Structural studies of proteins involved in neurodegenerative and muscular diseases
Lead Research Organisation:
MRC National Inst for Medical Research
Abstract
The accomplishment of the human genome together with the fast progresses made in gene mapping technology have opened for the first time the possibility of approaching hereditary disorders at a molecular level. We approach the study of human diseases by understanding their structure/function relationship. The role of the molecular structure in modern biology and medicine may be directly appreciated if we consider that structure determination of the DNA, the molecule which contains the whole genetic information, unveiled the secret of life. Our laboratory focuses on determining the 3D structure of proteins with specific interest for proteins involved in neurodegenerative diseases such as the Huntington Chorea, Friedreich ataxia, and Fragile X syndrome and muscular pathologies such as different types of cardio-myopathies. Despite the different symptoms, these diseases, all incurable, share the fact that in affected patients, the proteins encoded by the corresponding genes are produced in altered forms, or in smaller quantity down to their complete absence. By determining the shape of the proteins involved we can then understand the role of these mutations on the protein functions and ultimately design new therapeutical strategies. We use a combination of biochemical and biophysical techniques which help us to reconstruct the cellular role of the proteins of interest and characterise their structure/function relationship
Technical Summary
We focus on neurodegeneration and muscular pathologies.||A molecular approach to human genetic diseases More than 12 human genetic diseases have been associated with expansions of nucleotide repeats in their corresponding genes, all identified in the last 10 years. These diseases, currently incurable, are interesting both for their impact in the human population and for the unusual pattern of genetic behaviour. They are grouped into two sub-families according to whether the expansion occurs in coding or non-coding regions. In our group we have started an integrated approach which makes use of different biochemical and biophysical techniques to study the structure and function of the proteins encoded by several genes of the trinucleotide expansion family. Amongst them are FMRP, the protein responsible for fragile x and frataxin, the protein involved for Friedreichs ataxia. We want to understand the cellular role of these proteins and describe the mechanism of molecular recognition with their binding partners. We have also recently setup a systems biology project which aims at understanding the process of iron-sulfur cluster formation, in which frataxin is involved.||How muscles are assembled and regulated Understanding the molecular bases of muscle contraction has been one of the main research topics in biology for the last decades. Besides actin and myosin, which are the main players in muscle contraction, many other proteins have an essential role in determining muscle assembly and regulation. Several interactions have been described recently which are essential to anchor the muscle filaments to the modular proteins, such as titin, nebulin, and alpha-actinin. Dysfunctions in the interactions cause different types of cardio-myopathies and other muscle diseases. We are currently working to determine the structure of a number of protein complexes. This information will eventually allow us to reconstruct the muscle ultrastructure.
Organisations
- MRC National Inst for Medical Research, United Kingdom (Lead Research Organisation)
- University of the Balearic Islands (Collaboration)
- French National Institute of Agricultural Research (Collaboration)
- Italian Institute of Technology (Istituto Italiano di Tecnologia IIT) (Collaboration)
- University of Naples (Collaboration)
- University of York, United Kingdom (Collaboration)
- Free University of Brussels (ULB), Belgium (Collaboration)
- PA Consulting Group (Collaboration)
People |
ORCID iD |
| Annalisa Pastore (Principal Investigator) |
Publications
Politou AS
(2022)
An "Onion-like" Model of Protein Unfolding: Collective versus Site Specific Approaches.
in Chemphyschem : a European journal of chemical physics and physical chemistry
Aprile FA
(2021)
Man does not live by intrinsically unstructured proteins alone: The role of structured regions in aggregation.
in BioEssays : news and reviews in molecular, cellular and developmental biology
Monti M
(2021)
Aggregation is a Context-Dependent Constraint on Protein Evolution.
in Frontiers in molecular biosciences
Puglisi R
(2021)
The anatomy of unfolding of Yfh1 is revealed by site-specific fold stability analysis measured by 2D NMR spectroscopy.
in Communications chemistry
Vannocci T
(2021)
Label-Free, Real-Time Measurement of Metabolism of Adherent and Suspended Single Cells by In-Cell Fourier Transform Infrared Microspectroscopy.
in International journal of molecular sciences
Lyu C
(2021)
The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau.
in Frontiers in molecular biosciences
Temussi PA
(2021)
The seesaw between normal function and protein aggregation: How functional interactions may increase protein solubility.
