Disease Model Discovery
Lead Research Organisation:
MRC Mammalian Genetics Unit
Abstract
We remain ignorant of the function of the majority of genes in both the human and mouse genomes, and the roles they play in development, physiology and disease. Given the similarities between mouse and human and their respective genomes, one approach to understanding gene function in humans is to mutate the gene in the mouse and comprehensively study the characteristics (or phenotypes) that result from the mutation. A major focus of research at the MRC Harwell Institute is to undertake large-scale mutagenesis and phenotyping programmes to generate a comprehensive catalogue of mammalian gene function. MRC Harwell is a key participant in the International Mouse Phenotyping Consortium (IMPC) whose goals are to generate and characterise a mutant for every gene in the mouse genome. IMPC by the end of 2017 will have mutated and analysed around one-third of all the genes in the mouse genome. A particular focus at MRC Harwell and across other centres in the IMPC is to better identify and characterise genes that result in age-related disease. The burden on society from such diseases is increasing year on year and it is important that we address our limited understanding to develop new therapies and treatments. Many of the mutant lines studied by IMPC are being aged in order to find genes that when mutated cause age-related disease. MRC Harwell is studying a broad spectrum of diseases affecting quality of life in the aged, including deafness, diabetes and neurodegenerative diseases.
Technical Summary
The aim of the Disease Model Discovery programme is to generate novel mouse models of disease providing a key resource for the elucidation and characterisation of new genes and pathways involved with diverse disease systems. The programme delivers a critical underpinning to our intramural research programmes at MRC Harwell, as well as furnishing a wider platform for gene and pathway discovery for the biomedical sciences community within the UK and abroad. Currently, large-scale mutagenesis and phenotyping platforms at MRC Harwell focus on the International Mouse Phenotyping Consortium (IMPC) pipeline for the generation and identification of mouse models.
The IMPC mutagenesis and phenotyping pipeline is a key ongoing programme for the discovery of novel genes associated with both early-onset and late-onset disease phenotypes. However, there is an increasing focus on the delivery of late-onset phenotypes. Diseases associated with ageing pose an increasing social and financial burden on society and represent a vital imperative for research in the biomedical sciences. There have been considerable advances, for example through GWAS studies, in identifying putative loci and pathways involved in diseases of ageing. Nevertheless, our knowledge of the genes and pathways involved with late-onset disease is neither comprehensive nor complete. As part of MRC funding to Programme 1 over the next five years we plan to introduce over 100 genes into the IMPC pipeline encompassing both early-onset and late-onset phenotyping platforms. This effort will be supplemented by additional funding from the NIH which will enable us to feed a further ~200 genes into the IMPC pipeline for the determination of both early and late-onset phenotypes. Proposals for genes to enter late-onset phenotyping will be sought via the regular calls to the UK community for gene nominations as part of the wider IMPC effort at MRC Harwell. In line with the wider IMPC programme, all data is freely available and deposited in the IMPC database – see www.mousephenotype.org.
For the future the bulk of null mutations that enter the IMPC pipeline will be generated by CRISPR/Cas9. In addition, with funding from Strategy Board, the MRC has established the new GEMM (Genome Editing Mice for Medicine) programme at MRC Harwell, utilising the CRISPR/Cas9 route to introduce additional types of alleles, such as point mutations, enabling for example investigators to introduce and analyse human point mutations. This programme underpins the high demand across the human and clinical genetics communities for access to models of rare and Mendelian disorders. Moreover, it is an important pillar in the Genomics England and Precision Medicine Initiative in the US. MRC Harwell has established a collaboration with Genomics England and it is expected that many of the mutants generated in the GEMM programme will be pivotal in the validation and analysis of loci identified through the 100,000 genomes project.
In summary, Programme 1 at MGU Harwell is at the forefront of delivering mutants, disease models and data that are a critical pillar for functional genomics studies across the biomedical sciences spectrum and provide key resources for understanding the genetic bases for disease and an important tool for the development of novel therapeutic strategies.
The IMPC mutagenesis and phenotyping pipeline is a key ongoing programme for the discovery of novel genes associated with both early-onset and late-onset disease phenotypes. However, there is an increasing focus on the delivery of late-onset phenotypes. Diseases associated with ageing pose an increasing social and financial burden on society and represent a vital imperative for research in the biomedical sciences. There have been considerable advances, for example through GWAS studies, in identifying putative loci and pathways involved in diseases of ageing. Nevertheless, our knowledge of the genes and pathways involved with late-onset disease is neither comprehensive nor complete. As part of MRC funding to Programme 1 over the next five years we plan to introduce over 100 genes into the IMPC pipeline encompassing both early-onset and late-onset phenotyping platforms. This effort will be supplemented by additional funding from the NIH which will enable us to feed a further ~200 genes into the IMPC pipeline for the determination of both early and late-onset phenotypes. Proposals for genes to enter late-onset phenotyping will be sought via the regular calls to the UK community for gene nominations as part of the wider IMPC effort at MRC Harwell. In line with the wider IMPC programme, all data is freely available and deposited in the IMPC database – see www.mousephenotype.org.
