedings of a Workshop, Cited by National Academies Press on 16 Nov 2016
Geographic Reach North America 
Policy Influence Type Citation in systematic reviews
URL https://www.nap.edu/catalog/23680/implementation-of-lung-cancer-screening-proceedings-of-a-workshop
 
Description MRC SPHSU QQR Committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description MRC WITS Review (Development Pathways to Health Research Unit)
Geographic Reach Africa 
Policy Influence Type Participation in a advisory committee
 
Description MRC-PHE Centre Annual ISAB meeting
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Making Eye Health a Population Health Imperative: Vision for Tomorrow, Cited by National Academies Press on 15 Sep 2016
Geographic Reach North America 
Policy Influence Type Citation in systematic reviews
URL https://www.nice.org.uk/guidance/ng42/evidence
 
Description Motor neurone disease: assessment and management: Appendices A-Q, Cited by NICE on 24 Feb 2016
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in other policy documents
URL https://www.nice.org.uk/guidance/ng42/evidence
 
Description NHS Health Check Expert Scientific and Clinical Advisory Committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description NICE PH35 Public Health Programme Development Group Update
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description NICE Programme Development Group
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guidance committee
 
Description NICE: Expert Panel Mtg - Review of PH38
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description NIHR Public Health Research Programme Research Funding Board
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description NMRC TCR Flagship Programme Singapore
Geographic Reach Asia 
Policy Influence Type Participation in a advisory committee
 
Description Opinion on BPA
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL http://www.efsa.europa.eu/sites/default/files/scientific_output/files/main_documents/740e.pdf
 
Description Public Health England Health Checks Expert Scientific and Clinical Advisory Committee
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description Redesigning the Clinical Effectiveness Research Paradigm: Innovation and Practice-Based Approaches: Workshop Summary Cited by National Academies Press on 24 Dec 2016
Geographic Reach North America 
Policy Influence Type Citation in systematic reviews
URL https://www.nap.edu/catalog/18846/a-framework-for-assessing-effects-of-the-food-system
 
Description Review Panel Member, Wageningen University
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description U.S. Preventive Services Task Force: Diabetes
Geographic Reach North America 
Policy Influence Type Citation in other policy documents
 
Description WHO Cairo Eastern Mediterranean Region re Non-Communicable Disease Collaboration
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description WHO South-East Asia Journal of Public Health, Volume 5, Issue 1, April 2016, 1-75, Cited by World Health Organization on 08 Apr 2016
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL http://apps.who.int/iris/bitstream/10665/204979/1/Vol5%20Issu1.pdf
 
Description WHO Technical Meeting Physical Activity
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description WHO expert committee on the classification and diagnosis of diabetes
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
 
Description World Health Organization EMRO Advisory Group on NCD Surveillance
Geographic Reach Africa 
Policy Influence Type Influenced training of practitioners or researchers
Impact WHO technical expert providing advice on capacity building for NCD surveillance in the Eastern Mediterranean Region.
 
Description A pragmatic and scalable strategy using mobile technology to promote sustained lifestyle changes to prevent Type 2 diabetes in India and the UK (ICMR)
Amount £82,571 (GBP)
Funding ID MR/J000183/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2011 
End 08/2014
 
Description BBSRC CASE Studentship
Amount £72,540 (GBP)
Funding ID BB/G529983/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2008 
End 09/2012
 
Description BHF Project Grant (Twins)
Amount £279,688 (GBP)
Funding ID PG/07/108/23369 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2009 
End 01/2012
 
Description CRUK Programme Grant (EPIC Norfolk)
Amount £1,400,000 (GBP)
Funding ID C864/A14136 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2012 
End 03/2017
 
Description Capital Award
Amount £72,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2013 
End 03/2014
 
Description Capital Award
Amount £157,000 (GBP)
Funding ID 4050373855 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 03/2015
 
Description DSF Danish Strategic Research Award
Amount £359,702 (GBP)
Funding ID 2142-08-0005 
Organisation Danish Council for Strategic Research (DSF) 
Sector Public
Country Denmark
Start 10/2009 
End 09/2011
 
Description EU 6th Framework (Interact)
Amount € 2,867,144 (EUR)
Funding ID LSHM-CT_2006-037197 
Organisation Sixth Framework Programme (FP6) 
Sector Public
Country European Union (EU)
Start 10/2006 
End 09/2011
 
Description EU 7th Framework Programme (EPIC CVD)
Amount € 752,115 (EUR)
Funding ID 279233 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 01/2012 
End 12/2015
 
Description EU Co-ordination Action Grant (EPIC CA)
Amount € 105,538 (EUR)
Funding ID 006438 
Organisation Sixth Framework Programme (FP6) 
Sector Public
Country European Union (EU)
Start 01/2005 
End 11/2009
 
Description European Association for the Study of Diabetes (EASD) Rising Star Fellowship: Novel insights into the role of adipogenesis in the aetiology of insulin resistance: a multidisciplinary approach
Amount € 30,000 (EUR)
Organisation European Association for the Study of Diabetes (EASD) 
Sector Charity/Non Profit
Country European Union (EU)
Start 06/2015 
End 06/2016
 
Description European Joint Programming Initiative project on determinants of diet and physical activity (DEDIPAC)
Amount £12,336 (GBP)
Funding ID PO 4050354745 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 09/2016
 
Description European Medical Information Framework
Amount £1,102,000 (GBP)
Funding ID 115372 
Organisation European Commission 
Department Innovative Medicines Initiative (IMI)
Sector Multiple
Country European Union (EU)
Start 01/2013 
End 12/2017
 
Description Global Initiative on gene-environment interaction on diabetes/obesity risk (Interconnect)
Amount € 1,998,313 (EUR)
Funding ID 602068 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 10/2013 
End 09/2017
 
Description IDENTIFICATION OF RELEVANT BIOMARKERS FOR THE AETIOLOGY OF TYPE 2 DIABETES USING NEW GENETIC CONCEPTS
Amount £137,932 (GBP)
Funding ID 2013/04646/ALW 
Organisation NWO Rubicon Fellowship 
Sector Private
Country Netherlands
Start 06/2013 
End 08/2015
 
Description Investigating pathways to metabolic disease using 'omic' approaches: the MRC Fenland study
Amount £1,211,936 (GBP)
Funding ID MC_PC_13046 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 03/2014
 
Description Investigating the genetic determinants of health ageing:the MRC EPIC-Norfolk study
Amount £1,340,988 (GBP)
Funding ID MC_PC_13048 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 03/2014
 
Description LLHW Promoting Physical Activity
Amount £526,069 (GBP)
Funding ID MR/K025147/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2013 
End 05/2016
 
Description MRC National Prevention Research Initiative (Speedy)
Amount £392,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2006 
End 05/2009
 
Description MRC PHSRN
Amount £77,000 (GBP)
Funding ID PHSRN34 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2009 
End 09/2011
 
Description MRC Programme Grant
Amount £2,400,000 (GBP)
Funding ID G1000143 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2011 
End 12/2015
 
