China Kadoorie Biobank of 500,000 people aged 30-79

Lead Research Organisation: Medical Research Council

Abstract

The China Kadoorie Biobank (CKB) involves over 0.5 individuals aged 30-79 recruited during 2004-8 from 10 diverse regions of China. All participants underwent an extensive baseline visit and this data is linked to biological samples – including genetic samples - for future research use. A repeat survey in 20,000 participants was completed in 2008 and a new resurvey in around 25,000 (that includes some new measurements, including an ECG of the heart and a measurement of carotid artery atherosclerosis) commenced in 2013. Linkage to the hospital treatment records has been established for all participants and this will allow the long-term follow-up to determine the development of future disease. To date, over 250,000 fatal and non-fatal events of around 4,000 different types had been recorded emphasising the invaluable resource CKB will be for the reliable assessment of a wide range of chronic diseases, such as stroke, heart disease, cancer, diabetes and COPD.

Technical Summary

The China Kadoorie Biobank (CKB) involves over 0.5 million individuals aged 30-79 recruited during 2004-8 from 10 diverse regions of China, with extensive data collection at baseline and long-term storage of plasma (in Oxford and Beijing) and DNA-containing buffy coat (in Beijing). This resource will support a diverse range of research to assess the relevance for common chronic diseases of known and novel lifestyle, environmental, biochemical and genetic risk factors and their interactions. Chronic disease such as cancer, stroke, and coronary heart disease are now substantial causes of death and disability in low- and middle-income countries such as China. Several important causes of major chronic diseases are well established, but this knowledge is mainly based on studies in the West and may not explain much of the large heterogeneity in disease rates between Asian and Western populations or between different regions within China. Moreover, genetic risk factors and gene-environment interactions – that are likely to play important roles in disease aetiology – may also differ between Asian and Western populations. Although case-control studies may suffice for the study of purely genetic factors, large blood-based prospective studies are essential for the unbiased assessment of the relevance of both genetic and environmental factors, and their interactions. Following the baseline assessment of all 0.5 million participants, a resurvey of 20,000 participants was completed in 2008 and a second resurvey of around 25,000 commenced in 2013 to allow for appropriate correction for time-dependent regression dilution bias, with additional phenotyping enhancements (e.g. ECG, carotid IMT). Reliable linkage to electronic hospital treatment records has now been established in each study area. Participants are being followed up for cause-specific mortality and episodes of hospitalisation, with large enough numbers of disease events having already accumulated for prospective analyses of associations with a range of lifestyle and environmental factors. Independent validation and adjudication of outcomes has commenced for several major diseases (e.g. cancer, stroke, and coronary heart disease) that will improve disease phenotyping. Various high-throughput multi-omics technologies (e.g. GWAS, NMR) and standard assays will be used in “nested” case-control studies to assess the relevance of a wide range of known and novel blood-related factors to the onset rates of particular types of cancer, particular types of stroke, IHD, diabetes, lung disease and several other diseases.

Publications

10 25 50

 
Description AstraZeneca (Chinese case-control study)
Amount £150,000 (GBP)
Organisation AstraZeneca 
Sector Private
Country United Kingdom
Start 01/2006 
End 01/2015
 
Description BHF Centre for Research Excellence
Amount £198,595 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2016 
End 10/2018
 
Description BHF Oxford Centre for Research Excellence
Amount £51,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 03/2016
 
Description CRUK China fellowship
Amount £18,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2007 
End 02/2010
 
Description CRUK Oxford Centre Development Fund
Amount £29,400 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 03/2017
 
Description CRUK Project Grant
Amount £294,057 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2017 
End 10/2020
 
Description Chinese Ministry of Science and Technology
Amount £2,900,000 (GBP)
Organisation China Department of Science and Technology 
Sector Public
Country China
Start 07/2016 
End 12/2020
 
Description Chinese National Health and Family Planning Commission, Ministry of Health
Amount £185,000 (GBP)
Funding ID The impact of air pollution on residents and strategies of disease prevent and control in China 
Organisation National Health and Family Planning Commission of the People's Republic of China 
Sector Public
Country China
Start 06/2015 
End 06/2018
 
Description Clinical Research Training
Amount £206,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2011 
End 09/2014
 
Description Intermediate Clinical Research Fellowship
Amount £1,027,000 (GBP)
Funding ID FS/18/23/33512 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2018 
End 06/2023
 
Description Kadoorie Biobank study
Amount £2,500,000 (GBP)
Organisation Bavarian Nordic 
Sector Private
Country Denmark
Start 09/2009 
End 08/2014
 