in BioEssays : news and reviews in molecular, cellular and developmental biology
Millana Fañanás E
(2020)
On the mechanism of calcium-dependent activation of NADPH oxidase 5 (NOX5).
in The FEBS journal
Yan R
(2019)
The Structure of the Pro-domain of Mouse proNGF in Contact with the NGF Domain.
in Structure (London, England : 1993)
Pastore A
(2019)
Generalized View of Protein Folding: In Medio Stat Virtus.
in Journal of the American Chemical Society
Rasheed M
(2019)
Structural and functional characterization of a frataxin from a thermophilic organism
in The FEBS Journal
Yalinca H
(2019)
The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus.
in Frontiers in molecular biosciences
Santonocito R
(2019)
Recombinant mussel protein Pvfp-5ß: A potential tissue bioadhesive.
in The Journal of biological chemistry
Sicorello A
(2018)
The Structural Properties in Solution of the Intrinsically Mixed Folded Protein Ataxin-3
in Biophysical Journal
Willemse D
(2018)
Rv1460, a SufR homologue, is a repressor of the suf operon in Mycobacterium tuberculosis.
in PloS one
Lupoli F
(2018)
The role of oxidative stress in Friedreich's ataxia.
in FEBS letters
Ramaswamy S
(2018)
The structure of PghL hydrolase bound to its substrate poly-?-glutamate.
in The FEBS journal
Emendato A
(2018)
Glycation affects fibril formation of Aß peptides.
in The Journal of biological chemistry
Vannocci T
(2018)
Adding a temporal dimension to the study of Friedreich's ataxia: the effect of frataxin overexpression in a human cell model.
in Disease models & mechanisms
Zacco E
(2018)
The RNA-Recognition Motifs of TAR DNA-Binding Protein 43 May Play a Role in the Aberrant Self-Assembly of the Protein.
in Frontiers in molecular neuroscience
Puglisi R
(2018)
The role of chaperones in iron-sulfur cluster biogenesis
in FEBS Letters
Prischi F
(2017)
Hybrid Methods in Iron-Sulfur Cluster Biogenesis.
in Frontiers in molecular biosciences
Adinolfi S
(2017)
The Molecular Bases of the Dual Regulation of Bacterial Iron Sulfur Cluster Biogenesis by CyaY and IscX.
in Frontiers in molecular biosciences
Vannocci T
(2017)
The time dimension of neurodegeneration: the example of Friedreich's ataxia.
in Journal of neurology & neuromedicine
Pastore A
(2017)
The Emperor's new clothes: Myths and truths of in-cell NMR
in Archives of Biochemistry and Biophysics
Alfano C
(2017)
An optimized strategy to measure protein stability highlights differences between cold and hot unfolded states.
in Nature communications
Chiki A
(2017)
Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.
in Angewandte Chemie (International ed. in English)
Paoletti F
(2016)
Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor.
in Frontiers in molecular biosciences
Faggiano S
(2016)
The missing links to link ubiquitin: Methods for the enzymatic production of polyubiquitin chains.
in Analytical biochemistry
Corvino A
(2016)
Fragment-based de novo design of a cystathionine ?-lyase selective inhibitor blocking hydrogen sulfide production.
in Scientific reports
Ruggeri FS
(2015)
Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation.
in Nature communications
Faggiano S
(2015)
Allosteric regulation of deubiquitylase activity through ubiquitination.
in Frontiers in molecular biosciences
Popovic M
(2015)
Selective observation of the disordered import signal of a globular protein by in-cell NMR: the example of frataxins.
in Protein science : a publication of the Protein Society
Faggianelli N
(2015)
Analyzing the Effects of a G137V Mutation in the FXN Gene.
in Frontiers in molecular neuroscience
Vannocci T
(2015)
A new cellular model to follow Friedreich's ataxia development in a time-resolved way.
in Disease models & mechanisms
Sanfelice D
(2015)
Cold Denaturation Unveiled: Molecular Mechanism of the Asymmetric Unfolding of Yeast Frataxin.
in Chemphyschem : a European journal of chemical physics and physical chemistry
Adrover M
(2015)
Anatomy of an iron-sulfur cluster scaffold protein: Understanding the determinants of [2Fe-2S] cluster stability on IscU.
in Biochimica et biophysica acta
Yan R
(2015)
Ferredoxin, in conjunction with NADPH and ferredoxin-NADP reductase, transfers electrons to the IscS/IscU complex to promote iron-sulfur cluster assembly.
