Large randomised clinical trials in other (non-vascular) conditions

Lead Research Organisation: Medical Research Council

Abstract

Randomised controlled trials are the most reliable way to assess the benefits and risks of treatments for disease. Most treatments have moderate effects, which means that these trials need to be large, typically involving 10-30,000 patients. CTSU over the last two decades or more has pioneered the conduct of large simple randomised trials to provide uniquely reliable evidence on the benefits and risks of new and existing treatments in a range of patient groups. For example, these studies have clearly shown that the routine use of folic acid plus vitamin-B12 supplements is safe, but has no benefit in terms of preventing heart attacks, strokes or cancer, and the MRC trials of adult and childhood leukaemia, in which CTSU played a major role, have resulted in significant improvements in survival such that now most patients with leukaemia or childhood lymphoma can expect to be cured and to live normal lives for decades afterwards. Our future programme of work is continuing to undertake a number of large randomised trials to address important questions, such as the benefits or otherwise of high-dose vitamin-D to prevent fractures, cancer and cardiovascular disease in older people, the benefits and risks of various treatments in patients with kidney disease as well as conducting trials in dementia, schizophrenia, carotid surgery, malaria prevention amongst others.

Technical Summary

This programme aims to generate reliable evidence about widely applicable and cost-effective treatments using cost-effective randomised trials in a range of diseases which contribute substantially to the global burden of disease. Over the last several years, CTSU has developed streamlined methods to recruit large numbers of patients and conduct trials cost-effectively (e.g. ASCEND), including using factorial designs to address more than one question at a time (e.g. HPS, SEARCH, ASCEND), and to use record linkage to facilitate follow-up, both during the trial (e.g. ASCEND, 3C) and in the longer term (e.g. HPS, SEARCH). In addition, CTSU has been planning and piloting new trials of non-commercial questions (e.g. high-dose vitamin-D in older people) and collaborating with many other researchers in the design, conduct and analysis of trials in a range of other conditions, such as neurodegenerative disease, leukaemia, carotid artery disease etc. Our previous trials using these large streamlined designs have been able to reliably answer important public health questions. For example, the SEARCH trial clearly showed that lowering homocysteine using folic acid with vitamin-B12 while safe had no benefit in terms of major vascular events or other important outcomes, such as coronary events, stroke or cancer incidence. A further example of a large streamlined highly cost-effective trial is the ongoing ASCEND trial which has randomised over 15,000 diabetic patients without clinically manifest arterial disease to aspirin and/or omega-3 fatty acids (with matching placebos using a 2x2 factorial design) to assess their effects on cardiovascular disease, cancer and other major outcomes. CTSU has also played a key role over a number of decades in the MRC leukaemia trials in adults and children which have made a major contribution to the significant improvements in survival of these patients such that now most patients with leukaemia or lymphoma in childhood can expect to be cured and to live normal lives for decades afterwards. Our future programme of work will involve the long-term follow-up of some of our existing trials, for example, HPS to assess the long term benefit or risks of vitamin supplementation (vitamin-E, -C and ß-carotene), the completion of the main phase of follow-up in ASCEND (with the main results expected in 2017) and to commence a number of new major trials, including a study of high-dose vitamin-D to prevent fractures, cancer and cardiovascular disease in older people and various trials to evaluate treatments in chronic kidney disease.

Organisations

Publications

10 25 50
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AD Collaborative Group (2008) Aspirin in Alzheimer's disease (AD2000): a randomised open-label trial in The Lancet Neurology

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ASCEND Study Collaborative Group (2018) Effects of n-3 Fatty Acid Supplements in Diabetes Mellitus. in The New England journal of medicine

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ASCEND Study Collaborative Group (2018) Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus. in The New England journal of medicine

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ASCEND Study Collaborative Group (2018) Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus. in The New England journal of medicine

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ASTRAL Investigators (2009) Revascularization versus medical therapy for renal-artery stenosis. in The New England journal of medicine

 
Description MRC Network of Hubs for Trials Methodology Research: Risk-based monitoring of trials
Geographic Reach Multiple continents/international 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Our research has highlighted the value of risk-based approaches to monitoring of trials, which in August 2013 resulted in the FDA issuing new guidance for investigators.
URL http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM269919.pdf
 
Description MRC Network of Hubs for Trials Methodology Research: Using central statistical monitoring to detect fraud in an ongoing clinical trial
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact CTSU have continued our development of different central statistical monitoring methods , such as Key Risk Indicators and the "SMART" approach, which performs statistical tests on the values of all variables collected in a clinical trial to generate p-values and ranks that can be checked for randomness, plausibility and comparability. Using these techniques one particular site in an on-going trial was highlighted and found to have falsified certain blood results. Further investigation led to the dismissal of staff, reporting to regulatory agencies and site closure.
 