Description MRC/GSK Pilot programme to identify new targets and biomarkers
Amount £1,044,060 (GBP)
Funding ID G0701863 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2008 
End 12/2010
 
Description NIH Project Grant
Amount £1,854,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 01/2007 
End 12/2012
 
Description NIH Project Grant
Amount £1,133,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 08/2007 
End 07/2011
 
Description NIHR HTA
Amount £458,762 (GBP)
Funding ID 09/162/02 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 11/2012 
End 10/2019
 
Description NIHR HTA (Addition)
Amount £362,618 (GBP)
Funding ID 08/116/300 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 01/2010 
End 06/2014
 
Description NIHR HTA (GLINT)
Amount £193,000 (GBP)
Funding ID 09/01/48 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2013 
End 11/2015
 
Description NIHR Programme grant
Amount £1,048,000 (GBP)
Funding ID RP-PG-0606-1259 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2007 
End 09/2012
 
Description NIHR Senior Investigator Award
Amount £75,000 (GBP)
Funding ID NF-SI-0512-10135 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2013 
End 03/2018
 
Description Netherlands Organisation for Scientific Research
Amount € 162,760 (EUR)
Funding ID 825.13.004 
Organisation Netherlands Organisation for Scientific Research (NWO) 
Sector Public
Country Netherlands
Start 08/2013 
End 08/2015
 
Description UKCRC Centres of Excellence in Public Health Research
Amount £5,000,000 (GBP)
Organisation UK Clinical Research Collaboration 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2008 
End 09/2013
 
Description UU Supplementary Strategic Partnership (Cambridge Initiative)
Amount £2,500,000 (GBP)
Funding ID MR/L00002/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2013 
End 03/2018
 
Description Wellcome Trust Intermediate Fellowship
Amount £222,000 (GBP)
Funding ID 091143/Z/10/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2010 
End 12/2013
 
Description Wellcome Trust PhD Programme for Clinicians
Amount £51,200 (GBP)
Funding ID 091143/Z/10/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2011 
End 09/2015
 
Description Wellcome Trust PhD Programme for Clinicians (CK)
Amount £358,433 (GBP)
Funding ID 097451/Z/11/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2011 
End 09/2015
 
Description World Cancer Research Fund
Amount £83,836 (GBP)
Funding ID 2005/50 
Organisation World Cancer Research Fund 
Sector Charity/Non Profit
Country Global
Start 01/2006 
End 12/2008
 
Title DNA management system 
Description As a Unit we have invested in the formulation of a system for efficient storage and robotic rearraying of DNA. 
Type Of Material Improvements to research infrastructure 
Year Produced 2008 
Provided To Others? Yes  
Impact This system has massively increased the speed with which we can efficiently distribute DNA from large cohorts for genotyping. This system operates not only for studies wholey run by our Unit but also for collaborative studies such as EPIC-Norfolk, InterAct and EPIC-Heart. 
 
Title Liquid handling robotics 
Description Our Unit has invested in robotics to allow rapid rearraying and distribution of non-DNA based liquids such as plasma, serum and urine. 
Type Of Material Improvements to research infrastructure 
Year Produced 2010 
Provided To Others? Yes  
Impact The ability to realiquot samples from large cohort studies has massively enhanced the speed with which we can prepare samples for measurement. This facility operates not only for studies run by our Unit wholely but also for collaborative studies such as EPIC-Norfolk, InterAct and EPIC-Heart. 
 
Description AstraZeneca 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution This is a formal collaboration where we will provide insight and results on genetic validation of pre-specified targets of interest to AZ. We will review genetic evidence for particular targets for predefined outcomes.
Collaborator Contribution AZ will provide biological insight into putative novel targets identified by our genetic discovery analyses. This may involve both wet lab characterisation of particular target genes of in silico characterisation of targets.
Impact Only just started; no outputs yet.
Start Year 2015
 
Description EPIC-Europe 
Organisation Barcelona Institute of Ophthalmology
Country Spain 
Sector Academic/University 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation Danish Cancer Society
Country Denmark 
Sector Charity/Non Profit 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation Heidelberg University
Country Germany 
Sector Academic/University 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation Imperial College London
Department School of Public Health
Country United Kingdom 
Sector Academic/University 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation International Agency for Research on Cancer (IARC)
Country France 
Sector Public 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation Leibniz Association
Department German Institute of Human Nutrition (DIfE)
Country Germany 
Sector Public 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation Lund University
Department Faculty of Medicine
Country Sweden 
Sector Academic/University 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation National Institute for Public Health and Environment (RIVM)
Country Netherlands 
Sector Academic/University 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Public 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation Umea University
Department Department of Public Health and Clinical Medicine
Country Sweden 
Sector Academic/University 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation University of Athens
Country Greece 
Sector Academic/University 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation University of Oslo
Country Norway 
Sector Academic/University 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation University of Turin
Country Italy 
Sector Academic/University 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Europe 
Organisation Utrecht University
Country Netherlands 
Sector Academic/University 
PI Contribution EPIC-Europe is a 10 country cohort study which has been in existence from the early 1990s. NW is co-PI of EPIC-Norfolk which is one of the country-level cohorts which contributes to this study. NW leads the InterAct project which is the diabetes sub-study in EPIC-Europe.
Collaborator Contribution Other partners run country-specific cohorts which contribute to the whole consortium.
Impact Multiple publications resulting from work on different health endpoints (including diabetes) in the EPIC-Europe study.
 
Description EPIC-Norfolk Study 
Organisation University of Cambridge
Department Department of Public Health and Primary Care
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint leadership of the EPIC-Norfolk cohort study with specific responsibility for biological sample storage, retrieval and analysis. Leadership of analyses in EPIC-Norfolk of diabetes and obesity related work. Leadership of diabetes working group in EPIC-Europe.
Collaborator Contribution Joint organisation of the analyses of the EPIC-Norfolk cohort study including the third phase remeasurement. Participation of EPIC-Norfolk in EPIC-Europe activities.
Impact Multiple papers from EPIC-Norfolk and EPIC-Europe analyses.
 
Description GEM consortium (Sanger) 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Joint design of studies, analysis and publication of results.
Collaborator Contribution Joint work on understanding the genetic determinants of diabetes and related metabolic disorders including a genomewide scan within the EPIC-Norfolk cohort
Impact Publications on genetic determinants of diabetes and related metabolic disorders.
 
Description GSK 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution We will review results of ongoing Unit-led analyses with scientists at GSK.
Collaborator Contribution GSK will provide in silico and computational biological insight into putative novel targets identified by our genetic discovery analyses. This will principally involve in silico characterisation of targets.
Impact This collaboration just started; no outputs to be reported yet.
Start Year 2016
 
Description Hertfordshire Physical Activity Trial 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Our unit led the trial, developed and applied the intervention and conducted all measurements and analyses.
Collaborator Contribution Facilitation of recruitment of participants to the Hertfordshire Physical Activity Trial nested within the Herts Cohort Study.
Impact Papers on study design (Finucane BMC Endocrine Disorders 2009) and main study results (Finucance Diabetologia 2009 in press).
 