For the future the bulk of null mutations that enter the IMPC pipeline will be generated by CRISPR/Cas9. In addition, with funding from Strategy Board, the MRC has established the new GEMM (Genome Editing Mice for Medicine) programme at MRC Harwell, utilising the CRISPR/Cas9 route to introduce additional types of alleles, such as point mutations, enabling for example investigators to introduce and analyse human point mutations. This programme underpins the high demand across the human and clinical genetics communities for access to models of rare and Mendelian disorders. Moreover, it is an important pillar in the Genomics England and Precision Medicine Initiative in the US. MRC Harwell has established a collaboration with Genomics England and it is expected that many of the mutants generated in the GEMM programme will be pivotal in the validation and analysis of loci identified through the 100,000 genomes project.
In summary, Programme 1 at MGU Harwell is at the forefront of delivering mutants, disease models and data that are a critical pillar for functional genomics studies across the biomedical sciences spectrum and provide key resources for understanding the genetic bases for disease and an important tool for the development of novel therapeutic strategies.
Organisations
- MRC Mammalian Genetics Unit, United Kingdom (Lead Research Organisation)
- University of Oxford, United Kingdom (Collaboration)
- University College London, United Kingdom (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- Royal Free Hospital (Collaboration)
- Medical Research Council (Collaboration)
- Washington University in St Louis, United States (Collaboration)
- Unlisted (Collaboration)
- University of Cambridge (Collaboration)
- University of Liverpool, United Kingdom (Collaboration)
- Academic Medical Center (Collaboration)
- University of Manchester, Manchester, United Kingdom (Collaboration)
- University of Nottingham (Collaboration)
Publications

Acevedo-Arozena A
(2008)
ENU mutagenesis, a way forward to understand gene function.
in Annual review of genomics and human genetics

Acevedo-Arozena A
(2011)
A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis.
in Disease models & mechanisms

Achilli F
(2009)
An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy.
in Disease models & mechanisms

Anstee QM
(2013)
Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition.
in Nature communications

Ashrafian H
(2010)
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.
in PLoS genetics

Ayadi A
(2012)
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.
in Mammalian genome : official journal of the International Mammalian Genome Society

Baker J
(2010)
Identification of a Z-band associated protein complex involving KY, FLNC and IGFN1.
in Experimental cell research

Banks G
(2015)
Genetic background influences age-related decline in visual and nonvisual retinal responses, circadian rhythms, and sleep.
in Neurobiology of aging

Banks GT
(2011)
Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.
in The Journal of neuroscience : the official journal of the Society for Neuroscience

Barbaric I
(2007)
Spectrum of ENU-induced mutations in phenotype-driven and gene-driven screens in the mouse.
in Environmental and molecular mutagenesis
Description | Brown report - Independent Investigation into Animal Research at Imperial College, London |
Geographic Reach | National |
Policy Influence Type | Membership of a guidance committee |
Description | Chair, Action on Hearing Loss Pauline Ashley Fellowship Review Panel (2018-19) |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
Description | Chair, Advisory Board, UK Centre for Macaques |
Geographic Reach | National |
Policy Influence Type | Participation in advisory committee |
Description | Chair, International Mouse Phenotyping Consortium (IMPC) Steering Committee |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in advisory committee |
Description | Co-Chair, Scientific Advisory Board, Helmholtz Centrum, Munchen |
Geographic Reach | National |
Policy Influence Type | Participation in advisory committee |
Description | GENCODE SAB |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a advisory committee |
URL | http://www.gencodegenes.org/ |
Description | Medical Sciences Division Genomics Oversight Committee |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Membership of a guideline committee |
Description | Scientific Advisory Board, Czech Centre for Phenogenomics (CCP) |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a advisory committee |
Description | Scientific Advisory Board, Fondation De Cooperation Voir et Entendre |
Geographic Reach | National |
Policy Influence Type | Participation in advisory committee |
Description | Scientific Advisory Board, Phenomin, Institut Clinique Souris, France |
Geographic Reach | Asia |
Policy Influence Type | Participation in advisory committee |
Description | Scientific Advisory Committee, Centre Intégratif de Génomique (CIG), University of Lausanne |
Geographic Reach | National |
Policy Influence Type | Participation in advisory committee |
Description | Scientific Advisory Committee, Centre Intégratif de Génomique (CIG), University of Lausanne |
Geographic Reach | National |
Policy Influence Type | Participation in advisory committee |
Description | Special Advisor, Australian Phenomics Network |
Geographic Reach | Australia |
Policy Influence Type | Participation in a advisory committee |
Description | Strategic Policy Committee, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), Strasbourg, France |
Geographic Reach | National |
Policy Influence Type | Participation in advisory committee |
