Defining Signatures of Function and Selection within the Human Genome Sequence

Lead Research Organisation: MRC Functional Genetics Unit

Abstract

The sequencing of the human genome was a tremendous feat whose impact is beginning to be felt in the development of new therapies. However, the end of sequencing also marked the beginning of a long journey of discovery. We still need to understand how the different elements of our genomes make us more or less susceptible to diseases, and how our genome makes us different from other animals, including the chimpanzee. To help us on this journey, the genome sequences of many humans and of other animals have been, and will be, sequenced. Layered onto these genomes is functional information that can reveal the genetic switches that distinguish one cell type from another. In our genomic investigations we will often find things that are surprising, and will give us a better understanding of the large amount of functional DNA which, because it doesn’t make protein, we have previously considered ‘junk’. At the end of this journey we will have traversed the entire human genome -- 3 billion letters of it -- and pinpointed the DNA that, when changed, cause disease or else make us different from our evolutionary cousins.

Technical Summary

This work is narrowing the divide between a rapidly-increasing volume of genomic data and a less-rapidly expanding breadth of understanding of biological function. Its principal goal is to determine molecular mechanisms that contribute to human disease.
Overview
Sequencing the human genome was an enormous technological feat. The challenge for forthcoming years is to understand the molecular bases of human biology and disease using the insights that evolutionary analyses of this sequence afford. Only then will technological and conceptual advances be translated efficiently towards the clinic. Costs of genome sequencing and resequencing are plummeting, with costs halving every 12-20 months. Clearly, the steady trickle of genome sequences is becoming a torrent. The genomes of tens of thousands of patients, all model organisms, most mammals and primates, human parasites and pathogens will soon be available. Data management, analysis and interpretation are presenting huge logistical challenges. Nevertheless, these data have the exciting potential to link genotype variation at single base, kb and Mb scales to phenotypic differences that are relevant to the prevention, diagnosis and treatment of human disease.
Aims
Our research is placed at the intersection between disease genomics, computational biology and molecular mechanism determination. We are exploiting RNA and DNA sequence data to illuminate the molecular pathoetiology of human disease. We are beginning to develop transcriptional atlases for cells and tissues in order to better understand their functional repertoires. Our primary aim is, however, to exploit all genome-scale data sets to identify or prioritise genes that are mutated in human disease. For example, we have a large programme of work investigating the genetic variants that underlie the onset of Parkinson’s disease. Our computational-experimental RNA research (co-funded under an ERC Advanced Grant, with the Liu group) is identifying noncoding RNAs that explain the molecular mechanisms of Mendelian and complex neurological disorders. The group is also working with colleagues at the Sanger Institute to develop approaches to sequence DNA or RNA from single cells.

Organisations

Publications

10 25 50
 
Description Data Working Group reporting to the Chief Medical Officer, 2013
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Genomics Advisory Board task and finish group: Clinical Bioinformatics for Health Education England
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact Our findings will lead to an improvement in the use of genomic medicine in the NHS in the years to come.
URL http://www.nhsconfed.org/~/media/Confederation/Files/Events/ACE14/Playing%20our%20part%20Genomics%20...
 
Description MRC / RCUK advice to the Migration Advisory Committee, 2013
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Member of the Academy of Medical Sciences Committee on Training. This is setting the agenda for careers for clinical and nonclinical researchers.
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Improving the career structure will enhance the impact of investments in the workforce. This benefit will be captured quantitatively in the years to come.
 
Description Ponting - Advice re Scottish Highers Qualifications
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in advisory committee
 
Description BBSRC Project Grant (Defining the functional landscapes of metazoan genomes)
Amount £195,676 (GBP)
Funding ID BB/F007590/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2008 
End 06/2011
 
Description Berrow Lord Florey Scholarship (DQN)
Amount £110,000 (GBP)
Organisation Swiss National Science Foundation 
Sector Public
Country Switzerland
Start 10/2004 
End 09/2007
 
Description CJ Martin Biomedical Fellowship (MC)
Amount $165,334 (AUD)
Organisation National Health and Medical Research Council 
Sector Public
Country Australia
Start 01/2014 
End 12/2017
 
Description Clarendon Fund / Balliol College / German National Merit Foundation Scholarship (JP)
Amount £110,000 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 01/2006 
End 12/2008
 
Description Clarendon Scholarship (JT)/Keble College
Amount £82,608 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description Clarendon Scholarship (JT)/Keble College
Amount £15,000 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description Darwin Trust Scholarship (VC)
Amount £100,020 (GBP)
Organisation British Society for the History of Science (BSHS) 
Department Darwin Trust of Edinburgh
Sector Academic/University
Country United Kingdom
Start 10/2011 
End 09/2014
 
Description Delivering ELIXIR-UK
Amount £1,106,828 (GBP)
Funding ID BB/L005069/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2014 
End 12/2016
 
Description EC Marie Curie Fellowship (AM)
Amount £164,863 (GBP)
Organisation Marie Sklodowska-Curie Actions 
Sector Academic/University
Country Global
Start 01/2010 
End 01/2012
 
Description EMBO Long Term Fellowship (LSP)
Amount £53,248 (GBP)
Organisation European Molecular Biology Organisation 
Sector Learned Society
Country European Union (EU)
Start 09/2008 
End 09/2010
 
Description EMBO Long-Term Fellowship (MC)
Amount £63,384 (GBP)
Organisation European Molecular Biology Organisation 
Sector Learned Society
Country European Union (EU)
Start 07/2014 
End 06/2016
 
Description European Research Council Grant (DARCGENs)
Amount £1,883,830 (GBP)
Funding ID 249869 
Organisation European Research Council (ERC) 
Sector Public
Country European Union (EU)
Start 05/2010 
End 04/2015
 
Description Fischer Trust Research Grant/Fischer Trust (SM)
Amount £196,873 (GBP)
Organisation Fischer Family Trust (FFT) 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2010 
End 07/2013
 
Description GENCODYS Research Grant
Amount £564,089 (GBP)
Funding ID HEALTH-F4-2010 -241995 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 05/2010 
End 04/2015
 
Description Human Brain Project
Amount € 661,250 (EUR)
Funding ID 604102 
Organisation European Commission 
Department Future and Emerging Technologies
Sector Public
Country European Union (EU)
Start 10/2013 
End 03/2016
 