Description InterAct consortium 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Our unit leads the InterAct consortium which was funded by an EU FP6 award to establish a major case-cohort study for incident type 2 diabetes.
Collaborator Contribution EPIC-Europe partners (see additional collaboration) contribute to the construction and analysis of this case-cohort study.
Impact Multiple papers on lifestyle and genetic determinants of risk of type 2 diabetes in a consortium of 8 european countries.
 
Description Lausanne study 
Organisation Lausanne University Hospital (CHUV)
Country Switzerland 
Sector Hospitals 
PI Contribution Joint analysis and publication of data and results.
Collaborator Contribution Joint analysis and publication of data including the Lausanne Study.
Impact Outputs listed under G0701863
Start Year 2007
 
Description MAGIC consortium 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution We were part of the group that formed the MAGIC consortium which is designed to examine the genetic determinants of glucose and insulin traits.
Collaborator Contribution Multiple cohort studies with glucose and insulin measurement and GWAS data.
Impact Multiple papers on the genetic determinants of glucose and insulin related traits.
Start Year 2008
 
Description MRC CORD Metabolic Research Laboratories University of Cambridge 
Organisation University of Cambridge
Department Institute of Metabolic Science (IMS)
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributions to joint analyses and publications.
Collaborator Contribution Analyses of functional significance of common genetic variation found to be associated with diabetes and related metabolic traits. Analyses of association with diabetes and related metabolic traits of common variants in genes discovered by the MRL group in which rare mutations lead to monogenic disease.
Impact Papers on TBC1D4 and post-prandial hyperinsulinaemia (PNAS 2009), adiponectin and insulin resistance (Diabetes 2007) and SIM1 (IJO 2007).
 
Description MRC- GSK collaboration 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Joint analysis of data and reporting of results.
Collaborator Contribution We have collaborated with GSK in a separately funded MRC-GSK consortium which is reported under G0701863
Impact Outputs listed under G0701863
Start Year 2007
 
Description 2016 UKCRC conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact "NJW to open Conference

1440-1605 Workshop: Peer review - Esther van Sluijs, Andy Jones,
Andy Atkin, Nick Wareham

1620-1700 Keynote: Jim McKenna - Nick to convene session, (introduce speaker, facilitate questions, prompt discussion

1700 Close: Nick to close first day, highlight coach collection, etc

Friday 15 July 2016
1100-1200 Moderated poster session 1 - Nick to convene session, introduce concept, lead audience around posters, Introduce speakers, facilitate discussion.

1450 Handover and close - Nick to close Conference, thank and handover to next year's host"
Year(s) Of Engagement Activity 2016
 
Description Aberdean University Press Release on chocolate consumption 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Aberdean University Press Release on EPIC-Norfolk paper Chun Shing Kwok et al. "Habitual chocolate consumption and risk of cardiovascular disease among healthy men and women" Heart, Online (2015), on which Nick Wareham was included an author.

Widespread media coverage, including 70+ reports in online and print media
Year(s) Of Engagement Activity 2015
URL http://www.bbc.co.uk/news/uk-scotland-north-east-orkney-shetland-33145215
 
Description Age at menarche - T2DM risk (KO, CE) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact American Diabetes Association Press release on "Age at menarche and type 2 diabetes risk: the EPIC-InterAct study." Diabetes Care, PMID: 24159179

Limited coverage in international news media.
Year(s) Of Engagement Activity 2013
 
Description All Party Committee on Physical Activity 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Joint CEDAR/MRC Epidemiology submission (x2) to All Party Committee on Physical Activity.

Response from The Young Foundation (who are analysing sumbissions, 18.02.14: "we were just highlighting your responses to go to the co-chairs as two of the best responses. Some very useful insights which will be invaluable for us in drawing up our recommendations."
Year(s) Of Engagement Activity 2014
 
Description BBC Radio Cambridgeshire Breakfast interview (Obesity) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Interview on obesity for BBC Radio Cambridgeshire Breakfast show.

Increased awareness.
Year(s) Of Engagement Activity 2012
 
Description BBSRC ELIXIR UK Community Event, London 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Health professionals
Results and Impact Participation in workshop on data sharing in biological sciences across different research councils.

On-going.
Year(s) Of Engagement Activity 2009
 
Description Babraham Institute Sixth Form Science Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Schools
Results and Impact Prsentation on aetiology and prevention of diabetes to sixth form students.

None.
Year(s) Of Engagement Activity 2008
 
Description Baker IDI, Australia, International Strategic Advisory Board 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Member of the review panel for the International Strategic Advisory Board held at Baker IDI, Melbourne, Australia.

Increased awareness and improved collaboration.
Year(s) Of Engagement Activity 2013
URL http://www.bakeridi.edu.au/
 
Description British Academy Festival of Science 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Chaired Presidential Session at BA Festival of Science entitled "The seven ages of man: opportunities for prevention".

Press coverage in printed media and radio/TV.
Year(s) Of Engagement Activity 2006
 
Description British Council - Serious science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Lecture recorded by Serious Science for British Council educational programme.
Year(s) Of Engagement Activity 2016
 
Description CIHR - Catalyst Grant : Analysis of CLSA Data 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact CIHR - Catalyst Grant : Analysis of CLSA Data. Ottawa.
Year(s) Of Engagement Activity 2016
 
Description CIHR-MRC (UK) Workshop on Cohorts for Life-Long Health, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact Workshop presentation on aging cohorts.

Report on collaborative opportunities in aging research.
Year(s) Of Engagement Activity 2009
 
Description CSaP Laura Baynton 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact CSaP Laura Baynton (Head of "What Works" Team, Cabinet Office)
Year(s) Of Engagement Activity 2016
 
Description Cambridge Big Weekend 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cambridge Big weekend - Fun Lab. Unit volunteers ran the "Sugar cube challenge" exercise bike activity and displayed posters about sugar and health and physical activity. The Fun lab was open to the pubic from 12 noon until 5pm, and approximately 250 people visited the stand, with 120 taking in the "Sugar Cube Challenge".
Year(s) Of Engagement Activity 2015
 
Description Cambridge Festival of Ideas - Don't stop moving 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public lecture as part of the Cambridge Festival of Ideas "Don't stop moving: is the digital world friend or foe in fighting a sedentary future?". About 50 people attended the talk, which was followed by a very good discussion with the highly engages audience.
Year(s) Of Engagement Activity 2016
 
Description Cambridge News Health Section 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Short article in Cambridge News Health Section "Diabetes seminar in city" reporting on start of 2015 Cambridge Diabetes Seminar, hosted by the MRC Epidemiology Unit.
Year(s) Of Engagement Activity 2015
URL http://www.mrc-epid.cam.ac.uk/cds2015
 
Description Cambridge Obesity Initiative BBC Radio 4 Today Programme 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interview on the BBC Radio 4 Today Programme to discuss the announcement of The Cambridge Obesity Initiative and the combined funding of MRC and Wellcome Trust.