Description | UK-China Joint Steering Group - promoting scientific and technological innovation and cooperation in Laboratory Animal Science |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
Description | Aged Rodent Bioresource |
Amount | £386,888 (GBP) |
Funding ID | 094270/Z/10/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 06/2011 |
End | 06/2016 |
Description | Centre Of Excellence in Osteoarthritis |
Amount | £4,500,000 (GBP) |
Funding ID | CA/20205 |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2013 |
End | 01/2018 |
Description | Characterization of a novel mouse model of ALS |
Amount | $23,000 (USD) |
Organisation | Johns Hopkins University |
Department | The Robert Packard Center for ALS Research at Johns Hopkins |
Sector | Charity/Non Profit |
Country | United States |
Start | 08/2011 |
End | 08/2012 |
Description | Create |
Amount | £53,500 (GBP) |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 11/2008 |
End | 10/2011 |
Description | Disease Model Discovery |
Amount | £5,865,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2015 |
End | 04/2020 |
Description | EMMA Service |
Amount | £1,093,669 (GBP) |
Organisation | European Commission |
Department | Seventh Framework Programme (FP7) |
Sector | Public |
Country | European Union (EU) |
Start | 01/2009 |
End | 12/2012 |
Description | Eucomm |
Amount | £222,811 (GBP) |
Funding ID | 18931 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2006 |
End | 12/2012 |
Description | Eumodic |
Amount | £793,928 (GBP) |
Funding ID | 37188 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 02/2007 |
End | 01/2012 |
Description | Fluorescence lifetime imaging of new functional biomaterials for non-invasive early tumour diagnosis |
Amount | £50,000 (GBP) |
Funding ID | ST/K002082/1 |
Organisation | Science and Technologies Facilities Council (STFC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2012 |
End | 06/2013 |
Description | Harwell MND model screen resource |
Amount | £10,000 (GBP) |
Organisation | Motor Neurone Disease Association (MND) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2008 |
End | 06/2008 |
Description | Harwell technology network |
Amount | £75,000 (GBP) |
Organisation | Intellectual Property Office (IPO) |
Sector | Public |
Country | United Kingdom |
Start | 03/2011 |
End | 04/2012 |
Description | Huntingtons disease |
Amount | £1,316,780 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2007 |
End | 12/2011 |
Description | IMPC |
Amount | £4,500,000 (GBP) |
Organisation | National Institutes of Health (NIH) |
Sector | Public |
Country | United States |
Start | 01/2011 |
End | 01/2016 |
Description | IMPC |
Amount | £3,000,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2011 |
End | 01/2016 |
Description | IMPC (MPI2) |
Amount | $5,120,596 (USD) |
Organisation | National Institutes of Health (NIH) |
Sector | Public |
Country | United States |
Start | 07/2016 |
End | 07/2021 |
Description | Infrafrontier |
Amount | £464,076 (GBP) |
Funding ID | 211404 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 03/2008 |
End | 12/2012 |
Description | MRC ENU Mutagenesis Programme |
Amount | £8,000,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2009 |
End | 03/2015 |
Description | Mitochondria Proximity to Discovery |
Amount | £5,300 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 02/2016 |
End | 08/2016 |
Description | Motor neuron disease mouse models |
Amount | £254,819 (GBP) |
Funding ID | 38/82 |
Organisation | Motor Neurone Disease Association (MND) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2009 |
End | 08/2012 |
Description | MouseAGE |
Amount | € 8,000,000 (EUR) |
Funding ID | BM1402 |
Organisation | European Research Council (ERC) |
Sector | Public |
Country | Belgium |
Start | 12/2014 |
End | 12/2018 |
Description | PhD studentship |
Amount | £69,000 (GBP) |
Organisation | University of Sheffield |
Department | Sheffield Medical School |
Sector | Academic/University |
Country | United Kingdom |
Start | 08/2011 |
End | 09/2014 |
Description | PhD studentship |
Amount | £110,000 (GBP) |
Organisation | Motor Neurone Disease Association (MND) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2011 |
End | 09/2014 |
Description | Summer Studentship |
Amount | £5,000 (GBP) |
Organisation | The Genetics Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2011 |
End | 08/2012 |
Description | role of TDP43 in motor neurons through studying a unique Tdp43 mutant mouse |
Amount | € 100,000 (EUR) |
Organisation | Thierry Latran Foundation |
Sector | Charity/Non Profit |
Country | France |
Start | 08/2009 |
End | 08/2011 |
Title | Disease Model Discovery |
Description | A new collection of mouse mutants, largely produced from the Harwell ENU mutagenesis pipeline, covering a plethora of novel disease models in a host of disease areas - neurology, neurodegeneration, behaaviour, metabolism (diabesity and obesity), bone, cardiovascular disease and sensory systems amongst others |
Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
Year Produced | 2006 |
Provided To Others? | Yes |
Impact | A range of new publications has arisen. In addition, a number of new disease models are now available that are supporting translational research using these pre-clinical disease models. Models of age-related disease are now being developed as part of the Harwell ageing screen |
Title | EuroPhenome |
Description | A database of phenotypes produced in the EUCOMM consortium |
Type Of Material | Biological samples |
Year Produced | 2009 |
Provided To Others? | Yes |
Impact | EuroPhenome has come to be regarded as a standard database for collecting and disseminating rich phenotypis data on mouse disease models |
URL | http://europhenome.org/ |
Title | Genetics and pathophysiology of deafness |