Description MRC Bioinformatics Training Fellowship (CN)
Amount £224,772 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2009 
End 08/2012
 
Description MRC Biomedical Informatics Training Fellowship (GL)
Amount £156,878 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2005 
End 12/2008
 
Description MRC Strategic Programme award (CGAT)
Amount £2,500,000 (GBP)
Funding ID MC_EX_G1000902 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 08/2010 
End 07/2015
 
Description NSERC Scholarship (JT)/Keble College
Amount £38,738 (GBP)
Organisation Natural Sciences and Engineering Research Council of Canada (NSERC) 
Sector Public
Country Canada
Start 10/2010 
End 09/2013
 
Description New College Cambridge, Marshall Scholarship (TGB)
Amount £72,745 (GBP)
Organisation Marshall Scholarship 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2008 
End 10/2011
 
Description Nuffield Department of Medicine Scholarship (YL)
Amount £134,778 (GBP)
Organisation University of Oxford 
Department Nuffield Department of Medicine
Sector Academic/University
Country United Kingdom
Start 10/2011 
End 09/2014
 
Description Parkinson's UK Discovery Award
Amount £307,431 (GBP)
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2010 
End 01/2015
 
Description Post-doctoral fellowship (MF)
Amount £39,250 (GBP)
Organisation National Science Foundation (NSF) 
Sector Public
Country United States
Start 09/2010 
End 09/2011
 
Description Postdoctoral fellowship - AM
Amount £22,063 (GBP)
Organisation New University of Lisbon 
Department Foundation for Science and Technology
Sector Academic/University
Country Portugal
Start 04/2009 
End 01/2010
 
Description Postdoctoral fellowship - AM
Amount £26,573 (GBP)
Organisation Swiss National Science Foundation 
Sector Public
Country Switzerland
Start 04/2008 
End 03/2009
 
Description Self-funded DPhil studentship (H-JN)/Self-funded
Amount £109,388 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 01/2010 
End 10/2013
 
Description Singapore Bio-medical Research Council, A*STAR Graduate Academy DPhil (XH)
Amount £173,560 (GBP)
Organisation Agency for Science, Technology and Research (A*STAR) 
Sector Public
Country Singapore
Start 10/2012 
End 09/2016
 
Description Wellcome Trust Investigator Award
Amount £2,082,846 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Senior Investigator Award
Sector Private
Country United Kingdom
Start 09/2015 
End 08/2020
 
Description Wellcome Trust Research Training Fellowship (AH)
Amount £234,010 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2013 
End 08/2016
 
Description Wellcome Trust Strategic Award
Amount £2,400,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 12/2019
 
Description Wellcome Trust Technology Development Award
Amount £1,476,355 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2015 
End 07/2020
 
Description Wellcome Trust/NIH Scholarship (CW)
Amount £70,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2011 
End 09/2015
 
Title Comparative computational genomics 
Description The mouse genome sequencing project provided the first opportunity to compare two mammalian genome sequences. My group led the comparison of human and mouse genes, and produced several analyses focused on evolutionary rates and gene family changes that have since been the benchmark for similar studies. 
Type Of Material Improvements to research infrastructure 
Year Produced 2006 
Provided To Others? Yes  
Impact I believe that we provided the standard for subsequent studies. 
 
Title Mouse cortical cell layer transcriptomes 
Description Full annotations of protein coding and non-coding transcripts across 6 cortical cell layers 
Type Of Material Improvements to research infrastructure 
Year Produced 2011 
Provided To Others? Yes  
Impact Website with substantial numbers of visitors downloads: http://genserve.anat.ox.ac.uk/layers 
 
Title Neutral indel model 
Description A new evolutionary model that is able to: (a) predict the amount and location of functional sequence in animal genomes; and (b) assess the quality of genome sequence assemblies. 
Type Of Material Improvements to research infrastructure 
Year Produced 2006 
Provided To Others? Yes  
Impact The findings that ~3% of the human genome is functional and conserved in mouse, and that a further ~7% is functional and not conserved in mouse. 
 
Title OPTIC: database of orthologues and paralogues 
Description Database of orthologues and paralogues in amniotes (including mammals), fruit flies and nematode worms. 
Type Of Material Improvements to research infrastructure 
Year Produced 2008 
Provided To Others? Yes  
Impact OPTIC orthology assignments were added to HCOP http://www.genenames.org/cgi-bin/hcop.pl (June 15, 2009) 
URL http://www.genenames.org/cgi-bin/hcop.pl
 
Title Neutral Indel model (2014) 
Description Determination of the regions of the human genome that are functional. 
Type Of Material Data analysis technique 
Year Produced 2014 
Provided To Others? Yes  
Impact Considerable media and scientific attention leading to a paradigm shift in what is considered the functional elements in our genome. 
 
Description A ChIP-seq defined genome-wide map of vitamin D receptor binding: implications for disease and evolution 
Organisation University of Oxford
Department Nuffield Department of Clinical Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis of ChIP-Seq data and integration/analysis of multiple diverse data types.
Collaborator Contribution Data generation required for this project.
Impact High-profile publication in Genome Research and much media interest.
Start Year 2009
 
Description Abp gene duplications in diverse mammals 
Organisation University of Washington
Department Division of Medical Genetics
Country United States 
Sector Academic/University 
PI Contribution Analyses of the evolution of Abp genes in diverse mammalian genomes
Impact PMID: 18269759
Start Year 2007
 
Description Accurate estimation of gene evolutionary rates using XRATE 
Organisation University of California, Berkeley
Department Department of Bioengineering
Country United States 
Sector Academic/University 
PI Contribution Accurate Estimation of Gene Evolutionary Rates Using XRATE, with an Application to Transmembrane Proteins
Impact PMID: 19380462
Start Year 2007
 
Description Aicardi-Goutières syndrome genes 
Organisation University of Leeds
Department Leeds Institute of Molecular Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Prediction of the function, structure and evolution of genes mutated in Aicardi-Goutieres syndrome.
Impact PMID: 16845400
Start Year 2006
 
Description Aicardi-Goutières syndrome genes #2 
Organisation Medical Research Council (MRC)
Department MRC Human Genetics Unit
Country United Kingdom 
Sector Public 
PI Contribution Prediction of the evolution, structure and function of Aicardi-Goutieres syndrome genes.
Impact PMID: 16845400
Start Year 2006
 
