Mitochondrial Medicine

Lead Research Organisation: Medical Research Council

Abstract

This programme will allow us to identify new disease-genes and proteins, to investigate disease mechanisms, and to test new interventions for effective treatment of Mitochondrial Disorders, a group of genetic maladies characterized by dysfunction of oxidative phosphorylation (OXPHOS), the energy-supplying metabolic pathway carried out by the mitochondrial respiratory chain (MRC) complexes. Thirteen MRC protein subunits are encoded by mtDNA, which adds to the genetic, functional and structural complexity of OXPHOS, and of its disorders as well. The heterogeneity of mitochondrial disorders makes the identification of effective therapy an exceedingly difficult task. However, the elucidation of many of the pathophysiological features of these conditions give us now several clues for the development of therapeutic strategies, with the ultimate goal to cure mitochondrial disease.

Technical Summary

This project is aimed at identifying new genes responsible for mitochondrial disorders, characterized by isolated or combined defects of the mitochondrial respiratory chain (MRC) complexes by exome sequencing of human DNA samples using Illumina technology. An inter-institutional agreement between the MRC-MBU in Cambridge, UK and the Fondazione Istituto Neurologico Carlo Besta, Milan, Italy, allow us to get access to genomic DNA samples from numerous patients with biochemically defined mitochondrial diseases. To the same aim, collaborations have been established with other Research Centres in the UK, such as the Mitochondrial Disease Centre at the University of Newcastle and the Institute of Neurology at Queen Square in London; and abroad, e.g. the Max Planck Institute for Aging in Cologne, and the Institute of Human Genetics in Munich, Germany. We expect that the project will lead to the genetic definition of all or most of our cohort of probands, an achievement that will contribute to define the molecular-genetic basis of this vast group of conditions. The identification of new mitochondrial disease proteins is essential to further elucidate the pathogenesis of mitochondrial disorders, is important to complete our knowledge on the composition of the human mitochondrial proteome, and will contribute to the molecular characterization of mitochondrial energy-related pathways. This goal will be implemented by creating recombinant cell models for new mutant genes, in vitro characterization by proteomics approaches, and investigating suitable animal models, including mouse and zebrafish. Examples of gene products that will be studied include TTC19, an assembly factor for complex III; Mpv17, a mitochondrial protein of unknown function whose mutations cause profound depletion of mtDNA in livers of knockout mice and patients; FBXL4 and Apopt1, two proteins of unknown function associated with mtFDNA depletion and deficiency of cytochrome c oxidase, respectively; and Pitrm1, a mitochondrial protease we recently found mutated in patients showing a neurodegenerative disease. The molecular and functional characterization of new disease genes/proteins and pathways will underpin the development of rational therapeutic strategies. Effective therapy for OXPHOS diseases is missing. We have collected a huge series of mutant cell (fibroblast) lines and created numerous mouse recombinant lines with specific defects in genes associated with human mitochondrial disease. The availability of these tools will be exploited to develop experimental therapy transferable to humans. The translational agenda that will be implemented at the MBU will include three main strategies for experimental therapy, based on (a) Activators of mitochondrial biogenesis acting on the PGC1-alpha axis; (b) Gene replacement using adeno-associated viral vectors; (c) Xenogene targeting using alternative oxidases expressed in recombinant mouse lines.

Publications

10 25 50
 
Description FP7 ERC Advanced Grant
Amount € 2,004,200 (EUR)
Funding ID FP7-322424 
Organisation European Research Council (ERC) 
Sector Public
Country European Union (EU)
Start 07/2013 
End 06/2018
 
Title Mouse and cell lines 
Description Recombinant mouse lines for mitochondrial diseases and cell derivatives from primary human fibroblasts. 
Type Of Material Cell line 
Year Produced 2013 
Provided To Others? Yes  
Impact Publications. 
 
Title Next generation sequencing 
Description Whole exome sequencing of patients with mitochondrial disease aimed at identifying new oxphos-related genes relevant to human medicine. 
Type Of Material Biological samples 
Year Produced 2013 
Provided To Others? Yes  
Impact Several papers in high impact journals. 
 