Description | New mouse mutant models of deafness have been identified, archived and characterised to reveal novel pathways involved with sensorineural hearing loss and otitis media |
Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
Year Produced | 2006 |
Provided To Others? | Yes |
Impact | Publications, distributed research material, as well as translational research supported through DGF grants from MRCT |
Title | International Mouse Phenotyping Consortium, IMPC |
Description | The International Mouse Phenotyping Consortium is undertaking the generation and phenotyping for mouse mutants for every gene in the mouse genome. This will provide the biomedical sciences community with the first catalogue of mammalian gene function, which will transform our understanding of genetic pathways involved with disease. |
Type Of Material | Biological samples |
Year Produced | 2012 |
Provided To Others? | Yes |
Impact | A new mouse mutant resource is coming into being, and a wealth of phenotype data on mouse mutants is now becoming available at www.impc.org |
Title | Shared Ageing Research Materials (ShARM) |
Description | Wellcome funded biobank of tissues from ageing rodents |
Type Of Material | Biological samples |
Year Produced | 2011 |
Provided To Others? | Yes |
Impact | Facilitated ageing research and acknowledgements in publications. 24085518 |
URL | https://www.sharmuk.org/ |
Title | IMPC |
Description | Phenotypic data generated by IMPC |
Type Of Material | Database/Collection of data |
Year Produced | 2013 |
Provided To Others? | Yes |
Impact | International availability of primary phenotyping data |
URL | http://www.europhenome.org/ |
Title | Mousebook |
Description | A data base of models and mutations with phenotyping data form the Harwell Ageing Screen |
Type Of Material | Database/Collection of data |
Year Produced | 2014 |
Provided To Others? | Yes |
Impact | International profile of Harwell data |
URL | http://mousebook.org/ |
Description | Ageing Disease Pathways |
Organisation | University of Liverpool |
Department | Institute of Integrative Biology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Generation of a conditional KO and developmental analysis of a global KO |
Collaborator Contribution | Idenitifcation of the gene as a imporant in ageing disease and in vivo analysis of the conditional KO |
Impact | Generation of a novel conditional KO and novel results on the developmental effects of the gene |
Start Year | 2013 |
Description | Ageing Genetics |
Organisation | University of Liverpool |
Department | Integrative Genomics of Ageing Group |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Generation of a conditional knock-out of a gene associated with age-related pathologies |
Collaborator Contribution | identification of the gene and in vitro studies |
Impact | Recent collaboration. Genetics and bioinformatics |
Start Year | 2012 |
Description | Ageing Muscle |
Organisation | University of Reading |
Department | Skeletal Muscle Research Group |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Collaborative research into ageing muscle. Identification of models with abnormal ageing muscle phenotypes. |
Collaborator Contribution | Expertise in msucle stem cell biology |
Impact | Publications arising PMIDs 22593017 26644908 |
Start Year | 2011 |
Description | Biology of ageing testes |
Organisation | University of Edinburgh |
Department | MRC Centre for Reproductive Health |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Generation of a conditional KO of a gene associated with age-related pathologies and provision of ageing control tissues |
Collaborator Contribution | expertise in reproductive biology |
Impact | The programme is at an early stage but initial results are expected early next year |
Start Year | 2013 |
Description | Bone |
Organisation | University of Oxford |
Department | Kennedy Institute of Rheumatology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | ENU mutagenesis pipelines, phenotyping, and mouse genetics expertise |
Collaborator Contribution | expertise in bone mineralisation disorders |
Impact | A large number of mutations with bone disorders have been obtained and are being characterised. Further novel age-related mutants have been identified and are undergoing charaterisation and mapping. PMIDs 22028304 21533022 22161748 25860694 28194447 27959934 26657825 |
Description | Cardiovascular |
Organisation | University of Oxford |
Department | Wellcome Trust Centre for Human Genetics |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Provided ENU mutagenesis pipelines and expertise in mouse genetics |
Collaborator Contribution | expertise in mouse cardiovascular systems |
Impact | 18519639, 20566713 |
Description | DVM project |
Organisation | University of Nottingham |
Department | School of Veterinary Medicine and Science Nottingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are hosting a Wellcome funded DVM placement for two years, providing training and supervision for a research project. |
Collaborator Contribution | Administration of funding and training programme |
Impact | We are undertaking a screen for models of defective DNA repair and susceptibility to lymphomas |
Start Year | 2013 |
Description | FSGS |
Organisation | Washington University in St Louis |
Country | United States |
Sector | Academic/University |
PI Contribution | Data from novel model of FSGS, samples sent to US for analysis |
Collaborator Contribution | provision of expertise and advice, research reagents such as antibodies |
Impact | Project has advanced, to be written up later in the year |
Start Year | 2015 |
Description | Glomerular Basement Membrane dysfunction |
Organisation | Washington University in St Louis |
Department | Department of Cell Biology and Physiology |
Country | United States |