Description Kadoorie Charitable Foundation (Chinese prospective studies)
Amount £4,250,000 (GBP)
Organisation Kadoorie Charitable Foundation 
Sector Charity/Non Profit
Country Hong Kong
Start 01/2006 
End 01/2012
 
Description MRC Newton Fund
Amount £5,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2015 
End 03/2019
 
Description MRC air quality China
Amount £604,988 (GBP)
Funding ID MR/P025080/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2017 
End 02/2019
 
Description Medical Research Council Research Grant
Amount £185,000 (GBP)
Funding ID MR/S014551/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 11/2018 
End 04/2020
 
Description National Natural Science Foundation of China
Amount £380,000 (GBP)
Funding ID The long-term trends of coronary heart disease and ischemic stroke and their risk factors. 
Organisation National Natural Science Foundation of China 
Sector Public
Country China
Start 01/2014 
End 12/2018
 
Description Pancreatic Cancer UK Research Innovation Fund
Amount £73,852 (GBP)
Organisation Pancreatic Cancer UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
End 09/2017
 
Description Research Excellence Award
Amount £10,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2011 
End 12/2011
 
Description Research grant
Amount £1,603,224 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2014 
End 08/2016
 
Description Research grant
Amount £214,000 (GBP)
Organisation Merck 
Sector Private
Country Germany
Start 12/2012 
End 12/2014
 
Description Research grant
Amount £4,716,000 (GBP)
Organisation Kadoorie Charitable Foundation 
Sector Charity/Non Profit
Country Hong Kong
Start 04/2003 
End 04/2015
 
Description Research grant
Amount £1,485,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2013 
End 03/2016
 
Description Research grant
Amount £388,000 (GBP)
Organisation Novartis 
Sector Private
Country Global
Start 03/2010 
End 12/2011
 
Description Research grant
Amount £2,465,000 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 11/2011 
End 11/2015
 
Description Research grant
Amount £3,087,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2009 
End 08/2014
 
Description Research grant
Amount £1,111,000 (GBP)
Organisation Merck 
Sector Private
Country Germany
Start 02/2010 
End 01/2020
 
Description Research grant
Amount £18,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2007 
End 03/2010
 
Description Research grant
Amount £1,110,000 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 04/2012 
End 04/2015
 
Description Wellcome Longitudinal Population Studies Grant
Amount £6,760,000 (GBP)
Funding ID 212946/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2018 
End 08/2023
 
Description Wellcome Trust Biomedical Resources Grant
Amount £1,737,405 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 08/2018
 
Description Wellcome Trust Strategic Award
Amount £1,600,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2014 
End 08/2016
 
Description Academia Sinica Inst. 
Organisation Academia Sinica
Country Taiwan, Province of China 
Sector Academic/University 
PI Contribution Member, Scientific Review Committee
Collaborator Contribution n/a
Impact n/a
Start Year 2015
 
Description Academy of Medical Sciences Committee, Multiple Morbidities & Global Health 
Organisation Academy of Medical Sciences (AMS)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution member
Collaborator Contribution committee
Impact n/a
Start Year 2015
 
Description Assessing health risks associated with exposure to household and ambient air pollution in rural and urban China 
Organisation Fudan University
Department School of Public Health
Country China 
Sector Academic/University 
PI Contribution Development and execution of the project "Assessing health risks associated with exposure to household and ambient air pollution in rural and urban China"
Collaborator Contribution Provision of access to additional relevant datasets on air pollution and analytical support.
Impact Field data being collected.
Start Year 2017
 
Description BDI 
Organisation University of Oxford
Department Big Data Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Analyses of CKB data conducted according to group protocols and summary results supplied.
Collaborator Contribution Development of Anlaysis protocol for GWAS for miscarriage.
Impact Paper in preparation
Start Year 2017
 