Good feedback and further media interest.
Year(s) Of Engagement Activity 2013
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interactive stand at the Cambridge Science Festival. Typical attendance around 300 visitors, including children and adults.

Inquiries from school teachers and members of the public for further information. Excellent feedback from visitors and consistently good attendance at the stand.
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
URL http://www.cam.ac.uk/science-festival
 
Description Cambridge Science Festival 2014 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Cambridge Science Festival@Clinical School. Patterns of our Lives:Nature Versus Nurture

TBD
Year(s) Of Engagement Activity 2014
URL http://www.cam.ac.uk/science-festival
 
Description Centenary MRC Epidemiology Unit Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact MRC Epi Open Day in conjunction with MRC MDU. Visitors could see hands on stands and get refreshments. Visitors could also do tours of our volunteer testing facilties and try different measurements. Around 80 visitors attended with half of these also touring our laboratory facilities.

Excellent feedback, with 10% of visitors completing a feedback form. The event was very popular and we had many requests to repeat the day again in the future. We were also approached by a public health worker to provide learning resources as they felt out materials were very helpful and accessible.
Year(s) Of Engagement Activity 2013
 
Description Comment to the SMC on meta-analysis linking shift work with T2D incidence (NW) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Provided comment to the SMC on a new meta-analysis linking shift work with T2D incidence. "Shift work and diabetes mellitus: a meta-analysis of observational studies".

Invited to participate in BBC World Service Newshour radio interview (SG subsequently did the interview). Quoted on BBC website and in 3 national newspapers. e.g. http://www.bbc.co.uk/news/health-28442550, http://www.theguardian.com/society/2014/jul/25/shift-workers-higher-risk-type-2-diabetes-study
Year(s) Of Engagement Activity 2014
URL http://www.sciencemediacentre.org/expert-reaction-to-shift-work-and-type-2-diabetes-as-published-in-...
 
Description Diabetes Care Lotta et al press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Unit press release to medical reporters "Analysis of data from 140,000 individuals cast doubts on clinical value of current definitions of metabolic health" for paper "Definitions of metabolic health and risk of future type 2 diabetes in body mass index categories: a systematic review and network meta-analysis." Luca A. Lotta et al. Diabetes Care (2015).
Year(s) Of Engagement Activity 2015
 
Description Diabetologia press release Dietary Fibre 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Diabetologia press release "Study adds to evidence that increasing dietary fibre reduces the risk of developing diabetes" on InterAct paper "Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies"
//
Reported in Express, Daily Mail and Mirror, as well as in the Times of India and about 15 lower profile mainstream national and international online media outlets. Also covered by articles in more than 20 specialist health or science online news outlets.
Year(s) Of Engagement Activity 2015
URL http://www.express.co.uk/life-style/health/580110/high-fibre-vegetable-rich-diet-slashes-risk-diabet...
 
Description Diet after divorce - Wall Street Journal 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Wall Street Journal article "Diet After Divorce: Men vs. Women" http://www.wsj.com/articles/diet-after-divorce-men-vs-women-1464013038 on Soc. Sci. Med. paper "Marital transitions and associated changes in fruit and vegetable intake: Findings from the population-based prospective EPIC-Norfolk cohort, UK." PubMed:27082023
Year(s) Of Engagement Activity 2016
URL http://www.wsj.com/articles/diet-after-divorce-men-vs-women-1464013038
 
Description EASD Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chairing presentations on session "Diabetes Prevention: What has the additional trial added?" 16th September 2016
Year(s) Of Engagement Activity 2016
 
Description EPIC Norfolk Study Public Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Presentation to over 3000 participants in the EPIC-Norfolk Study.

Press coverage.
Year(s) Of Engagement Activity 2006
 
Description East of England Wellbeing Show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact MRC Epidemiology Stand and talk by Nick Wareham at East of England Well Being Show http://www.eastofenglandwell-beingshow.org.uk/ attended by approximately 1,000 members of the public. Our stand included promotional material for studies that are now recruiting, and an activity to see how exercise affects heart rate.

To be determined.
Year(s) Of Engagement Activity 2014
URL http://www.eastofenglandwell-beingshow.org.uk/
 
Description EpiNews 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Media (as a channel to the public)
Results and Impact Report on Cambridge Diabetes Seminar in EpiNews, the magazine of the UCC Department of Epidemiology and public Health.
Year(s) Of Engagement Activity 2015
 
Description Exercise Press Release AJCN 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press Release "Lack of Exercise responsible for twice as many deaths as obesity" on research paper: Ekelund, U et al. Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC) American Journal of Clinical Nutrition; Published Online 14 Jan 2015 http://ajcn.nutrition.org/content/early/2015/01/14/ajcn.114.100065.abstract
//
Global news coverage - 200+ reports in TV, radio, print and online news in more than 30 countries. Reported in 10 UK National Newspapers, including front page in Daily Mail http://www.dailymail.co.uk/health/article-2910206/Lack-exercise-kills-TWICE-people-obesity.html. Nick Wareham interviewed by BBC News at One (TV) and main evening ITV News, and BBC Radio 4 Today programme. Channel 4 also covered the story in main evening News. Ulf Ekelund did several live interviews with UK and Scandanavian media, including live interview on Danish TV2 http://nyhederne.tv2.dk/samfund/2015-01-16-opsigtsvaekkende-forskning-20-minutters-gang-kan-redde-dit-liv and pre-recorded interviews on Norwegian TV (NRK) and shown on their equivalent to 10 o clock news http://www.nrk.no/norge/stillesitting-dobbelt-sa-dodelig-som-fedme-1.12147291 and Swedish National TV (SVT; Oskar Skagerlind) http://www.svt.se/nyheter/sverige/brist-pa-motion-farligare-an-fetma. Covered by NBC News and CBS news in the US, as well as major newspapers.
//
Year(s) Of Engagement Activity 2015
URL http://www.eurekalert.org/pub_releases/2015-01/uoc-loe011315.php
 
Description Fenland 2 BBC Radio Cambridge 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Fenland Team and study volunteers interviewed by reporter from BBC Radio Cambridgeshire.

BBC Radio Cambridgeshire broadcast a report and live interview with NF on the Fenland study on the first day of testing for Fenland Phase 2 in Cambridge. Subsequently BBC Look East asked to film the start of testing for Fenland Phase 2 in Ely.
Year(s) Of Engagement Activity 2014
URL http://www.mrc-epid.cam.ac.uk/phase-2-of-fenland-study-launches/
 
Description Fenland 2: Look East 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact BBC Look East TV interview (SG and SB) re the launch of Fenland Study 2, following up 12000 middle-aged residents of the Fenland area. Reporter also filmed and interviewed members of the study team and a study participant at the testing centre in Ely.