Description Analysis of the orang utan genome 
Organisation Washington University in St Louis
Department Genome Center
Country United States 
Sector Academic/University 
PI Contribution Analysis of the orang utan genome sequence
Collaborator Contribution Privileged access to the orang utan genome sequence
Impact High profile publication and greater awareness of genetic evidence for diversity of existing orangs.
Start Year 2010
 
Description Anolis lizard genome project 
Organisation Broad Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution In-depth analysis of Anolis lizard genome sequence
Collaborator Contribution Privileged access to unpublished data
Impact High profile publication in Nature and press coverage
Start Year 2009
 
Description CENP-A chaperones Scm3 and HJURP 
Organisation Wellcome Trust
Department Wellcome Trust Centre for Cell Biology
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Determination that CENP-A chaperones Scm3 and HJURP are homologous
Impact PMID: 19563746
Start Year 2008
 
Description Convergent evolution of platypus and reptile venom genes 
Organisation University of Sydney
Department Faculty of Veterinary Science
Country Australia 
Sector Academic/University 
PI Contribution Analyses of the evolution of venom genes.
Impact PMID: 18463304
Start Year 2007
 
Description Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair 
Organisation University of Dundee
Department MRC Protein Phosphorylation and Ubiquitylation Unit
Country United Kingdom 
Sector Public 
PI Contribution Prediction of the evolution and function of SLX4/BTBD12.
Impact PMID: 19595721
Start Year 2008
 
Description Copy Number Variants in Health and Disease 
Organisation Radboud University Nijmegen
Department Radboud Institute for Molecular Life Sciences (RIMLS)
Country Netherlands 
Sector Academic/University 
PI Contribution Analyses of the evolution of CNVs observed in the normal human population, and prediction of causative genes underlying learning disability.
Impact PMID: 18687881 PMID: 19557186
Start Year 2007
 
Description Copy number variants in autism 
Organisation Hospital for Sick Children, Toronto
Country Canada 
Sector Hospitals 
PI Contribution Analysis of copy number variants in autism and prediction of strong candidate genes for autism disorders.
Collaborator Contribution Identification of copy number variants in autism
Impact High-profile publication in Nature.
Start Year 2009
 
Description Evolution of Prdm9, a determinant of recombination crossover position 
Organisation Fred Hutchinson Cancer Research Center (FHCRC)
Country United States 
Sector Charity/Non Profit 
PI Contribution Determined the complex and rapid evolution of this important gene across animal evolution.
Collaborator Contribution Strong intellectual contribution to project that enabled publication in a high impact journal.
Impact Publication of an important manuscript in a high impact journal, as well as interest from the meda (including New Scientist).
Start Year 2008
 
Description Evolution of mammalian ejaculate proteins 
Organisation University of Liverpool
Department School of Veterinary Science Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis of the evolution of mammalian ejaculate proteins.
Impact PMID: 18032407
Start Year 2006
 
Description G&T-Sequencing 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Contribution to method development; data analysis.
Collaborator Contribution Central contributions to method development; data analysis
Impact Scientific publication. Multi-disciplinary collaboration: bioinformatics/experimental. Method being commercialised.
Start Year 2013
 
Description GENCODYS, Cognitive Disorders FP7 
Organisation Radboud University Nijmegen Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution The FP7 GENCODYS project is a European collaboration spanning many institutions across Europe working together on understanding the genetic contributions to cognitive disorders. Our contributions to this project are to predict the candidate genes whose disruption leads to cognitive impairment.
Impact The GENCODYS project was awarded in 2009 although the grant will start early in 2010.
Start Year 2009
 
Description Genome analysis of the platypus 
Organisation University of Washington
Department Genome Institute
Country United States 
Sector Academic/University 
PI Contribution Comparisons of platypus genes with genes from other amniotes.
Impact PMID: 18464734
Start Year 2007
 
Description Genome assembly quality: assessment and improvement using the neutral indel model 
Organisation University of Washington
Department Genome Institute
Country United States 
Sector Academic/University 
PI Contribution Development of a computational method to assess genome assembly quality.
Collaborator Contribution Technical expertise in genome assembly quality.
Impact High profile publication and continued application of new method to subsequent genome assemblies.
Start Year 2009
 
Description Genome of the marsupial Monodelphis domestica 
Organisation Broad Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution Analysis of the genome of the marsupial, Monodelphis domestica
Impact PMID: 17495919
Start Year 2006
 
Description Homology of Treslin/Ticrr and Sld3 
Organisation Cancer Research UK
Department Cancer Research UK London Research Institute (LRI)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Analysis of Sld3/Treslin sequences.
Collaborator Contribution Expertise in Treslin/Sld3 function.
Impact High-profile publication in Current Biology.
Start Year 2009
 
Description KMT2/Set1 histone lysine methyltransferase 
Organisation Medical Research Council (MRC)
Department MRC Cancer Cell Unit
Country United Kingdom 
Sector Public 
PI Contribution Computational analysis of KMT2/Set1 histone lysine methyltransferase sequence.
Collaborator Contribution Experimental studies of KMT2/Set1 histone lysine methyltransferase.
Impact Publication of results.
Start Year 2008
 
Description Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes 
Organisation National Institutes of Health (NIH)
Department National Human Genome Research Institute (NHGRI)
Country United States 
Sector Public 
PI Contribution In-depth analysis of noncoding RNA sequence.
Collaborator Contribution Sequencing and intellectual contribution to project.
Impact High-profile publication in Genome Biology.
Start Year 2007
 
Description MMS22L-TONSL Complex in recombination 
Organisation University of Dundee
Department MRC Protein Phosphorylation and Ubiquitylation Unit
Country United Kingdom 
Sector Public 
PI Contribution In-depth sequence analysis.
Collaborator Contribution Experimental data and analysis.
Impact High-profile publication in Molecular Cell.
Start Year 2009
 
Description Mouse Genome Sequencing Consortium #1 
Organisation National Center for Biotechnology Information (NCBI)
Country United States 
Sector Public 
PI Contribution Comparison of predicted gene models from the mouse and the human genomes.
Impact PMID: 19468303
Start Year 2006
 