Description Beijing Genomics Institute 
Organisation Beijing Genomics Institute
Country China 
Sector Academic/University 
PI Contribution In kind contributions to assay costs for various DNA projects. CKB are working with BGI on various research projects including DNA extraction and large-scale GWAS of 100,000 CKB samples. We are also collaborating with BGI's Research organisation on a Mitochondrial DNA Project. This Project involves a pilot project of high-coverage sequencing of the mitochondrial genomes of up to 100 parent-offspring trios (300 samples) from the China Kadoorie Biobank, followed by the main project of sequencing of 15,000 additional samples. These results can be used to assess the inheritance patterns of mitochondrial genomes, including the extent of heteroplasmy and paternal inheritance. Also conducting whole-genome sequencing of 10,000 samples from the China Kadoorie Biobank. The results of this project can be used to construct sequencing reference panels for imputation of genetic variants in individuals of Chinese ancestry, to assess the quality of genome-wide genotyping data, to investigate human population diversity, both within China and globally, and to identify novel genetic variants of potential relevance to human disease. Assisting with a Replication of BMI and height associations from low-coverage NGS association analyses. Framework agreements for the above projects and future research collaborations ( eg on methylation, microbiome DNA) have been agreed and are awaiting signature. Also conducting whole-genome sequencing of 10,000 samples from the China Kadoorie Biobank. The results of this project can be used to construct sequencing reference panels for imputation of genetic variants in individuals of Chinese ancestry, to assess the quality of genome-wide genotyping data, to investigate human population diversity, both within China and globally, and to identify novel genetic variants of potential relevance to human disease. Assisting with a Replication of BMI and height associations from low-coverage NGS association analyses. Framework agreements for the above projects and future research collaborations ( eg on methylation, microbiome DNA) have been agreed and being finalised
Collaborator Contribution BGI are providing the facilities and technical infrastructure for the conduct of genomic assays including data handling and shared analysis
Impact Large scale GWAS of 100,000 CKB samples complete data available for analysis. Lookup of GWAS association for ~1900 SNPs provided. Manuscript published in Cell for BMI and height GWAS
Start Year 2015
 
Description Broad Institute 
Organisation Broad Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution Sitting/standing height ratio GWAS
Collaborator Contribution Sitting/standing height ratio GWAS
Impact Analysis plan complete. Initial analyses ongoing
Start Year 2018
 
Description Cambridge Cardiology 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Metaanalysis of NMR metabolomics GWAS
Collaborator Contribution Metaanalysis of NMR metabolomics GWAS
Impact Analysis complete, data supplied
Start Year 2019
 
Description China Kadoorie Built Environment Urban Morphometric Platform 
Organisation University of Hong Kong
Country Hong Kong 
Sector Academic/University 
PI Contribution Co-development of CKBUMP: China Kadoorie Built Environment Urban Morphometric Platform. To investigate a range of environmental exposures and their impact on health. CKB to provide health outcomes from Biobank participants.
Collaborator Contribution Co-development of CKBUMP: China Kadoorie Built Environment Urban Morphometric Platform. To investigate a range of environmental exposures and their impact on health. HK to provide expertise in geocoding and development of environmental exposure metrics.
Impact Work programme being developed
Start Year 2017
 
Description China Salt Substitution and Stroke Trial 
Organisation AkzoNobel
Country Netherlands 
Sector Private 
PI Contribution Member
Collaborator Contribution n/a
Impact n/a
Start Year 2014
 
Description Chinese Academy of Sciences: Health Effects of fatty acids and irons 
Organisation Chinese Academy of Sciences
Department Institute for Nutritional Sciences
Country China 
Sector Learned Society 
PI Contribution Established a large research project on dietary/environmental determinants and health effects of fatty acids and ions, based on CKB. This project has received major funding support from Chinese Academy of Sciences' Innovation fund to measure a whole range of fatty acid profile in erythrocyte membrane (n=10,000), ionomic profile in urine samples, as well as Hb1Ac among 25,000 resurvey participants.
Collaborator Contribution SIBS will conduct assays on samples from the China Kadoorie Biobank (CKB), including 25,000 urine and 25,000 blood red cell samples collected at the second resurvey. Red cell samples will be reformatted, and fatty acids (30 in total) assays will be conducted among the first 10,000 samples and HbA1c assays will be conducted among the total of 25,000 samples. Urine samples will be reformatted and ionomic (29 in total) and creatinine assays will be conducted.
Impact sample datasets being generated
Start Year 2016
 
Description Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes 
Organisation German Cancer Research Center
Country Germany 
Sector Public 
PI Contribution Guidance and collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes"
Collaborator Contribution Collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes"
Impact Project funded by CRUK
Start Year 2017
 
Description Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes 
Organisation International Agency for Research on Cancer (IARC)
Country France 
Sector Public 
PI Contribution Guidance and collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes"
Collaborator Contribution Collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes"
Impact Project funded by CRUK
Start Year 2017
 
Description Fudan University 
Organisation Fudan University
Country China 
Sector Academic/University 
PI Contribution Development and execution of the project "Assessing health risks associated with exposure to household and ambient air pollution in rural and urban China"
Collaborator Contribution Provision of access to additional relevant datasets on air pollution and analytical support
Impact Field data collected, currently being analysed.
Start Year 2014
 