Report broadcast on BBC Look East. In the working days following the broadcast there was a sharp increase in phone inquiries from participants concerning phase 2, and about 20 people sent in the response to their invitation, including several from Ely where the response rate had previously been low.
Year(s) Of Engagement Activity 2014
URL http://www.mrc-epid.cam.ac.uk/phase-2-of-fenland-study-launches/
 
Description Fenland Study Public Meetings - BBC Radio Cambridgeshire 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Nick Wareham interviewed by BBC Radio Cambridgeshire to discuss the Fenland Study, coinciding with the Fenland Study Public Meeting in Cambridge http://www.bbc.co.uk/programmes/p03xmz9n
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/p03xmz9n
 
Description Fenland Study public meetings - Cambridge, Ely, Wisbech 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact Public Meetings for Fenland Study participants in Cambridge, Ely, and Wisbech. The event consisted of a poster display & meet and greet session (30 minutes), followed by a presentation (20 minutes) and panel discussion with audience Q&A (40 minutes). The three meetings were well attended, with about 550 people in total, and there was a very high level of audience engagement, with many excellent questions and good feedback after the event.
Year(s) Of Engagement Activity 2016
 
Description Festival of Ideas 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk on "Don't stop moving. Is the digital world friend or foe in fighting a sedentary future?"
Year(s) Of Engagement Activity 2016
 
Description Fun Lab Cambridge County Council Big Day Out 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact MRC Epidemiology Unit stand inside the University of Cambridge Fun Lab tent at the Cambridge Big Day Out on Parkers Piece in Cambridge. We took our hands-on stand on physical activity and our research.

We saw over 100 visitors during the afternoon and reached a very different audience who may not be likely to engage with a science festival or academic event, including both adults and children.
Year(s) Of Engagement Activity 2013
 
Description Gene Variants Alzheimers press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact "PLoS Medicine Press release on new publication reporting association between gene variants associated with high blood pressure and Alzheimer's disease. Robert Scott spoke with Robin bisson at GeneticExperts.org to help ensure that correct message got across.
//
Covered by 5 online medical news outlets
//
Increase in requests for further information.
//
http://medicalxpress.com/news/2015-06-genetically-higher-bp-linked-antihypertensive.html"
Year(s) Of Engagement Activity 2015
URL http://medicalxpress.com/news/2015-06-genetically-higher-bp-linked-antihypertensive.html
 
Description Genetic Approach to drug development - Press Release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact University of Cambridge Press Release "Genetic approach could help identify side-effects at early stages of drug development" https://www.cam.ac.uk/research/news/genetic-approach-could-help-identify-side-effects-at-early-stages-of-drug-development on Science Translational Medicine paper "A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease" Pubmed:27252175. Also posted on Unit News blog http://www.mrc-epid.cam.ac.uk/blog/genetic-approach-drug-development/. RS invited to speak with Kendall K. Morgan to prepare an article for the NIH Director's blog, published on 14/06/2016 https://directorsblog.nih.gov/2016/06/14/precision-medicine-using-genomic-data-to-predict-drug-side-effects-and-benefits/ Also reported in 7 specialist online news outlets, including Medical News Today, Drug Discovery & Development, and Science Daily.
Year(s) Of Engagement Activity 2016
URL http://www.mrc-epid.cam.ac.uk/blog/genetic-approach-drug-development/
 
Description Genetic and lifestyle role in obesity (Telegraph) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Feature in the Telegraph newspaper on the role of genetics and lifestyle factors in obesity.

Dissemination to a wide readership.
Year(s) Of Engagement Activity 2013
 
Description Global Challenges Research Fund reviewing 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Global Challenges Research Fund reviewing
Year(s) Of Engagement Activity 2016
 
Description Great Snackington - Cambridge Market Square (Exhibition) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact For this activity Dr Tarra Penney worked with local artist Aurora Cacciapuoti to develop artwork for the "Great Snackington" game leaflet and webpage, which illustrates in a fun way the influence our local environment has on our food choices. The activity is aimed primarily at children and their parents. £2,000 applied for and received from Medical Research Council to cover costs of preparing and purchasing the licence to the artwork for three years, and for printing the game leaflets, posters for our stand, promotional leaflets for the MRC Festival of Medical Research, and T-shirts for Unit members taking part in the activity. MRC Festival stall in Market Squarre Cambridge "Great Snackington: Why we eat what we eat" developed by Tarra Penney and Aurora Cacciapuoti. About 350 copies of the "Great Snackington game were handed out, and about 50 copies of the MRC Cambridge colouring book. Spoke with more than 50 people, including Cambridge MP Daniel Zeichner, Cambridge Green Party leader Stuart Tuckwood, and several school teachers who expressed an interest in the game.
Year(s) Of Engagement Activity 2017
URL http://www.mrc-epid.cam.ac.uk/snackington/
 
Description Hertfordshire Study Public Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Presentation of results to the participants in the Hertfordshire Physical Activity Trial.

Press coverage.
Year(s) Of Engagement Activity 2008
 
Description Hills Road Career Day, 2013 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Three members of the MRC Epidemiology unit;attended the annual Hills Road 6th Form 'HillsFest 2013'. The day enables lower sixth students to try different activities and gain an insight into potential career paths through a variety of visiting companies and organisations. 11 students attended the session which involved both a theoretical and practical element, allowing students to get involved in live demonstrations of heart rate monitors and learn about movement monitors and tri-axial accelerometers.

Good attendance and a request to repeat the activity again. Good student feedback and follow up interest in work experience.
Year(s) Of Engagement Activity 2013
 
Description Hills Road Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Two members of the MRC Epidemiology Unit attended the annual Hills Road 6th Form 'HillsFest 2016'. The day enables lower sixth students to try different activities and gain an insight into potential career paths through a variety of visiting companies and organisations. Unit staff gave short presentation on physical activity measurement, and students also participated in a step test activity to determine cardiovascular fitness, and in a discussion to gather suggestions for physical activity promotion in schoolchildren for the GoActive study. 29 students attended the Unit event, and feedback was very positive.
Year(s) Of Engagement Activity 2016
 
Description Hills Road Sixth Form College 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Talks on science of diabetes aetiology and prevention to local sixth form college.

None.
Year(s) Of Engagement Activity 2007,2008
 
Description Innovations International Article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Collaboration with Innovations International on preparation of summary of European InterAct project on gene-lifestyle interactions on diabetes risk.

Production of an accessible summary of the science for a policy audience.
Year(s) Of Engagement Activity 2011
 
Description InterAct 'Sugar sweetened drinks and diabetes' media coverage 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release on ' Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct'. Diabetologia. 2013 Jul;56(7):1520-30. doi: 10.1007/s00125-013-2899-8. Epub 2013 Apr 26.
PMID: 23620057


49 news stories internationally (source Google news). Including follow-up interview requests in print and TV, including a feature on the BBC1 'The One Show', which reaches a wide and diverse audience with peak viewing around 6 million.
Year(s) Of Engagement Activity 2013
 
Description Invited talk at Hills Road Sixth Form College Medical Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Talk to 65 students at Hills Road sixth form college.