Description Mouse Genome Sequencing Consortium #2 
Organisation The Jackson Laboratory
Country United States 
Sector Charity/Non Profit 
PI Contribution Comparisons of the predicted gene models from the mouse and human genome sequences.
Impact PMID: 19468303
Start Year 2006
 
Description Mouse cortical cell transcriptome study 
Organisation National Cancer Institute (NCI)
Country United States 
Sector Public 
PI Contribution Analysis and interpretation of RNASeq data from mouse cortical cell layers.
Collaborator Contribution Provision of high throughput RNA Seq data.
Impact High profile publication and press coverage. Website: http://genserve.anat.ox.ac.uk/layers
Start Year 2009
 
Description Mouse strains' genomes project 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution In-depth analyses of genomic data
Collaborator Contribution Privileged access to unpublished data
Impact High profile publication in Nature
Start Year 2009
 
Description Mutations in BMP4 
Organisation University of Oxford
Department Department of Physiology, Anatomy and Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution Predictions of the consequences of mutations in BMP4.
Impact PMID: 18252212
Start Year 2007
 
Description PAK3- and PIM1-like Kinase Gene Families in the Zebra Finch 
Organisation Oregon Health and Science University
Country United States 
Sector Academic/University 
PI Contribution Identification and analysis of zebra finch kinase genes.
Collaborator Contribution Contribution of experimental evidence supporting theoretical predictions resulting in publication of results.
Impact Publication of results.
Start Year 2009
 
Description REC-1 and HIM-5 in double stranded break formation 
Organisation Francis Crick Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Successful prediction of evolution and function
Collaborator Contribution Experimental validation of prediction
Impact Scientific publication. Multi-disciplinary: bioinformatics plus experimental project.
Start Year 2014
 
Description Rare and heterogeneous developmental delay syndromes. 
Organisation Children's Hospital of Philadelphia
Department Division of Human Genetics and Molecular Biology
Country United States 
Sector Hospitals 
PI Contribution Predicted genes underlying rare and heterogeneous developmental delay syndromes.
Collaborator Contribution Access to confidential patient data.
Impact Greater understanding of rare variants in a common and complex set of disorders.
Start Year 2010
 
Description Retinitis pigmentosa genes 
Organisation University College London
Department Institute of Ophthalmology UCL
Country United Kingdom 
Sector Academic/University 
PI Contribution Prediction of the evolution, function and structure of retinitis pigmentosa genes.
Impact PMID: 18836446 PMID: 17924349
Start Year 2007
 
Description Sld3 project 
Organisation Cancer Research UK
Department Cancer Research UK London Research Institute (LRI)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Better understanding of Sld3 evolution
Collaborator Contribution Privileged access to unpublished experimental data.
Impact High profile publication
Start Year 2010
 
Description Songbird gene evolution 
Organisation Uppsala University
Department Department of Evolution, Genomics and Systematics
Country Sweden 
Sector Academic/University 
PI Contribution Analysis of bird gene evolutionary rates.
Collaborator Contribution Analysis of gene evolution in birds.
Impact High-profile publication in Genome Biology.
Start Year 2009
 
Description Stc1: A Critical Link between RNAi and Chromatin Modification Required for Heterochromatin Integrity 
Organisation Wellcome Trust
Department Wellcome Trust Centre for Cell Biology
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Determination of evolutionary relationships for Stc1.
Collaborator Contribution Experimental data that demonstrated that Stc1 associates with RITS on centromeric transcripts and recruits CLRC, thereby coupling RNAi to chromatin modification.
Impact Publication of very high impact publication in Cell.
Start Year 2009
 
Description Structural and Mechanistic Insights Into RA Domains of Phospholipase C Epsilon 
Organisation Institute of Cancer Research UK
Country United Kingdom 
Sector Academic/University 
PI Contribution Prediction of structure, function and evolution of RA domains in PLC epsilon.
Impact PMID: 16483931
Start Year 2006
 
Description Structure-function mapping of BbCRASP-1 
Organisation University of Oxford
Department Department of Biochemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Structure, function and evolution predictions for BbCRASP-1.
Impact PMID: 16530476
 
Description The genome sequence of a songbird 
Organisation University of Washington
Department Genome Institute
Country United States 
Sector Academic/University 
PI Contribution Analysis of zebra finch protein coding genes.
Collaborator Contribution Sequencing of the zebra finch genome
Impact High-profile publication in Nature, as well as widespread media interest.
Start Year 2008
 
Description The obesity-associated FTO gene #1 
Organisation University of Oxford
Department Department of Physiology, Anatomy and Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution Prediction of the function, structure and evolution of the FTO gene and protein.
Impact PMID: 17991826
Start Year 2006
 
Description The obesity-associated FTO gene #2 
Organisation University of Oxford
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Prediction of the evolution, function and structure of the FTO gene and product.
Impact PMID: 17991826
Start Year 2006
 
Description The obesity-associated FTO gene #3 
Organisation University of Cambridge
Department Institute of Metabolic Science (IMS)
Country United Kingdom 
Sector Academic/University 
PI Contribution Prediction of the evolution, function and structure of the FTO gene and protein.
Impact PMID: 17991826
Start Year 2006
 
Description The protein composition of mitotic chromosomes 
Organisation Wellcome Trust
Department Wellcome Trust Centre for Cell Biology
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Sequence analysis of identified proteins.
Collaborator Contribution Generation and analysis of protein data.
Impact High-profile publication in Cell.
Start Year 2009
 
Description UIF, a New mRNA Export Adaptor 
Organisation University of Sheffield
Department Department of Molecular Biology and Biotechnology
Country United Kingdom 
Sector Academic/University 
PI Contribution Prediction of the evolution and function of UIF.
Impact PMID: 19836239
Start Year 2008
 
Title A Method for Assaying FTO (2-Oxoglutarate Dependent Oxygenase) Activity 
Description An assay for the activity of FTO, a protein whose gene's variants are implicated in obesity. http://www.wipo.int/pctdb/en/wo.jsp?WO=2008155556 
IP Reference US2010216832 
Protection Patent granted
Year Protection Granted 2010
Licensed Commercial In Confidence
Impact Not known
 
Description 'Health in the Headlines' panel discussion - Cheltenham 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact CP took part in 'Health in the Headlines' panel discussion and audience question and answer session at the Cheltenham Science Festival, chaired by Prof Robert Winston

Greater awareness in the general public about the impact of genomics on future health issues.
Year(s) Of Engagement Activity 2010
 
Description Article- Sciencemag.org - Feb 2011 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Quoted in an article for sciencemag.org about titled "Human Genome 10th Anniversary- Will Computers Crash Genomics?"