Description Fudan University - CKB Air 
Organisation Fudan University
Department School of Public Health
Country China 
Sector Academic/University 
PI Contribution Working closely with the CKB group in China and Oxford to develop a joint research project on health effects of air-pollution based on the CKB study population. This project, named as CKB-Air, has now received major funding support from Chinese government. By linking CKB participants' unique national ID number and geo-coding to local air quality monitoring data and hospitalisation data it should generate a huge amount of additional data that can then be incorporated into main CKB database for research use. Fudan has access to air quality data.
Collaborator Contribution See above
Impact Collaboration lead to the development of a project proposal which has received funding from the MRC Global Challenges Research Fund . project called "Assessing health risks associated with exposure to household and ambient air pollution in rural and urban China"
Start Year 2016
 
Description GIANT: Genetic Investigation of ANthropometric Traits 
Organisation Broad Institute
Department The Genetic Investigation of ANthropometric Traits (GIANT)
Country United States 
Sector Academic/University 
PI Contribution GWAS Data for ~28k subjects supplied to assist various meta analyses being conducted by this group. CKB involved in convening the trans-ethnic analysis sub-group.
Collaborator Contribution Large meta-analysis of Height, BMI, WHR, WHRadjBMI; Joint / consortium publications
Impact papers under preparation
Start Year 2017
 
Description GLGC 
Organisation Global Lipids Genetic Consortium (GLGC)
Country United States 
Sector Charity/Non Profit 
PI Contribution GWAS Data for ~18k subjects supplied to assist various meta analyses being conducted by this group.
Collaborator Contribution Large meta-analysis of TC, LDL-c, HDL-c, TG
Impact Papers under preparation
Start Year 2017
 
Description George Institute for Global Health 
Organisation George Institute for Global Health
Country Australia 
Sector Academic/University 
PI Contribution CKB team have provided access to data and advised on drafts of several papers considering the relationships between women's reproductive factors (such as number of pregnancies and age at menarche) and adiposity, incident cardiovascular disease and diabetes.
Collaborator Contribution Two George Institute staff have dedicated significant time to analysis of results and drafting of papers
Impact Five review papers have been published to date.
Start Year 2015
 
Description Global Lipids Genetics Consortium 
Organisation Global Lipids Genetic Consortium (GLGC)
Country United States 
Sector Charity/Non Profit 
PI Contribution CKB plans to share genomics data or contribute to GWAS meta analyses being conducted by this group.
Collaborator Contribution Access to additional GWAS data to increase the likelihood of novel significant findings.
Impact In progress
Start Year 2017
 
Description Imperial College London 
Organisation Imperial College London
Department Department of Epidemiology and Biostatistics
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of relevant baseline from CKB to contribute to the Non-Communicable Disease (NCD) Risk Factor Collaboration funded by the Wellcome Trust.
Collaborator Contribution Providing estimates of country/regional trends in major cardio-metabolic risk factors for non-communicable diseases (NCDs), globally; these include body mass index, cholesterol, blood pressure and glucose.
Impact Papers under preparation
Start Year 2017
 
Description Imperial College London 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Signals of natural selection for lipid traits
Collaborator Contribution Signals of natural selection for lipid traits
Impact Draft analysis plan received. KK visitor within CKB, conducting analyses. Manuscript submitted.
Start Year 2019
 
Description International Stroke Genetics Consortium 
Organisation Massachusetts General Hospital
Department International Stroke Genetics Consortium
Country United States 
Sector Charity/Non Profit 
PI Contribution CKB plans to share genomics data or contribute to GWAS meta-analyses being conducted by this group. Summary statistics have been shared for GWAS of: (i) sub-arachnoid haemorrhage/ unruptured intracranial aneurysm; (ii) incident all stroke; (iii) fatal stroke, and mortality of incident stroke. Results of other analyses will only be shared after publication of CKB specific stroke genetics paper.
Collaborator Contribution Long-term collaboration. Access to additional GWAS data to increase the likelihood of novel significant findings.
Impact In Progress
Start Year 2016
 
Description Lund University: Pancreatic Cancer 
Organisation Lund University
Department Department of Immunotechnology
Country Sweden 
Sector Hospitals 
PI Contribution Access to CKB samples as part of a case control study. Including details metabolomic and proteomic profiling.
Collaborator Contribution Proteomic Assays, joint analysis of results.
Impact Assays completed, currently working on joint research papers realting to early diagnosis
Start Year 2016
 
Description McGill University 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Validation of genetic risk score for bone mineral density
Collaborator Contribution List of variants and weights supplied.
Impact Analysis ongoing
Start Year 2018
 