Title Mitochondrial disease genes 
Description Development of database on new mitochondrial disease genes. 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact We have published a few papers on new mitochondrial disease genes. 
 
Title Recombinant Mouse models of mitochondrial disease 
Description We have developed numerous mouse lines of mitochondrial disease and have build up a database containing the genotypes, phenotypes and response to medications of these lines. 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact Our research is largely based on the study of mouse models both to understand the pathomechanisms of mitochondrial disease and test pharmacological or gene therapeutic approaches to mitigate the phenotype. 
 
Description Ashcroft 
Organisation University College London
Department Division of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaborative support for work on mitochondrial function.
Collaborator Contribution Provision of advice and reagents.
Impact ..
Start Year 2013
 
Description Auwerx 
Organisation Swiss Federal Institute of Technology in Lausanne (EPFL)
Department Laboratory of Integrative Systems Physiology (LISP)
Country Switzerland 
Sector Academic/University 
PI Contribution Identification of mitochondrial biogenesis.
Collaborator Contribution Testing cell lines.
Impact ..
Start Year 2013
 
Description Besta 
Organisation Carlo Besta Neurological Institute
Country Italy 
Sector Public 
PI Contribution Genetic analysis of patient DNA samples.
Collaborator Contribution Identification and characterisation of mitochondrial disease patients.
Impact Publications.
Start Year 2013
 
Description Dr Carlo Dionisi-Vici 
Organisation Ospedale Pediatrico Bambino Gesu (OPBG)
Country Italy 
Sector Hospitals 
PI Contribution Genetic and biochemical definition of patients with ethylmalonic encephalopathy and follow up of patients under pharmacological treatment or treated with liver transplantation.
Collaborator Contribution Clinical management of patients with ethylmalonic encephalopathy.
Impact Several papers in high impact journals.
Start Year 2010
 
Description Ferrero 
Organisation University of Parma
Department Department of Life Sciences
Country Italy 
Sector Academic/University 
PI Contribution Collaboration on modelling several human diseases in yeast.
Collaborator Contribution Provision of scientific material.
Impact ..
Start Year 2013
 
Description Jacobs 
Organisation Tampere University of Technology
Country Finland 
Sector Academic/University 
PI Contribution Creation of genetically defined recombinant mitochondrial disease mouse models.
Collaborator Contribution Creation of transgenic mice expressing alternative oxidases.
Impact ..
Start Year 2012
 
Description Mitochondrial Neurodegeneration 
Organisation German Centre for Neurodegenerative Diseases
Country Germany 
Sector Public 
PI Contribution We found a mutation in a family with neurodegeneration in PITRM1 a gene encoding a mitochondrial metalloprotease. We found accumulation of A-beta amyloid in a hemyzygous +/- mutant mouse for this gene. We have established a collaboration with Prof. Gasser to produce IPSC and programmed neuronal cell lines carrying the mutation and study the cell biology of abnormal PITRM1 function. We also plan to carry out a screening for PITRM1 variants in samples from patients with neurodegeneration provided by Prof. Gasser and other suitable sources.
Collaborator Contribution Prof. Gasser and his collaborators will give us access to the DZNE biobank of DNA samples from patients with neurodegeneration and will develop the cell biology section of the project.
Impact We have published one paper in EMBO Molecular Medicine at the end of 2015 reporting the PITRM1 mutation and the characterisation of the PITRM1 homozygous knockout mouse. No collaborative output with DNZE has been produced yet as the collaboration just started in 2016.
Start Year 2016
 
Description Professor Andrea Ballabio 
Organisation University of Naples
Department Medical School Naples
Country Italy 
Sector Academic/University 
PI Contribution Investigation of the phenotype of crosses between mouse models of mitochondrial disease and a transgenic mouse over-expressing TFEB, a master regulator of autophagy and lysosomal biogenesis.
Collaborator Contribution Creation and characterisation of a TFEB over-expressing mouse.
Impact Not yet.
Start Year 2012
 
Description Professor Cesare Galli 
Organisation University of Bologna
Country Italy 
Sector Academic/University 
PI Contribution Phenotypic characterisation of recombinant swine models for mitochondrial disease.
Collaborator Contribution Creation of recombinant swine models for mitochondrial disease.
Impact Not yet.
Start Year 2013
 