Several students requested work experience placements in the Unit.
Year(s) Of Engagement Activity 2009
 
Description LSHTM (London School of Hygiene and Tropical Medicine) lecture on PA and NCDs 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Nick gave a lecture on PA and NCDs to students at the University
Year(s) Of Engagement Activity 2014,2016
 
Description LSHTM lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact Lecture at London School of Hygiene and Tropical Medicine on physical activity and chronic disease.

Recruitment of one course participant subsquently to Unit PhD programme.
Year(s) Of Engagement Activity 2009
 
Description London Youth Science Forum 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 10 Students visited the Unit as part of London International Youth Science Forum activities. Luca Lotta gave an ovreview of the Unit's research programmes, and an introduction to his own recent research on the discovery of biomarkers and causal mechanisms for the metabolic consequences of obesity. They were then taken on a tour of Unit facilities, which included demonstrations of body composition and physical activity assessment. They were also provided withprinted information on the Unit, it's organization and research activities.

To be determined.
Year(s) Of Engagement Activity 2014
URL http://www.liysf.org.uk/
 
Description MIMS Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Lecture on Nutrition and Preventive Medicine
Year(s) Of Engagement Activity 2016
 
Description Maastricht public health student visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Maastricht public health student visit. In total 70 undergraduate students visited the unit to find out about our public health research and tour the facilties as part of a two day trip to London and Cambridge.

We received excellent feedback from the students and tutors who organised the study tour. The students found trip interesting and enjoyable and the tutors felt it fitted well with the aims of the trip and was an excellent balance of theory and practical aspects. We have been asked to repeat the visit.
Year(s) Of Engagement Activity 2013
 
Description Managing obesity takes more than individual willpower - Media Interview, The Menara Star, Malaysia 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interviewed by Wolfson Press Fellow for article "Managing obesity takes more than individual willpower" see http://www.star2.com/living/viewpoints/2016/02/07/managing-obesity-takes-more-than-individual-willpower/
Year(s) Of Engagement Activity 2016
URL http://www.star2.com/living/viewpoints/2016/02/07/managing-obesity-takes-more-than-individual-willpo...
 
Description NICE annual conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presentation of NICE Guidance on Prevention of Diabetes at NICE conference.

Coverage of guidance in National Press was positive.
Year(s) Of Engagement Activity 2011
 
Description NIHR Steering Group for NIHR Themed Review on Type 2 Diabetes 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact "To produce a themed review of NIHR and other relevant published research on Type 2 diabetes that is relevant to commissioners, clinicians, service managers and patients by July 2016.

To prepare a scoping review, showcasing recent NIHR and other relevant research, for those planning and delivering diabetes prevention and care services. This will focus on what we know already, emerging research findings from current studies and planned research. This would be a 12-15 page document, with quotes from a range of stakeholders in an engaging style."
Year(s) Of Engagement Activity 2016
 
Description NW comments in The Times 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Nick Wareham interviewed for comments by The Times for a piece on the EU Data Protection and impact on research data. 29/01/14


TBD
Year(s) Of Engagement Activity 2014
URL http://www.thetimes.co.uk/tto/science/article3988732.ece
 
Description Neighbourhood takeaways and social inequalities - AJCN 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact University of Cambridge Press Release "Neighborhoods with more takeaways amplify social inequalities in unhealthy eating and obesity" on AJCN paper PubMed:27169835. Also Conversation article "Local takeaways create a double burden for obesity". BBC Radio Cambridgeshire interview - Breakfast Show - TB - http://www.bbc.co.uk/programmes/p03s87g8 (Starts 1:20:00). Online article in Daily Express http://www.express.co.uk/life-style/health/669230/living-near-takeaway-obese-or-overweight, Medical Xpress, Western Daily Press, Medical News Today and 2 blogs.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/p03s87g8
 
Description Newsweek Jan 2015 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nick Wareham Newsweek interview for article Prepare for the Pill to Make You Thin

Quoted in Newsweek cover story Prepare for the Pill to Make You Thin. Provided useful information on importance of public health measures to balance biomedical focus of the article.
Year(s) Of Engagement Activity 2015
URL http://www.newsweek.com/2015/01/30/prepare-pill-make-you-thin-301250.html
 
Description Novo-sponsored Diabesity Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Talk on "Progress in identifying gene-environment interactions underlying type 2 diabetes risk"
Year(s) Of Engagement Activity 2016
 
Description PLOS Medicine Special Issue - Diabetes - Blog post 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact MRC Epidemiology Unit blog post 'MRC Epidemiology Unit heads up PLOS diabetes special issue' http://www.mrc-epid.cam.ac.uk/blog/plos-diabetes-special-issue/ on PLOS Medicine special issue edited by Prof Nick Wareham and Professor William Herman. Subsequently covered by the University of Cambridge School of Clinical Medicine Newsletter. Associated with PubMed:27458730, 27433799, 27434045, 27434027, 27403943, 27404268
Year(s) Of Engagement Activity 2016
 
Description PLOS Medicine Special Issue - Reddit AMA 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Participated in a Reddit Ask Me Anything online forum https://www.reddit.com/r/science/comments/4uu8p2/plos_science_wednesday_hi_reddit_were_nick_jenna/ discussing PLOS Medicine special issue on diabetes prevention. The session was busy, with plenty of questions and comments.
Year(s) Of Engagement Activity 2016
URL https://www.reddit.com/r/science/comments/4uu8p2/plos_science_wednesday_hi_reddit_were_nick_jenna/
 
Description PLOS Medicine press release - Special Issue - Diabetes 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact PLOS Medicine press release 'Different types of PUFAs are associated with differential risks for type 2 diabetes' codrafted with Unit http://www.eurekalert.org/pub_releases/2016-07/p-dto071416.php, on paper PubMed:27434045. Several experts commented favourably on the article via the Science Media Centre http://www.sciencemediacentre.org/expert-reaction-to-study-looking-at-different-types-of-polyunsaturated-fatty-acid-and-type-2-diabetes-risk/. The press release was shared on several specialist news outlets such as Medical News Today http://www.medicalnewstoday.com/releases/311791.php, and as a result FI was invited to do an interview for Medical Research.com http://medicalresearch.com/author-interviews/study-evaluates-effects-of-polyunsaturated-fats-on-development-of-diabetes/26247/
Year(s) Of Engagement Activity 2016
URL http://www.sciencemediacentre.org/expert-reaction-to-study-looking-at-different-types-of-polyunsatur...
 
Description PLoS Medicine - high blood pressure and Alzheimer's disease 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact PLoS Medicine Press release on new publication reporting association between gene variants associated with high blood pressure and Alzheimer's disease. Robert Scott spoke with Robin bisson at GeneticExperts.org to help ensure that correct message got across.
//
Covered by 5 online medical news outlets
Year(s) Of Engagement Activity 2015
URL http://medicalxpress.com/news/2015-06-genetically-higher-bp-linked-antihypertensive.html
 
Description Papworth Patient Association 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Talk attended by 100+ members of the public.