Description NMR metabolomics in CKB 
Organisation University of Oulu
Department Department of Pharmacology and Toxicology
Country Finland 
Sector Academic/University 
PI Contribution Access to CKB samples.
Collaborator Contribution Expertise on - and access to - MNR metabolomics platform for analysis of CKB samples (stroke case-control study and Pancreatic cancer case-control study.
Impact Papers forthcoming.
Start Year 2015
 
Description Nanjing Medical University 
Organisation Nanjing Medical University
Country China 
Sector Academic/University 
PI Contribution Access to data resulting from genotyping.
Collaborator Contribution Contributing research and analystical expertise. CKB/ Oxford hosted a post-doctoral researcher from Nanjing who is continuing to work on this project since his return.
Impact Papers currently being drafted.
Start Year 2015
 
Description Nightingale Health, Finland 
Organisation Nightingale Health Ltd.
Country Finland 
Sector Private 
PI Contribution Metaanalysis of SNPs and gene-specific GRSs with lipid/NMR data. Results sent for 13 SNPs, 3 GRSs, 228 traits, up to 17k samples.
Collaborator Contribution academic partnership
Impact Paper published in Circulation
Start Year 2018
 
Description Peking University PKU 
Organisation Peking University
Country China 
Sector Academic/University 
PI Contribution Replication of fingerprint GWAS. Lookup of GWAS association for 118 SNPs with 20 fingerprint features provided. Results of GWAS provided for metaanalysis.
Collaborator Contribution academic partnership
Impact Paper published in Circulation
Start Year 2018
 
Description ROHgen - (Runs of Homozygosity) 
Organisation ReproGen Consortium
Country Global 
Sector Academic/University 
PI Contribution CKB plans to share genomics data or contribute to GWAS meta analyses being conducted by this group.
Collaborator Contribution Access to additional GWAS data to increase the likelihood of novel significant findings.
Impact In progress
Start Year 2016
 
Description Reprogen 
Organisation ReproGen Consortium
Country Global 
Sector Academic/University 
PI Contribution Conducting GWAS of reproductive traits.
Collaborator Contribution GWAS analyses complete. Currently doing lookup of existing (known) hits, and various heritability analyses. In discussion about future joint analyses/papers
Impact Joint papers
Start Year 2017
 
Description Short-and long-term effects of outdoor pollution 
Organisation Chinese University of Hong Kong
Country Hong Kong 
Sector Academic/University 
PI Contribution Development of a programme of collaborative research to examine both short- and long- term effects of outdoor air pollution (together with climate model and geocoding) on health outcomes. Individual socio-demographic factors, as well as climate-related factors and indoor air pollutants would also be examined as independent and interacting factors which contribute to health outcomes.
Collaborator Contribution Development of a programme of collaborative research to examine both short- and long- term effects of outdoor air pollution (together with climate model and geocoding) on health outcomes. Individual socio-demographic factors, as well as climate-related factors and indoor air pollutants would also be examined as independent and interacting factors which contribute to health outcomes.
Impact Development of project: Assessing health risks associated with exposure to household and ambient air pollution in rural and urban China
Start Year 2017
 
Description Social Science Genetics Association Consortium 
Organisation Social Science Genetics Association Consortium
Country Global 
Sector Charity/Non Profit 
PI Contribution GWAS of socioeconomic traits
Collaborator Contribution GWAS results supplied for ~10 different traits.
Impact Discussions continuing
Start Year 2018
 
Description Spirometer/BiLEVE 
Organisation University of Leicester
Department Department of Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis in CKB of associations between spirometry measures/COPD and genetic loci identified by the Leicester group.
Collaborator Contribution Ongoing long-term collaboration.
Impact Two papers published in Nature Genetics "Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets", "New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries"
Start Year 2015
 
Description UK BiLEVE 
Organisation UK Biobank
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution GWAS Data for ~33k subjects supplied to assist various meta analyses being conducted by this group.
Collaborator Contribution Consortium is investigating SNP and GRS associations with COPD and COPD exacerbations.
Impact One peer-reviewed paper published, others under preparation
Start Year 2017
 
Description UNC School of Medicine 
Organisation University of North Carolina at Chapel Hill
Country United States 
Sector Academic/University 
PI Contribution GWAS of various psychiatric and related traits
Collaborator Contribution Analysis plan received for GWAS of Major Depression and for Depressive Symptoms. GWAS completed, summary statistics supplied.
Impact Central analysis ongoing
Start Year 2018
 