Sector | Academic/University |
PI Contribution | We have identified a novel mutation in Lama5 resulting in chronic kidney disease and we are working with Prof Jeff Miner to characterise this in detail |
Collaborator Contribution | Expertise in glomerular basement membrane biology and reagents |
Impact | JM has provided reagents to enable us to carry out experiments and we have sent samples to him for EM analysis |
Start Year | 2015 |
Description | Liver |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | ENU mutagenesis pipelines and expertise in mouse genetics |
Collaborator Contribution | expertise in liver physiology and disease |
Impact | Identification of a novel mouse, the alcomouse, with high alcohol intake Idenitification of mice with increased sensitivity to paracetomol |
Description | Macrophage Function |
Organisation | University of Oxford |
Department | Sir William Dunn School of Pathology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of Mutant mice and genotypic characterisation of mutants |
Collaborator Contribution | Screening of macrophage function in mutant mice |
Impact | Novel Mutants affecting macrophage giant cell formation |
Start Year | 2006 |
Description | Macrophage Signalling Pathways |
Organisation | University of Oxford |
Department | Kennedy Institute of Rheumatology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of mutant tissues for analysis, expertise in mutagenesis and mouse genetics |
Collaborator Contribution | Expertise in analysis of macrophage function |
Impact | Identification of mutations affecting macrophage signalling which are currently undergoing further charcterisation and mapping |
Start Year | 2008 |
Description | Mitochondrial Dysfunction |
Organisation | University of Oxford |
Department | Nuffield Department of Obstetrics & Gynaecology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have identified mutants affecting mitochondrial function and giving rise to a number of phenotypes |
Collaborator Contribution | Expertise in the analysis of mitochondrial function |
Impact | Collaborative grant to fund meetings with industry |
Start Year | 2015 |
Description | Neurodegeneration |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | ENU mutagenesis and mouse genetics expertise in modifier screens |
Collaborator Contribution | expertise in Huntington's disease and cell biology systems for the study of HD |
Impact | Various modifier mutants, and interacting loci that are contributing to our understanding of HD pathways |
Start Year | 2006 |
Description | Neurodegeneration 2 |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | ENU mutagenesis, mouse genetics expertise, particularly in modifier screens |
Collaborator Contribution | expertise in motor neuron disease and genetics |
Impact | identified modifiers which will be the subject of future work and publications |
Start Year | 2007 |
Description | Neurodegeneration 3 |
Organisation | Medical Research Council (MRC) |
Department | MRC Laboratory of Molecular Biology (LMB) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | ENU mutagenesis and expertise in modifier screens |
Collaborator Contribution | expertise in tauopathies |
Impact | Modifier screens are underway |
Start Year | 2007 |
Description | Neuromuscular |
Organisation | University of Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | ENU mutagenesis and mouse genetics expertise, as well as expertise in neuromuscular genetics |
Collaborator Contribution | expertise in the neuromuscular junction development |
Impact | 19683573 19578180 |
Description | Novel models of Cardiac Disease |
Organisation | Academic Medical Center |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | We are undertaking a screen for novel models of cardiac disease. My group is undertaking ECG screening of mapping of mutant mice. providding genetics expertise. |
Collaborator Contribution | Providing expertise in cardiac electrophysiology and additonal phenotypic characterisation of mice |
Impact | We have identified a novel model of sudden cardiac death |
Start Year | 2013 |
Description | Osteoarthritis |
Organisation | University of Oxford |
Department | Kennedy Institute of Rheumatology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | This was a collaborative proposal to the ARUK to Fund a Centre of Excellence in Osteoarthritis. The MGU contribution is to provide expertise in mouse genetics and model generation |
Collaborator Contribution | Provision of disease expertise, clinical studies and cohorts, and epidmiology |
Impact | Succesful award of the Centre of Excellence |
Start Year | 2012 |
Description | Outbred Phenotyping |
Organisation | University of Oxford |
Department | Wellcome Trust Centre for Human Genetics |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Importation and phenotyping of outbred mice for QTL analysis and identification of contributory alleles |
Collaborator Contribution | Genotyping and analysis of mapping data |
Impact | Nicod et al Genome-wide association of multiple complex traits in outbred mice by ultra-low coverage sequencing. Nature Genetics, 2016, 48 (8): 912 (PMID 27376238) |
Start Year | 2008 |
Description | Renal Disease |
Organisation | Imperial College London |
Department | Section of Renal and Vascular Inflammation |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are undertaking detailed mapping and characterisation of renal mutants an dinvestigating genetic modifiers of disease. |
Collaborator Contribution | Expertise in models of Renal Disease Dr Paul K Potter has been awarded an Honorary Senior Lectureship with Imperial College |
Impact | We have mapped a novel model of Alports syndrome and are charcterising and mapping two further mutations. We are submitting a Wellcome Trust Training Fellowship proposal to identify genetic modifers of Alport Disease |