Description MRC Network of Hubs for Trials Methodology Research: Using routine electronic health records to efficiently recruit patients to a randomised trial
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact CTSU have for more than a decade used routine medical records to efficiently identify, invite and recruit patients to a number of randomised trials. This has involved the development and ongoing optimisation of a number of dedicated systems to handle disparate, often incomplete and potentially inaccurate routine electronic health records. Using these systems we have recently successfully completed the recruitment of 30,000 patients (including 8,000 from the UK) to the REVEAL study.
URL http://www.ctsu.ox.ac.uk/research/mega-trials/hps3-reveal
 
Description NICE Type 2 diabetes guideline
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description NICE decision on tolvaptan
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Richard Haynes was involved in the NICE decision making on tolvaptan (a new treatment for polycystic kidney disease) [but only the early stages and not the whole thing.] CTSU is also a partner with the Kidney Health Initiative (which is a CTTI-like collaboration between FDA and American Society of Nephrology). Richard co-chairs a working group on data standards in diabetic kidney disease.
 
Description Alzheimer's Research UK
Amount £155,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2016 
End 07/2018
 
Description BHF CRE Infrastructure Award Research grant: A comparison of the risk of cardiovascular events and cancer in the ASCEND study population with a similar population of people with diabetes identified using electronic primary care records.
Amount £30,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 03/2019
 
Description BHF Special Project Grant ASCEND
Amount £1,087,533 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 12/2018
 
Description Research grant (3C trial)
Amount £530,000 (GBP)
Organisation Pfizer Ltd 
Sector Private
Country United Kingdom
Start 10/2009 
End 09/2017
 
Description Research grant (3C trial)
Amount £250,000 (GBP)
Organisation NHS Blood and Transplant (NHSBT) 
Sector Public
Country United Kingdom
Start 04/2010 
End 03/2015
 
Description Research grant (3C trial)
Amount £350,000 (GBP)
Organisation Novartis 
Sector Private
Country Global
Start 10/2009 
End 09/2017
 
Description Research grant (ACST-2 trial)
Amount £199,000 (GBP)
Organisation Department of Health (DH) 
Sector Public
Country United Kingdom
Start 04/2007 
End 03/2014
 
Description Research grant (ACST-2 trial)
Amount £62,000 (GBP)
Organisation BUPA 
Department BUPA Foundation
Sector Private
Country United Kingdom
Start 10/2007 
End 03/2014
 
Description Research grant (ASCEND)
Amount £1,590,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2009 
End 12/2013
 
Description Research grant (ASCEND)
Amount £1,677,000 (GBP)
Organisation Abbott 
Department Abbott UK
Sector Private
Country United Kingdom
Start 01/2004 
End 12/2015
 
Description Research grant (ASCEND)
Amount £53,000 (GBP)
Organisation Bayer 
Department Bayer HealthCare
Sector Private
Country Germany
Start 01/2004 
End 12/2013
 
Description Research grant (ASCEND)
Amount £1,627,000 (GBP)
Organisation Bayer 
Department Bayer HealthCare
Sector Private
Country Germany
Start 01/2004 
End 12/2015
 
Description Research grant (ATLAS trial)
Amount £503,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 10/2011 
End 01/2016
 
Description Research grant (ATTILA trial)
Amount £392,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 01/2013 
End 03/2017
 
Description Research grant (BEST-D)
Amount £108,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2012 
End 06/2014
 
Description Research grant (BEST-D)
Amount £48,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2012 
End 03/2014
 
Description Research grant (HARP-III)
Amount £1,549,000 (GBP)
Organisation Novartis 
Sector Private
Country Global
Start 09/2013 
End 09/2016
 
Description Research grant (MADE trial)
Amount £457,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2013 
End 05/2018
 