Description University of Bristol 
Organisation University of Bristol
Department MRC Integrative Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution GWAS of flushing
Collaborator Contribution Visiting researcher from Bristol working within CKB.
Impact Analyses ongoing
Start Year 2018
 
Description University of Cambridge 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Provision of relevant baseline and follow-up data from CKB and guidance on anlaysis plans and interpretation of results.
Collaborator Contribution Cambridge will conduct an analysis of the associations between fish and soya bean intake and incidence of type 2 diabetes: an individual participant meta-analysis.
Impact papers under preparation
Start Year 2017
 
Description University of Cambridge - Dept of Medicine 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of controls data (300 CKB samples) for GWAS of ANCA vasculitis being conducted by Cambridge.
Collaborator Contribution The genotype data suppliedto Oxford is being used to compare the performance of the China Kadoorie Biobank and UK BioBank arrays in ethnically distinct cohorts.
Impact Joint research papers.
Start Year 2016
 
Description University of Edinburgh 
Organisation University of Edinburgh
Department Centre for Population Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of relevant baseline and follow-up data from CKB and guidance on analysis plans and interpretation of results.
Collaborator Contribution Edinburgh will investigate and describe the association between socioeconomic status and prevalent and incident diabetes in China with investigation of the role of mediating and confounding factors.
Impact Papers under preparation
Start Year 2017
 
Description University of Leicester 
Organisation University of Leicester
Department Department of Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Access to data resulting from genotyping, joint analyses
Collaborator Contribution CKB has included additional custom respiratory content into its array design and Prof Tobin will assist in examining this GWAs data alongside baseline and prospective datasets
Impact Nature genetics paper. Nat Genet 2017; 49(3):416-425. More under preparation
Start Year 2015
 
Description University of Oulu 
Organisation University of Oulu
Country Finland 
Sector Academic/University 
PI Contribution Results sent for 13 SNPs, 3 GRSs, 228 traits, up to 17k samples
Collaborator Contribution Meta-analysis of SNPs and gene-specific GRSs with lipid/NMR data. Also providing expertise on MNR metabolomics platform and analysis of CKB samples (stroke case-control study and Pancreatic cancer case-control study).
Impact paper published in Circulation: Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment
Start Year 2017
 
Description University of Oxford - OCDEM 
Organisation University of Oxford
Department Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Access to relevant CKB data including genomics data and diabetes outcome data. Paper drafting and internal genomics expertise and supervision.
Collaborator Contribution Provision of a post graduate research assistant working on the the identification and characterization of genetic variants that influence predisposition to type 2 diabetes and related traits.
Impact Contributed several novel and interesting findings including published research papers
Start Year 2014
 
Description University of Oxford Biomedical Engineering 
Organisation University of Oxford
Department Mathematical, Physical & Life Sciences Division
Country United Kingdom 
Sector Academic/University 
PI Contribution Access to ECG wave data from CKB resurvey. Joint analyses.
Collaborator Contribution the development of machine learning methods for modelling ECG time series data within the CKB, and where we plan to develop tools for automatically fusing ECG-based data into disease sub-phenotyping for the CKB cohort. Also keen to explore other aspects of the CKB data resource, including genotypical biomarker data.
Impact One research paper published
Start Year 2014
 
Description Wellcome Trust Centre for Human Genetics 
Organisation University of Oxford
Department Wellcome Trust Centre for Human Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution Access to data resulting from genotyping.
Collaborator Contribution Collaborated in the design of a customised genotyping array for genomewide analysis, which is complementary to the UK Biobank array, and will facilitate future joint projects in the genomics of common diseases.
Impact Groups at the WTCHG work closely with the CKB team in genome wide data imputation and analysis, for work on stroke, as well as the partial cohort-wide genotyping funded by the MRC-Newton fund.
Start Year 2015
 
Description 10th International Genomics Conference, Shenzhen, China 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 10th International Genomics Conference, Shenzhen, China
Year(s) Of Engagement Activity 2015
 
Description 12th Chinese Nutrition Congress, Beijing, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 12th Chinese Nutrition Congress, Beijing, China
Year(s) Of Engagement Activity 2015
 
Description 16th World Conference on Tobacco or Health, Abu Dhabi, UAE 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 16th World Conference on Tobacco or Health, Abu Dhabi, UAE
Year(s) Of Engagement Activity 2015
 
Description BBC TV interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact BBC Tv interview as a result of the paper: Consumption of spicy foods and total and cause specific mortality: population based cohort study. British Medical Journal. 2015;351:h3942
Year(s) Of Engagement Activity 2015
 