Greater appreciation of the importance of computational genomics among the general public.
Year(s) Of Engagement Activity 2011
URL http://www.sciencemag.org/content/331/6018/666.full
 
Description BBC Discussion- The Forum Aug 2011 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Chris Ponting took part in BBC World Service programme: 'The Forum' discussing "In genetics, what is the nature of the biological barriers that keep species separate?" http://www.bbc.co.uk/programmes/p00jcgmx. http://www.bbc.co.uk/programmes/p004kln9/episodes/player

Greater awareness among hte world service audience of the parallels between 'walls' in science (in speciation, and in defining organisms) and 'walls' used in common parlance.
Year(s) Of Engagement Activity 2011
URL http://www.bbc.co.uk/programmes/p004kln9/episodes/player
 
Description BBC Radio 4 Today programme interview (Aug 2011) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact C.P. - Gene activity in mammals' brains mapped for the first time opening window on diseases like Parkinson's and Alzheimer's. Radio 4 Today programme interview

no actual impacts realised to date
Year(s) Of Engagement Activity 2011
URL http://news.bbc.co.uk/today/hi/today/newsid_9572000/9572445.stm.
 
Description BBC Radio 4 interview (2010) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact C.P. interviewed by Richard Dawkins as part of the series "The Age of the Genome" broadcast on BBC Radio 4, 9pm. Davies and Ponting interviews with Richard Dawkins as part of the series "The Age of the Genome" broadcast on

no actual impacts realised to date
Year(s) Of Engagement Activity 2010
URL http://www.bbc.co.uk/programmes/p008r4l4
 
Description BBC Radio 4 interview (December 2012) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact C.P interviewed about ENCODE on Radio 4 Frontiers science programme. http://www.bbc.co.uk/programmes/b01p424w
http://www.bbc.co.uk/programmes/b01p424w

no actual impacts realised to date
Year(s) Of Engagement Activity 2012
URL http://www.bbc.co.uk/programmes/b01p424w
 
Description BBC World Service Broadcast (Aug 2011) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact C.P. took part in BBC World Service programme: 'The Forum' discussing "In genetics, what is the nature of the biological barriers that keep species separate?"

no actual impacts realised to date
Year(s) Of Engagement Activity 2011
URL http://www.bbc.co.uk/programmes/p00jcgmx
 
Description Cambridge Triple Helix debate 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact CP was a panel member in a debate entitled "Battle of the Sciences" hosted by the Cambridge Triple Helix (undergraduate society) on 28 October in Cambridge.



Substantial interest from undergraduate science students on the various routes taken in academic career progression.
Year(s) Of Engagement Activity 2010
 
Description Contributed to an Acad Med Sci event at IBM in London June 2013 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Chris Ponting contributed to an Acad Med Sci event at IBM in London - 'Crossing the great divide? Moving between academia and industry'.


Greater awareness/understanding of UK industry of genomics and the work of both the FGU and MRC
Year(s) Of Engagement Activity 2013
 
Description Disability art and science 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Contributor to the "Resonant Frequency: Disability art and science" project at Science Oxford, 7 December 2007.

Eventually project folded due to lack of funds.
Year(s) Of Engagement Activity 2007
 
Description Feature in Daily Mail online 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact C.P. - Gene activity in mammals' brains mapped for the first time opening window on diseases like Parkinson's and Alzheimer's. Daily Mail online, 24/08/2011. University press release: http://www.ox.ac.uk/media/news_stories/2011/110825.html. http://www.dailymail.co.uk/sciencetech/article-2029730/Gene-activity-brain-mapped-time-help-Parkinsons-Alzheimers.html

http://www.ox.ac.uk/media/news_stories/2011/110825.html.

no actual impacts realised to date
Year(s) Of Engagement Activity 2011
URL http://www.ox.ac.uk/media/news_stories/2011/110825.
 
Description Feature in MRC Network magazine Autumn 2012 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Bioinformatics Fellow's (CN) work developing facial recognition software featured in the Autumn 2012 edition of MRC Network magazine, in recognition of his recent award of Centenary funding


Greater awareness of work of FGU amongst MRC community
Year(s) Of Engagement Activity 2012
 
Description Feature in University of Oxford staff magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Ponting group work on the zebra finch genome was featured in Blueprint, the Staff magazine for the University of Oxford.
Feature on work on the zebra finch genome in Blueprint, the Staff magazine for the University of Oxford.

no actual impacts realised to date
Year(s) Of Engagement Activity 2010
 
Description Genetics Society News article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact CP wrote an article "DNA Trust and Error" for the July 2010 issue of "Genetics Society News" (issue 63, pp46-47).

Greater awareness within scientific disciplines of the importance of this issue.
Year(s) Of Engagement Activity 2010
 
Description Interview Radio 4 Frontiers science programme, December 2012 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Chris Ponting interviewed about ENCODE on Radio 4 Frontiers science programme.

Greater national awareness/understanding of genomics and the work of both the FGU and MRC
Year(s) Of Engagement Activity 2012
URL http://www.bbc.co.uk/programmes/b01p424w
 
Description Interview- Radio 4 Aug 2011 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Chris Ponting - Gene activity in mammals' brains mapped for the first time opening window on diseases like Parkinson's and Alzheimer's. Radio 4 Today programme interview. http://news.bbc.co.uk/today/hi/today/newsid_9572000/9572445.stm.

Greater awareness among the UK public of the importance of knowing which genes are active in the brain.
Year(s) Of Engagement Activity 2011
URL http://news.bbc.co.uk/today/hi/today/newsid_9572000/9572445.stm
 
Description Interview- SFARI.org Sept 2011 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Chris Ponting and Zoltan Molnar (DPAG) discussed their new report in Neuron of the transcriptomic atlas of gene expression in the mouse brain with Virginia Hughes, reporter with the autism news website sfari.org. Article published on SFARI's website: https://sfari.org/news-and-opinion/news/2011/researchers-map-gene-expression-in-layers-of-mouse-brain

Greater awareness among families with individuals with autism of the fundamental research focused on understanding neurodevelopmental conditions.
Year(s) Of Engagement Activity 2011
URL https://sfari.org/news-and-opinion/news/2011/researchers-map-gene-expression-in-layers-of-mouse-brai...
 