Feedback of results from local studies involving residents of Papworth.
Year(s) Of Engagement Activity 2009
 
Description Podcast 'Lifestyle & Metabolic Risk' MyHealthyWaist.org 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Podcast 'Lifestyle and cardiometabolic risk: an update.' By The International Chair on Cardiometabolic Risk. My Healthy Waist


Easily accessible available resource for health professionals.
Year(s) Of Engagement Activity 2013
URL http://www.myhealthywaist.org/documentation-centre/index.html?no_cache=1&tx_stdoccenter_pi1%5bmod_ty...
 
Description Population Health Working Group Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Population Health Working Group Meeting:
Professional practitioners including healthcare professionals
Year(s) Of Engagement Activity 2016
 
Description Press Release - JAMA - LDL lowering and Diabetes 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact JAMA Press release "Certain LDL-C-Lowering Genetic Variants Associated with Higher Risk of Type 2 Diabetes" for paper "Association between Low-Density Lipoprotein Cholesterol Lowering Genetic Variants and Risk of Type 2 Diabetes" PubMed:27701660. Unit news blog post http://www.mrc-epid.cam.ac.uk/blog/new-genetic-analysis-provides-insight-side-effects-cholesterol-lowering-drugs/. Three reports in specialist online health & science news resources. http://www.medicalnewstoday.com/articles/313272.php, https://www.genomeweb.com/genetic-research/type-2-diabetes-risk-linked-genetic-variants-associated-low-ldl-cholesterol, http://www.newswise.com/articles/certain-ldl-c-lowering-genetic-variants-associated-with-higher-risk-of-type-2-diabetes. Featured in University of Cambridge School of Clinical Medicine newsletter on 14/10/2016.
Year(s) Of Engagement Activity 2016
URL http://www.mrc-epid.cam.ac.uk/blog/new-genetic-analysis-provides-insight-side-effects-cholesterol-lo...
 
Description Press coverage following paper on TV viewing and mortality 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Our paper on TV viewing and mortality was announced in a press release and generated considerable coverage in printed and broadcast media. I did several radio interviews, a TV interview for regional news and participated in a live radio discussion programme.

Dissemination of Unit research findings and opportunity to thank research participants for their contributions.
Year(s) Of Engagement Activity 2010
 
Description Press coverage following small changes paper 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact In 2008 we published a paper on the potential impact of small achievable changes on longeveity. This was covered by multiple printed media outlets, TV and radio.

Coverage in all forms of media nationally and internationally.
Year(s) Of Engagement Activity 2008
 
Description Press coverage related to Abdominal Obesity conference 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Undertook interviews for press which were then disseminated via International Chair of Cardiometabolic Disease website aimed at public and health care professionals.

The myhealthywaist website on which this series on interviews is placed (see http://www.myhealthywaist.org/welcome/index.html ) is an accessible repository of scientific insights into the challenge of abdominal obesity.
Year(s) Of Engagement Activity 2011
 
Description Press coverage related to EASD 2011 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Presented results of studies of gene-lifestyle interaction on risk of type 2 diabetes at EASD and at press conference related to this meeting.

Press conference generated interest in the implications of interactions for public health.
Year(s) Of Engagement Activity 2011
 
Description Press interview at EASD 2012 conference. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press interview following a post an invited speaker at the European Association for Study of Obesity, Berlin. 2012.

Increased awareness.
Year(s) Of Engagement Activity 2012
 
Description Press release - Branched-chain amino acids - MRC 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact MRC Press release "Genetic differences in amino acid metabolism are linked to a higher risk of diabetes" on PLoS Medicine paper "Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis", sent to specialist medical and pharma sector news outlets and reporters. Reported by Medialxpress, DrugTargetReview and MedIndia. Also reported in University of Cambridge School of Clinical Medicine newsletter on 21 December 2016.
Year(s) Of Engagement Activity 2016
 
Description Press release - adipose storage - University of Cambridge 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact University of Cambridge press release "Inability to safely store fat increases risk of diabetes and heart disease" on Nature Genetics paper "Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance" PubMed:27841877. LL had phone interviews with journalists from BBC Radio 4 and BBC News online, and with Cambridge TV. Reported by BBC News online http://www.bbc.co.uk/news/health-37973303 and on the BBC Radio 4 Six O'Clock News http://www.bbc.co.uk/programmes/b082962f (segment starts at 21:58) and iPlayer/red button, and by NHS Choices http://www.nhs.uk/news/2016/11November/Pages/Fat-storage-problems-may-increase-diabetes-risk.aspx. Luca Lotta was interviewed by Cambridge TV http://www.cambridge-tv.co.uk/15-11-2016-evening-news/ (Interview starts at 4:50) and the paper was reported by Cambridge News and the Cambridge Network. Altmetric score on 123 on 16/11 reflected a substantial engagement on twitter. The paper was also covered in reports on at least 24 online news outlets, mostly medical and scientific but including some international outlets. Also featured in University of Cambridge School of Clinical Medicine newsletter on 25/11/2016 and Wolfson College newsletter.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/news/health-37973303
 
Description Press release EPIC Norfolk 4th Health Check 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Press release on EPIC Health Check 4. BBC Radio Norfolk interview.

Follow-up up coverage in the Eastern Daily Press and Evening News covering Norfolk. This helped increase awareness of the 4th health check for previous volunteers to boost recruitment and contact those who had moved.
Year(s) Of Engagement Activity 2013
 
Description Press release InterAct study on regional obesity 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release and media coverage for a paper from the InterAct study on regional and overall obesity PMID:22679397. A total of 70 stories noted internationally (source Google News).

Increased awareness.
Year(s) Of Engagement Activity 2012
 
Description Press releases on Plos Medicine paper (NW, CL) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact University of Cambridge press release Journal and Cambridge University press releases on Plos Medicine paper "Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study".

Article in the Telegraph (Calcutta), newspaper with daily circulation of 500,000 http://www.telegraphindia.com/1140522/jsp/nation/story_18368862.jsp#.U4RTOygkS4U, and several online health/scientific outlets (21/05/14) including http://www.eurekalert.org/pub_releases/2014-05/p-lia051314.php
Year(s) Of Engagement Activity 2014
URL http://www.mrc-epid.cam.ac.uk/universal-approach-to-tackling-unhealthy-lifestyles-more-appropriate-f...
 
Description Public Meetings - 20 years of the EPIC Nofolk Study (2013) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Over 500 people attended a single day of lectures and displays on the EPIC Norfolk Study, which is currently doing the 4th health check following 20 years of follow-up time.

Extremely popular meeting, very well supported and generated lot of positive feedback and further requests for information. Including generating additional regional media coverage and boosting follow-up retention of volunteers.
Year(s) Of Engagement Activity 2013
 
Description Public Meetings for the Fenland Study 2013 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact We held two regional public meetings for Fenland Study volunteers in Cambridge and Ely. In total over 400 people attended over the two public meetings.