Description Professor Laurence Bindoff 
Organisation University of Bergen
Country Norway 
Sector Academic/University 
PI Contribution Biochemical and molecular characterisation of human mutant cell lines for POLG encoding the mitochondrial DNA polymerase. Characterisation of a knock out mouse model for PIPRM1 in mitochondrial protease.
Collaborator Contribution Identification and clinical characterisation of patients with POLG and PIPRM1 mutations. Neuropathological neuro imaging studies and creation of patient derived cell lines.
Impact Several papers in high impact journals.
 
Description Professor Luca Scorrano 
Organisation University of Padova
Country Italy 
Sector Academic/University 
PI Contribution Investigation of the effect of OPA1 over-expression on a genetic mouse model of severe mitochondrial myopathy.
Collaborator Contribution Creation of an OPA1 over-expressing transgenic mouse model.
Impact Two papers submitted to Cell Metabolism.
Start Year 2013
 
Description Professor Michael Hanna 
Organisation University College London
Department Faculty of Medical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Genetic investigation of patients and clinical trials for developing drug based therapies for mitochondrial diseases.
Collaborator Contribution Genetic investigation of patients and clinical trials for developing drug based therapies for mitochondrial diseases.
Impact Not yet.
Start Year 2013
 
Description Professor Robert Taylor 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Identification and characterisation of mitochondrial disease genes from patients' samples shared with partner organisation.
Collaborator Contribution Identification and characterisation of mitochondrial disease genes from patients' samples shared with partner organisation.
Impact Several papers in high impact journals.
Start Year 2012
 
Description Professor Rodolfo Costa 
Organisation University of Padova
Country Italy 
Sector Academic/University 
PI Contribution Biochemical characterisation of fly models of mitochondrial disorders.
Collaborator Contribution Creation of knock down flies for genes involved in oxidative phosphorylation.
Impact Several papers in high impact journals.
 
Description Professor Rosario Rizzuto 
Organisation University of Padova
Country Italy 
Sector Academic/University 
PI Contribution Provision of human cell lines and trans-mitochondrial cybrids from patients with different pathogenic mutations in mitochondrial DNA.
Collaborator Contribution Investigation of the autophagic and mitophagic flux in vivo.
Impact One paper submitted to Hum. Mol. Genet.
Start Year 2011
 
Description Prokisch 
Organisation Helmholtz Zentrum München
Department Institute of Human Genetics
Country Germany 
Sector Public 
PI Contribution Genetic screening of mitochondrial disease patients.
Collaborator Contribution Next generation sequencing of selected DNA samples.
Impact Numerous publications.
Start Year 2011
 
Description Ramon Marti-Sevres 
Organisation University of Barcelona
Country Spain 
Sector Academic/University 
PI Contribution Experimental trial on mouse models of a gene replacement therapy against MNGIE. Transfer of these observations in a clinical trial on patients.
Collaborator Contribution Creation of a mouse model for MNGIE and participation in the future clinical trial.
Impact One publication in Mol. Ther. More will follow.
Start Year 2012
 
Description AIM National Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to present current work.
Year(s) Of Engagement Activity 2016
 
Description Attendance at conferences and scientific meetings 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Various conferences throughout the year.

Potential collaborations; networking opportunities at which to promote the Unit/MRC/research.
Year(s) Of Engagement Activity 2013
 
Description Big Biology Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Members of the MRC MBU, with a guest from the MRC Cancer Unit, participated in the Big Biology Day 2016 at Hills Road Sixth Form College. Scientists explained the Unit's research with hands-on activities, such as crystallography, DNA sequencing puzzles and computer-based protein analysis.... and good use was made of the whiteboard!
Year(s) Of Engagement Activity 2016,2018
URL http://www.mrc-mbu.cam.ac.uk/news/2650/big-biology-day-2016
 
Description Bioenergetics Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact In house training lecture given to PhD Students on Mitochondrial Medicine. One hour lecture followed by one hour discussion group one week later.
Year(s) Of Engagement Activity 2016
 