Description Item re Human Brain Project award on BBC Science and Environment page. January 2013 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Announcement of 1bn euro awarded to Human Brain Project which Chris Ponting is involved in. Item on BBC Science and Environment page.


Greater national awareness of involvement of both the FGU and MRC in genomics and brain research
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/news/science-environment-21231960
 
Description Lecture - Lee Middle School, Silver Springs, Maryland 27th May 2011 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Grant T Belgard (NIH DPhil student, Ponting Group) gave a talk at Middle School Career day, Col E Brooke Lee Middle School, Silver Springs, Maryland (pupils aged 10-13 years).

Greater enthusiasm from school students for science.
Year(s) Of Engagement Activity 2011
 
Description Lecture - Shady Grove Middle School May 2011 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact T Grant Belgard (NIH DPhil Student, Ponting Group) gave a talk at a STEM expo, Shady Grove Middle School, Howard County, Maryland (Pupils age 10-12)

Greater enthusiasm from school students for science.
Year(s) Of Engagement Activity 2011
 
Description Letter to the Guardian newspaper 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Ponting and Talbot wrote a letter to the Guardian newspaper protesting at Oliver James' insistence that "genes play little part in how our children turn out" http://www.guardian.co.uk/science/2010/jan/28/genetics-dna-neurobiology-family-parenting

Greater awareness of the role of genomics in diagnosing and treating neurodevelopmental disorders.
Year(s) Of Engagement Activity 2010
URL http://www.guardian.co.uk/science/2010/jan/28/genetics-dna-neurobiology-family-parenting
 
Description MRC stand at the Cheltenham Science Festival 9-10 June 2011 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Tamara Sirey (DARCGENs post-doc), Charlotte Tibbit (DARCGENs research assistant), and Sian Davies (Lui DTA student) attended the Cheltenham Science Festival and helped out on the MRC stand 9-10 June 2011

Greater awareness among the general public of MRC activities.
Year(s) Of Engagement Activity 2011
 
Description MRC stand at the Oxford Science Festival 26 Feb 2011 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Chris Rands (Ponting DTA student), Tamara Sirey (DARCGENs post-doc), Jennifer Tan (Clarendon DPhil student) and Joana Figueiredo (Kevin Talbot MSc student) all volunteered on the MRC stand at the Oxford Science Festival

Greater enthusiasm from the UK public for science.
Year(s) Of Engagement Activity 2011
 
Description Media coverage of Genome Research paper on Vitamin D 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CP and AH co-authors on Genome Research paper on: Insufficient exposure to sunshine, resulting in low levels of vitamin D, could play a part in a wide-range of diseases, from multiple sclerosis to rheumatoid arthritis, type 1 diabetes, some cancers and even dementia, Reported in Guardian, Financial Times, Independent, Daily Mail, Metro, Scotsman. Also:



Contribution to a wider push towards new health guidelines on vitamin D levels.
Year(s) Of Engagement Activity 2010
 
Description Media coverage of PLos Genetics Article that only 8.2 of human DNA has functional role (July 2014) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Wide international coverage of paper in Plos Genetics by CP and former students/staff CR, SM and GL: "8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage" http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004525. Coverage between 24 - 28 July 2014 in:
The Guardian - http://www.theguardian.com/science/2014/jul/24/10-percent-human-dna-functional-genome-biological-baggage
Daily Mail - http://www.dailymail.co.uk/sciencetech/article-2704534/Only-TENTH-human-DNA-does-important-rest-just-junk.html
The Daily Telegraph - http://www.telegraph.co.uk/science/science-news/10988624/90-per-cent-of-human-DNA-does-nothing-at-all-scientists-find.html
NBC News online (USA) - http://www.nbcnews.com/science/science-news/beyond-lucy-10-percent-brain-myth-debunked-how-about-junk-n164286
LiveScience.com (USA) - http://www.livescience.com/46986-human-genome-junk-dna.html
Yahoo News (USA), via LiveScience - http://news.yahoo.com/people-just-8-2-dna-study-finds-182422711.html
Business Standard (India), via ANI newswire - http://www.business-standard.com/article/news-ani/merely-8-2-percent-of-dna-functional-in-human-beings-114072500404_1.html
3 News New Zealand - http://www.3news.co.nz/90-percent-of-DNA-just-filler---study/tabid/1160/articleID/354418/Default.aspx
German Daily News - http://www.sueddeutsche.de/wissen/genetik-nur-bruchteil-der-dna-soll-funktional-sein-1.2061295
University of Oxford : http://www.ox.ac.uk/news/2014-07-25-82-our-dna-%E2%80%98functional%E2%80%99


Better understanding by general public of functional role of DNA
Year(s) Of Engagement Activity 2014
URL http://www.theguardian.com/science/2014/jul/24/10-percent-human-dna-functional-genome-biological-bag...
 
Description Media coverage of zebra finch genome 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CP and AH were interviewed about the zebra finch genome on BBC1 South Today and BBC Radio Oxford and this was also covered by the Daily Mail http://www.dailymail.co.uk/sciencetech/article-1262738/Could-songbird-teach-secrets-speech.html, ABC (USA), http://abcnews.go.com/Technology/wireStory?id=10251162, and the Times of India, http://timesofindia.indiatimes.com/life/health-fitness/health/Songbirds-help-cure-autism/articleshow/5753633.cms

Greater international awareness of genomics research performed by the MRC FGU.
Year(s) Of Engagement Activity 2010
URL http://www.dailymail.co.uk/sciencetech/article-1262738/Could-songbird-teach-secrets-speech.html
 
Description Media interviews on genomes 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with national and international media (print, radio and web-based) on the following genome projects: marsupial, platypus and mouse.