in Biochimica et biophysica acta
Pastore A
(2015)
Editorial overview: Folding and binding: Old concepts, new ideas, novel insights.
in Current opinion in structural biology
Menon RP
(2014)
Mapping the self-association domains of ataxin-1: identification of novel non overlapping motifs.
in PeerJ
Faggiano S
(2014)
The challenge of producing ubiquitinated proteins for structural studies.
in Cells
Vilanova B
(2014)
Trapping a salt-dependent unfolding intermediate of the marginally stable protein Yfh1.
in Frontiers in molecular biosciences
Yan R
(2014)
The scaffold protein IscU retains a structured conformation in the Fe-S cluster assembly complex.
in Chembiochem : a European journal of chemical biology
De Rocco D
(2014)
Mutations of cytochrome c identified in patients with thrombocytopenia THC4 affect both apoptosis and cellular bioenergetics.
in Biochimica et biophysica acta
De Chiara C
(2014)
Chemical shift assignment of the ataxin-1 AXH domain in complex with a CIC ligand peptide.
in Biomolecular NMR assignments
Sanfelice D
(2014)
Characterization of the conformational fluctuations in the Josephin domain of ataxin-3.
in Biophysical journal
Gershenson A
(2014)
Energy landscapes of functional proteins are inherently risky.
in Nature chemical biology
Iannuzzi C
(2014)
The role of zinc in the stability of the marginally stable IscU scaffold protein.
in Protein science : a publication of the Protein Society
Pastore A
(2014)
Chronochemistry in neurodegeneration.
in Frontiers in molecular neuroscience
| Description | Co-chairperson in the annual grant evaluation for the Portuguese Science Ministry |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | We advised the government on the distribution of National grants |
| Description | Consultant for the evaluation of National Grants in Italy (MURST, MIUR, PRIN), Belgium, France (Pasteur Institute, BLANC), UK (Wellcome, MRC, BBSRC), Swiss National Science Foundation, Portugal and Spain |
| Geographic Reach | Asia |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | I refereed National Grants |
| Description | Member of an International panel for the assessment of Italian Scientists organized by the Italian Ministry |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | We advised the Government on the distribution of National Grants |
| Description | Panel member in a quinquennial evaluation of the Forth (Eraklion) and Fleming Institutes (Athens) |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | We advised the Greek government on these Institutions. |
| Description | Panel member of a DFG assessment to decide on applications for high field (1.2 GHz) spectrometers in Germany |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | We advised the Government on the purchase of 1.2GHz NMR spectrometers in Munich, Frankfurt and Gottingen |
| Description | Panel member of the Roadmap Working Group of Experts for Biological and Medical Sciences (EU grants) |
| Geographic Reach | Asia |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | We advised EU on the creation of new Infrastructures |
| Description | Panel member of the Scientific Advisory Board of Biotechnology Institute in Helsinki, Finland |
| Geographic Reach | Asia |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Ataxia (UCL) |
| Amount | £36,000 (GBP) |
| Organisation | Ataxia UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2009 |
| End | 01/2012 |
| Description | BC-British-Italian Partnership Programme-2006 |
| Amount | £1,040 (GBP) |
| Organisation | British Council |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | BC-Travel Grant |
| Amount | £1,000 (GBP) |
| Organisation | British Council |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2006 |
| End | 12/2007 |
| Description | BC-Travel Grant-2006 |
| Amount | £500 (GBP) |
| Organisation | British Council |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2006 |
| End | 12/2008 |
| Description | EFACTS 2010-2014 |
| Amount | £350,000 (GBP) |
| Funding ID | 242193 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 05/2010 |
| End | 05/2014 |
| Description | FARA (Frataxin Research) |
| Amount | £28,291 (GBP) |
| Organisation | Ataxia UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2006 |
| End | 12/2008 |
| Description | Fellowship |
| Amount | £18,000 (GBP) |
| Organisation | Kids company |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 08/2015 |
| Description | Grant |
| Amount | $35,000 (USD) |
| Organisation | National Ataxia Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 03/2015 |
| End | 08/2015 |
| Description | Grant |
| Amount | £245,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2015 |
| End | 08/2018 |
| Description | MRC Research Grant |
| Amount | £1,074,682 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Department | MRC National Institute for Medical Research (NIMR) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2011 |
| End | 04/2017 |
| Description | Motor Neuro Disorder Association |
| Amount | £221,595 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2015 |
