Priment Clinical Trials Unit

Lead Research Organisation: Medical Research Council

Abstract

Priment is a collaboration between the MRC General Practice Research Framework and University College Londons Research Departments of Primary Care and Population Health and Mental Health Sciences. This collaboration allows a variety of people to come together to provide expertise across a wide range of studies. This includes developing the study ideas, designing the study, collecting the data, analysing it and writing up the study for publication.We focus on mental health projects but also do research in other topics that are encountered in the community and general practice settingOur work examines whether treatments are effective such as the use of psychological treatment for treatment of depression, assisting people with smoking cessation or reducing alcohol consumption.

Technical Summary

Priment is a UK Clinical Research Collaboration (CRC) fully registered clinical trials unit. It is an academic collaboration between University College London’s Research Departments of Primary Care and Population Health and Mental Health sciences and the MRC General Practice Research Framework.

It is made up of multidisciplinary teams of clinical researchers in psychiatry, palliative care, primary care, psychology, nursing, epidemiology, trial management and statistics. This group develops, designs, runs and analyses clinical trials and other large studies on a range of disorders such as severe (i.e. schizophrenia) and common mental disorders (i.e. depression and anxiety disorders), dementias and neurodegenerative disorders, sexually transmitted infections and other clinical conditions commonly encountered in primary care.

Some of the trials conducted through Priment include the evaluation of cognitive and behaviour therapy and nurse led case management for depression in primary care, smoking cessation interventions in primary care, care packages for severe mental illnesses in primary care and the use of self management programmes in people with osteoarthritis.

Current projects include: RCTs involving art therapy for schizophrenia, an interactive web-based intervention for reducing excessive alcohol consumption, and a programme designed to promote activity in the over 65s. Other epidemiological and early trial development work include the development and evaluation of pathways of care for people with alcohol misuse disorders in one primary care trust, investigating the impact of religious belief on mental health outcomes, examining the effects of parental mood on child development and assessing cardiovascular and cancer morbidity in people with severe mental illnesses.

Publications

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