Interviewed as part of a Nature podcast for the platypus genome project: http://uk.youtube.com/watch?v=iFzSqqEHBP8 Generated spoof article: http://www.newsbiscuit.com/2009/06/29/tedious-scientists-hail-uninspiring-mouse-genome-breakthrough/ !
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description Meeting and Presentation- Parkinson's Disease Charity/PDUK Setp 2011 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Chris Ponting involved with Parkinson's Disease charity and patient/carers groups via meeting and presentations to the Oxford PDUK branch

Participation of people with Parkinson's in OPDC review and activities.
Year(s) Of Engagement Activity 2011
 
Description Nature news article (Sep 2012) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact C.P. quoted in news article in Nature on 'ENCODE: The human encyclopaedia' Nature489,46-48(06 September 2012), http://www.nature.com/news/encode-the-human-encyclopaedia-1.11312

no actual impacts realised to date
Year(s) Of Engagement Activity 2012
URL http://www.nature.com/news/encode-the-human-encyclopaedia-1.11312
 
Description Organised Genetics Society Communication Workshop, April 2013 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Chris Ponting coorganised a Genetics Society Communication Workshop at which a member of his group was a presenter and two FGU graduate students were interviewed by the Naked Scientists.

Greater national awareness/understanding amongst scientists of genomics and the work of both the FGU and MRC
Year(s) Of Engagement Activity 2013
URL http://www.thenakedscientists.com/HTML/podcasts/specials/show/20130425-2/
 
Description Oxford Science Blog - Human Genome 10th anniversary 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact CP contributed to an Oxford Science Blog in the run up to the tenth anniversary of the announcement of the Human Genome Draft sequence. http://www.ox.ac.uk/media/science_blog/100326.html.

Greater international awareness of genomics research performed by the MRC FGU.
Year(s) Of Engagement Activity 2010
URL http://www.ox.ac.uk/media/science_blog/100326.html
 
Description Oxford Science Blog - Human Genome 10th anniversary 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact C.P. contributed to an Oxford Science Blog in the run up to the tenth anniversary of the announcement of the Human Genome Draft sequence.

no actual impacts realised to date
Year(s) Of Engagement Activity 2010
URL http://www.ox.ac.uk/media/science_blog/100326.html.
 
Description Parliamentary Question 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Research into the molecular etiology of learning disability was referred to in a recent response to a Parliamentary Question: http://www.theyworkforyou.com/wrans/?id=2009-01-27b.250129.h.

Not known
Year(s) Of Engagement Activity 2009
URL http://www.theyworkforyou.com/wrans/?id=2009-01-27b.250129.h
 
Description Participant in Radio 4's Material World programme. March 2013 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Chris Ponting took part in a discussion entitled "Is junk DNA really rubbish?" aired on Radio 4's Material World programme.


Greater national awareness/understanding of genomics and the work of both the FGU and MRC
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/programmes/b01qwhtp
 
Description Public seminars on Darwin 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Darwin Festival, Cambridge. 6-10th July, 2009, invited by Prof Patrick Bateson, to mark the 200th anniversary of Darwin's birth. Talk available from http://sms.cam.ac.uk/media/667391 Interviewed by the 'Naked Scientist' website. Also gave talk at the Bath Royal Literary and Scientific Institution, http://www.brlsi.org/darwin2009/science.html.

Not known.
Year(s) Of Engagement Activity 2009
 
Description Quoted in Nature, Sept 2012 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CP quoted in news article in Nature on 'ENCODE: The human encyclopaedia' Nature489,46-48(06 September 2012), http://www.nature.com/news/encode-the-human-encyclopaedia-1.11312


Greater international awareness of involvement of both the FGU and MRC in genomics research
Year(s) Of Engagement Activity 2012
URL http://www.nature.com/news/encode-the-human-encyclopaedia-1.11312
 
Description Quoted in New Scientist, Sept 2012 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CP quoted re ENCODE in article in New Scientist on 'The ever deepening mystery of the human genome' http://www.newscientist.com/article/mg21528810.300-the-ever-deepening-mystery-of-the-human-genome.html?full=true


Greater international awareness of involvement of both the FGU and MRC in genomics research
Year(s) Of Engagement Activity 2012
URL http://www.newscientist.com/article/mg21528810.300-the-ever-deepening-mystery-of-the-human-genome.ht...
 
Description Quoted in Sciencemag.org article 27th May 2011 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Chris Ponting quoted in news article in Science article on "Disease Risk Links To Gene Regulation." www.sciencemag.org/content/332/6033/1031.full.pdf
Science Vol 332 27th May 2011

Improved awareness that DNA changes linked to gene regulation are important for disease.
Year(s) Of Engagement Activity 2011
URL http://www.sciencemag.org/content/332/6033/1031.full.pdf
 
Description Quoted in Scientific American re ENCODE project, April 2013 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Chris Ponting quoted in Scientific American over results from the ENCODE project.


Greater international awareness of involvement of both the FGU and MRC in genomics research
Year(s) Of Engagement Activity 2013
URL http://www.scientificamerican.com/article.cfm?id=friction-over-function-encode
 
Description Quoted in the Wall Street Journal, Sept 2012 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CP quoted re ENCODE in article in The Wall Street Journal on''Junk DNA' Debunked' http://online.wsj.com/article/SB10000872396390443589304577633560336453228.html


Greater international awareness of involvement of both the FGU and MRC in genomics research
Year(s) Of Engagement Activity 2012
URL http://online.wsj.com/article/SB10000872396390443589304577633560336453228.html
 
Description Quoted- Parkinson's UK 2011 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Chris Ponting is quoted in a piece written by Parkinson's UK on the Monument Discovery Award for their magazine, Progress (with a circulation of 30,000), on the Parkinson's project being undertaken by the OPDC in Oxford.

Participation of people with Parkinson's in OPDC review
Year(s) Of Engagement Activity 2011
 
Description Radio 4 interview - 'The Age of the Genome' series 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CP interviewed by Richard Dawkins as part of the 4 part series "The Age of the Genome" broadcast on BBC Radio 4, 9pm, June - July 2010

Greater international awareness of genomics research performed by the MRC FGU.
Year(s) Of Engagement Activity 2010
URL http://www.bbc.co.uk/programmes/p008r4l4
 
Description Radio interview - Australian Broadcasting Corporation 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Professor C.P. was interviewed by Robyn Williams for ABC's The Science Show. http://www.abc.net.au/radionational/programs/scienceshow/genome-research---achievements-and-hopes/3073444
Chris Ponting was interviewed by Robyn Williams for ABC's The Science Show.

no actual impacts realised to date
Year(s) Of Engagement Activity 2010
URL http://www.abc.net.au/radionational/programs/scienceshow/genome-research---achievements-and-hopes/30...
 