| End | 08/2018 |
| Description | Newton Fellowship |
| Amount | £96,000 (GBP) |
| Organisation | The Royal Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2015 |
| End | 10/2017 |
| Description | Novexin-Research Grant2006 |
| Amount | £500 (GBP) |
| Organisation | Expedeon Protein Solutions (formerly Novexin Ltd) |
| Sector | Private |
| Country | United Kingdom |
| Start | 01/2006 |
| End | 12/2007 |
| Description | Paincage |
| Amount | € 400,000 (EUR) |
| Funding ID | 603191 |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 03/2014 |
| End | 03/2017 |
| Description | RS-International Joint Project |
| Amount | £12,000 (GBP) |
| Organisation | The Royal Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2006 |
| End | 12/2007 |
| Description | Studies of the effects of glycation on amylin aggregation |
| Amount | £15,000 (GBP) |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2011 |
| End | 12/2011 |
| Description | Understanding the aggregation properties of TDP43 in FTD |
| Amount | £5,000,000 (GBP) |
| Organisation | UK Dementia Research Institute |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 08/2021 |
| Description | University of Michigan (NIH) |
| Amount | £39,775 (GBP) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 05/2010 |
| End | 05/2011 |
| Description | University of Sussex |
| Amount | £159,726 (GBP) |
| Organisation | University of Sussex |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2008 |
| End | 05/2011 |
| Title | Production of mylated peptides |
| Description | We developed a robust method to glycate peptides |
| Type Of Material | Biological samples |
| Provided To Others? | No |
| Impact | This allows the facile production of peptides with this post-translational modification |
| Title | Production of post-translational modification in proteins |
| Description | We designed a strategy to ubiquitinate ataxin-3 |
| Type Of Material | Biological samples |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | We have provided a new methodology to produce suitable amounts of mono-ubiquitinated ataxin-3 |
| Title | a new model for the causes of Friedreich's ataxia |
| Description | We identified the function of frataxin and provided a model for how its absence causes the disease |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | We provided information on how to mutate proteins for validating our model. |
| Description | Protein stability and cold denaturation |
| Organisation | University of Naples |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | We have provided spectrometer access, protein material, know-how on NMR measurements. |
| Collaborator Contribution | Protein stability, crowding and confinement. |
| Impact | Five pubblications (163) Sanfelice, D., Tancredi, T., Politou, A., Pastore, A. And Temussi, P. (2009) Cold denaturation and aggregation: a comparative NMR study for titin I28 in bulk and in a confinded environment. JACS 131, 11662-11663. (157) Esposito, V., Pastore, A., Martin, S., de los Rios, P., Temussi, P.A. (2008) Cold denaturation of yeast frataxin offers the clue to understand the effect of alcohols on protein stability.JACS 130, 9963-9970. (152) Pastore, C., Franzese, M., Sica, F., Temussi, P. and Pastore, A. (2007) Understanding the binding properties of an unusual metal binding protein: a study of bacterial frataxin. Febs J. 274, 4199-4210 (150) Pastore, A., Martin, S.R, Politou, A., Kondapalli, K.C., Stemmler, T., Temussi, P. A. (2007) Unbiased cold denaturation: low and high temperature unfolding of Yeast frataxin under physiological conditions. JACS 129; 5374-5375. (147) Pastore, A., Salvadori, S., Temussi, P.A. (2007) Peptides and proteins in a confined environment: NMR spectra at natural isotopic abundance. J. Pept. Sci. 15, 795-807. |
| Start Year | 2006 |
| Description | Rational design of RNA aptamers |
| Organisation | Italian Institute of Technology (Istituto Italiano di Tecnologia IIT) |
| Department | Neuroscience and Brain Technologies IIT |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | We are developing RNA aptamers against TDP-43 |
| Collaborator Contribution | The partner Gian Gaetnao Tartaglia is the author of the software used for the prediction. |
| Impact | We have held together a grant from MNDA and published four papers together. We are now in the process of sending off a manuscript and a grant application to ADDF. |
| Start Year | 2016 |
| Description | Studies of how glycation influences cell toxicity |
| Organisation | University of Naples |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | We have a long term experience in understanding the factors that influence aggregation propensity |
| Collaborator Contribution | The Italian group is currently working on the effects of glycation on toxicity. we therefore send them glycated amylin and Abeta to test for roxicity. |
| Impact | We have complemented our studies on the structural and aggregation effects of glycation. |
| Start Year | 2014 |
| Description | Studies of how glycation influences the aggregation propensityof polypeptides |