Received excellent written feedback, both with completed feedback forms and unsolicited emails. Several follow up requests for further information.
Year(s) Of Engagement Activity 2013
 
Description Quebec-UK Cardiometabolic Diseases Symposium, March 2013 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Convener of the Quebec-UK Cardiometabolic Diseases Symposium, March 2013, Cambridge, UK.
"Towards clinical and public health solutions to the epidemic of cardiometabolic diseases."

This meeting discussed research aimed at both types of solution, focusing on the assessment and management of metabolically unhealthy obesity and secondly on the growing research basis for public health solutions.
Year(s) Of Engagement Activity 2013
URL http://www.cedar.iph.cam.ac.uk/blog/quebec-uk/
 
Description Radio 5 Live 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Nick Wareham interviewed on Radio 5 Live, where he discussed the importance of infrastructure in encouraging physical activity, following poblication of a new study from Norway which showed PA is correlated with longevity.
Year(s) Of Engagement Activity 2015
URL http://www.bbc.co.uk/programmes/b05tk7k3
 
Description Radio interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Discussion on live radio show concerning rising prevalence of type 2 diabetes.

None
Year(s) Of Engagement Activity 2011
 
Description Research Horizons no 28 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Media (as a channel to the public)
Results and Impact Interviewed for article in Research Horizons - the University of Cambridge research magazine - on the mobile phone messaging service being developed by Professor Ambady Ramachandran, Director at the Diabetes Research Centre in Chennai, India, with support from the Unit

Article published in issue 28 of Research Hiorizons - entitled "Phone for a Doctor" " which examines how mobile technologies may be able to help manage diabetes in India.
Year(s) Of Engagement Activity 2015
URL http://www.cam.ac.uk/system/files/issue_28_research_horizons.pdf
 
Description Reuters - Protein - InterAct (NW) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Reuters report on paper "Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-INTERACT Case-Cohort Study."

Republished online by Fox News and The Chicago Tribune.
Year(s) Of Engagement Activity 2014
URL http://www.reuters.com/article/2014/04/14/us-animal-protein-diabetes-idUSBREA3D1HV20140414
 
Description South Korea Boda media group 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact 2014 paper by Conklin AI, Forouhi NG, Suhrcke M, Surtees P, Wareham NJ, Monsivais P (PMID 14195083) resulted in interview request .

Participation in documentary film produced by South Korea Boda media group for broadcast in South Korea
Year(s) Of Engagement Activity 2015
 
Description Speech at House of Commons evening reception (Noncommunicable diseases) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Invited speaker at the House of Commons evening reception on Non communicable diseases.

Improved awareness.
Year(s) Of Engagement Activity 2012
 
Description Symposium with AstraZeneca 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Presenter - Symposium with AstraZeneca
Year(s) Of Engagement Activity 2016
URL http://www.metabolism.cam.ac.uk/pushing-boundaries-science-metabolism/
 
Description Symposium with AstraZeneca 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Symposium with AstraZeneca - metabolic disease, Murray Edwards College
Year(s) Of Engagement Activity 2015
URL http://www.metabolism.cam.ac.uk/pushing-boundaries-science-metabolism/
 
Description The Food Chain -The Truth About Diabetes 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Two dietary saturated fat research papers referred to in BBC World Service programme The Food Chain episode The Truth About Diabetes
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/p03gyqb0
 
Description UK Biobank Annual International Scientific Advisory Board Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact UK Biobank Annual International Scientific Advisory Board Meeting - talk
Year(s) Of Engagement Activity 2015
 
Description UoM + CAM press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact University of Michigan and University of Cambridge Press Releases "Early detection and treatment of type 2 diabetes may reduce heart disease and mortality"on William H. Herman et al. Early detection and treatment of type 2 diabetes reduces cardiovascular morbidity and mortality: A simulation of the results of the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION-Europe). Diabetes Care (2015)

Will Herman interviwed by Michigan Radio (NPR). Report in Cambridge news and 4 medical news outlets.
Year(s) Of Engagement Activity 2015
URL http://www.cambridge-news.co.uk/Early-diabetes-detection-study-welcomed-charity/story-26573844-detai...
 
Description UofM Health Press Release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact University of Michigan Press Release on papers "Largest ever genome-wide study strengthens genetic link to obesity " & "Genetic studies of body mass index yield new insights for obesity biology"
//
50+ reports in National and International print and online media
//
http://www.theguardian.com/society/2015/feb/11/obesity-genes-help-determine-size-and-shape-studies-find"
Year(s) Of Engagement Activity 2015
URL http://www.uofmhealth.org/news/archive/201502/largest-ever-genome-wide-study-strengthens-genetic-lin...
 
Description Vitamin D Genetic Study 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Lancet Press Release "Genetic study casts further doubt that vitamin D prevents the development of type 2 diabetes" on paper Ye Z. et al "The association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a Mendelian randomisation study"Lancet Diabetes & Endocrinology. NF also provided Q&A to Medscape and MedicalResearch.com. Featured on MRC News blog.

Commentary in Lancet Diabetes & Endocrinology. About 30 reports in online international news media, mostly online health and science outlets, including Medscape, Forbes, Science Codex, MedicalXpress and Medical News Today. http://medicalxpress.com/news/2014-10-genetic-vitamin-d-diabetes.html Also features on MRC News blog.
Year(s) Of Engagement Activity 2014
URL http://www.mrc.ac.uk/news-events/news/study-casts-further-doubt-vitamin-d-prevents-type-2-diabetes/
 
Description Vitamin D deficiency (NW) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact University of Cambridge Press Release "One in ten people over forty years old in Britain is vitamin D deficient", on paper Kay-Tee Khaw, Robert Luben, and Nicholas Wareham "Serum 25-hydroxyvitamin D, mortality, and incident cardiovascular disease, respiratory disease, cancers, and fractures: a 13-y prospective population study" AJCN, Published online September 17, 2014, doi: 10.3945/ajcn.114.086413

Reported in Daily Mail and Sunday World. Also reported in 6 articles in online health and science media, for example http://www.dailymail.co.uk/health/article-2770245/Vitamin-D-danger-indoor-lives-Lack-sunlight-increases-risk-heart-disease-cancer.html#ixzz3EQuGRR5I and http://medicalxpress.com/news/2014-09-ten-people-forty-years-britain.html
Year(s) Of Engagement Activity 2014
URL http://www.cam.ac.uk/research/news/one-in-ten-people-over-forty-years-old-in-britain-are-vitamin-d-d...
 
Description WHO/IDF Cambridge Seminar 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The Cambridge Diabetes Seminar provides a unique opportunity for participants from a range of backgrounds including clinical, research and public health, to engage in discussion, debate and collaboration on prominent issues in diabetes epidemiology. It aims to provide all those attending with a common goal to become better equipped in the epidemiological and public health aspects of diabetes and helps to foster international networks.
Year(s) Of Engagement Activity 2015
URL http://www.mrc-epid.cam.ac.uk/cds2015/