Description Radio interview - Australian Broadcasting Corporation (ABC) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview on Australian Broadcasting Corporation radio's The Science Show:
http://www.abc.net.au/rn/scienceshow/stories/2010/2780299.htm on the Ponting group's contributions to mouse, opossum and platypus genome sequencing projects

Greater international awareness of genomics research performed by the MRC FGU.
Year(s) Of Engagement Activity 2010
URL http://www.abc.net.au/rn/scienceshow/stories/2010/2780299.htm
 
Description Represented Unit at MRC Centenary Mini Science Festival, Oxford, June 2013 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Helped to man the Unit stall/exhibits and talk to public at the MRC Centenary Mini Science Festival in Bonn Square, Oxford, 22 June 2013


Greater local public awareness of research work undertaken by the Unit and MRC
Year(s) Of Engagement Activity 2013
 
Description School Visit - Oxford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Schools
Results and Impact Taking a year 6 lesson on genetics: introduction to genes, genomes and DNA changes.

Enthusing students!
Year(s) Of Engagement Activity 2006,2007
 
Description School Visit- Shady Grove Middle School, Maryland- 26 Feb 2011 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact T Grant Belgard (NIH DPhil Student, Ponting Group) Judged poster at Shady Grove Middle School, Howard County STEM (Science, Technology, Engineering, Mathematics) Fair, Howard Country Maryland

Greater enthusiasm from school students for science.
Year(s) Of Engagement Activity 2011
 
Description School- Work Experience April 2011 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact John-Paul Flavell took part in a school work placement shadowing Chris Rands and Charlottle Tibbit.

Greater enthusiasm from a UK school student for science.
Year(s) Of Engagement Activity 2011
 
Description SciBar Public Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact General Public Talk on "In your DNA - the Evolutionary Journey of your Genome" SciBar
Year(s) Of Engagement Activity 2015
 
Description Science Festival - Volunteer at MRC stand Oxford Science Festival Feb 2012 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact MRC DTA student (CR) helped out at the Oxford Science Festival


Promoting science within the region and raising profile of the work of both the FGU and MRC
Year(s) Of Engagement Activity 2012
 
Description Science Panelist for AskScience 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Christoffer Nellaker (Ponting Group) under a psueudonym acts as a science panelist on the "AskScience" section of the social bookmarking site Reddit. This is an ongoing activity where users ask questions and scientists post replies, frequently leading to extended discussions. Beyond the science related questions sometimes questions are posted to the entire Reddit community giving further oppoortunities for public engagement. The AskScience subsection of Reddit has over 50,000 subscribing users and AskReddit has over 300,000.

Greater enthusiasm from international general public for science and science questions.
Year(s) Of Engagement Activity 2010,2011
 
Description Science in Theatre production Sept 2012 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact CP involved in Science in Theatre - helping with production intended for school age children to be held at the Pegasus Theatre


Promoting science within the region and raising profile of the work of both the FGU and MRC
Year(s) Of Engagement Activity 2012
 
Description Twitter communication of PLos Genetics paper (August 2014) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Chris Ponting used social media website "Twitter" to share news of Plos Genetics paper that only 8.2 of human DNA has functional role. The tweet received 14044 Page Views in less than 1 month.


Better understanding of functional role of DNA by an even wider number of general public
Year(s) Of Engagement Activity 2014
 
Description University press release- Daily Mail Online Aug 2011 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Chris Ponting - Gene activity in mammals' brains mapped for the first time opening window on diseases like Parkinson's and Alzheimer's. Daily Mail online, 24/08/2011. University press release: http://www.ox.ac.uk/media/news_stories/2011/110825.html.

Greater awareness in the UK public of the importance of knowing which genes are active in the brain.
Year(s) Of Engagement Activity 2011
URL http://www.ox.ac.uk/media/news_stories/2011/110825.html
 
Description Visit from theatre producers May 2012 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact May 30 - CP hosted Jonny Heron (theatre director), Nomi Everall (producer) and Kirsten Shepherd-Barr (drama academic) to discuss plans for science-based drama and so that they could observe genetics/genomics in action.


Greater local awareness of involvement of both the FGU and MRC in genomics research
Year(s) Of Engagement Activity 2012
 
Description Wall Street Journal article 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact C.P. quoted re ENCODE in article in The Wall Street Journal on''Junk DNA' Debunked' http://online.wsj.com/article/SB10000872396390443589304577633560336453228.html

no actual impacts realised to date
Year(s) Of Engagement Activity 2012
URL http://online.wsj.com/article/SB10000872396390443589304577633560336453228.html
 
Description Work Experience- Nuffield Science Bursary Scheme Aug 2011 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Dr Kristin Nicodemus hosted a year 12 student, Marianne Pearson, from Henry Bx School, Witney, Oxfordshire School as part of the Nuffield Science Bursary scheme co-ordinated by Science Oxford for students in the Oxford area. The programme offers a 4-6 week placement for year 12 students (aged 17) during the summer holiday where they either complete or contribute to a piece of STEM research which is then written up as a project or project report.

Renewed enthusiasm from a year 12 student for science
Year(s) Of Engagement Activity 2011
 
Description Work quoted in New Scientist Article- 16 Feb 2011 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Chris Ponting's work was quoted in New Scientist article " Evoluton's X Factor: Shuffling up new species."

www.newscientist.com/article/mg20927991.500-evolutions-x-factor-shuffling-up-new-species.html?full=true

Better appreciation among the general public on the current scientific understanding of how speciation occurs.
Year(s) Of Engagement Activity 2011
URL http://www.newscientist.com/article/mg20927991.500-evolutions-x-factor-shuffling-up-new-species.html...
 
Description Writers/scientists collaboration project 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Volunteered to contribute to the writers/scientists collaboration project, working with PEN (http://www.writersservices.com/mag/m_pen.htm). Result in: http://www.englishpen.org/aboutenglishpen/partnerships/medicalresearchcouncil

Contribution towards the understanding of science and scientists by writers.
Year(s) Of Engagement Activity 2007
URL http://www.writersservices.com/mag/m_pen.htm