| Organisation | University of the Balearic Islands |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | We have a long term experience in production of recombinant proteins and peptides. We have helped their group to set up a lab for this purpose and sent there one of our postdoc for 3 months to instruct the researchers there. |
| Collaborator Contribution | The group there has been working for several years on glycation. Their contribution has been invaluable for starting our research for the DiabetesUK grant. We are also constantly exchange expertise, know-how, protocols and materials. |
| Impact | We have been able to smoothly start the work planned for this grant. We have produced preliminary data which were crucial to obtain the current grant (started only 10 months ago). |
| Start Year | 2011 |
| Description | Studies of misfolding diseases: polyQ and prion diseases |
| Organisation | French National Institute of Agricultural Research |
| Country | France |
| Sector | Academic/University |
| PI Contribution | NMR spectrometr time, know-how on NMR structural determination |
| Collaborator Contribution | know-how on light scatterins, calorimetry and kinetics. |
| Impact | Two publications in prreparation |
| Start Year | 2008 |
| Description | Studies of the frataxin function |
| Organisation | Free University of Brussels |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | We have developed an assay which has allowed us to elucidate the function of frataxin |
| Collaborator Contribution | co-authored publications and in vivo experiments to test our functional hypotheses |
| Impact | As a result of this collaboration we are now part of an EU grant awarded for 2009-2012. Pandolfo, M., Pastore, A. (2008) The pathogenesis of Friedreich ataxia and the structure and function of frataxinJ. of Neurol. 256 Suppl 1:9-17 |
| Start Year | 2010 |
| Description | The mechanism of protein aggregation |
| Organisation | Moscow State University |
| Department | Biochemistry Department |
| Country | Russian Federation |
| Sector | Academic/University |
| PI Contribution | We have been collaborating on the effects of metals on the aggregation of the Abeta peptides. |
| Collaborator Contribution | They produced the peptide and analysed the data collected in London |
| Impact | We have been accepted a paper in Scientific reports. |
| Description | Understanding the structural bases of stretch activation in muscle |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Biophysical studies, structural know-how. |
| Collaborator Contribution | Material, know-how and exhange of personnel |
| Impact | (117) De Nicola, G., Biekofsky, R., Kelly, G., Agianian, B., Bullard, B., Pastore, A. (2004) Assignment of the 1H, 13C, and 15N resonances of holo isoform 4 of Lethocerus indicus Troponin C. J. of Biomol. NMR, 29, 461-462. (151) DeNicola, G., Burkart, C., Qiu, F., Agianian, B., Labeit, S., Martin, S., Bullard, B., Pastore, A. (2007) The structure of Lethocerus troponin C: New insights into the mechanism of stretch activation in muscles. Structure 15, 813-824. |
| Start Year | 2006 |
| Title | NON-ANAPHYLACTIC FORMS OF GRASS POLLEN Ph1 p 6 ALLERGEN AND THEIR USE |
| Description | The invention relates to a hypoallergenic immunogenic molecule derived from the Phl p 6 allergen, wherein the Phl p 6 molecule has an N-terminal and/or C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity. The invention also relates to a hypoallergenic immunogenic combination of molecules derived from the Phl p 6 allergen, comprising: (i) a Phl p 6 molecule having an N-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, and (ii) a Phl p 6 molecule having a C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, which two molecules together encompass the complete sequence of Phl p 6. The invention further relates to the use of the hypoallergenic immunogenic molecule or molecule mixture in hyposensitization and diagnosis. |
| IP Reference | WO0130816 |
| Protection | Patent granted |
| Year Protection Granted | 2001 |
| Licensed | Yes |
| Impact | This provides the bases for drug development against grass pollen allergies. |
| Title | the function of frataxin |
| Description | We have identified the function of frataxin and its role in friedreich's ataxia |
| IP Reference | |
| Protection | Trade Mark |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | Our research has completely revolutionaised the field of FRDA research |
| Description | Press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release for our work on Friedreich's ataxia The promotion of reserach on this disease. The establishment of a EU network to support the research further. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Publication of a science dissemination in Frontiers for young minds |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | I published an article in frontiers for Young Minds which is directed to children in the range of 8 to 16 years old. This initiative is meant to disseminate research among young people. |
| Year(s) Of Engagement Activity | 2017 |