Description Bologna University - Keynote Speaker 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited to deliver keynote speech
Year(s) Of Engagement Activity 2016
 
Description Broadening Horizons (Anglia Ruskin) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Careers fair for primary school students
Year(s) Of Engagement Activity 2016
 
Description Convention, Rome 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to present on specialist field in Mitochondrial Medicine.
Year(s) Of Engagement Activity 2016
 
Description Dissemination of scientific achievements via the internet 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Dissemination of scientific achievements and publications to the general public, scientists and others via Alpha Galileo, the Unit's website, Twitter and Facebook.

https://www.facebook.com/mrc.mbu/;
Twitter - @MRC_MBU; http://
www.mrc-mbu.cam.ac.uk/
http://www.alphagalileo.org/
http://www.mrc-mbu.cam.ac.uk/people/massimo-zeviani
Year(s) Of Engagement Activity 2015,2016,2017,2018
URL https://www.facebook.com/mrc.mbu/
 
Description EBEC ascientific Meeting. Garda 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to present.
Year(s) Of Engagement Activity 2016
 
Description Genetics Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact University College, London Genetics Meeting - Attendee
Year(s) Of Engagement Activity 2016
 
Description International Myopathies Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The workshop was designed to discuss ideas, generate new ideas for the future and catch up with current and new collaborators.
Year(s) Of Engagement Activity 2016
 
Description Key Note Speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact George Karpati Lecture, Montreal. Invitation to attend and deliver the keynote presentation.
Year(s) Of Engagement Activity 2016
 
Description Lectures on Mitochondrial Medicine at The Scuola Galileiana, University of Padova, Italy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Massimo Zeviani delivered eight lectures (titles below) in the Mitochondrial Biology and Genetics Lecture Series: joint initiative between the Galilean School of Higher Education and PhD Courses in Biosciences and Biomedical Sciences of the University of Padova.

Introduction to mitochondrial biology and mtDNA genetics; Mitochondria and the evoluation of eukaryotes; The respiratory chain and oxidative phosphorylation; Methods of investigation in mitochondrial disorders; Disorders of mitochondrial DNA; Disorders of nucleus-mitochondria cross talk; Nuclear-gene mutations and OXPHOS disorders; Mitochondrial dysfunction in medicine;

Impact: greater awareness.
Year(s) Of Engagement Activity 2015
 
Description MBU Annual Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Unit was opened to visitors for a tour and a series of talks on our research activities. Approximately 60 people attended.


Further interest from general public - they want to visit in 2015! Also, interest from sixth form science students in scientific careers. And the Unit was invited to participate in the Society of Biology's Big Biology Day (annually - October).
Year(s) Of Engagement Activity 2014,2015
URL http://www.mrc-mbu.cam.ac.uk/news/2335/open-day-2015
 
Description MEET (Mitochondrial European Education Training) Symposium 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact From bench to bedside, and back: Patients MEET Researchers - providing an opportunity for patients and scientists to meet and discuss mitochondrial diseases.
Year(s) Of Engagement Activity 2016
URL http://www.itn-meet.org/MEET-Symposium-2016
 
Description MRC MBU Annual Open Day (MRC Festival of Medical Research) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Overview of work at the MRC MBU; explanations of how mitochondrial dysfunction causes mitochondrial diseases. Audience: Secondary school students, tutors, general public and scientists from neighbouring institutes. Impact: increased awareness.
Year(s) Of Engagement Activity 2015,2016,2017
URL http://www.mrc-mbu.cam.ac.uk/news/2335/open-day-2015
 
Description MRC MBU Centenary Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact To celebrate the Centenary of the Medical Research Council, the Mitochondrial Biology Unit opened its doors to the public on 20 June for demonstrations and presentations based on the theme 'How do we get energy out of food?'.

Visitors were shown three presentations explaining where energy comes from, how it is 'stored' in chemical bonds, how energy is released during the breakdown of food and used to generate the cellular energy currency ATP, and what happens when these complex processes fail in mitochondrial dysfunction and disease. Visitors were also invited to view mitochondria in human cells, observing the complex networks they form.