Description Research grant (VIDAL trial)
Amount £9,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2013 
End 03/2016
 
Description Research grant (leukaemia trials)
Amount £189,000 (GBP)
Organisation The Kay Kendall Leukaemia Fund 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2007 
End 03/2010
 
Description Research grant (leukaemia trials)
Amount £411,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2003 
End 09/2009
 
Description Research grant (leukaemia trials)
Amount £1,677,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2003 
End 09/2008
 
Description Research grant (leukaemia trials)
Amount £188,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2010 
End 12/2017
 
Description Research grant (leukaemia trials)
Amount £993,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2009 
End 05/2013
 
Description Research grant (leukaemia trials)
Amount £289,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2008 
End 05/2009
 
Description Research grant (the Stroke Oxygen Study, SOS)
Amount £29,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2011 
End 06/2015
 
Description Royal College of Surgeons Research Fellowship
Amount £10,000 (GBP)
Organisation Royal College of Surgeons of England 
Sector Learned Society
Country United Kingdom
Start  
 
Description 3C 
Organisation Cambridge University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Freeman Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Guy's and St Thomas' NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Hull and East Yorkshire Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Leeds Teaching Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Manchester University NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation NHS Greater Glasgow and Clyde (NHSGGC)
Department Western Infirmary, Glasgow
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Nottingham University Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Oxford University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Plymouth Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Portsmouth Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Royal Free London NHS Foundation Trust
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Royal Infirmary of Edinburgh
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Royal Liverpool and Broadgreen University Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Royal London Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation Sheffield Teaching Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation University Hospital of Wales
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation University Hospitals Birmingham NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation University Hospitals Coventry and Warwickshire NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description 3C 
Organisation York Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU co-ordinates the collaboration.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2008
 