Start Year | 2009 |
Description | Renal GECIP |
Organisation | Royal Free Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Expertise in generation and analysis of mouse models of disease |
Collaborator Contribution | Expertise in clinical and basic renal research |
Impact | None yet |
Start Year | 2015 |
Description | Uteroplacental |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | ENU mutagenesis, mouse genetics expertise |
Collaborator Contribution | Expertise in uteroplacental disorders |
Impact | Several potential mutants with defects in uteroplacental function have been identified |
Start Year | 2007 |
Description | , American Society for Bone and Mineral Research |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited Lecture, Symposium, American Society for Bone and Mineral Research, Bone-omics: Translating Genomic Discoveries into Clinical Applications |
Year(s) Of Engagement Activity | 2017 |
Description | 2nd European Advanced School for Mouse Phenogenomics |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Presentation and contribution to workshop - Dr Paul K Potter |
Year(s) Of Engagement Activity | 2017 |
Description | 7th Molecular Pharmacology Workshop on Osteoarthritis |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited speaker- presented details of Ageing Screen programme and novel models of osteoarthrirtis |
Year(s) Of Engagement Activity | 2017 |
Description | A history of genetics at MRC Harwell |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | A presentation to 50 members of the public at the Vale and dowland museum Wantage. There was a great deal of interest and another presentation was requested for next year |
Year(s) Of Engagement Activity | 2013 |
Description | Alport International Workshop |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The presentation sparked discussion on appropriate models for research |
Year(s) Of Engagement Activity | 2014,2015 |
URL | http://www.alportuk.org/ |
Description | Animal Models for Therapeutic use |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentations to industry researchers, interest in novel models |
Year(s) Of Engagement Activity | 2010,2011,2012 |
Description | Annual Open day for schools |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | Yes |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Local School Children (GCSE level) come on a day to do hands on lab work in our custom built teaching lab. They meet scientists and learn about our research. These children have come back to do work experience in year 12 and summer studentships in their graduate studies. Some have come to do their Ph.D. subsequently. |
Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010,2011 |
Description | BBSRC working group |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Working group is formulating advice for BBSRC policy and funding of ageing research Information gathering and policy advice |
Year(s) Of Engagement Activity | 2014 |
Description | BSRA presentations |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Questions after presentations Requests for further information |
Year(s) Of Engagement Activity | 2014 |
Description | Botnar Institute presentation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Discussions after talk and potential new collaborations New interest in on-going research |
Year(s) Of Engagement Activity | 2014 |
Description | British Science Festival |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Presentation at the BSF to a mixed audience of approximmately 40 people. The talk was also videod and is avaiable on the understanding Animals in Research Website. |
Year(s) Of Engagement Activity | 2011 |
URL | http://www.youtube.com/watch?v=1ORRLseGhlQ |
Description | British Science Festival Birmingham |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Interest and questions from participants Questions from Audience demonstrated increased understanding |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.britishscienceassociation.org/british-science-festival/birmingham-2014 |
Description | Careers Fair Kineton High School |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Questions about careers and research |
Year(s) Of Engagement Activity | 2015 |
Description | Careers fair Shipston High School |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Questions about research |
Year(s) Of Engagement Activity | 2015 |
Description | Cheltenham Science Festival |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Direct discussions with members of the public Activities undertaken by memers of the public Answering questions from the public and explaining processes behind research |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.cheltenhamfestivals.com/science/ |
Description | Didcot Sixth Form |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Questions about science careers and research |
Year(s) Of Engagement Activity | 2015 |
Description | Downs School Career Fair |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Lots of questions from pupils better understanding of research careers |
Year(s) Of Engagement Activity | 2014 |
Description | European Society of Human Genetics |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Symposium Mouse phenotyping for clinical research, informed people on latest developments in mouse research |
Year(s) Of Engagement Activity | 2015 |
Description | European Teratology Society |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited speaker at international meeting. |
Year(s) Of Engagement Activity | 2015 |