Description BBC World interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with BBC World as a result of the paper: Contrasting male and female trends in tobacco-attributed mortality in China: evidence from successive nationwide prospective cohort studies. Lancet 2015; 386:1447-56
Year(s) Of Engagement Activity 2015
 
Description BRAIN 2016, Hong Kong 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact international symposium
Year(s) Of Engagement Activity 2016
 
Description Big Data for Health Policy Workshop, University of Toronto, Canada 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Big Data for Health Policy Workshop, University of Toronto, Canada
Year(s) Of Engagement Activity 2014
 
Description Cancer Research UK public engagement day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Participation in a Cancer Research UK public engagement day held in Oxford on the 16th March 2016. Organised a table top statistics activity for Secondary School participants.
Year(s) Of Engagement Activity 2016
 
Description China CDC (Centre for Disease Control), Beijing, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact China CDC (Centre for Disease Control), Beijing, China
Year(s) Of Engagement Activity 2015
 
Description China West Lake Forum, Hangzhou, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact China West Lake Forum, Hangzhou, China
Year(s) Of Engagement Activity 2015
 
Description Coverage of Spicey Food and Mortality paper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release and widespread media ( print and online) coverage for the following paper "Consumption of spicy foods and total and cause specific mortality: population based cohort study". British Medical Journal. 2015;351:h3942 See also BMJ Editorial by Nita Forouhi

Typical Headline: "Frequent spicy meals linked to human longevity " ( The Guardian)
Year(s) Of Engagement Activity 2015
 
Description Coverage on study in Pharmaceutical industry trade journal 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Some coverage of paper on LPa2 emphasising the implications for drug target discovery and pharmaceutical inductrial practice.

https://www.drugtargetreview.com/news/12376/prospective-biobank-studies/
Year(s) Of Engagement Activity 2016
URL http://www.drugtargetreview.com/news/12376/prospective-biobank-studies/
 
Description Diabetes and mortality in China 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Global press release attracting significant print and online media coverage on the following paper "Association between diabetes and cause-specific mortality in rural and urban areas of China". JAMA. 2017;317(3):280-289. doi:10.1001/jama.2016.19720

Typical Headline "Diabetes causes loss of 9 years of life in Chinese patients"

Editorial article accompanied by an editorial editorial in the same journal by Margaret Chan Director General of the World health Organisation
Year(s) Of Engagement Activity 2016,2017
 
Description Frontiers in CVD Translational Research Symposium, South Korea 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact international symposium
Year(s) Of Engagement Activity 2016
 
Description GlaxoSmithKline (GSK), Research Triangle Park, North Carolina, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact GlaxoSmithKline (GSK), Research Triangle Park, North Carolina, USA
Year(s) Of Engagement Activity 2014
 
Description Global Health Summit, Toronto, Canada 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Global Health Summit, Toronto, Canada
Year(s) Of Engagement Activity 2014
 
Description Hong Kong Public Health Forum, Hong Kong, China 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Hong Kong Public Health Forum, Hong Kong, China
Year(s) Of Engagement Activity 2015
 
Description IARC Seminar Series, Lyon, France 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IARC Seminar Series, Lyon, France
Year(s) Of Engagement Activity 2015
 
Description Institute of Biomedical Sciences, Academia Sinica, Taiwan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Institute of Biomedical Sciences, Academia Sinica, Taiwan
Year(s) Of Engagement Activity 2015
 
Description International Symposium on Mendelian Randomization, Bristol, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact International Symposium on Mendelian Randomization, Bristol, UK
Year(s) Of Engagement Activity 2015
 
Description Media coverage following conference presentation 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Media coverage: China Kadoorie Biobank

http://www.nutrition2me.com/news/industry-news/item/825-a-fruit-a-day-could-keep-cvd-at-bay
http://www.brightsurf.com/news/headlines/99980/Fruit_consumption_cuts_CVD_risk_by_up_to_40_percent.html
http://medicalxpress.com/news/2014-09-fruit-consumption-cvd-percent.html
http://www.medicalnewstoday.com/articles/281903.php
http://www.mailonsunday.co.uk/health/article-2739813/An-apple-half-day-reduce-chance-suffering-heart-attack-40.html
http://www.dailymail.co.uk/health/article-2739813/An-apple-half-day-reduce-chance-suffering-heart-attack-40.html
http://www.nla-eclipsweb.com/service/redirector/article/15439511.html


None
Year(s) Of Engagement Activity 2014
 
Description Oxfordshire Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presentation at the Oxfordshire Science Festival : Oxford SciFest 25th and 26th June, Oxford Town Hall. On the topic "NDPH Epidemiology in Action"
Year(s) Of Engagement Activity 2016
 