Description ACST-2 
Organisation AZ Sint-Blasius
Country Belgium 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation AZ Sint-Jan Brugge-Oostende
Country Belgium 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Addenbrooke's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Aintree University Hospital
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Albert Szent-Györgyi Medical University
Country Hungary 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Antwerp University Hospital
Country Belgium 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Attikon Hospital
Department Department of Vascular Surgery
Country Greece 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation August Pi i Sunyer Biomedical Research Institute
Department Hospital Clinic of Barcelona
Country Spain 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Birmingham City Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Bishop Auckland Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Brussels Saint-Luc University Hospital (UCL)
Country Belgium 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Central Clinical Hospital
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Central Military Hospital
Country Czech Republic 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Cheltenham General Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation China-Japan Friendship Hospital
Country China 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation China-Japan Friendship Hospital
Country China 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Circolo Hospital and Macchi Foundation
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Clinical Center of Serbia
Country Serbia 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Clinique Saint Michel
Country Belgium 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Colchester Hospital University NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation County Durham and Darlington NHS Foundation Trust
Department University Hospital of North Durham
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Dedinje Cardiovascular Unit
Country Serbia 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Derriford Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation East-Tallinn Central Hospital
Country Estonia 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Evangelismos Hospital
Country Greece 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Fondazione IRCCS Policlinico San Matteo
Country Italy 
Sector Charity/Non Profit 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Foothills Medical Centre
Country Canada 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Freeman Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Ghent University Hospital
Country Belgium 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Great Western Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Haga Hospital
Country Netherlands 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Hegau-Bodensee-Klinikum
Country Germany 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Helsingborg Hospital
Country Sweden 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Henri Mondor Hospital
Country France 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Hospital Center of Mouscron
Country Belgium 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Hospital Civil de Guadalajara (HCG)
Country Mexico 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Hospital Saint Joseph Moscati
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Hull Royal Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation IASO General Hospital
Country Greece 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation IRCCS Policlinico San Donato
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Imelda Hospital
Country Belgium 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Institute for Cancer Research
Country Italy 
Sector Charity/Non Profit 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Italian Auxological Institute
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Izola General Hospital
Country Slovenia 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation John Radcliffe Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Kasr El Aini University Hospital
Country Egypt 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Kent and Canterbury Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Kohnan Hospital
Country Japan 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Kokuritsu Hospital Organization Sendai Medical Care Center
Country Japan 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Kokuritsu Hospital Organization Sendai Medical Care Center
Country Japan 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Liberec Regional Hospital
Country Czech Republic 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Luton and Dunstable University Hospital NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Malmo Vascular Centre
Country Sweden 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Manchester Royal Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Medical Center Leeuwarden
Country Netherlands 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Medical University of Warsaw
Country Poland 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Mirano Hospital
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Municipal Hospital Karlsruhe
Country Germany 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation National Scientific Centre of Surgery named after A N Syzgan
Country Kazakhstan 
Sector Public 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Newcastle General Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation North Cumbria University Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Nottingham University Hospitals NHS Trust
Department Nottingham University Hospitals Charity
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Novosibirsk Research Institute of Circulation Pathology
Country Russian Federation 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Nuovo Ospedale Civile Sant' Agostino Estense (NOCSAE Modena)
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Oslo University Hospital
Country Norway 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Peking Union Medical College Hospital
Country China 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Pius-Hospital Oldenburg
Country Germany 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Policlinico Universitario di Catania Gaspare Rodolico
Country Italy 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Poznan University of Medical Sciences
Country Poland 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Rambam Medical Centre
Country Israel 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Rechts der Isar Hospital
Country Germany 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Regional Hospital Center of the Citadel
Country Belgium 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Regional Hospital San Camillo-Forlanini
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Regional Specialist Hospital in Olsztyn
Country Poland 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Rijnstate Hospital
Country Netherlands 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Royal London Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Royal Preston Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Royal Victoria Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Saint John of God Clinical Research Centre
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation San Francesco Hospital
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation San Giacomo Hospital
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation San Paolo Hospital
Country Brazil 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Santa Maria Hospital
Country Portugal 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Sapienza University of Rome
Country Italy 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Semmelweiss University
Country Hungary 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Southend University Hospital NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation St Anne's University Hospital
Country Czech Republic 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation St Antonius Hospital
Country Netherlands 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation St James's University Hospital (Jimmy's)
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation St Mary's Hospital, London
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation St. Franziskus-Hospital
Country Germany 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Sunderland Royal Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Sveta Marina Hospital
Country Bulgaria 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Södersjukhuset (SÖS) Hospital, Stockholm
Country Sweden 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation The Walton Centre NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Tokuda Hospital Sofia
Country Bulgaria 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Umberto I- ASO Mauriziano
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University Clinical Centre (UCC) Maribor
Country Slovenia 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University Hospital Düsseldorf
Country Germany 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University Hospital Jena
Country Germany 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University Hospital Ostrava
Country Czech Republic 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University Hospital of Larissa
Country Greece 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University Hospital of Santa Maria alle Scotte
Country Italy 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University Medical Center Hamburg-Eppendorf
Country Germany 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University Medical Center Utrecht (UMC)
Country Netherlands 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Aberdeen
Department Institute of Medical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Bari
Country Italy 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Basel
Country Switzerland 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Bologna
Country Italy 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Dresden
Country Germany 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Florence
Country Italy 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Innsbruck
Country Austria 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Leipzig
Country Germany 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Palermo
Country Italy 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Perugia
Department Vascular Endovascular Unit of Perugia
Country Italy 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Sao Paulo
Country Brazil 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Sheffield
Department Sheffield Vascular Institute
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation University of Toledo
Department Medical Centre
Country United States 
Sector Academic/University 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Weston Park Hospital
Department Weston Park Hospital Cancer Charity
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation Wythenshawe Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ACST-2 
Organisation York Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU in collaboration with the Nuffield Department of Surgical Science, University of Oxford co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2006
 
Description ASCEND-Eye 
Organisation Birmingham Heartlands Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ASCEND-Eye 
Organisation Doncaster and Bassetlaw Hospitals NHS Foundation Trust
Department Doncaster Royal Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ASCEND-Eye 
Organisation East Sussex Healthcare NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ASCEND-Eye 
Organisation Farnham Hospital
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ASCEND-Eye 
Organisation Hertford County Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ASCEND-Eye 
Organisation Homerton University Hospital
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ASCEND-Eye 
Organisation Hull Royal Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ASCEND-Eye 
Organisation John Radcliffe Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ASCEND-Eye 
Organisation King's Mill Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ASCEND-Eye 
Organisation Mid Yorkshire Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ASCEND-Eye 
Organisation Norfolk and Norwich University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ASCEND-Eye 
Organisation Public Health Wales NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Collaborator Contribution Each partnering Diabetic Eye Screening Programme is facilitating the data linkage by identifying appropriate staff to run a query on their local database. All collaborations commenced in November-December 2018 and are ongoing This project is in the early stages of finalising data sharing agreements before data extractions can begin.
Impact tbc
Start Year 2018
 