Description | Harwell Genetics Course |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Training course in genetics: lots of interest and questions about techniques and research |
Year(s) Of Engagement Activity | 2015 |
Description | Harwell Genetics Training Course |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Training course in mouse genetics, participants reported they had learnt a lot |
Year(s) Of Engagement Activity | 2015 |
Description | Harwell Open Day |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | Yes |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Activity stands, DNA preparation Direct engagement with public. Improved understanding of research carried out at Harwell |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.har.mrc.ac.uk/news-events/news-archive/harwell-campus-family-fun-day |
Description | Harwell Campus Science Up Close open day |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other audiences |
Results and Impact | Lots of questions and interest in research |
Year(s) Of Engagement Activity | 2015 |
Description | I'm a Scientist (Ageing) |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | Sara Falcone won prize |
Year(s) Of Engagement Activity | 2015 |
Description | ICGEB Theoretical Course |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Lectures on Mouse Genetics; Models for Human Diseases. questions and interest in modelling disease |
Year(s) Of Engagement Activity | 2015 |
Description | ICMR Reading University |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on ShARM and Mouse AGE projects |
Year(s) Of Engagement Activity | 2016 |
Description | ICMR Reading university |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Research presentation at Reading university |
Year(s) Of Engagement Activity | 2015 |
Description | INFRAFRONTIER Industry and Innovation workshop |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited speaker, INFRAFRONTIER Industry and Innovation workshop, - Shared Ageing Research Materials and MouseAGE projects presented |
Year(s) Of Engagement Activity | 2017 |
Description | International Ageing and Martix Conference of the Wellcome Trust Centre for Cell Matrix Research |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Invited keynote presentation to conference |
Year(s) Of Engagement Activity | 2015 |
Description | Jerome S. Brody 2018 Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited presentation at Boston Medical School - Dr Paul K Potter |
Year(s) Of Engagement Activity | 2017 |
Description | Keynote Lecture on "Building the first comprehensive catalogue of a mammalian genome" as part of the 10th Anniversary Conference of the International Mouse Phenotyping Consortium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Study participants or study members |
Results and Impact | Important update to a worldwide conference on progress on the IMPC |
Year(s) Of Engagement Activity | 2021 |
Description | Keynote Lecture, 10th International Conference on Cholesteotoma and Ear Surgery |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Keynote lecture |
Year(s) Of Engagement Activity | 2016 |
Description | Keynote Lecture, FELASA Congress |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Keynote Lecture |
Year(s) Of Engagement Activity | 2017 |
Description | Keynote lecture "Building the first comprehensive catalogue of a mammalian genome" to Phenogemomics Conference at CCP, Prague, Czech Republic |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | A major talk to scientists at all levels in important issue for biomedical sciences |
Year(s) Of Engagement Activity | 2021 |
Description | LASA winter meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Keynote Presentation |
Year(s) Of Engagement Activity | 2015 |
Description | Larkmead School Career Fair |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Lots of questions better understanding of research careers |
Year(s) Of Engagement Activity | 2014 |
Description | London Matrix Group |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Extensive discussion afterwards and continued contact with new collaborators This talk has led directly to two new collaborations |
Year(s) Of Engagement Activity | 2014 |
Description | MRC Centenary Open Day |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | An Open day was organised with stalls displaying research areas, tours of facilities, activities, and presentations ~250 memebers of the public attended from children to U3A members |
Year(s) Of Engagement Activity | 2013 |
Description | MRC Harwell Festival |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Open day festival |
Year(s) Of Engagement Activity | 2014,2016 |
URL | http://www.har.mrc.ac.uk/mrc-festival |
Description | Magdalen College School Careers Fair |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | MRC stand allowed students to question about careers Better understanding of research careers |
Year(s) Of Engagement Activity | 2014 |
Description | Magdalen College School, Headington School |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Questions about research careers |
Year(s) Of Engagement Activity | 2015 |
Description | Mellanby Centre for Bone Research |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation to researchers in Sheffield. Young researchers Q+A session about career pathways and advice. New collaboration over bone uCT |
Year(s) Of Engagement Activity | 2015 |
Description | Mellanby Centre for Bone Research |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Invited Speaker - research presentation |
Year(s) Of Engagement Activity | 2016 |
Description | MouseAGE Training Course |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Organised training course on the use of mice in ageing, much discussion and follow up. feedback was very positive eg very informative workshop |