Description PE talk for CRUK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Over 100 students educated in the principles of a prospective epidemiological study
Year(s) Of Engagement Activity 2018,2019
 
Description PE talk for CRUK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact one public engagement talk at a fundraiser in aid of CRUK. It was on the 28th Oct 2017
Year(s) Of Engagement Activity 2017
 
Description Participation in HiTECH Innovation events 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact HiStar Innovation and Entrepreneurship Competition aims to stimulate scientific innovation and accelerate start-ups. All innovators or start-up teams will be given access to leading authorities from academia, industry, commercial enterprise and business from both China and the UK. Our partners include more than 10 accelerators and at least 40 venture capital firms/trusts based in both China and the UK, with additional support from the government of Beijing, Shanghai, Hangzhou, Shenzhen and Hong Kong and numerous China based industrial parks. Prof Chen was one of the judges for the final pitches mainly focus on judging those life science related startups.
Year(s) Of Engagement Activity 2016
 
Description Press coverage for report on Smoking and all-cause mortality in China 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Global press release attracting significant print and online media coverage on the following paper "Contrasting male and female trends in tobacco-attributed mortality in China: evidence from successive nationwide prospective cohort studies. Lancet 2015; 386:1447-56 (doi: 10.1016/S0140-6736(15)00340-2)."

Typical Headline: "Smoking set to kill one in three young men in China"
Year(s) Of Engagement Activity 2015,2016
 
Description Press coverage for research paper on egg consumption and cardiovascular disease in China 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Significant worldwide media coverage (Print and online) for the following paper "Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults". Heart 2018; 104(21):1756-63
Year(s) Of Engagement Activity 2018
 
Description Press coverage for research paper on high cholesterol and risk of stroke inc Radio interview for BBC radio Oxford. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Global Press release and significant worldwide media coverage (Print and online) for the following paper: "Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults". Nature Medicine 2019.
Year(s) Of Engagement Activity 2019
 
Description Press covereage for research paper loss-of-function variant in CETP and risk of CVD in Chinses adults 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Global Press release and significant worldwide media coverage (Print and online) for the following paper "Association of CETP gene variants with risk for vascular and nonvascular diseases among Chinese adults. JAMA Cardiol 2018; 3(1):34-43"
Year(s) Of Engagement Activity 2018
 
Description Press covereage for research paper on fresh fruit consumption and cardiovascular disease in China 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Global Press release and significant worldwide media coverage (Print and online) for the following paper "Fresh fruit consumption and major cardiovascular disease in China". N Engl J Med 2016, 374;14 1332-1343
Year(s) Of Engagement Activity 2016
 
Description Press covereage for research paper on solid fuel use and cardiovascular disease in China 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Global Press release and significant worldwide media coverage (Print and online) for the following paper: "Solid Fuel Use and Risks of Respiratory Diseases: A Cohort Study of 280,000 Chinese Never-Smokers". Am J Respir Crit Care Med 2019; 199(3):352-361
Year(s) Of Engagement Activity 2018
 
Description Radio Interview on Smoking 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact National Radio Interveiw onfor BB Scotland on Smoking and Mortality paper in China
Year(s) Of Engagement Activity 2016
 
Description Radio Interview. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Radio Interivew on Diabetes and Mortality in China with the BBC World Service.
Year(s) Of Engagement Activity 2016
 
Description Richard Doll Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact NDPH Richard Doll Seminar, Oxford
Year(s) Of Engagement Activity 2015
 
Description Richard Doll Symposium on Smoking, Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Richard Doll Symposium on Smoking, Oxford
Year(s) Of Engagement Activity 2015
 
Description School of Public Health, Chinese University of Hong Kong, China 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact School of Public Health, Chinese University of Hong Kong, China
Year(s) Of Engagement Activity 2015
 
Description School of Public Health, Harvard University, Boston, US 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact School of Public Health, Harvard University, Boston, US
Year(s) Of Engagement Activity 2015
 
Description Shantou University Medical College, Shantou, China 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Shantou University Medical College, Shantou, China
Year(s) Of Engagement Activity 2015
 
Description Sichuan CDC, Chengdu, China 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Sichuan CDC, Chengdu, China
Year(s) Of Engagement Activity 2015
 
Description TV Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact TV interview conducted online for China Central TV in Beijing - on predicted effects of smoking on mortality in China
Year(s) Of Engagement Activity 2016
 
Description WuxiApp Tec, Shanghai, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact WuxiApp Tec, Shanghai, China
Year(s) Of Engagement Activity 2015,2016