Description ATLAS trial of antipsychotic treatment 
Organisation Bradford District Care NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Cambridgeshire and Peterborough NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Crosshouse Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Devon Partnership NHS Trust
Department Wonford House Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Kingsway Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation NHS Forth Valley
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation NHS Tayside
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation National Institute for Health Research
Department INVOLVE
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Norfolk and Suffolk NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation North Staffordshire Combined Healthcare NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Northumberland, Tyne and Wear NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Nottinghamshire Healthcare NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Oxford Health NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Pennsylvania Hospital
Country United States 
Sector Hospitals 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation South London and Maudsley (SLAM) NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation South Staffordshire and Shropshire Healthcare NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation South West Yorkshire Partnership NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Southampton City Primary Care Trust (PCT)
Department Moorgreen Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Surrey and Borders Partnership NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Sussex Partnership NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation The Barberry Centre
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation University of Cambridge
Department St Catharine's College
Country United Kingdom 
Sector Academic/University 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation West London Mental Health NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description ATLAS trial of antipsychotic treatment 
Organisation Worcestershire Health and Care NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates this trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None
Start Year 2013
 
Description Atrial Fibrillation 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution joint academic partnership
Collaborator Contribution joint academic partnership
Impact n/a
Start Year 2017
 
Description BEST-D collaboration Nuffield Department of Clinical and Laboratory Sciences 
Organisation University of Oxford
Department Nuffield Division of Clinical Laboratory Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution BEST-D study leads
Collaborator Contribution Shared blood samples for the BEST-D study. Undertaken study of impact of vitamin D on TRegulatory cells.
Impact Results are being written up
Start Year 2017
 
Description MADE trial 
Organisation Berkshire Healthcare NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Birmingham and Solihull Mental Health NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Cambridgeshire and Peterborough NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Camden and Islington NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Cornwall Partnership NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Coventry and Warwickshire Partnership NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Derbyshire Healthcare NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Kent and Medway NHS and Social Care Partnership Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Leeds and York Partnership NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Leicestershire Partnership NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Lincolnshire Partnership NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Manchester Mental Health and Social Care NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation NHS Ayrshire and Arran
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Norfolk and Suffolk NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Northamptonshire Healthcare NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Northumberland, Tyne and Wear NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Nottinghamshire Healthcare NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Oxford Health NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Solent NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation South London and Maudsley (SLAM) NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation South Staffordshire and Shropshire Healthcare NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation St George's Healthcare NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Surrey and Borders Partnership NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation Sussex Partnership NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation University Hospitals of Leicester NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description MADE trial 
Organisation West London Mental Health NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution CTSU co-ordinates the trial.
Collaborator Contribution Local collaborators screen, recruit and follow-up trial participants.
Impact None.
Start Year 2013
 
Description ORION-4 
Organisation The Medicines Company
Country Global 
Sector Private 
PI Contribution New trial HPS-4/TIMI 65/ORION-4, collaboration with The Medicines Company on a large scale outcomes study of inclisiran. Funding agreed December 2017 from the Medicines Company to the University of Oxford. Further collaboration with TIMI study group and Harvard University to coordinate the trial.
Collaborator Contribution Funding for the study
Impact n/a
Start Year 2017
 
Description UK HARP III 
Organisation Aberdeen Royal Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Dorset County Hospital NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Leicester General Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Manchester Royal Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Nottingham University Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Oxford University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Plymouth Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Portsmouth Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Princess Royal Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Queen Elizabeth Hospital Birmingham
Country United Kingdom 
Sector Hospitals 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Royal Berkshire NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Royal Derby Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Royal Devon and Exeter Hospital
Country United Kingdom 
Sector Academic/University 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Royal Free Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Royal Stoke University Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Salford Royal NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Sheffield Teaching Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation Southmead Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation The Royal Wolverhampton NHS Trust
Country United Kingdom 
Sector Academic/University 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description UK HARP III 
Organisation York Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution study lead
Collaborator Contribution recruitment of study participants
Impact n/a
Start Year 2015
 