Year(s) Of Engagement Activity | 2015 |
Description | MouseAGE training School |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Training school for MouseAGE members of the use of mice in ageing studies. Tours of facilities and lectures |
Year(s) Of Engagement Activity | 2015 |
Description | NC3Rs working group |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Currently preparing paper for release. Expected to have international impact Paper for publication. Advice to NC3Rs |
Year(s) Of Engagement Activity | 2013,2014 |
Description | Oulu Post Gradaute Training Course |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Contributed to training course with research presentation and careers advice |
Year(s) Of Engagement Activity | 2012 |
Description | Oxford NC3Rs Day |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Invited speaker at NC3Rs meeting |
Year(s) Of Engagement Activity | 2017 |
Description | Oxford NC3Rs day |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation by Dr Paul K Potter at NC3Rs workshop on Ageing studies in mice |
Year(s) Of Engagement Activity | 2017 |
Description | Oxfordshire Science Festival-Bonn Square, Oxford |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | Yes |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Better understanding of brain function and dementia increased interest in genetics research |
Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014 |
URL | http://www.oxfordshiresciencefestival.com/about.html |
Description | Presentation at Reading University |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Research presentation led to new collaborations and connections |
Year(s) Of Engagement Activity | 2015 |
Description | Presentation at Renal Research Forum |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Interest in current research |
Year(s) Of Engagement Activity | 2015 |
Description | Presentation at Royal Free |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Research presentation resulted in new collaborations |
Year(s) Of Engagement Activity | 2015 |
Description | Presentation at University of Sheffield |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation to Mellanby Centre for Bone Research, presented to research professionals and students. Discussion with students on careers resulted in interest in variety of career paths and advice on progression. Interest in starting new collaborations |
Year(s) Of Engagement Activity | 2016 |
Description | Public Lecture on "Illuminating the Dark Genome: Bringing Insights in Gene Function to Genomic Medicine" John Curtin School of Medical Research, Canberra, Australia |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A public lecture on "Illuminating the Dark Genome: Bringing Insights in Gene Function to Genomic Medicine" given at the John Curtin School of Medical Research, Canberra, Australia to a wide but informed audience from the general public |
Year(s) Of Engagement Activity | 2018 |
Description | RIKEN Symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Advance of Mouse Phenotyping for Biomedical Research, RIKEN Symposium, Yokohama, Japan |
Year(s) Of Engagement Activity | 2015 |
Description | Radio 5 Live |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Live broadcast from the Mary Lyon Centre on national radio The programme recieved an industry award |
Year(s) Of Engagement Activity | 2013 |
Description | Renal Research Forum |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Research presentation to mainly clinical renal researchers at Imperial College |
Year(s) Of Engagement Activity | 2015 |
Description | Scouts visit to MRC Harwell |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Making DNA and hands on activity resulted in a better understanding of genetics research Sparked interest and questions |
Year(s) Of Engagement Activity | 2014 |
Description | St Birinus School visit to Harwell |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Plenty of discussion and questions better understanding of research infrastructure and model studies |
Year(s) Of Engagement Activity | 2014 |
Description | Students@Harwell committee poster competition |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Exchange of information and expertise surrounding research on site |
Year(s) Of Engagement Activity | 2015 |
Description | Swiss Lab Animal Science Association |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation by Dr Paul K Potter to Animal Sciences group on studying ageing mice |
Year(s) Of Engagement Activity | 2017 |
Description | U3A visit |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | U3A visit to learn more about research on site |
Year(s) Of Engagement Activity | 2017 |
Description | UAR Open Labs for Didcot Girls' School |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Stimulated questions about animal research and provided information |
Year(s) Of Engagement Activity | 2015 |
Description | UCL Centre for Nephrology |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Research presentation at the Royal Free Hospital |
Year(s) Of Engagement Activity | 2015 |
Description | University of the Third Age and Probus Club |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Presentations and practical demonstrations to visitors Great interest in return visits |
Year(s) Of Engagement Activity | 2011 |
Description | Womens Institute Talks |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Several presentations to Womens Instiute goups, including local groups and a presentation to the Annual Meeting The intial presentation has led to further request for local presentations and visits of the WI to MRC Harwell |
Year(s) Of Engagement Activity | 2008,2009,2010,2011 |