For most of our visitors, this was the first time that they had been inside the Unit and their feedback indicated that there was a high level of interest in mitochondria, how they work, and what important roles they play in the body. Our visitors came from a cross-section of the local and wider community, and they were very interested to learn about our research through talks and informative diagrams and images.

Attendees: 22
Staff: 5
Students: 9


Interest was generated from schools (proposed visits) and from members of the general public. The Unit will be holding similar events in the future.
Year(s) Of Engagement Activity 2013
 
Description Media interest 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Provision of an image to the BBC for Professor Brian Cox's "Human Universe" series.

Not yet known.
Year(s) Of Engagement Activity 2014
 
Description Mitochondrial Medicine Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Part of the organising committee for a large Mitochondrial Medicine Conference held at Hinxton Hall.
Year(s) Of Engagement Activity 2016
 
Description Networking meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact Two day collaboration and network meeting to strengthen working relationships between Cambridge University and Colleague in Newcastle University
Year(s) Of Engagement Activity 2016
 
Description Public Engagement Training 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Topics covered: Who are the public and what do they think?
Understanding body language
Intentions and measuring success
Engagement in practice - case studies/experiences
Places to find further support and methods to engage further
Year(s) Of Engagement Activity 2017
 
Description Remix Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact First of many meeting in regards to the Remix Project. An ongoing commitment.
Year(s) Of Engagement Activity 2016
 
Description Research Sympoisum 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited to this workshop to further strengthen collaboration relationships and discuss current science
Year(s) Of Engagement Activity 2016
 
Description SIN Congress Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited to attend conference as specialist in field of Mitochondrial Medicine.
Year(s) Of Engagement Activity 2016
 
Description SSIEM Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to present Keynote Speach
Year(s) Of Engagement Activity 2016
 
Description Science Day - Queen Edith's Primary School, Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Members of the MBU visited Queen Edith's Primary School, Cambridge to participate in their Science Day. This was a carousel-type event, with students in years 1-4 rotating around the room. The demonstrations included Lego models, computer games, pipetting and DNA sequencing puzzles. Feedback from a teacher: Thank you so much for coming here today. The children have not stopped talking about it since leaving the room.
Year(s) Of Engagement Activity 2017
 
Description Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Invited to deliver a presentation in Oxford for the Harwell Seminar
Year(s) Of Engagement Activity 2016
 
Description St Mary's School, Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact The aims of the event was to give Year 5 and 6 students a greater insight into some of the career options available to them so that they are better informed in advance of making career choices.
Year(s) Of Engagement Activity 2017,2018
URL http://www.mrc-mbu.cam.ac.uk/news/2765/careers-carousel-st-marys-school-cambridge
 
Description Symposium attendance 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited to present current work in the field of Mitochondrial Medicine.
Year(s) Of Engagement Activity 2016
 
Description The Big Bang Fair Eastern 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Computer games aimed at understanding mitochondrial dysfunction, Posters explaining the science, Movies.

Impact: increased awareness. Feedback: Thank you for your email, it was lovely to meet you all too. The girls had a lovely time. I am happy to let you know that the school gives permission for you to use the image. Thank you also for inspiring and educating our girls.
Year(s) Of Engagement Activity 2015,2016,2017
URL http://nearme.thebigbangfair.co.uk/eastern/
 
Description University of Cambridge Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Demonstrating how mitochondrial dysfunction leads to illness and giving insight into the work of the MBU.

?The whole CSF presence in the Clinical School was excellent, and the MRC's contribution was very much appreciated. 

Interest in attending the Unit's open day in June.
Year(s) Of Engagement Activity 2015,2016,2017,2018
URL http://www.sciencefestival.cam.ac.uk/about/past-festivals/2015-cambridge-science-festival
 
Description Website videos 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Participation in video filming for MBU website (Cambridge TV)
Year(s) Of Engagement Activity 2016
 
Description Work Experience 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Visit by three Year 10 students (age 15) to the Unit for one week each - work experience/shadowing in various research groups/environments, chaperoned throughout by individual members of the Unit. Presentation by the visitors at the end of the week.
Year(s) Of Engagement Activity 2016,2017
 
Description Workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact EMBO Workshop held in Tammsvik.
Year(s) Of Engagement Activity 2016