Description CTTI webinar Apr15 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Webinar: Translating Qulity by Design Principles into Practice
Year(s) Of Engagement Activity 2015
 
Description CTTI webinar July 15 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Webinar: Quality by Design Project: Recommendations and Toolkit
Year(s) Of Engagement Activity 2015
 
Description Co-chair of Global risk-based monitoring 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Sept 2018, Carol Knott invited as speaker and co-chair of 2 day conference: Global Risk-based Monitoring. Run in London for 60 attendees: Pharmaceutical Industry Quality Assurance Directors from across Europe. Outcome was sharing of methods of providing trial oversight without huge expenditure on routine on-site visits.
Year(s) Of Engagement Activity 2018
 
Description Communication with trial participants 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Ongoing communication with trial participants (ASCEND, REVEAL - lipids) by means of study newsletters
Year(s) Of Engagement Activity 2015
 
Description HTMR webinar Clinical trials safety and regulation: application of risk-based methodological approaches 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented HTMR webinar
Year(s) Of Engagement Activity 2016
URL https://htmr-ctsu.webex.com/htmr-ctsu/lsr.php?RCID=a33108f72e6431f22764126000ccda0c
 
Description Media interviews at ESC congress 2017 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Series of media interviews undertaken by Martin Landray and Louise Bowman as a result of the publication of results of the REVEAL Trial. The results were announced at ESC Congress, August 2017 in Barcelona. Interviews with a wide variety of media organisations from around the globe.
Year(s) Of Engagement Activity 2017
 
Description Oxford Open Doors 2018 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Oxford Open Doors 2018- various members of staff presented at this event in October 2018
Year(s) Of Engagement Activity 2018
 
Description PPI - PIRRIST 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact A collaboration between CTSU and DPH to run PIRRIST (Developing a patient and public involvement intervention to enhance recruitment and retention in surgical trials)
This project seeks to evaluate current PPI practice in UK surgical trials, and is supported by the MRC Network of Hubs for Trials Methodology with a £50,000 project grant (commenced Jan 2016)
RB= Lead Applicant (Co-applicants: Jo Crocker, Jonathan Cook, Shaun Treweek, Sian Rees and Alan Chant)
Year(s) Of Engagement Activity 2015
 
Description PPI meeting for Six Counties Kidney Patient Association 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Richard Haynes spoke at a patient meeting for the Six Counties Kidney Patient Association in May. He spoke about the need for randomized trials in nephrology to an audience of around 30 dialysis patients or their relatives.
Year(s) Of Engagement Activity 2015
 
Description Participant meeting for REVEAL 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Emily Sammons presented an update on the REVEAL trial at a participant meeting at the Royal Berkshire hospital on October 21st 2015. Around 50 participants attended.
Year(s) Of Engagement Activity 2015
 
Description Press release: 3C study - kidney transplant drug halves the risk of early rejection and is less toxic 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Media coverage:

http://www.brightsurf.com/news/headlines/99059/Kidney_transplant_drug_halves_the_early_risk_of_rejection_and_allows_less_toxic_treatment.html
http://medicalxpress.com/news/2014-07-kidney-transplant-drug-halves-early.html
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61095-3/fulltext


None.
Year(s) Of Engagement Activity 2014
 
Description Workshop - Effective Monitoring in Clinical Trials 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact May 2018, Carol Knott Invited by University of Oslo to run a day long workshop: Effective Monitoring in Clinical Trials for 30 Monitors and Quality Assurance Managers from across Norway. The focus was on performing a trial risk assessment and implementing 'risk-based monitoring'. Follow-up advice also provided about identifying 'trigger factors' for making on-site visits.
Year(s) Of Engagement Activity 2018
 
Description Workshop - Engaging tricky sites: hints and tips 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact May 2018, Carol Knott Invited to run an In-Conference workshop at Society for Clinical Trials (SCT 2018) Portland, Oregon, US: Engaging tricky sites: hints and tips. The focus was on managing research sites through the trial life-cycle, to maximize efficiency of recruitment and maintaining compliance. Worked with international panel self, plus 3 others to deliver workshop for 80 attendees. Follow-up advice has been sought and provided to 3 workshop attendees from US Universities developing monitoring plans
Year(s) Of Engagement Activity 2018